sumatriptan-naproxen
(IGRAQVLKCQVBQA-DBQHITQZSA-M)
Structure
- SMILES
- OC(=O)CCC(=O)O.CNS(=O)(=O)Cc1ccc2c(c1)c(CCN(C)C)c[nH]2.COc1ccc2c(c1)ccc(c2)[C@@H](C(=O)[O-])C.[Na+]
- Molecular Formula:
- C32H40N3NaO9S
- Molecular Weight:
- 665.729
- Log P:
- 4.4305
- Hydrogen Bond Acceptor:
- 11
- Hydrogen Bond Donor:
- 4
- TPSA:
- 197.54
- CAS Number(s):
- 811794-26-0
Synonym(s)
1.
sumatriptan-naproxen
2.
Treximet
External Link(s)
| MeSH | C000611385 |
| PubChem Compound | 23709079 |
| Therapeutic Target Database | D07NJI |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Nausea | FAERS: 47 | US FAERS | |
| 2 | Drug ineffective | FAERS: 38 | US FAERS | |
| 3 | Dizziness | FAERS: 29 | US FAERS | |
| 4 | Vomiting | FAERS: 24 | US FAERS | |
| 5 | Chest Pain | FAERS: 21 | US FAERS | |
| 6 | Chest discomfort | FAERS: 17 | US FAERS | |
| 7 | Headache | FAERS: 16 | US FAERS | |
| 8 | Burning sensation | FAERS: 15 | US FAERS | |
| 9 | Palpitations | FAERS: 15 | US FAERS | |
| 10 | Hypersensitivity | FAERS: 14 | US FAERS | |
| 11 | Malaise | FAERS: 14 | US FAERS | |
| 12 | Feeling abnormal | FAERS: 13 | US FAERS | |
| 13 | Myalgia | FAERS: 12 | US FAERS | |
| 14 | Anxiety | FAERS: 11 | US FAERS | |
| 15 | Dyspepsia | FAERS: 9 | US FAERS | |
| 16 | Drug administration error | FAERS: 8 | US FAERS | |
| 17 | Muscle tightness | FAERS: 8 | US FAERS | |
| 18 | Pain | FAERS: 8 | US FAERS | |
| 19 | Myocardial Infarction | FAERS: 7 | US FAERS | |
| 20 | Neck Pain | FAERS: 7 | US FAERS | |
| 21 | Nonspecific reaction | FAERS: 7 | US FAERS | |
| 22 | Somnolence | FAERS: 7 | US FAERS | |
| 23 | Adverse event | FAERS: 6 | US FAERS | |
| 24 | Arthralgia | FAERS: 6 | US FAERS | |
| 25 | Fatigue | FAERS: 6 | US FAERS | |
| 26 | Product quality issue | FAERS: 6 | US FAERS | |
| 27 | Pruritus | FAERS: 6 | US FAERS | |
| 28 | Tremor | FAERS: 6 | US FAERS | |
| 29 | Urticaria | FAERS: 6 | US FAERS | |
| 30 | Abdominal discomfort | FAERS: 5 | US FAERS | |
| 31 | Ageusia | FAERS: 5 | US FAERS | |
| 32 | Overdose | FAERS: 5 | US FAERS | |
| 33 | Stevens-Johnson Syndrome | FAERS: 5 | US FAERS | |
| 34 | Swelling | FAERS: 5 | US FAERS | |
| 35 | Asthenia | FAERS: 4 | US FAERS | |
| 36 | Flushing | FAERS: 4 | US FAERS | |
| 37 | Musculoskeletal Pain | FAERS: 4 | US FAERS | |
| 38 | Nasal discomfort | FAERS: 4 | US FAERS | |
| 39 | Wrong technique in drug usage process | FAERS: 4 | US FAERS | |
| 40 | Asthma | FAERS: 3 | US FAERS | |
| 41 | Cyanosis | FAERS: 3 | US FAERS | |
| 42 | Gastritis | FAERS: 3 | US FAERS | |
| 43 | Impaired work ability | FAERS: 3 | US FAERS | |
| 44 | Lip swelling | FAERS: 3 | US FAERS | |
| 45 | Oropharyngeal pain | FAERS: 3 | US FAERS | |
| 46 | Unevaluable event | FAERS: 3 | US FAERS | |
| 47 | Abdominal Pain | FAERS: 2 | US FAERS | |
| 48 | Acute myocardial infarction | FAERS: 2 | US FAERS | |
| 49 | Angina Pectoris | FAERS: 2 | US FAERS | |
| 50 | Back Pain | FAERS: 2 | US FAERS | |
| 51 | Cold sweat | FAERS: 2 | US FAERS | |
| 52 | Discomfort | FAERS: 2 | US FAERS | |
| 53 | Disorientation | FAERS: 2 | US FAERS | |
| 54 | Erythema | FAERS: 2 | US FAERS | |
| 55 | Feeling jittery | FAERS: 2 | US FAERS | |
| 56 | Mental impairment | FAERS: 2 | US FAERS | |
| 57 | Musculoskeletal discomfort | FAERS: 2 | US FAERS | |
| 58 | Musculoskeletal stiffness | FAERS: 2 | US FAERS | |
| 59 | Nervousness | FAERS: 2 | US FAERS | |
| 60 | Performance status decreased | FAERS: 2 | US FAERS | |
| 61 | Prescribed overdose | FAERS: 2 | US FAERS | |
| 62 | Serotonin Syndrome | FAERS: 2 | US FAERS | |
| 63 | Skin lesion | FAERS: 2 | US FAERS | |
