MetaADEDB 2.0 @ LMMD
Diflunisal
(HUPFGZXOMWLGNK-UHFFFAOYSA-N)
Structure
SMILES
Fc1ccc(c(c1)F)c1ccc(c(c1)C(=O)O)O
Type(s)
Approved; Investigational
ATC code(s)
N02BA11
Molecular Formula:
C13H8F2O3
Molecular Weight:
250.198
Log P:
3.0356
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
2
TPSA:
57.53
CAS Number(s):
22494-42-4
Synonym(s)
1.
Diflunisal
2.
Apo-Diflunisal
3.
Dolobid
4.
Dolobis
5.
Dolocid
6.
MK-647
7.
Novo-Diflunisal
8.
Nu-Diflunisal
9.
Apo Diflunisal
10.
ApoDiflunisal
11.
MK 647
12.
MK647
13.
Novo Diflunisal
14.
NovoDiflunisal
15.
Nu Diflunisal
16.
NuDiflunisal
External Link(s)
MeSHD004061
PubChem Compound3059
BindingDB50240510
ChEBI39669
CHEMBLCHEMBL898
DrugBankDB00861
DrugCentral880
IUPHAR/BPS Guide to PHARMACOLOGY7162
KEGGcpd:C01691
dr:D00130
Therapeutic Target DatabaseD08LFZ
ZINC20243
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1UrticariaFAERS: 3
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
2DizzinessFAERS: 2
Canada Vigilance: 2		Canada Vigilance
SIDER
US FAERS
3Lip swellingFAERS: 2US FAERS
4NauseaFAERS: 2
Canada Vigilance: 2		7100020CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
5PruritusFAERS: 2
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
6Activities of daily living impairedFAERS: 1US FAERS
7Adverse eventFAERS: 1US FAERS
8AstheniaFAERS: 1
Canada Vigilance: 2		Canada Vigilance
OFFSIDES
SIDER
US FAERS
9Blood urine presentFAERS: 1US FAERS
10Burning sensationFAERS: 1US FAERS
11Chest PainFAERS: 1OFFSIDES
SIDER
US FAERS
12ChillsFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
13Drug ineffectiveFAERS: 1US FAERS
14Drug prescribing errorFAERS: 1US FAERS
15EcchymosisFAERS: 1US FAERS
16ErythemaFAERS: 1US FAERS
17FatigueFAERS: 1OFFSIDES
SIDER
US FAERS
18Feeling abnormalFAERS: 1OFFSIDES
SIDER
US FAERS
19FlatulenceFAERS: 1SIDER
US FAERS
20HeadacheFAERS: 13308026CTD
SIDER
US FAERS
21HypersensitivityFAERS: 1SIDER
US FAERS
22Loss of personal independence in daily activitiesFAERS: 1US FAERS
23PainFAERS: 1OFFSIDES
US FAERS
24Product prescribing errorFAERS: 1US FAERS
25Stevens-Johnson SyndromeFAERS: 1
Canada Vigilance: 1		25811541CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
26StomatitisFAERS: 12967101CTD
SIDER
US FAERS
27SyncopeFAERS: 1SIDER
US FAERS
28Toxic Epidermal NecrolysisFAERS: 1SIDER
US FAERS
29Wrong technique in product usage processFAERS: 1US FAERS
30AbasiaOFFSIDES
31Abdominal AbscessOFFSIDES
32Abdominal PainCanada Vigilance: 12967101CTD
Canada Vigilance
33Abnormal visionOFFSIDES
34Acid refluxOFFSIDES
35Acute anaphylaxisSIDER
36Acute kidney injury3763032
6444363
7100020		CTD
37Acute myocardial infarctionOFFSIDES
38AgranulocytosisSIDER
39Amyloid Neuropathies, Familial20030258
25595224		CTD
40Anaphylactic shockSIDER
41Anaphylactoid ReactionCanada Vigilance: 2Canada Vigilance
42Anemia, Hemolytic2967101CTD
43Anemia6515560CTD
44AneurysmOFFSIDES
45AngioedemaSIDER
46AnhedoniaOFFSIDES
47AnhidrosisOFFSIDES
48Ankle FractureOFFSIDES
49Anorexia7100020CTD
OFFSIDES
SIDER
50AnosmiaOFFSIDES
51AnxietyOFFSIDES
52Aortic AneurysmOFFSIDES
53Arteriopathic diseaseOFFSIDES
54ArthritisOFFSIDES
55AsthmaOFFSIDES
56AtherosclerosisOFFSIDES
57Atrial tachycardiaOFFSIDES
58Blood cholesterolOFFSIDES
59Blood creatine decreasedOFFSIDES
60Blood sodiumOFFSIDES
61Blue Toe SyndromeOFFSIDES
62Bone lesionOFFSIDES
63Brain ConcussionOFFSIDES
64BronchitisOFFSIDES
65BronchospasmCanada Vigilance: 1Canada Vigilance
SIDER
66Carotid artery occlusionOFFSIDES
67CellulitisOFFSIDES
68Ceruloplasmin decreasedOFFSIDES
69Chemical and Drug Induced Liver Injury3617008CTD
70CholestasisSIDER
71CirrhosisOFFSIDES
