Drug Tolerance
(UMLS:C0013220)
- Definition:
- Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
- UMLS ID:
- C0013220
- MeSH ID:
- D004361
Classification:
- Physiological Phenomena
- MeSH Tree Number(s):
- G07.690.773.992
Synonym(s)
1.
Drug Tolerance
2.
Drug tolerance
3.
Drug tolerance, NOS
4.
Tolerance
5.
drug tolerance
6.
drug tolerances
7.
drugs tolerance
Associated Drug(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination | FAERS: 160 Canada Vigilance: 9 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 2 | Fentanyl | FAERS: 54 | OFFSIDES US FAERS | |
| 3 | Pregabalin | FAERS: 49 | US FAERS | |
| 4 | Alprazolam | FAERS: 38 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 5 | Gabapentin | FAERS: 33 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 6 | Modafinil | FAERS: 32 | US FAERS | |
| 7 | 4-hydroxybutyric acid | FAERS: 29 | US FAERS | |
| 8 | Buprenorphine | FAERS: 27 | US FAERS | |
| 9 | fexofenadine | FAERS: 23 | US FAERS | |
| 10 | Clonazepam | FAERS: 22 | US FAERS | |
| 11 | Zolpidem | FAERS: 20 | SIDER US FAERS | |
| 12 | Lisdexamfetamine Dimesylate | FAERS: 19 | US FAERS | |
| 13 | Morphine | FAERS: 16 Canada Vigilance: 4 | Canada Vigilance SIDER US FAERS | |
| 14 | Baclofen | FAERS: 15 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 15 | Ibuprofen | FAERS: 15 | US FAERS | |
| 16 | Sildenafil Citrate | FAERS: 14 | US FAERS | |
| 17 | Varenicline | FAERS: 11 | US FAERS | |
| 18 | Lorazepam | FAERS: 10 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 19 | Tadalafil | FAERS: 10 | OFFSIDES US FAERS | |
| 20 | Zolpidem | FAERS: 10 | US FAERS | |
| 21 | entecavir | FAERS: 10 | US FAERS | |
| 22 | Tramadol | FAERS: 9 | US FAERS | |
| 23 | Imatinib Mesylate | FAERS: 8 | US FAERS | |
| 24 | Sertraline | FAERS: 8 | US FAERS | |
| 25 | Celecoxib | FAERS: 7 | OFFSIDES US FAERS | |
| 26 | Cetirizine | FAERS: 7 | US FAERS | |
| 27 | Eszopiclone | FAERS: 7 | US FAERS | |
| 28 | Glatiramer Acetate | FAERS: 7 | US FAERS | |
| 29 | Methylphenidate | FAERS: 7 Canada Vigilance: 1 | Canada Vigilance OFFSIDES US FAERS | |
| 30 | Venlafaxine Hydrochloride | FAERS: 7 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 31 | suvorexant | FAERS: 7 | US FAERS | |
| 32 | Amphetamine | FAERS: 6 | US FAERS | |
| 33 | Latanoprost | FAERS: 6 | US FAERS | |
| 34 | Levetiracetam | FAERS: 6 | US FAERS | |
| 35 | Tramadol | FAERS: 6 | SIDER US FAERS | |
| 36 | Fentanyl | FAERS: 5 | US FAERS | |
| 37 | Fluticasone | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 38 | Lenalidomide | FAERS: 5 | US FAERS | |
| 39 | Lorcet | FAERS: 5 | US FAERS | |
| 40 | Methotrexate | FAERS: 5 | US FAERS | |
| 41 | Olanzapine | FAERS: 5 | SIDER US FAERS | |
| 42 | Quetiapine Fumarate | FAERS: 5 | US FAERS | |
| 43 | Advil PM | FAERS: 4 | US FAERS | |
