MetaADEDB 2.0 @ LMMD
repaglinide
(FAEKWTJYAYMJKF-QHCPKHFHSA-N)
Structure
SMILES
CCOc1cc(ccc1C(=O)O)CC(=O)N[C@H](c1ccccc1N1CCCCC1)CC(C)C
Type(s)
Approved; Investigational
ATC code(s)
A10BD14; A10BX02
Molecular Formula:
C27H36N2O4
Molecular Weight:
452.586
Log P:
5.6758
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
2
TPSA:
78.87
CAS Number(s):
135062-02-1
Synonym(s)
1.
repaglinide
2.
2-ethoxy-4-(2-((3-methyl-1-(2-(1-piperidinyl)phenyl)butyl)amino)-2-oxoethyl)benzoic acid
3.
2-ethoxy-N-(alpha-(2-methyl-1-propyl)-2-piperidinobenzyl)-4-carbamoylmethylbenzoic acid
4.
AG-EE 388
5.
AG-EE 388 ZW
6.
AG-EE 623 ZW
7.
GlucoNorm
8.
NovoNorm
9.
Prandin
10.
repa-glinide
11.
repaglinide, (+-)-isomer
External Link(s)
MeSHC072379
PubChem Compound65981
BindingDB50153520
ChEBI8805
CHEMBLCHEMBL1272
DrugBankDB00912
DrugCentral2366
IUPHAR/BPS Guide to PHARMACOLOGY6841
KEGGcpd:C07670
dr:D00594
Therapeutic Target DatabaseD0N5YA
ZINC3798537
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 11
Canada Vigilance: 2
Canada Vigilance
US FAERS
2Blood glucose increasedFAERS: 10
Canada Vigilance: 1
Canada Vigilance
US FAERS
3Blood glucose decreasedFAERS: 8OFFSIDES
US FAERS
4Suicide attemptFAERS: 8US FAERS
5HeadacheFAERS: 5
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
6Medication ErrorFAERS: 5US FAERS
7NauseaFAERS: 5OFFSIDES
SIDER
US FAERS
8Product substitution issueFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
9DizzinessFAERS: 4OFFSIDES
US FAERS
10EpistaxisFAERS: 4OFFSIDES
US FAERS
11Abdominal PainFAERS: 3OFFSIDES
SIDER
US FAERS
12Anaphylactic shockFAERS: 3SIDER
US FAERS
13AstheniaFAERS: 3OFFSIDES
US FAERS
14ConstipationFAERS: 3SIDER
US FAERS
15Diabetes mellitus inadequate controlFAERS: 3
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
16Drug abuseFAERS: 3US FAERS
17EpilepsyFAERS: 3US FAERS
18FatigueFAERS: 3US FAERS
19MalaiseFAERS: 3US FAERS
20OverdoseFAERS: 3US FAERS
21TremorFAERS: 3US FAERS
22AlopeciaFAERS: 2SIDER
US FAERS
23AphasiaFAERS: 2US FAERS
24Chest discomfortFAERS: 2US FAERS
25Drug exposure during pregnancyFAERS: 2US FAERS
26Food cravingFAERS: 2OFFSIDES
US FAERS
27HepatotoxicityFAERS: 2US FAERS
28PalpitationsFAERS: 2SIDER
US FAERS
29PruritusFAERS: 2SIDER
US FAERS
30PurpuraFAERS: 2US FAERS
31SoporFAERS: 2OFFSIDES
US FAERS
32Sudden Cardiac DeathFAERS: 2US FAERS
33Unevaluable eventFAERS: 2US FAERS
34UrticariaFAERS: 2SIDER
US FAERS
35Visual ImpairmentFAERS: 2SIDER
US FAERS
36VomitingFAERS: 2SIDER
US FAERS
37Weight decreasedFAERS: 2US FAERS
38Abdominal discomfortFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
39Accidental exposure to productFAERS: 1US FAERS
40Acute Coronary SyndromeFAERS: 1OFFSIDES
SIDER
US FAERS
41Amaurosis FugaxFAERS: 1US FAERS
42AmaurosisFAERS: 1US FAERS
43AnxietyFAERS: 1US FAERS
44Atrial FibrillationFAERS: 1US FAERS
45Back PainFAERS: 1SIDER
US FAERS
46Blood urea increasedFAERS: 1US FAERS
47Cerebrovascular accidentFAERS: 1US FAERS
48Chest PainFAERS: 1SIDER
US FAERS
49CholecystitisFAERS: 1US FAERS
50Coronary Artery DiseaseFAERS: 1US FAERS
51DehydrationFAERS: 1OFFSIDES
US FAERS
52Depressed Level of ConsciousnessFAERS: 1US FAERS
53DiplopiaFAERS: 1US FAERS
54Drug dispensing errorFAERS: 1US FAERS
55Drug prescribing errorFAERS: 1US FAERS
56DyspepsiaFAERS: 1OFFSIDES
SIDER
US FAERS
