MetaADEDB 2.0 @ LMMD
naldemedine
(AXQACEQYCPKDMV-RZAWKFBISA-N)
Structure
SMILES
O=C(C1=C(O)[C@H]2[C@]34[C@](C1)(O)[C@@H](Cc1c4c(O2)c(O)cc1)N(CC3)CC1CC1)NC(c1onc(n1)c1ccccc1)(C)C
Type(s)
Approved; Investigational
ATC code(s)
A06AH05
Molecular Formula:
C32H34N4O6
Molecular Weight:
570.636
Log P:
3.8086
Hydrogen Bond Acceptor:
10
Hydrogen Bond Donor:
4
TPSA:
141.18
CAS Number(s):
916072-89-4
Synonym(s)
1.
naldemedine
2.
S-297995
3.
Symproic
External Link(s)
MeSHC000620491
PubChem Compound54732242
CHEMBLCHEMBL2105755
DrugBankDB11691
DrugCentral5220
IUPHAR/BPS Guide to PHARMACOLOGY9150
KEGGdr:D10188
Therapeutic Target DatabaseD0Q3PD
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 72US FAERS
2Abdominal PainFAERS: 39US FAERS
3NauseaFAERS: 18US FAERS
4Malignant neoplasm progressionFAERS: 14US FAERS
5ConstipationFAERS: 12US FAERS
6Unevaluable eventFAERS: 11US FAERS
7Drug withdrawal syndromeFAERS: 7US FAERS
8VomitingFAERS: 6US FAERS
9Abdominal discomfortFAERS: 5US FAERS
10Inappropriate schedule of drug administrationFAERS: 4US FAERS
11Wrong technique in product usage processFAERS: 4US FAERS
12FlatulenceFAERS: 3US FAERS
13No adverse eventFAERS: 3US FAERS
14ChillsFAERS: 2US FAERS
15Drug ToleranceFAERS: 2US FAERS
16HypersensitivityFAERS: 2US FAERS
17Inadequate analgesiaFAERS: 2US FAERS
18Inappropriate schedule of product administrationFAERS: 2US FAERS
19Prescribed underdoseFAERS: 2US FAERS
20Prescription drug used without a prescriptionFAERS: 2US FAERS
21TremorFAERS: 2US FAERS
22UrticariaFAERS: 2US FAERS
23Cerebrovascular accidentFAERS: 1US FAERS
24DehydrationFAERS: 1US FAERS
25Drug dispensing errorFAERS: 1US FAERS
26Drug screen positiveFAERS: 1US FAERS
27Feeling abnormalFAERS: 1US FAERS
28Flank PainFAERS: 1US FAERS
29FlushingFAERS: 1US FAERS
30IleusFAERS: 1US FAERS
31Infrequent bowel movementsFAERS: 1US FAERS
32Intentional product use issueFAERS: 1US FAERS
33Intestinal ObstructionFAERS: 1US FAERS
34MalaiseFAERS: 1US FAERS
35OverdoseFAERS: 1US FAERS
36PainFAERS: 1US FAERS
37Pancreatic carcinomaFAERS: 1US FAERS
38Product use in unapproved indicationFAERS: 1US FAERS
39PruritusFAERS: 1US FAERS
40Respiratory DepressionFAERS: 1US FAERS
41Restless Legs SyndromeFAERS: 1US FAERS
42SinusitisFAERS: 1US FAERS
43Therapeutic product ineffective for unapproved indicationFAERS: 1US FAERS
44Urinary RetentionFAERS: 1US FAERS
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