| 44 | Diazepam | FAERS: 4 | US FAERS | |
| 45 | Furosemide | FAERS: 4 | US FAERS | |
| 46 | Loperamide | FAERS: 4 | US FAERS | |
| 47 | Nexium 24hr | FAERS: 4 | US FAERS | |
| 48 | Oxycodone | FAERS: 4 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 49 | Ramipril | FAERS: 4 | US FAERS | |
| 50 | Risperidone | FAERS: 4 | US FAERS | |
| 51 | Sumatriptan | FAERS: 4 | US FAERS | |
| 52 | levocetirizine | FAERS: 4 | US FAERS | |
| 53 | 1-N'-[2-[[5-[(Dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-N-methyl-2-nitroethene-1,1-diamine;hydron;chloride | FAERS: 3 | US FAERS | |
| 54 | Acetaminophen | FAERS: 3 | US FAERS | |
| 55 | Afatinib | FAERS: 3 | US FAERS | |
| 56 | Deferasirox | FAERS: 3 | US FAERS | |
| 57 | Fluoxetine | FAERS: 3 | US FAERS | |
| 58 | Formoterol Fumarate | FAERS: 3 | US FAERS | |
| 59 | Gefitinib | FAERS: 3 | US FAERS | |
| 60 | Hydromorphone | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 61 | Lurasidone Hydrochloride | FAERS: 3 | US FAERS | |
| 62 | Methylphenidate | FAERS: 3 | US FAERS | |
| 63 | Modafinil | FAERS: 3 | US FAERS | |
| 64 | PCI 32765 | FAERS: 3 | US FAERS | |
| 65 | Tapentadol | FAERS: 3 | US FAERS | |
| 66 | desloratadine | FAERS: 3 | US FAERS | |
| 67 | pomalidomide | FAERS: 3 | US FAERS | |
| 68 | ropinirole | FAERS: 3 | US FAERS | |
| 69 | 2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride | FAERS: 2 | US FAERS | |
| 70 | Adderall | FAERS: 2 | US FAERS | |
| 71 | Advil Congestion Relief | FAERS: 2 | US FAERS | |
| 72 | Anastrozole | FAERS: 2 | US FAERS | |
| 73 | Aripiprazole | FAERS: 2 | US FAERS | |
| 74 | Atomoxetine Hydrochloride | FAERS: 2 | US FAERS | |
| 75 | Bosentan | FAERS: 2 | US FAERS | |
| 76 | Buprenorphine, Naloxone Drug Combination | FAERS: 2 | US FAERS | |
| 77 | Citalopram | FAERS: 2 | SIDER US FAERS | |
| 78 | Dasatinib | FAERS: 2 | US FAERS | |
| 79 | Desvenlafaxine Succinate | FAERS: 2 | US FAERS | |
| 80 | Dextromethorphan | FAERS: 2 | US FAERS | |
| 81 | Dimethyl Fumarate | FAERS: 2 | US FAERS | |
| 82 | Exenatide | FAERS: 2 | US FAERS | |
| 83 | Fingolimod Hydrochloride | FAERS: 2 | US FAERS | |
| 84 | Ketamine | FAERS: 2 | US FAERS | |
| 85 | Lamivudine | FAERS: 2 | OFFSIDES US FAERS | |
| 86 | Linezolid | FAERS: 2 | US FAERS | |
| 87 | Loratadine | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 88 | Metformin | FAERS: 2 | US FAERS | |
| 89 | Methadone | FAERS: 2 | US FAERS | |
| 90 | Octreotide | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 91 | Oxcarbazepine | FAERS: 2 | US FAERS | |
| 92 | Pramipexole | FAERS: 2 | US FAERS | |
| 93 | Raltegravir Potassium | FAERS: 2 | US FAERS | |
| 94 | Ranitidine | FAERS: 2 | US FAERS | |
| 95 | Simvastatin | FAERS: 2 | US FAERS | |
| 96 | Sorafenib | FAERS: 2 | US FAERS | |
| 97 | Tamsulosin | FAERS: 2 | US FAERS | |