| 64 | Therapeutic response delayed | FAERS: 2 | US FAERS | |
| 65 | Throat irritation | FAERS: 2 | US FAERS | |
| 66 | Ulcer | FAERS: 2 | US FAERS | |
| 67 | Abasia | FAERS: 1 | US FAERS | |
| 68 | Accidental overdose | FAERS: 1 | US FAERS | |
| 69 | Agitation | FAERS: 1 | US FAERS | |
| 70 | Allergic respiratory symptom | FAERS: 1 | US FAERS | |
| 71 | Angioedema | FAERS: 1 | US FAERS | |
| 72 | Aphagia | FAERS: 1 | US FAERS | |
| 73 | Blood glucose decreased | FAERS: 1 | US FAERS | |
| 74 | Blood urine present | FAERS: 1 | US FAERS | |
| 75 | Bone pain | FAERS: 1 | US FAERS | |
| 76 | Breast tenderness | FAERS: 1 | US FAERS | |
| 77 | Cardiac enzymes increased | FAERS: 1 | US FAERS | |
| 78 | Crying | FAERS: 1 | US FAERS | |
| 79 | Dehydration | FAERS: 1 | US FAERS | |
| 80 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 81 | Diverticulum | FAERS: 1 | US FAERS | |
| 82 | Dreamy state | FAERS: 1 | US FAERS | |
| 83 | Drug abuse | FAERS: 1 | US FAERS | |
| 84 | Drug screen positive | FAERS: 1 | US FAERS | |
| 85 | Dysarthria | FAERS: 1 | US FAERS | |
| 86 | Dysgraphia | FAERS: 1 | US FAERS | |
| 87 | Ejection Fraction Decreased | FAERS: 1 | US FAERS | |
| 88 | Enteritis | FAERS: 1 | US FAERS | |
| 89 | Expired drug administered | FAERS: 1 | US FAERS | |
| 90 | Eye pain | FAERS: 1 | US FAERS | |
| 91 | Eyelid pain | FAERS: 1 | US FAERS | |
| 92 | Facial Paresis | FAERS: 1 | US FAERS | |
| 93 | Gastric ulcer | FAERS: 1 | US FAERS | |
| 94 | Genital pain | FAERS: 1 | US FAERS | |
| 95 | Hyperventilation | FAERS: 1 | US FAERS | |
| 96 | Hypoaesthesia facial | FAERS: 1 | US FAERS | |
| 97 | Hypotension | FAERS: 1 | US FAERS | |
| 98 | Impaired driving ability | FAERS: 1 | US FAERS | |
| 99 | Incorrect dose administered | FAERS: 1 | US FAERS | |
| 100 | Incorrect drug administration duration | FAERS: 1 | US FAERS | |
| 101 | Incorrect drug dosage form administered | FAERS: 1 | US FAERS | |
| 102 | Mastication disorder | FAERS: 1 | US FAERS | |
| 103 | Medication Error | FAERS: 1 | US FAERS | |
| 104 | Medication overuse headache | FAERS: 1 | US FAERS | |
| 105 | Middle insomnia | FAERS: 1 | US FAERS | |
| 106 | Monoplegia | FAERS: 1 | US FAERS | |
| 107 | Muscle Fatigue | FAERS: 1 | US FAERS | |
| 108 | Mydriasis | FAERS: 1 | US FAERS | |
| 109 | No adverse event | FAERS: 1 | US FAERS | |
| 110 | Oropharyngeal discomfort | FAERS: 1 | US FAERS | |
| 111 | Pityriasis Rosea | FAERS: 1 | US FAERS | |
| 112 | Post-Traumatic Stress Disorder | FAERS: 1 | US FAERS | |
| 113 | Product label issue | FAERS: 1 | US FAERS | |
| 114 | Product physical issue | FAERS: 1 | US FAERS | |
| 115 | Rash erythematous | FAERS: 1 | US FAERS | |
| 116 | Renal pain | FAERS: 1 | US FAERS | |
| 117 | Respiratory arrest | FAERS: 1 | US FAERS | |
| 118 | Serum Sickness | FAERS: 1 | US FAERS | |
| 119 | Sinusitis | FAERS: 1 | US FAERS | |
| 120 | Syncope | FAERS: 1 | US FAERS | |
| 121 | Tachycardia | FAERS: 1 | US FAERS | |
| 122 | Tension Headache | FAERS: 1 | US FAERS | |
| 123 | Therapeutic response changed | FAERS: 1 | US FAERS | |
| 124 | Therapeutic response unexpected | FAERS: 1 | US FAERS | |
| 125 | Therapy cessation | FAERS: 1 | US FAERS | |
| 126 | Tinnitus | FAERS: 1 | US FAERS | |
| 127 | Toxicity to various agents | FAERS: 1 | US FAERS | |
| 128 | Trismus | FAERS: 1 | US FAERS | |
| 129 | Vasospasm | FAERS: 1 | US FAERS | |
| 130 | Vertigo | FAERS: 1 | US FAERS | |
| 131 | Weight decreased | FAERS: 1 | US FAERS | |
| 132 | Wrong technique in product usage process | FAERS: 1 | US FAERS |
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