MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Vindesine

(HHJUWIANJFBDHT-KOTLKJBCSA-N)

Structure

SMILES: COc1cc2N(C)[C@@H]3[C@@]4(c2cc1[C@]1(C[C@@H]2CN(CCc5c1[nH]c1c5cccc1)C[C@](C2)(O)CC)C(=O)OC)CCN1[C@H]4[C@@]([C@H]([C@]3(O)C(=O)N)O)(CC)C=CC1
Type(s): Approved; Investigational
ATC code(s): L01CA03
Molecular Formula:: C43H55N5O7
Molecular Weight:: 753.926
Log P:: 3.3735
Hydrogen Bond Acceptor:: 11
Hydrogen Bond Donor:: 5
TPSA:: 164.82
CAS Number(s):: 53643-48-4

Synonym(s)

Vindesine

Compound 112531

Desacetylvinblastine Amide

Eldisine

Enison

NSC-245467

Vindesin

Vindesine Sulfate

NSC 245467

10.

NSC245467

11.

Sulfate, Vindesine

External Link(s)

MeSH	D014751
PubChem Compound	40839
ChEBI	36373
CHEMBL	CHEMBL219146
DrugBank	DB00309
KEGG	dr:D01769 dr:D06304
Therapeutic Target Database	D04RLY
ZINC	8214470