| 98 | Tamsulosin | FAERS: 2 | US FAERS | |
| 99 | Tapentadol | FAERS: 2 | US FAERS | |
| 100 | Temazepam | FAERS: 2 | US FAERS | |
| 101 | Tramadol | FAERS: 2 | US FAERS | |
| 102 | eletriptan | FAERS: 2 | US FAERS | |
| 103 | naldemedine | FAERS: 2 | US FAERS | |
| 104 | oxybutynin | FAERS: 2 | US FAERS | |
| 105 | pazopanib | FAERS: 2 | US FAERS | |
| 106 | tetrahydrozoline | FAERS: 2 | US FAERS | |
| 107 | tofacitinib | FAERS: 2 | US FAERS | |
| 108 | zaleplon | FAERS: 2 | US FAERS | |
| 109 | 4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide | FAERS: 1 | US FAERS | |
| 110 | Abiraterone Acetate | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 111 | Adzenys XR-ODT | FAERS: 1 | US FAERS | |
| 112 | Albuterol | FAERS: 1 | US FAERS | |
| 113 | Atorvastatin | FAERS: 1 | US FAERS | |
| 114 | Azithromycin | FAERS: 1 | US FAERS | |
| 115 | Binedaline hydrochloride | FAERS: 1 | US FAERS | |
| 116 | Bisacodyl | FAERS: 1 | OFFSIDES US FAERS | |
| 117 | Cabozantinib S-malate | FAERS: 1 | US FAERS | |
| 118 | Canagliflozin | FAERS: 1 | US FAERS | |
| 119 | Chlorpheniramine | FAERS: 1 | US FAERS | |
| 120 | Cinacalcet | FAERS: 1 | US FAERS | |
| 121 | Citalopram | FAERS: 1 | US FAERS | |
| 122 | Deamino Arginine Vasopressin | FAERS: 1 | US FAERS | |
| 123 | Deamino Arginine Vasopressin | FAERS: 1 | OFFSIDES US FAERS | |
| 124 | Desogestrel | FAERS: 1 | US FAERS | |
| 125 | Dextroamphetamine | FAERS: 1 | US FAERS | |
| 126 | Dextromethorphan | FAERS: 1 | US FAERS | |
| 127 | Diphenhydramine | FAERS: 1 | US FAERS | |
| 128 | Duavee | FAERS: 1 | US FAERS | |
| 129 | Duloxetine Hydrochloride | FAERS: 1 | US FAERS | |
| 130 | Eplerenone | FAERS: 1 | US FAERS | |
| 131 | Esomeprazole | FAERS: 1 | US FAERS | |
| 132 | Estradiol | FAERS: 1 | US FAERS | |
| 133 | Ethacrynic Acid | FAERS: 1 | US FAERS | |
| 134 | Everolimus | FAERS: 1 | US FAERS | |
| 135 | Ezetimibe | FAERS: 1 | US FAERS | |
| 136 | F8 protein, human | FAERS: 1 | US FAERS | |
| 137 | Fluticasone-Salmeterol Drug Combination | FAERS: 1 | US FAERS | |
| 138 | Glyburide | FAERS: 1 | US FAERS | |
| 139 | Guaifenesin | FAERS: 1 | US FAERS | |
| 140 | Haloperidol | FAERS: 1 | US FAERS | |
| 141 | Hydromorphone | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance OFFSIDES SIDER US FAERS | |
| 142 | Ibandronic Acid | FAERS: 1 | US FAERS | |
| 143 | Insulin Glargine | FAERS: 1 | US FAERS | |
| 144 | Isotretinoin | FAERS: 1 | US FAERS | |
| 145 | LCZ 696 | FAERS: 1 | US FAERS | |
| 146 | Lamotrigine | FAERS: 1 | US FAERS | |
| 147 | Leflunomide | FAERS: 1 | OFFSIDES US FAERS | |
| 148 | Loperamide | FAERS: 1 | US FAERS | |
| 149 | Lubiprostone | FAERS: 1 | OFFSIDES US FAERS | |
| 150 | Mesalamine | FAERS: 1 | US FAERS | |
| 151 | Methadone | FAERS: 1 | US FAERS | |
