Mechlorethamine
(HAWPXGHAZFHHAD-UHFFFAOYSA-N)
Structure
- SMILES
- ClCCN(CCCl)C
- Type(s)
- Approved; Investigational
- ATC code(s)
- L01AA05
- Molecular Formula:
- C5H11Cl2N
- Molecular Weight:
- 156.054
- Log P:
- 1.3958
- Hydrogen Bond Acceptor:
- 1
- Hydrogen Bond Donor:
- 0
- TPSA:
- 3.24
- CAS Number(s):
- 51-75-2
Synonym(s)
1.
Mechlorethamine
2.
Chlorethazine
3.
Chlormethine
4.
Mechlorethamine Oxide
5.
Mustine
6.
Nitrogen Mustard
7.
Nitrogen Mustard N-Oxide
8.
Bis(2-chloroethyl)methylamine
9.
Caryolysine
10.
Cloramin
11.
Embichin
12.
Mechlorethamine Hydrochloride
13.
Mechlorethamine Hydrochloride N-Oxide
14.
Mechlorethamine N-Oxide
15.
Methylchlorethamine
16.
Mitomen
17.
Mustargen
18.
NSC-10107
19.
NSC-762
20.
Nitrogranulogen
21.
Nitromin
22.
Hydrochloride N-Oxide, Mechlorethamine
23.
Hydrochloride, Mechlorethamine
24.
Mechlorethamine Hydrochloride N Oxide
25.
Mechlorethamine N Oxide
26.
N-Oxide, Mechlorethamine Hydrochloride
27.
N-Oxide, Nitrogen Mustard
28.
NSC 10107
29.
NSC 762
30.
NSC10107
31.
NSC762
32.
Nitrogen Mustard N Oxide
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Pruritus | FAERS: 145 | US FAERS | |
| 2 | Application site pruritus | FAERS: 100 | US FAERS | |
| 3 | Application site erythema | FAERS: 88 | US FAERS | |
| 4 | Erythema | FAERS: 88 | US FAERS | |
| 5 | Application site pain | FAERS: 75 | US FAERS | |
| 6 | Skin irritation | FAERS: 55 | US FAERS | |
| 7 | Disease Progression | FAERS: 46 | US FAERS | |
| 8 | Dry skin | FAERS: 43 | US FAERS | |
| 9 | Therapy non-responder | FAERS: 43 | US FAERS | |
| 10 | Application site irritation | FAERS: 35 | US FAERS | |
| 11 | Drug ineffective | FAERS: 30 | US FAERS | |
| 12 | Malaise | FAERS: 29 | US FAERS | |
| 13 | Mycosis Fungoides | FAERS: 23 | US FAERS | |
| 14 | Pain | FAERS: 20 | US FAERS | |
| 15 | Skin lesion | FAERS: 20 | US FAERS | |
| 16 | Application site vesicles | FAERS: 19 | US FAERS | |
| 17 | Application site burn | FAERS: 18 | US FAERS | |
| 18 | Pain of skin | FAERS: 18 | US FAERS | |
| 19 | Application site rash | FAERS: 17 | US FAERS | |
| 20 | Drug dose omission | FAERS: 17 | US FAERS | |
| 21 | Nasopharyngitis | FAERS: 17 | US FAERS | |
| 22 | Nausea | FAERS: 17 Canada Vigilance: 1 | 5067790 | CTD Canada Vigilance US FAERS |
| 23 | Burning sensation | FAERS: 15 | US FAERS | |
| 24 | Fatigue | FAERS: 15 | US FAERS | |
| 25 | Headache | FAERS: 15 | 7049028 | CTD US FAERS |
| 26 | Hypersensitivity | FAERS: 15 | US FAERS | |
| 27 | Scab | FAERS: 15 | US FAERS | |
| 28 | Dermatitis | FAERS: 14 | US FAERS | |
| 29 | Occupational exposure to product | FAERS: 14 | US FAERS | |
| 30 | Application site swelling | FAERS: 13 | US FAERS | |
| 31 | Alopecia | FAERS: 12 | US FAERS | |
| 32 | Application site dryness | FAERS: 12 | US FAERS | |
| 33 | Intentional dose omission | FAERS: 12 | US FAERS | |
| 34 | Application site discharge | FAERS: 11 | US FAERS | |
| 35 | Application site reaction | FAERS: 11 | US FAERS | |
| 36 | Eye irritation | FAERS: 11 | US FAERS | |
