MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Sulfadiazine

(SEEPANYCNGTZFQ-UHFFFAOYSA-N)

Structure

SMILES: Nc1ccc(cc1)S(=O)(=O)Nc1ncccn1
Type(s): Approved; Investigational; Vet_approved
ATC code(s): G01AE10; J01EC02; J01EE02; J01EE06
Molecular Formula:: C10H10N4O2S
Molecular Weight:: 250.277
Log P:: 2.5946
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 2
TPSA:: 106.35
CAS Number(s):: 68-35-9; 141582-64-1

Synonym(s)

Sulfadiazine

Sulfazin

Sulfazine

Sulphadiazine

Zinc Sulfadiazine

Sulfadiazine, Zinc

External Link(s)

MeSH	D013411
PubChem Compound	5215
BindingDB	50166571
ChEBI	9328
CHEMBL	CHEMBL439
DrugBank	DB00359
DrugCentral	2500
KEGG	cpd:C07658 dr:D00587
Therapeutic Target Database	D05LKP
ZINC	120319

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Hypersensitivity	FAERS: 10		SIDER US FAERS
2	Abdominal Pain	FAERS: 2		SIDER US FAERS
3	Asthenia	FAERS: 2		OFFSIDES US FAERS
4	Back Pain	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
5	Dysuria	FAERS: 2		US FAERS
6	Malaise	FAERS: 2		US FAERS
7	Mental status changes	FAERS: 2		OFFSIDES US FAERS
8	Pancreatitis	FAERS: 2		SIDER US FAERS
9	Pneumonitis	FAERS: 2		US FAERS
10	Polyuria	FAERS: 2		SIDER US FAERS
11	Proteinuria	FAERS: 2		US FAERS
12	Rectal tenesmus	FAERS: 2		US FAERS
13	Vomiting	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
14	jaundice	FAERS: 2		US FAERS
15	Activities of daily living impaired	FAERS: 1		US FAERS
16	Acute kidney injury	FAERS: 1	View details 1524357 1598436 1776146 2362647 2385768 3389358 7598556 7786252 8133705 8243240 8513601 8714165 8773165 8949595 9038528 10395422 10939760 14650303 15206032 15909603 16550134 16732870 17907889 18701149	CTD US FAERS
17	Alanine Aminotransferase Increased	FAERS: 1		US FAERS
18	Argyria	FAERS: 1		US FAERS
19	Arthralgia	FAERS: 1		SIDER US FAERS
20	Aspartate Aminotransferase Increased	FAERS: 1		US FAERS
21	Burning sensation	FAERS: 1		SIDER US FAERS
22	Clostridium difficile infection	FAERS: 1		US FAERS
23	Colitis	FAERS: 1		US FAERS
24	Crystal urine present	FAERS: 1		US FAERS
25	Dizziness	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
26	Drug dispensing error	FAERS: 1		US FAERS
27	Drug level fluctuating	FAERS: 1		US FAERS
28	Encephalitis	FAERS: 1	8773165	CTD OFFSIDES US FAERS
29	Excoriation	FAERS: 1		US FAERS
30	Histiocytosis haematophagic	FAERS: 1		OFFSIDES US FAERS
31	Hydronephrosis	FAERS: 1		OFFSIDES US FAERS
32	Medication Error	FAERS: 1		US FAERS
33	Megacolon	FAERS: 1		US FAERS
34	Memory impairment	FAERS: 1		US FAERS
35	Nausea	FAERS: 1		SIDER US FAERS
36	Nephrolithiasis	FAERS: 1	View details 7973549 8513601 15025231 15206032	CTD US FAERS
37	Pain	FAERS: 1		OFFSIDES US FAERS
38	Pancytopenia	FAERS: 1		US FAERS
39	Procedural hypotension	FAERS: 1		US FAERS
40	Rash erythematous	FAERS: 1		US FAERS
41	Rhabdomyolysis	FAERS: 1		US FAERS
42	Stevens-Johnson Syndrome	FAERS: 1		OFFSIDES SIDER US FAERS
43	Tachycardia	FAERS: 1		US FAERS
44	Toxic Epidermal Necrolysis	FAERS: 1		SIDER US FAERS
45	Toxicity to various agents	FAERS: 1		US FAERS
46	Toxoplasmosis	FAERS: 1	View details 8228015 8773165 9043986 14650303 15909603 16550134 18701149	CTD OFFSIDES US FAERS
47	Tremor	FAERS: 1		US FAERS
48	Urticaria	FAERS: 1 Canada Vigilance: 9	11792017	CTD SIDER Canada Vigilance US FAERS
49	Wrong drug administered	FAERS: 1		US FAERS
50	Acute respiratory failure			OFFSIDES
51	Agranulocytosis			SIDER
52	Anaphylactic shock			SIDER
53	Anaphylactoid Reaction			SIDER
54	Angioedema	Canada Vigilance: 1		Canada Vigilance
55	Anorexia			SIDER
56	Antiphospholipid antibodies positive			OFFSIDES
57	Anuria	Canada Vigilance: 1	4761062	CTD SIDER Canada Vigilance
58	Apathy			OFFSIDES
59	Arthritis			OFFSIDES
60	Aspergillosis			OFFSIDES
61	Ataxia			OFFSIDES SIDER
62	Bacterial colonisation			SIDER
63	Bacterial disease carrier			SIDER
64	Beta-2 glycoprotein antibody positive			OFFSIDES
65	Blood Glucose			OFFSIDES
66	Blood albumin decreased			OFFSIDES
67	Blood magnesium decreased			OFFSIDES
68	Blood phosphorus decreased			OFFSIDES
69	Blood potassium decreased			OFFSIDES
70	Brain Diseases		8228015	CTD
71	Brain natriuretic peptide increased			OFFSIDES