| 152 | Methylphenidate | FAERS: 1 | US FAERS | |
| 153 | Methylprednisolone Hemisuccinate | FAERS: 1 | US FAERS | |
| 154 | Metoprolol | FAERS: 1 | US FAERS | |
| 155 | Metoprolol | FAERS: 1 | US FAERS | |
| 156 | Metronidazole | FAERS: 1 | US FAERS | |
| 157 | Mycophenolic Acid | FAERS: 1 | US FAERS | |
| 158 | Naproxen | FAERS: 1 | US FAERS | |
| 159 | Nicotine | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 160 | Nitroglycerin | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance SIDER US FAERS | |
| 161 | Oxycodone and acetaminophen | FAERS: 1 | US FAERS | |
| 162 | Oxymorphone | FAERS: 1 | US FAERS | |
| 163 | Pamidronate | FAERS: 1 | US FAERS | |
| 164 | Prednisone | FAERS: 1 | US FAERS | |
| 165 | Promethazine | FAERS: 1 | US FAERS | |
| 166 | Quetiapine Fumarate | FAERS: 1 | US FAERS | |
| 167 | Rabeprazole | FAERS: 1 | US FAERS | |
| 168 | Remifentanil | FAERS: 1 | US FAERS | |
| 169 | Rivastigmine | FAERS: 1 | US FAERS | |
| 170 | Ropivacaine | FAERS: 1 | US FAERS | |
| 171 | Rosuvastatin Calcium | FAERS: 1 | US FAERS | |
| 172 | Scopolamine | FAERS: 1 | US FAERS | |
| 173 | Spironolactone | FAERS: 1 | US FAERS | |
| 174 | Sunitinib | FAERS: 1 | US FAERS | |
| 175 | Testosterone | FAERS: 1 | US FAERS | |
| 176 | Tolterodine Tartrate | FAERS: 1 | US FAERS | |
| 177 | Trazodone | FAERS: 1 | US FAERS | |
| 178 | Trazodone | FAERS: 1 | OFFSIDES US FAERS | |
| 179 | Valproic Acid | FAERS: 1 | US FAERS | |
| 180 | Valproic Acid | FAERS: 1 | US FAERS | |
| 181 | Verapamil | FAERS: 1 | US FAERS | |
| 182 | Warfarin | FAERS: 1 | US FAERS | |
| 183 | carbidopa, levodopa drug combination | FAERS: 1 | US FAERS | |
| 184 | carbidopa, levodopa drug combination | FAERS: 1 | OFFSIDES US FAERS | |
| 185 | dofetilide | FAERS: 1 | US FAERS | |
| 186 | eltrombopag | FAERS: 1 | US FAERS | |
| 187 | eluxadoline | FAERS: 1 | US FAERS | |
| 188 | fosaprepitant | FAERS: 1 | US FAERS | |
| 189 | insulin glulisine | FAERS: 1 | US FAERS | |
| 190 | levocetirizine | FAERS: 1 | US FAERS | |
| 191 | methylnaltrexone | FAERS: 1 | US FAERS | |
| 192 | nepafenac | FAERS: 1 | US FAERS | |
| 193 | osimertinib | FAERS: 1 | US FAERS | |
| 194 | posaconazole | FAERS: 1 | US FAERS | |
| 195 | ramelteon | FAERS: 1 | US FAERS | |
| 196 | rofecoxib | FAERS: 1 | OFFSIDES US FAERS | |
| 197 | sibutramine | FAERS: 1 | US FAERS | |
| 198 | tasimelteon | FAERS: 1 | US FAERS | |
| 199 | teriflunomide | FAERS: 1 | US FAERS | |
| 200 | treprostinil | FAERS: 1 | US FAERS | |
| 201 | ziprasidone | FAERS: 1 | US FAERS | |
| 202 | Amitriptyline | OFFSIDES | ||
| 203 | Benzodiazepines | OFFSIDES | ||
| 204 | Bupivacaine | OFFSIDES | ||
| 205 | Bupropion | OFFSIDES | ||
| 206 | Cabergoline | OFFSIDES | ||
| 207 | Celiprolol | OFFSIDES | ||
| 208 | Chlordiazepoxide | OFFSIDES | ||