| 37 | Malignant neoplasm progression | FAERS: 11 | US FAERS | |
| 38 | Skin Erosion | FAERS: 11 | US FAERS | |
| 39 | Application site exfoliation | FAERS: 10 | US FAERS | |
| 40 | Pneumonia | FAERS: 10 | 20883710 | CTD US FAERS |
| 41 | Skin Ulcer | FAERS: 10 | 18930110 | CTD US FAERS |
| 42 | Application site scab | FAERS: 9 | US FAERS | |
| 43 | Back Pain | FAERS: 9 | US FAERS | |
| 44 | Product dose omission | FAERS: 9 | US FAERS | |
| 45 | Skin reaction | FAERS: 9 | US FAERS | |
| 46 | Vomiting | FAERS: 9 Canada Vigilance: 2 | 5067790 | CTD Canada Vigilance US FAERS |
| 47 | Musculoskeletal stiffness | FAERS: 8 | US FAERS | |
| 48 | Therapy cessation | FAERS: 8 | US FAERS | |
| 49 | Asthenia | FAERS: 7 | US FAERS | |
| 50 | Influenza | FAERS: 7 | US FAERS | |
| 51 | Nasal discomfort | FAERS: 7 | US FAERS | |
| 52 | Peripheral swelling | FAERS: 7 | US FAERS | |
| 53 | Swelling | FAERS: 7 | US FAERS | |
| 54 | Application site papules | FAERS: 6 | US FAERS | |
| 55 | Expired product administered | FAERS: 6 | US FAERS | |
| 56 | Inflammation | FAERS: 6 | 18930110 22981630 | CTD US FAERS |
| 57 | Night sweats | FAERS: 6 | US FAERS | |
| 58 | Rash erythematous | FAERS: 6 | US FAERS | |
| 59 | Skin hypertrophy | FAERS: 6 | US FAERS | |
| 60 | Thermal burn | FAERS: 6 | US FAERS | |
| 61 | Unevaluable event | FAERS: 6 | US FAERS | |
| 62 | Urticaria | FAERS: 6 | US FAERS | |
| 63 | Ankle Fracture | FAERS: 5 | US FAERS | |
| 64 | Application site inflammation | FAERS: 5 | US FAERS | |
| 65 | Application site warmth | FAERS: 5 | US FAERS | |
| 66 | Cerebrovascular accident | FAERS: 5 | US FAERS | |
| 67 | Dizziness | FAERS: 5 | US FAERS | |
| 68 | Feeling abnormal | FAERS: 5 | US FAERS | |
| 69 | Inappropriate schedule of drug administration | FAERS: 5 | US FAERS | |
| 70 | Memory impairment | FAERS: 5 | US FAERS | |
| 71 | Nervousness | FAERS: 5 | US FAERS | |
| 72 | Product storage error | FAERS: 5 | US FAERS | |
| 73 | Skin weeping | FAERS: 5 | US FAERS | |
| 74 | Abdominal discomfort | FAERS: 4 | US FAERS | |
| 75 | Accidental exposure to product | FAERS: 4 | US FAERS | |
| 76 | Cataract | FAERS: 4 | US FAERS | |
| 77 | Cystitis | FAERS: 4 | US FAERS | |
| 78 | Drug administration error | FAERS: 4 | US FAERS | |
| 79 | General physical health deterioration | FAERS: 4 | US FAERS | |
| 80 | Joint stiffness | FAERS: 4 | US FAERS | |
| 81 | Mycosis fungoides recurrent | FAERS: 4 | US FAERS | |
| 82 | No adverse event | FAERS: 4 | US FAERS | |
| 83 | Product quality issue | FAERS: 4 | US FAERS | |
| 84 | Skin texture abnormal | FAERS: 4 | US FAERS | |
| 85 | Tinea Pedis | FAERS: 4 | US FAERS | |
| 86 | Urinary tract infection | FAERS: 4 | US FAERS | |
| 87 | skin abrasion | FAERS: 4 | US FAERS | |
| 88 | Adverse event | FAERS: 3 | US FAERS | |
| 89 | Application site erosion | FAERS: 3 | US FAERS | |
| 90 | Application site fissure | FAERS: 3 | US FAERS | |
| 91 | Application site wound | FAERS: 3 | US FAERS | |
| 92 | Arthralgia | FAERS: 3 | US FAERS | |