72	Cellulitis			OFFSIDES
73	Central nervous system lesion			OFFSIDES
74	Chills			SIDER
75	Cholangiolitis			OFFSIDES
76	Chorioretinitis		1776146	CTD
77	Circumstance or information capable of leading to medication error			OFFSIDES
78	Confabulation			OFFSIDES
79	Conjunctival irritation			OFFSIDES
80	Crystalluria			SIDER
81	Cytolytic hepatitis			OFFSIDES
82	Deafness			OFFSIDES
83	Dehydration			OFFSIDES
84	Dependence			OFFSIDES
85	Depressed Level of Consciousness			OFFSIDES
86	Dermatitis	Canada Vigilance: 2		Canada Vigilance SIDER
87	Device malfunction			OFFSIDES
88	Disease Progression			OFFSIDES
89	Diuresis			SIDER
90	Drug Eruptions		11792017	CTD
91	Drug abuser			OFFSIDES
92	Drug addict			OFFSIDES
93	Drug resistance			OFFSIDES
94	Drug toxicity			OFFSIDES
95	Enterocolitis			OFFSIDES
96	Eosinophilic myocarditis			SIDER
97	Erythema Multiforme			OFFSIDES SIDER
98	Erythema	Canada Vigilance: 1		Canada Vigilance OFFSIDES
99	Exfoliative rash			OFFSIDES
100	Flatulence	Canada Vigilance: 1		Canada Vigilance
101	Flushing	Canada Vigilance: 1		Canada Vigilance
102	Formication			OFFSIDES
103	Gamma-Glutamyltransferase Increased			OFFSIDES
104	Gastrointestinal Pain			SIDER
105	General physical health deterioration			OFFSIDES
106	Glomerulonephritis		3972708	CTD
107	Glossitis			OFFSIDES
108	Goiter			OFFSIDES
109	Granulocytes maturation arrest			OFFSIDES
110	Headache	Canada Vigilance: 1		Canada Vigilance SIDER
111	Hematuria		3389358	CTD
112	Hepatic necrosis			SIDER
113	Hepatitis			SIDER
114	Hydrocephalus			OFFSIDES
115	Hypersplenism acquired			OFFSIDES
116	Hypertransaminasaemia			OFFSIDES
117	Hypophagia			OFFSIDES
118	Immunosuppression			OFFSIDES
119	Kidney Calculi		View details 1438755 7598556 8773165 10939760	CTD
120	Kidney Diseases		10555419	CTD
121	Kidney Failure			OFFSIDES
122	Leukoencephalitis, Acute Hemorrhagic		17907889	CTD
123	Leukopenia neonatal			OFFSIDES
124	Leukopenia	Canada Vigilance: 1		Canada Vigilance SIDER
125	Listeriosis			OFFSIDES
126	Lupus Erythematosus, Systemic		68769	CTD
127	Lupus Erythematosus			SIDER
128	Meningitis		4761062	CTD
129	Microlithiasis			OFFSIDES
130	Multi-organ disorder			OFFSIDES
131	Muscle Weakness			OFFSIDES
132	Musculoskeletal discomfort			SIDER
133	Musculoskeletal stiffness			OFFSIDES
134	Mycosis Fungoides			OFFSIDES
135	Necrolysis epidermal			SIDER
136	Nephrogenic Diabetes Insipidus			OFFSIDES
137	Nephrosis			SIDER
138	Nephrotic Syndrome			SIDER
139	Neuritis			SIDER
140	Nocardia Infections		7598556	CTD
141	Oliguria			SIDER
142	Oral fungal infection			OFFSIDES
143	Osteolysis			OFFSIDES
144	Paracoccidioidomycosis		1340011	CTD
145	Paradoxical drug reaction			OFFSIDES
146	Partner stress			SIDER
147	Phlebitis			OFFSIDES
148	Pleocytosis			OFFSIDES
149	Pneumonia, Bacterial		7598556	CTD
150	Polyarteritis Nodosa			SIDER
151	Portal Hypertension			OFFSIDES
152	Pruritus	Canada Vigilance: 1		Canada Vigilance SIDER
153	Psychomotor Agitation		4131182	CTD
154	Purpura	Canada Vigilance: 1		Canada Vigilance SIDER
155	Reaction gastrointestinal			SIDER
156	Renal Colic			OFFSIDES
157	Renal Insufficiency		View details 1340011 1436353 3400670 8272240 8463770 9043986 11322040 16351495	CTD
158	Retinitis		18701149	CTD
159	Schistosomiasis			OFFSIDES
160	Sepsis			SIDER
161	Seroconversion test positive			OFFSIDES
162	Serositis			OFFSIDES
163	Serum Sickness			SIDER
164	Sinusitis		10888991	CTD
165	Skin lesion			OFFSIDES
166	Skin necrosis			SIDER
167	Staphylococcal abscess			OFFSIDES
168	Status Epilepticus			OFFSIDES
169	Stomatitis			SIDER
170	Thoracic vertebral fracture			OFFSIDES
171	Thrombocytopenia			SIDER
172	Tinnitus	Canada Vigilance: 1		Canada Vigilance SIDER
173	Toxoplasmosis, Cerebral		View details 1598436 1863412 2385768 3389358 3400670 7741386 7973549 8243240 8272240 8463770 8949595 10555419 15025231 15206032 16732870	CTD
174	Ultrasound scan abnormal			OFFSIDES
175	Urolithiasis		View details 1340011 1863412 2385768 3400670 8949595 15909603 18701149	CTD
176	Vascular purpura			SIDER
177	Venous Insufficiency			OFFSIDES
178	Vertigo			SIDER
179	furuncle			OFFSIDES

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