MetaADEDB 2.0 @ LMMD
fosaprepitant
(BARDROPHSZEBKC-OITMNORJSA-N)
Structure
SMILES
Fc1ccc(cc1)[C@H]1[C@H](OCCN1Cc1[nH]c(=O)n(n1)P(=O)(O)O)O[C@@H](c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C
Type(s)
Approved
Molecular Formula:
C23H22F7N4O6P
Molecular Weight:
614.407
Log P:
4.3042
Hydrogen Bond Acceptor:
9
Hydrogen Bond Donor:
3
TPSA:
139.72
CAS Number(s):
172673-20-0
Synonym(s)
1.
fosaprepitant
2.
Emend for injection
3.
L 785,298
4.
L-785,298
5.
L785,298
6.
fosaprepitant dimeglumine
External Link(s)
MeSHC579707
PubChem Compound135413538
219090
ChEBI64321
CHEMBLCHEMBL1199324
DrugBankDB06717
DrugCentral4470
IUPHAR/BPS Guide to PHARMACOLOGY7623
KEGGdr:D06597
dr:D10895
ZINC3939013
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1FlushingFAERS: 26SIDER
US FAERS
2Back PainFAERS: 18US FAERS
3ErythemaFAERS: 17SIDER
US FAERS
4HypersensitivityFAERS: 14SIDER
US FAERS
5Chest PainFAERS: 11SIDER
US FAERS
6Chest discomfortFAERS: 10SIDER
US FAERS
7Infusion site painFAERS: 10SIDER
US FAERS
8HypotensionFAERS: 9SIDER
US FAERS
9NauseaFAERS: 9SIDER
US FAERS
10Infusion site erythemaFAERS: 7SIDER
US FAERS
11Infusion site urticariaFAERS: 6US FAERS
12Infusion site reactionFAERS: 5US FAERS
13Anaphylactic shockFAERS: 4SIDER
US FAERS
14DizzinessFAERS: 4SIDER
US FAERS
15Infusion site discomfortFAERS: 4US FAERS
16PainFAERS: 4SIDER
US FAERS
17Respiratory distressFAERS: 4US FAERS
18Abdominal PainFAERS: 3SIDER
US FAERS
19Adverse eventFAERS: 3US FAERS
20Hypoaesthesia facialFAERS: 3US FAERS
21HypoxiaFAERS: 3US FAERS
22Infusion site swellingFAERS: 3US FAERS
23TachycardiaFAERS: 3US FAERS
24DiscomfortFAERS: 2SIDER
US FAERS
25Feeling abnormalFAERS: 2SIDER
US FAERS
26Infusion site phlebitisFAERS: 2US FAERS
27OverdoseFAERS: 2US FAERS
28PruritusFAERS: 2SIDER
US FAERS
29ThrombosisFAERS: 2US FAERS
30Abdominal discomfortFAERS: 1SIDER
US FAERS
31Anaphylactoid ReactionFAERS: 1US FAERS
32AnxietyFAERS: 1SIDER
US FAERS
33ArthralgiaFAERS: 1US FAERS
34BronchospasmFAERS: 1US FAERS
35Cardiac ArrestFAERS: 1US FAERS
36Catheter site extravasationFAERS: 1US FAERS
37CyanosisFAERS: 1US FAERS
38DehydrationFAERS: 1US FAERS
39Drug ToleranceFAERS: 1US FAERS
40Drug ineffectiveFAERS: 1US FAERS
41ExtravasationFAERS: 1US FAERS
42Infusion site irritationFAERS: 1US FAERS
43Intestinal ObstructionFAERS: 1US FAERS
44LaryngospasmFAERS: 1US FAERS
45MalaiseFAERS: 1SIDER
US FAERS
46Metastatic NeoplasmFAERS: 1US FAERS
47Muscle tightnessFAERS: 1US FAERS
48Musculoskeletal PainFAERS: 1US FAERS
49Oxygen saturation increasedFAERS: 1US FAERS
50PallorFAERS: 1US FAERS
51PhlebitisFAERS: 1US FAERS
52PresyncopeFAERS: 1US FAERS
53Product quality issueFAERS: 1US FAERS
54RestlessnessFAERS: 1US FAERS
55Skin irritationFAERS: 1US FAERS
56ToothacheFAERS: 1US FAERS
57Unresponsive to stimuliFAERS: 1US FAERS
58Urinary IncontinenceFAERS: 1US FAERS
59Abnormal bowel soundsSIDER
60Alanine Aminotransferase IncreasedSIDER
61AngioedemaSIDER
62Aspartate Aminotransferase IncreasedSIDER
63AstheniaSIDER
64Blood albumin decreasedSIDER
65Blood alkaline phosphatase increasedSIDER
66Blood and lymphatic system disordersSIDER
67Blood glucose increasedSIDER
68Blood potassium decreasedSIDER
69Blood urine presentSIDER
70BradycardiaSIDER
71Chest tightnessSIDER
72ConjunctivitisSIDER
73ConstipationSIDER
74DermatitisSIDER
75DisorientationSIDER
76Duodenal ulcer perforationSIDER
77DysarthriaSIDER
78DysgeusiaSIDER
79DyspepsiaSIDER
80DysuriaSIDER
81Ear and labyrinth disordersSIDER
82EructationSIDER
83Erythema MultiformeSIDER
84Euphoric moodSIDER
85FatigueSIDER
86Febrile NeutropeniaSIDER
87FlatulenceSIDER
88Gastrointestinal PainSIDER
89Gastrointestinal sounds abnormalSIDER
90GlycosuriaSIDER
91HeadacheSIDER
92InfectionSIDER
93InfestationSIDER
94Infusion site indurationSIDER
95Infusion site pruritusSIDER
96Infusion site thrombophlebitisSIDER
97Infusion site thrombosisSIDER
98Intraoperative HemorrhageSIDER
99LethargySIDER
100MalnutritionSIDER
101Neutropenic colitisSIDER
102Neutrophil count decreasedSIDER
103Oropharyngeal painSIDER
104PalpitationsSIDER
105PolydipsiaSIDER
106Post procedural infectionSIDER
107Postoperative infectionSIDER
108Procedural nauseaSIDER
109PrurigoSIDER
110Pulmonary function test decreasedSIDER
111Respiratory DepressionSIDER
112ShockSIDER
113Skin lesionSIDER
114SneezingSIDER
115SomnolenceSIDER
116Stevens-Johnson SyndromeSIDER
117StomatitisSIDER
118SubileusSIDER
119SyncopeSIDER
120Throat irritationSIDER
121ThrombophlebitisSIDER
122TinnitusSIDER
123Toxic Epidermal NecrolysisSIDER
124Upper-airway cough syndromeSIDER
125Upset stomachSIDER
126Urinary tract infectionSIDER
127Urine output increasedSIDER
128UrticariaSIDER
129VomitingSIDER
130Weight decreasedSIDER
131WheezingSIDER
132Wound dehiscenceSIDER
133nervous system disorderSIDER
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