| 93 | Blood glucose increased | FAERS: 3 | US FAERS | |
| 94 | Bronchitis | FAERS: 3 | US FAERS | |
| 95 | Cardiac Flutter | FAERS: 3 | US FAERS | |
| 96 | Cellulitis | FAERS: 3 | US FAERS | |
| 97 | Discomfort | FAERS: 3 | US FAERS | |
| 98 | Exposure via direct contact | FAERS: 3 | US FAERS | |
| 99 | Inappropriate schedule of product administration | FAERS: 3 | US FAERS | |
| 100 | Infection | FAERS: 3 | US FAERS | |
| 101 | Intentional product misuse | FAERS: 3 | US FAERS | |
| 102 | Lymphadenopathy | FAERS: 3 | US FAERS | |
| 103 | Metastatic Neoplasm | FAERS: 3 | US FAERS | |
| 104 | Myalgia | FAERS: 3 | US FAERS | |
| 105 | Myocardial Infarction | FAERS: 3 | US FAERS | |
| 106 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 107 | Pregnancy of partner | FAERS: 3 | US FAERS | |
| 108 | Sinusitis | FAERS: 3 | US FAERS | |
| 109 | Abasia | FAERS: 2 | US FAERS | |
| 110 | Abdominal Pain | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 111 | Accidental exposure to product by child | FAERS: 2 | US FAERS | |
| 112 | Accidental overdose | FAERS: 2 | US FAERS | |
| 113 | Acne | FAERS: 2 | US FAERS | |
| 114 | Acute kidney injury | FAERS: 2 | US FAERS | |
| 115 | Application site hypertrophy | FAERS: 2 | US FAERS | |
| 116 | Atrial tachycardia | FAERS: 2 | US FAERS | |
| 117 | Atypical mycobacterium test positive | FAERS: 2 | US FAERS | |
| 118 | Bacterial sepsis | FAERS: 2 | US FAERS | |
| 119 | Chemical burn of skin | FAERS: 2 | US FAERS | |
| 120 | Chemotherapy | FAERS: 2 | US FAERS | |
| 121 | Chest Pain | FAERS: 2 | US FAERS | |
| 122 | Depressed mood | FAERS: 2 | US FAERS | |
| 123 | Diabetes Mellitus | FAERS: 2 | US FAERS | |
| 124 | Drain placement | FAERS: 2 | US FAERS | |
| 125 | Dysarthria | FAERS: 2 | US FAERS | |
| 126 | Dyschezia | FAERS: 2 | US FAERS | |
| 127 | Dysuria | FAERS: 2 | US FAERS | |
| 128 | Ear discomfort | FAERS: 2 | US FAERS | |
| 129 | Exposure via inhalation | FAERS: 2 | US FAERS | |
| 130 | Extra dose administered | FAERS: 2 | US FAERS | |
| 131 | Eye pain | FAERS: 2 | US FAERS | |
| 132 | Failure to Thrive | FAERS: 2 | US FAERS | |
| 133 | Hypotension | FAERS: 2 | US FAERS | |
| 134 | Impaired work ability | FAERS: 2 | US FAERS | |
| 135 | Infectious Mononucleosis | FAERS: 2 | US FAERS | |
| 136 | Lower respiratory tract infection | FAERS: 2 | US FAERS | |
| 137 | Medication Error | FAERS: 2 | US FAERS | |
| 138 | Nonspecific reaction | FAERS: 2 | US FAERS | |
| 139 | Product container issue | FAERS: 2 | US FAERS | |
| 140 | Productive Cough | FAERS: 2 | US FAERS | |
| 141 | Respiratory Failure | FAERS: 2 | US FAERS | |
| 142 | Rhabdomyolysis | FAERS: 2 | US FAERS | |
| 143 | Skin Induration | FAERS: 2 | US FAERS | |
| 144 | Skin Papilloma | FAERS: 2 | US FAERS | |
| 145 | Spinal column injury | FAERS: 2 | US FAERS | |
| 146 | Squamous cell carcinoma | FAERS: 2 | US FAERS | |
| 147 | Sunburn | FAERS: 2 | US FAERS | |
| 148 | Therapy partial responder | FAERS: 2 | US FAERS | |
| 149 | Thrombosis | FAERS: 2 | US FAERS | |