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Acute kidney injury	2170045 2982552	CTD
2	Adenocarcinoma	7438123	CTD
3	Agranulocytosis	7193278	CTD
4	Alanine Aminotransferase Increased		OFFSIDES
5	Alopecia	View details 455584 455585 6249481 6683629 6707719 7438123	CTD
6	Amnesia		OFFSIDES
7	Anemia	6683629	CTD
8	Angina Pectoris	3948198 7060049	CTD
9	Antithrombin III decreased		OFFSIDES
10	Anuria		OFFSIDES
11	Aphthous Stomatitis		OFFSIDES
12	Ascites		OFFSIDES
13	Aspergillosis		OFFSIDES
14	Azotemia	3019976	CTD
15	Benign Prostatic Hyperplasia		OFFSIDES
16	Biopsy liver abnormal		OFFSIDES
17	Blindness, Cortical	2312856	CTD
18	Blood Glucose		OFFSIDES
19	Blood alkaline phosphatase increased		OFFSIDES
20	Blood creatinine increased		OFFSIDES
21	Blood lactate dehydrogenase increased		OFFSIDES
22	Blood sodium increased		OFFSIDES
23	Bone Marrow Diseases	View details 455265 2982552 3040918 6249481 6268296	CTD
24	Bradycardia		OFFSIDES
25	Brain Edema	17018103	CTD
26	Brain Ischemia	2312856	CTD
27	Brain Neoplasms	7438126	CTD
28	Brain scan abnormal		OFFSIDES
29	Bronchial Neoplasms	2053780	CTD
30	Bronchitis		OFFSIDES
31	Carcinoma, Small Cell	6282107	CTD
32	Carcinoma, Transitional Cell	8602639	CTD
33	Carcinoma	455585 455587	CTD
34	Cataract		OFFSIDES
35	Cauda Equina Syndrome		OFFSIDES
36	Cellulitis	481319 6282107 6707719	CTD
37	Cheilitis		OFFSIDES
38	Chills	6707719	CTD
39	Clostridium difficile colitis		OFFSIDES
40	Coagulation factor VII level decreased		OFFSIDES
41	Colorectal Neoplasms	6249481 7273021	CTD
42	Constipation	View details 455585 6249481 6268296 6299598 7193278 7438123	CTD
43	Cytolytic hepatitis		OFFSIDES
44	Delusional disorder, persecutory type		OFFSIDES
45	Demyelinating Diseases	17018103	CTD
46	Dental abscess		OFFSIDES
47	Diarrhea	6249481	CTD
48	Disease recurrence		OFFSIDES
49	Disseminated Intravascular Coagulation	1729088	CTD
50	Drowsiness		OFFSIDES
51	Drug resistance		OFFSIDES
52	Dysphonia		OFFSIDES
53	Enteral Nutrition		OFFSIDES
54	Enterocolitis		OFFSIDES
55	Epistaxis		OFFSIDES
56	Escherichia infection		OFFSIDES
57	Esophageal Neoplasms	455587 1519930	CTD
58	Febrile Neutropenia		OFFSIDES
59	Febrile bone marrow aplasia		OFFSIDES
60	Fever	6249481 6707719 7438123	CTD
61	Gamma-Glutamyltransferase Increased		OFFSIDES
62	Gastric mucosal lesion		OFFSIDES
63	Gastrointestinal Diseases	6707719 7038420	CTD
64	General physical condition		OFFSIDES
65	Glioblastoma	7438126	CTD
66	Head and Neck Neoplasms	7438126	CTD
67	Hematuria	8602639	CTD
68	Hepatitis B positive		OFFSIDES
69	Histiocytosis haematophagic		OFFSIDES
70	Hodgkin Disease	455587 7038420	CTD
71	Hyperpigmentation		OFFSIDES
72	Hypoxia		OFFSIDES
73	Ileus	6268296 10928138	CTD
74	Incontinence		OFFSIDES
75	Infection		OFFSIDES
76	Injury asphyxiation		OFFSIDES
77	Intestinal Pseudo-Obstruction	2312856 17617780	CTD
78	Legionella serology positive		OFFSIDES
79	Leukopenia	View details 455585 455587 3857971 6288237 6299598 6305668 7248983 7438123 7438126 9256897 10928138	CTD
80	Locked-In Syndrome		OFFSIDES
81	Lung Neoplasms	View details 1729088 2170045 3040918 3818785 6268296 7438126	CTD
82	Lung diseases	2982552	CTD
83	Lymphoma, Non-Hodgkin	455587 3327022	CTD
84	Lymphoma	7273021 7438126	CTD OFFSIDES
85	Mechanical ventilation		OFFSIDES
86	Multiple Myeloma	7262159	CTD
87	Muscle Weakness	View details 2930717 6299598 7193278 7438123	CTD
88	Myeloblast count increased		OFFSIDES
89	Nausea	View details 2982552 6249481 7438123 10928138	CTD
90	Neoplasms, Experimental	17878523	CTD
91	Neuroblastoma	7038420 7438126	CTD
92	Neurotoxicity Syndromes	View details 455585 2930717 2982552 6268296 6305668 6683629 6707719 7248983 7438123 7438126	CTD
93	Neutropenia	6707719	CTD
94	Neutropenic infection		OFFSIDES
95	Oxygen saturation abnormal		OFFSIDES
96	Pain of skin		OFFSIDES
97	Pain	View details 2930717 6707719 7193278 7438123	CTD
98	Paresthesia	View details 6249481 6299598 7193278 7438123	CTD
99	Peripheral Nervous System Diseases	View details 455587 6249481 6268296 6299598 7307235 7438126	CTD
100	Pharmaceutical product complaint		OFFSIDES
101	Phlebitis	View details 481319 6249481 6282107 6707719	CTD OFFSIDES
102	Plasminogen decreased		OFFSIDES
103	Pneumocystis jiroveci pneumonia		OFFSIDES
104	Prostatic Neoplasms	6683629 7438126	CTD
105	Pulmonary Infarction		OFFSIDES
106	Radiation Pneumonitis		OFFSIDES
107	Reflex, Abnormal	6249481 7307235 7438123	CTD
108	Residual urine		OFFSIDES
109	Restrictive pulmonary disease		OFFSIDES
110	Sarcoma	7438126	CTD
111	Scab		OFFSIDES
112	Sinusitis		OFFSIDES
113	Status Epilepticus		OFFSIDES
114	Stevens-Johnson Syndrome		OFFSIDES
115	Stomach Neoplasms	1519930 2930717	CTD
116	Stomatitis	6249481	CTD
117	Testicular Neoplasms	455587 7438126	CTD
118	Thrombocytopenia	View details 455585 3857971 6282107 6299598 9256897	CTD
119	Thrombocytosis	6282107	CTD
120	Treatment related secondary malignancy		OFFSIDES
121	Upper airway obstruction		OFFSIDES
122	Ventricular hypokinesia		OFFSIDES
123	Vocal Cord Paralysis		OFFSIDES
124	Vomiting	View details 2982552 6249481 7438123 10928138	CTD
125	Weight Gain		OFFSIDES
126	leiomyosarcoma	7438126	CTD
127	leukemia	6268296 7193278	CTD
128	melanoma	View details 455584 455587 2930717 6707719 7273021 7438126 16225601	CTD
129	treatment failure		OFFSIDES

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