MetaADEDB 2.0 @ LMMD
Hydroxyzine
(ASDOKGIIKXGMNB-UHFFFAOYSA-N)
Structure
SMILES
OC(=O)c1cc2ccccc2c(c1O)Cc1c(O)c(cc2c1cccc2)C(=O)O.OCCOCCN1CCN(CC1)C(c1ccc(cc1)Cl)c1ccccc1
Molecular Formula:
C44H43ClN2O8
Molecular Weight:
763.274
Log P:
7.3231
Hydrogen Bond Acceptor:
10
Hydrogen Bond Donor:
5
TPSA:
151
CAS Number(s):
10246-75-0
Synonym(s)
1.
Hydroxyzine
2.
2-(2-(4-((4-Chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)ethanol
3.
Atarax
4.
Durrax
5.
Hydroxyzine Dihydrochloride
6.
Hydroxyzine Hydrochloride
7.
Hydroxyzine Pamoate
8.
Orgatrax
9.
Vistaril
10.
Pamoate, Hydroxyzine
External Link(s)
MeSHD006919
PubChem Compound25096
54740721
ChEBI31680
CHEMBLCHEMBL1200467
KEGGdr:D01096
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 17US FAERS
2SomnolenceFAERS: 8US FAERS
3Completed SuicideFAERS: 7OFFSIDES
US FAERS
4AnxietyFAERS: 6OFFSIDES
US FAERS
5VomitingFAERS: 6US FAERS
6NauseaFAERS: 5OFFSIDES
US FAERS
7HeadacheFAERS: 4US FAERS
8Cardiac ArrestFAERS: 3US FAERS
9Drug effect incompleteFAERS: 3US FAERS
10FatigueFAERS: 3US FAERS
11PruritusFAERS: 3US FAERS
12Respiratory arrestFAERS: 3US FAERS
13SwellingFAERS: 3US FAERS
14Chest PainFAERS: 2OFFSIDES
US FAERS
15CryingFAERS: 2US FAERS
16DizzinessFAERS: 2OFFSIDES
US FAERS
17Mood swingsFAERS: 2US FAERS
18PainFAERS: 2OFFSIDES
US FAERS
19PalpitationsFAERS: 2US FAERS
20ParanoiaFAERS: 2OFFSIDES
US FAERS
21PsoriasisFAERS: 2OFFSIDES
US FAERS
22TremorFAERS: 2US FAERS
23Allergy to chemicalsFAERS: 1US FAERS
24Atrial FibrillationFAERS: 1US FAERS
25Cerebral vasoconstrictionFAERS: 1US FAERS
26Chest discomfortFAERS: 1US FAERS
27ColitisFAERS: 1US FAERS
28CystFAERS: 1US FAERS
29Drug DependenceFAERS: 1US FAERS
30Drug abuseFAERS: 1US FAERS
31Drug ineffective for unapproved indicationFAERS: 1US FAERS
32Drug screen positiveFAERS: 1US FAERS
33DysphemiaFAERS: 1US FAERS
34DysuriaFAERS: 1OFFSIDES
US FAERS
35Erythema MultiformeFAERS: 1US FAERS
36General physical condition abnormalFAERS: 1US FAERS
37Gluten sensitivityFAERS: 1US FAERS
38Hepatic EncephalopathyFAERS: 1US FAERS
39Intentional drug misuseFAERS: 1US FAERS
40LethargyFAERS: 1OFFSIDES
US FAERS
41MalaiseFAERS: 1US FAERS
42Neck PainFAERS: 1US FAERS
43OverdoseFAERS: 1OFFSIDES
US FAERS
44Personality ChangeFAERS: 1US FAERS
45Product appearance confusionFAERS: 1US FAERS
46Product quality issueFAERS: 1US FAERS
47Product substitution issueFAERS: 1US FAERS
48Product use in unapproved indicationFAERS: 1US FAERS
49Reaction to excipientFAERS: 1US FAERS
50Skin reactionFAERS: 1US FAERS
51Skin test positiveFAERS: 1US FAERS
52Suicide attemptFAERS: 1US FAERS
53Therapeutic product effect decreasedFAERS: 1US FAERS
54UrticariaFAERS: 1US FAERS
55VertigoFAERS: 1US FAERS
56Weight decreasedFAERS: 1US FAERS
57Abdominal PainOFFSIDES
58Abdominal discomfortOFFSIDES
59Abnormal visionOFFSIDES
60Accidental deathOFFSIDES
61Acid refluxOFFSIDES
62AcidosisOFFSIDES
63Acute respiratory failureOFFSIDES
64Adjustment disorder with depressed moodOFFSIDES
65AgoraphobiaOFFSIDES
66Alanine Aminotransferase IncreasedOFFSIDES
67AnhidrosisOFFSIDES
68AnorexiaOFFSIDES
69ApathyOFFSIDES
70ApneaOFFSIDES
71ArthropathyOFFSIDES
72AstheniaOFFSIDES
73AsthmaOFFSIDES
74AstigmatismOFFSIDES
75AtelectasisOFFSIDES
76Bipolar DisorderOFFSIDES
77Blood GlucoseOFFSIDES
78Blood albumin decreasedOFFSIDES
79Blood alkaline phosphatase increasedOFFSIDES