| 150 | Tooth Extraction | FAERS: 2 | US FAERS | |
| 151 | Tooth Infection | FAERS: 2 | US FAERS | |
| 152 | Tremor | FAERS: 2 | 7049028 | CTD US FAERS |
| 153 | Visual Impairment | FAERS: 2 | US FAERS | |
| 154 | Weight decreased | FAERS: 2 | US FAERS | |
| 155 | Wrong technique in product usage process | FAERS: 2 | US FAERS | |
| 156 | cancer surgery | FAERS: 2 | US FAERS | |
| 157 | Abscess | FAERS: 1 | US FAERS | |
| 158 | Anxiety | FAERS: 1 | US FAERS | |
| 159 | Application site discomfort | FAERS: 1 | US FAERS | |
| 160 | Application site hypersensitivity | FAERS: 1 | US FAERS | |
| 161 | Application site induration | FAERS: 1 | US FAERS | |
| 162 | Application site infection | FAERS: 1 | US FAERS | |
| 163 | Application site scar | FAERS: 1 | US FAERS | |
| 164 | Application site ulcer | FAERS: 1 | US FAERS | |
| 165 | Application site urticaria | FAERS: 1 | US FAERS | |
| 166 | Arthritis | FAERS: 1 | US FAERS | |
| 167 | Atrial Fibrillation | FAERS: 1 | US FAERS | |
| 168 | Bed rest | FAERS: 1 | US FAERS | |
| 169 | Biopsy | FAERS: 1 | US FAERS | |
| 170 | Blood glucose decreased | FAERS: 1 | US FAERS | |
| 171 | Blood urine present | FAERS: 1 | US FAERS | |
| 172 | Cartilage injury | FAERS: 1 | US FAERS | |
| 173 | Colitis | FAERS: 1 | US FAERS | |
| 174 | Cystoscopy | FAERS: 1 | US FAERS | |
| 175 | Cyst | FAERS: 1 | US FAERS | |
| 176 | Dehydration | FAERS: 1 | US FAERS | |
| 177 | Disorientation | FAERS: 1 | US FAERS | |
| 178 | Diverticulitis | FAERS: 1 | US FAERS | |
| 179 | Dysphonia | FAERS: 1 | US FAERS | |
| 180 | Eczema weeping | FAERS: 1 | US FAERS | |
| 181 | Endodontic procedure | FAERS: 1 | US FAERS | |
| 182 | Excoriation | FAERS: 1 | US FAERS | |
| 183 | Eye Burns | FAERS: 1 | US FAERS | |
| 184 | Facial paralysis | FAERS: 1 | US FAERS | |
| 185 | Food Allergy | FAERS: 1 | US FAERS | |
| 186 | Formication | FAERS: 1 | US FAERS | |
| 187 | Gout | FAERS: 1 | US FAERS | |
| 188 | Immune thrombocytopenic purpura | FAERS: 1 | US FAERS | |
| 189 | Impaired driving ability | FAERS: 1 | US FAERS | |
| 190 | Intestinal resection | FAERS: 1 | US FAERS | |
| 191 | Joint swelling | FAERS: 1 | US FAERS | |
| 192 | Limb discomfort | FAERS: 1 | US FAERS | |
| 193 | Limb fracture | FAERS: 1 | US FAERS | |
| 194 | Lip swelling | FAERS: 1 | US FAERS | |
| 195 | Macule | FAERS: 1 | US FAERS | |
| 196 | Medical device implantation | FAERS: 1 | US FAERS | |
| 197 | Mental status changes | FAERS: 1 | US FAERS | |
| 198 | Metastasis | FAERS: 1 | US FAERS | |
| 199 | Micrographic skin surgery | FAERS: 1 | US FAERS | |
| 200 | Miliaria | FAERS: 1 | US FAERS | |
| 201 | Miscarriage of partner | FAERS: 1 | US FAERS | |
| 202 | Muscle Fatigue | FAERS: 1 | US FAERS | |
| 203 | Mycosis fungoides refractory | FAERS: 1 | US FAERS | |
| 204 | Mycosis fungoides stage IV | FAERS: 1 | US FAERS | |
| 205 | Nephrectomy | FAERS: 1 | US FAERS | |
| 206 | Neuralgia | FAERS: 1 | US FAERS | |
| 207 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 208 | Oropharyngeal surgery | FAERS: 1 | US FAERS | |