| 209 | Cisapride | OFFSIDES | ||
| 210 | Codeine | OFFSIDES | ||
| 211 | Cyproheptadine | OFFSIDES | ||
| 212 | Desvenlafaxine Succinate | Canada Vigilance: 1 | Canada Vigilance | |
| 213 | Dextropropoxyphene | SIDER | ||
| 214 | Dicyclomine | OFFSIDES | ||
| 215 | Diflunisal | OFFSIDES | ||
| 216 | Diphenoxylate | OFFSIDES | ||
| 217 | Doxepin | OFFSIDES | ||
| 218 | Estrogens, Conjugated (USP) | OFFSIDES | ||
| 219 | Fluocinonide | OFFSIDES | ||
| 220 | Fluoxetine | SIDER | ||
| 221 | Flurazepam | OFFSIDES | ||
| 222 | Folic Acid | OFFSIDES | ||
| 223 | Hydralazine | OFFSIDES | ||
| 224 | Hydrocortisone | OFFSIDES | ||
| 225 | Hydron;carbonate | OFFSIDES | ||
| 226 | Hydroxyurea | OFFSIDES | ||
| 227 | Hydroxyzine | OFFSIDES | ||
| 228 | Imatinib Mesylate | OFFSIDES | ||
| 229 | Indinavir | OFFSIDES | ||
| 230 | Labetalol | OFFSIDES | ||
| 231 | Mefloquine | OFFSIDES SIDER | ||
| 232 | Melatonin | OFFSIDES | ||
| 233 | Meperidine | OFFSIDES | ||
| 234 | Methocarbamol | OFFSIDES | ||
| 235 | Metolazone | OFFSIDES | ||
| 236 | Mirtazapine | SIDER | ||
| 237 | Nabumetone | OFFSIDES | ||
| 238 | Nadolol | OFFSIDES | ||
| 239 | Naloxone | OFFSIDES | ||
| 240 | Naltrexone | OFFSIDES | ||
| 241 | Nitrofurantoin | OFFSIDES | ||
| 242 | Nizatidine | OFFSIDES | ||
| 243 | Nortriptyline | OFFSIDES | ||
| 244 | Octreotide | Canada Vigilance: 1 | Canada Vigilance OFFSIDES | |
| 245 | Ofloxacin | OFFSIDES | ||
| 246 | Orphenadrine | OFFSIDES | ||
| 247 | Oxaprozin | OFFSIDES | ||
| 248 | Paroxetine | SIDER | ||
| 249 | Perphenazine | OFFSIDES | ||
| 250 | Phenelzine | OFFSIDES | ||
| 251 | Phenolphthalein | OFFSIDES | ||
| 252 | Piroxicam | OFFSIDES | ||
| 253 | Primidone | OFFSIDES | ||
| 254 | Propylthiouracil | OFFSIDES | ||
| 255 | Salmeterol Xinafoate | OFFSIDES | ||
| 256 | Selenium | OFFSIDES | ||
| 257 | Sevoflurane | OFFSIDES | ||
| 258 | Sulindac | OFFSIDES | ||
| 259 | Sumatriptan | OFFSIDES | ||
| 260 | Theophylline | OFFSIDES | ||
| 261 | Tiagabine | OFFSIDES | ||
| 262 | Trimipramine | OFFSIDES | ||
| 263 | Venlafaxine Hydrochloride | SIDER | ||
| 264 | Zonisamide | OFFSIDES | ||
| 265 | abacavir | OFFSIDES | ||
| 266 | alosetron | OFFSIDES | ||
| 267 | benazepril | OFFSIDES | ||
| 268 | fosamprenavir | OFFSIDES | ||
| 269 | hydrocodone tartrate, ibuprofen drug combination | OFFSIDES | ||
| 270 | isoniazid, pyrazinamide, rifampin drug combination | OFFSIDES | ||
| 271 | magnesium citrate | OFFSIDES | ||
| 272 | naratriptan | OFFSIDES | ||
| 273 | nefazodone | OFFSIDES SIDER | ||
| 274 | sibutramine | OFFSIDES | ||
| 275 | testosterone 17 beta-cypionate | OFFSIDES | ||
| 276 | tizanidine | OFFSIDES | ||
| 277 | trimethobenzamide | OFFSIDES | ||
| 278 | valdecoxib | OFFSIDES | ||
| 279 | ziprasidone | SIDER |
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