80Blood cholesterolOFFSIDES
81Blood creatine decreasedOFFSIDES
82Blood follicle stimulating hormone decreasedOFFSIDES
83Blood glucose decreasedOFFSIDES
84Blood lactate dehydrogenase increasedOFFSIDES
85Blood sodiumOFFSIDES
86Blood urea increasedOFFSIDES
87Blurred visionOFFSIDES
88Bone density decreasedOFFSIDES
89Bone painOFFSIDES
90BradycardiaOFFSIDES
91BursitisOFFSIDES
92Cardiac FlutterOFFSIDES
93CellulitisOFFSIDES
94Ceruloplasmin decreasedOFFSIDES
95Choking sensationOFFSIDES
96CholangiolitisOFFSIDES
97Chronic Obstructive Airway DiseaseOFFSIDES
98ConfabulationOFFSIDES
99Congenital tricuspid valve incompetenceOFFSIDES
100Decreased LibidoOFFSIDES
101DehydrationOFFSIDES
102DependenceOFFSIDES
103Depressed moodOFFSIDES
104DiabetesOFFSIDES
105Diabetic RetinopathyOFFSIDES
106Diabetic ulcerOFFSIDES
107DiarrheaOFFSIDES
108DiplopiaOFFSIDES
109Disease ProgressionOFFSIDES
110DiverticulosisOFFSIDES
111DiverticulumOFFSIDES
112DrowsinessOFFSIDES
113Drug ToleranceOFFSIDES
114Drug abuserOFFSIDES
115Drug addictOFFSIDES
116Drug delivery device implantationOFFSIDES
117DysmorphismOFFSIDES
118DystoniaOFFSIDES
119Emotional disorderOFFSIDES
120Emotional distressOFFSIDES
121Erosive gastritisOFFSIDES
122Eye painOFFSIDES
123Failure to ThriveOFFSIDES
124Fatty LiverOFFSIDES
125Feeding disorder neonatalOFFSIDES
126Feeling ColdOFFSIDES
127Flank PainOFFSIDES
128Food cravingOFFSIDES
129Gene mutation identification testOFFSIDES
130Hallucinations, mixedOFFSIDES
131HemiparesisOFFSIDES
132HepatosplenomegalyOFFSIDES
133HypoxiaOFFSIDES
134Impaired work abilityOFFSIDES
135IncontinenceOFFSIDES
136InfectionOFFSIDES
137Intention tremorOFFSIDES
138Intervertebral disc disorderOFFSIDES
139Joint Range of Motion DecreasedOFFSIDES
140Kidney FailureOFFSIDES
141Leukopenia neonatalOFFSIDES
142Lung hyperinflationOFFSIDES
143Lymphocyte count decreasedOFFSIDES
144Markedly reduced dietary intakeOFFSIDES
145Mental status changesOFFSIDES
146MicrocephalyOFFSIDES
147Multi-organ disorderOFFSIDES
148Multiple MyelomaOFFSIDES
149Multiple drug overdose intentionalOFFSIDES
150Musculoskeletal PainOFFSIDES
151Nervous tensionOFFSIDES
152Neutrophil count decreasedOFFSIDES
153NocturiaOFFSIDES
154Nodule on extremityOFFSIDES
155Occult blood positiveOFFSIDES
156Oropharyngitis fungalOFFSIDES
157OverweightOFFSIDES
158PCO2 decreasedOFFSIDES
159PallorOFFSIDES
160PancreatitisOFFSIDES
161Parent-child problemOFFSIDES
162Peritoneal DialysisOFFSIDES
163Pharyngolaryngeal PainOFFSIDES
164PhonophobiaOFFSIDES
165PolyneuropathyOFFSIDES
166Post procedural cellulitisOFFSIDES
167Post procedural complicationOFFSIDES
168Presenile dementiaOFFSIDES
169ProctitisOFFSIDES
170Productive CoughOFFSIDES
171Psychomotor skills impairedOFFSIDES
172Pulmonary Valve StenosisOFFSIDES
173Pulmonary congestionOFFSIDES
174Renal salt-wasting syndromeOFFSIDES
175Respiratory FailureOFFSIDES
176RhinorrheaOFFSIDES
177Sinus headacheOFFSIDES
178SinusitisOFFSIDES
179SnoringOFFSIDES
180StaringOFFSIDES
181StressOFFSIDES
182Temperature intoleranceOFFSIDES
183Unevaluable eventOFFSIDES
184Unresponsive to pain stimuliOFFSIDES
185Urinary tract infection enterococcalOFFSIDES
186Weight GainOFFSIDES
187White blood cell count abnormalOFFSIDES
188Williams SyndromeOFFSIDES
189effusionOFFSIDES
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