57Facial ParesisFAERS: 1US FAERS
58Flat affectFAERS: 1US FAERS
59HepatitisFAERS: 1OFFSIDES
SIDER
US FAERS
60Inappropriate schedule of drug administrationFAERS: 1US FAERS
61InflammationFAERS: 1US FAERS
62MarasmusFAERS: 1US FAERS
63Musculoskeletal PainFAERS: 1US FAERS
64Myocardial InfarctionFAERS: 1SIDER
US FAERS
65Ocular icterusFAERS: 1OFFSIDES
US FAERS
66PallorFAERS: 1US FAERS
67Pancreatic carcinomaFAERS: 1US FAERS
68PneumoniaFAERS: 1US FAERS
69Product counterfeitFAERS: 1OFFSIDES
US FAERS
70Protein total decreasedFAERS: 1US FAERS
71Skin reactionFAERS: 1US FAERS
72SplenomegalyFAERS: 1US FAERS
73StillbirthFAERS: 1US FAERS
74SwellingFAERS: 1US FAERS
75SyncopeFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
76TachycardiaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
77Therapy cessationFAERS: 1US FAERS
78Transaminases abnormalFAERS: 1US FAERS
79Ultrasound liver abnormalFAERS: 1US FAERS
80Urinary tract infectionFAERS: 1SIDER
US FAERS
81Uterine RuptureFAERS: 1US FAERS
82VasculitisFAERS: 1SIDER
US FAERS
83jaundiceFAERS: 1SIDER
US FAERS
84Abdominal InfectionOFFSIDES
85Abdominal rigidityOFFSIDES
86AbscessOFFSIDES
87AbuseOFFSIDES
88Acid refluxOFFSIDES
89AcidosisOFFSIDES
90AcneOFFSIDES
91ActinomycosisOFFSIDES
92Acute left ventricular failureOFFSIDES
93Acute myocardial infarctionOFFSIDES
94Acute otitis mediaOFFSIDES
95Albumin globulin ratio abnormalOFFSIDES
96Anaphylactoid ReactionSIDER
97Angina PectorisSIDER
98AngioedemaOFFSIDES
99AngioplastyOFFSIDES
100AnhedoniaOFFSIDES
101AnorexiaOFFSIDES
102Antiviral drug level above therapeuticOFFSIDES
103AnuriaOFFSIDES
104AphoniaOFFSIDES
105Arterial bypass operationOFFSIDES
106ArteriosclerosisOFFSIDES
107ArthralgiaSIDER
108AsterixisOFFSIDES
109AsthmaOFFSIDES
110Auricular swellingOFFSIDES
111BiopsyOFFSIDES
112Bladder NeoplasmOFFSIDES
113Blood GlucoseOFFSIDES
114Blood creatine increasedOFFSIDES
115Blood creatinine increasedOFFSIDES
116Blood erythropoietin increasedOFFSIDES
117Blood glucose abnormalOFFSIDES
118Blood glucose fluctuationOFFSIDES
119Blood immunoglobulin A increasedOFFSIDES
120Blood ketone bodyOFFSIDES
121Body TemperatureOFFSIDES
122BronchitisSIDER
123BursitisOFFSIDES
124Cardioactive drug level increasedOFFSIDES
125Catheter placementOFFSIDES
126Caustic injuryOFFSIDES
127CellulitisOFFSIDES
128Cerebral atrophyOFFSIDES
129Cervical cord compressionOFFSIDES
130Chronic Obstructive Airway DiseaseOFFSIDES
131Chronic left ventricular failureOFFSIDES
132CirrhosisOFFSIDES
133ClonusOFFSIDES
134ColitisOFFSIDES
135Compression fractureOFFSIDES
136Concomitant disease progressionOFFSIDES
137Cor pulmonaleOFFSIDES
138Coronary angioplastyOFFSIDES
139Creatinine renal clearance decreasedOFFSIDES
140Creatinine renal clearance increasedOFFSIDES
141Cytolytic hepatitisOFFSIDES
142DermabrasionOFFSIDES
143DermatitisSIDER
144DiabetesOFFSIDES
145Diabetes Mellitus12610074CTD
146Diabetic FootOFFSIDES
147Diabetic NephropathyOFFSIDES
148Diabetic RetinopathyOFFSIDES
149Diaphragmatic HerniaOFFSIDES
150DiarrheaOFFSIDES
151Diastolic dysfunctionOFFSIDES
152DrowsinessOFFSIDES
153Dry skinOFFSIDES
154Early satietyOFFSIDES
155Economic problemOFFSIDES
156EczemaOFFSIDES
157Electrocardiogram abnormalSIDER
158Emotional disorderOFFSIDES
159EnteritisOFFSIDES
160ErysipelasOFFSIDES
161Erythema MultiformeSIDER
162ErythemaSIDER