72Completed SuicideOFFSIDES
73ConstipationSIDER
74CryingOFFSIDES
75DeafnessSIDER
76DebridementOFFSIDES
77DehydrationOFFSIDES
78DermatitisSIDER
79DiabetesOFFSIDES
80DiarrheaOFFSIDES
81DisorientationSIDER
82Diverticular perforationOFFSIDES
83DiverticulitisOFFSIDES
84Drug ToleranceOFFSIDES
85Drug abuserOFFSIDES
86Drug screen positiveOFFSIDES
87Drug withdrawal headacheOFFSIDES
88DysgeusiaOFFSIDES
89DyspepsiaSIDER
90DysphoniaOFFSIDES
91Dysthymic DisorderOFFSIDES
92DysuriaCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
93Economic problemOFFSIDES
94Emotional distressOFFSIDES
95Endodontic procedureOFFSIDES
96Endometrial HyperplasiaOFFSIDES
97Eosinophilia6444363CTD
98Erectile dysfunctionOFFSIDES
99EructationSIDER
100Erythema MultiformeSIDER
101Esophageal StenosisOFFSIDES
102Essential HypertensionOFFSIDES
103Exanthema2967101CTD
104ExcoriationOFFSIDES
105Eye painOFFSIDES
106Face LiftOFFSIDES
107Facial paralysisCanada Vigilance: 1Canada Vigilance
108Fatty LiverOFFSIDES
109Fever2967101CTD
110FlushingCanada Vigilance: 1Canada Vigilance
SIDER
111GastritisSIDER
112Gastrointestinal Diseases25014874CTD
113Gastrointestinal PainSIDER
114Gastrointestinal perforationSIDER
115General physical health deteriorationOFFSIDES
116Hepatitis COFFSIDES
117HepatitisSIDER
118Hepatomegaly2967101CTD
119HyperkeratosisOFFSIDES
120Hypersensitive syndromeSIDER
121HypotensionCanada Vigilance: 1Canada Vigilance
122Impaired work abilityOFFSIDES
123IncontinenceOFFSIDES
124InfectionOFFSIDES
125Injection site erythemaOFFSIDES
126Injection site phlebitisOFFSIDES
127Intentional misuseOFFSIDES
128Joint Range of Motion DecreasedOFFSIDES
129Kidney Diseases370954
699625		CTD
130LacerationOFFSIDES
131Leukocytoclastic vasculitisSIDER
132LightheadednessSIDER
133Loose toothOFFSIDES
134MacrocytosisOFFSIDES
135Medical device removalOFFSIDES
136Multiple MyelomaOFFSIDES
137Muscle WeaknessOFFSIDES
138Musculoskeletal stiffnessOFFSIDES
139Myofascial Pain Syndromes3308026CTD
140NasopharyngitisOFFSIDES
141Nephritis, Interstitial6444363
7100020		CTD
142Nephrotic SyndromeSIDER
143NervousnessSIDER
144Oculogyric crisisCanada Vigilance: 1Canada Vigilance
145Oliguria6444363
7100020		CTD
146Oral Cavity FistulaOFFSIDES
147OsteomyelitisOFFSIDES
148OsteoporosisOFFSIDES
149OsteoradionecrosisOFFSIDES
150OverweightOFFSIDES
151PCO2 decreasedOFFSIDES
152Pain, Postoperative3422792CTD
153PalpitationsCanada Vigilance: 2Canada Vigilance
SIDER
154Peptic UlcerSIDER
155PeriarthritisOFFSIDES
156Pharmaceutical product complaintOFFSIDES
157PhonophobiaOFFSIDES
158Physical assaultOFFSIDES
159Pneumonia9187209CTD
160PneumoperitoneumOFFSIDES
161PneumothoraxOFFSIDES
162PolyuriaOFFSIDES
163Poor quality drug administeredOFFSIDES
164Posterior capsule opacificationOFFSIDES
165Primary sequestrumOFFSIDES
166Protein total decreasedOFFSIDES
167Protein urine presentSIDER
168ProteinuriaSIDER
169Pulmonary congestionOFFSIDES
170Retinal Artery OcclusionOFFSIDES
171Retinal artery embolismOFFSIDES
172Secondary sequestrumOFFSIDES
173SequestrectomyOFFSIDES
174ShockSIDER
175SinusitisOFFSIDES
176SomnolenceSIDER
177Splenomegaly2967101CTD
178SweatingSIDER
179Systemic Vasculitis9187209CTD
180TensionSIDER
181TheftOFFSIDES
182ThrombocytopeniaCanada Vigilance: 1Canada Vigilance
SIDER
183TinnitusSIDER
184Toe operationOFFSIDES
185Tooth ExtractionOFFSIDES
186Upper airway obstructionOFFSIDES
187Venous occlusionOFFSIDES
188VertigoSIDER
189Visual ImpairmentSIDER
190Visual disturbanceSIDER
191VomitingCanada Vigilance: 2Canada Vigilance
SIDER
192jaundice8935606CTD
SIDER
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