| 209 | Papule | FAERS: 1 | US FAERS | |
| 210 | Paternal exposure during pregnancy | FAERS: 1 | US FAERS | |
| 211 | Piloerection | FAERS: 1 | US FAERS | |
| 212 | Product administered at inappropriate site | FAERS: 1 | US FAERS | |
| 213 | Psoriasis | FAERS: 1 | US FAERS | |
| 214 | Pulmonary thrombosis | FAERS: 1 | US FAERS | |
| 215 | Purulent discharge | FAERS: 1 | US FAERS | |
| 216 | Renal mass | FAERS: 1 | US FAERS | |
| 217 | Sepsis | FAERS: 1 | 4688040 | CTD US FAERS |
| 218 | Skin tightness | FAERS: 1 | US FAERS | |
| 219 | Sleep disorder due to a general medical condition | FAERS: 1 | US FAERS | |
| 220 | Slow speech | FAERS: 1 | US FAERS | |
| 221 | Sluggishness | FAERS: 1 | US FAERS | |
| 222 | Sneezing | FAERS: 1 | US FAERS | |
| 223 | Superinfection | FAERS: 1 | US FAERS | |
| 224 | Symptom recurrence | FAERS: 1 | US FAERS | |
| 225 | Systemic bacterial infection | FAERS: 1 | US FAERS | |
| 226 | T-Cell Lymphoma | FAERS: 1 | US FAERS | |
| 227 | Therapeutic product ineffective | FAERS: 1 | US FAERS | |
| 228 | Therapy change | FAERS: 1 | US FAERS | |
| 229 | Throat irritation | FAERS: 1 | US FAERS | |
| 230 | Unintentional use for unapproved indication | FAERS: 1 | US FAERS | |
| 231 | Upper respiratory tract congestion | FAERS: 1 | US FAERS | |
| 232 | Ureteral stent insertion | FAERS: 1 | US FAERS | |
| 233 | Viral upper respiratory tract infection | FAERS: 1 | US FAERS | |
| 234 | Wound Complication | FAERS: 1 | US FAERS | |
| 235 | furuncle | FAERS: 1 | US FAERS | |
| 236 | Acute Lung Injury | 26273949 30060251 | CTD | |
| 237 | Brain Diseases | 6385604 | CTD | |
| 238 | Brain Edema | 19847756 | CTD | |
| 239 | Bronchiolitis | 20883710 | CTD | |
| 240 | Cold sweat | Canada Vigilance: 1 | Canada Vigilance | |
| 241 | Confusion | 7049028 | CTD | |
| 242 | Deafness | 3753658 | CTD | |
| 243 | Dementia | 7049028 | CTD | |
| 244 | Dysgeusia | Canada Vigilance: 1 | Canada Vigilance | |
| 245 | Edema | 7308258 | CTD | |
| 246 | Fever | 5013538 | CTD | |
| 247 | Gastrointestinal Diseases | 6089632 | CTD | |
| 248 | Hallucinations | 7049028 | CTD | |
| 249 | Hematuria | 6250267 | CTD | |
| 250 | Hemorrhage | 7308258 | CTD | |
| 251 | Hodgkin Disease | CTD | ||
| 252 | Hydrocephalus | 5013538 | CTD | |
| 253 | Laryngospasm | Canada Vigilance: 1 | Canada Vigilance | |
| 254 | Leukopenia | Canada Vigilance: 1 | Canada Vigilance | |
| 255 | Lung Injury | 26243812 | CTD | |
| 256 | Lung diseases | 22981630 | CTD | |
| 257 | Myelitis, Transverse | 4688040 | CTD | |
| 258 | Nerve Degeneration | 19847756 | CTD | |
| 259 | Neutropenia | Canada Vigilance: 1 | Canada Vigilance | |
| 260 | Neutrophil Chemotactic Response, Abnormal | 23845566 | CTD | |
| 261 | Paraplegia | 7049028 | CTD | |
| 262 | Peritonitis | 4688040 | CTD | |
| 263 | Pseudomonas Infections | 4688040 | CTD | |
| 264 | Pulmonary Fibrosis | 4688040 26273949 | CTD | |
| 265 | Seizures | 7049028 | CTD | |
| 266 | Vertigo | 7049028 | CTD |
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