163Essential TremorOFFSIDES
164Extremity necrosisOFFSIDES
165Fatty LiverOFFSIDES
166Femoral pulse decreasedOFFSIDES
167Fixed eruptionOFFSIDES
168FlatulenceOFFSIDES
169Floppy iris syndromeOFFSIDES
170Food AllergyOFFSIDES
171Food aversionOFFSIDES
172Gastric infectionOFFSIDES
173Gastric ulcer helicobacterOFFSIDES
174GastroduodenitisOFFSIDES
175GastroenteritisOFFSIDES
176Gastrointestinal PainSIDER
177Gastrointestinal sounds abnormalOFFSIDES
178General physical health deteriorationOFFSIDES
179Genital HerpesOFFSIDES
180Glutamate dehydrogenase increasedOFFSIDES
181GranulocytosisOFFSIDES
182Hantaviral infectionOFFSIDES
183HemiparesisOFFSIDES
184Hepatitis B positiveOFFSIDES
185HypercapniaOFFSIDES
186HypercreatininaemiaOFFSIDES
187HyperpigmentationOFFSIDES
188HypersensitivitySIDER
189Hypertensive cardiomyopathyOFFSIDES
190Hypertensive heart diseaseOFFSIDES
191Hyperviscosity syndromeOFFSIDES
192HypokinesiaOFFSIDES
193HypoxiaOFFSIDES
194Idiopathic urticariaOFFSIDES
195Immunosuppressant drug level decreasedOFFSIDES
196Impaired gastric emptyingOFFSIDES
197Injection site dermatitisOFFSIDES
198Injection site urticariaOFFSIDES
199Intention tremorOFFSIDES
200Jaundice, Obstructive23956101CTD
201Joint sprainOFFSIDES
202Kidney FailureOFFSIDES
203LacerationOFFSIDES
204Large intestine perforationOFFSIDES
205LethargyOFFSIDES
206LeukopeniaSIDER
207Lichen PlanusOFFSIDES
208LipaseOFFSIDES
209Locked-In SyndromeOFFSIDES
210Lupus hepatitisOFFSIDES
211Macular pseudoholeOFFSIDES
212MalnutritionSIDER
213Mixed liver injuryOFFSIDES
214Monoclonal immunoglobulin presentOFFSIDES
215Multiple drug overdose intentionalOFFSIDES
216Muscle WeaknessOFFSIDES
217Musculoskeletal discomfortSIDER
218MyelocytosisOFFSIDES
219Nodule on extremityOFFSIDES
220Nutritional condition abnormalOFFSIDES
221OliguriaOFFSIDES
222OrthopneaOFFSIDES
223Orthostatic hypertensionOFFSIDES
224OsteolysisOFFSIDES
225PROTHROMBIN TIMEOFFSIDES
226PancreatitisOFFSIDES
SIDER
227ParakeratosisOFFSIDES
228Pelvic abscessOFFSIDES
229PhotodermatosisOFFSIDES
230PneumoperitoneumOFFSIDES
231Polysubstance dependenceOFFSIDES
232Potentiating drug interactionOFFSIDES
233Progressive supranuclear palsyOFFSIDES
234Protein-losing gastroenteropathyOFFSIDES
235PsoriasisOFFSIDES
236Pulmonary arterial hypertensionOFFSIDES
237Purulent dischargeOFFSIDES
238QuadriparesisOFFSIDES
239RalesOFFSIDES
240Renal embolismOFFSIDES
241Respiratory tract congestionOFFSIDES
242RhinitisSIDER
243RhinorrheaOFFSIDES
244SchizophreniaOFFSIDES
245Sinus bradycardiaOFFSIDES
246SinusitisSIDER
247Skin hypertrophyOFFSIDES
248Skin lesionOFFSIDES
249Skin necrosisOFFSIDES
250Skin tightnessOFFSIDES
251Somogyi phenomenonOFFSIDES
252Squamous cell carcinoma of skinOFFSIDES
253Stevens-Johnson Syndrome25811541CTD
SIDER
254Sudden deathOFFSIDES
255Therapeutic response unexpectedOFFSIDES
256Thoracic vertebral fractureOFFSIDES
257Throat cancerOFFSIDES
258ThrombocytopeniaSIDER
259TineaOFFSIDES
260Tongue bitingOFFSIDES
261Transaminases increasedOFFSIDES
262UlcerOFFSIDES
263VIIth nerve paralysisOFFSIDES
264Vaginal mycosisOFFSIDES
265Ventricular FibrillationOFFSIDES
266Visual disturbanceSIDER
267Weight GainOFFSIDES
268White blood cell count abnormalOFFSIDES
269XerosisOFFSIDES
270bone marrow fibrosisOFFSIDES
271furuncleOFFSIDES
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