triptolide
(DFBIRQPKNDILPW-CIVMWXNOSA-N)
Structure
- SMILES
- O=C1OCC2=C1CC[C@]1([C@H]2C[C@H]2[C@@]3([C@@]41O[C@H]4[C@@H]1O[C@@]1([C@H]3O)C(C)C)O2)C
- Type(s)
- Investigational
- Molecular Formula:
- C20H24O6
- Molecular Weight:
- 360.401
- Log P:
- 1.1031
- Hydrogen Bond Acceptor:
- 6
- Hydrogen Bond Donor:
- 1
- TPSA:
- 84.12
- CAS Number(s):
- 38748-32-2
Synonym(s)
1.
triptolide
2.
PG490
External Link(s)
| MeSH | C001899 |
| PubChem Compound | 107985 |
| BindingDB | 50241049 |
| ChEBI | 9747 |
| CHEMBL | CHEMBL463763 |
| DrugBank | DB12025 |
| KEGG | cpd:C09204 |
| Therapeutic Target Database | D0I6LH |
| ZINC | 8234271 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Acute kidney injury | 19546256 | CTD | |
| 2 | Anorexia | 20223271 | CTD | |
| 3 | Carcinoma, Pancreatic Ductal | 24842335 | CTD | |
| 4 | Cardiomyopathies | 25169008 | CTD | |
| 5 | Cardiotoxicity | 30009776 | CTD | |
| 6 | Chemical and Drug Induced Liver Injury | CTD | ||
| 7 | Diarrhea | 20223271 | CTD | |
| 8 | Fatty Liver | 20223271 | CTD | |
| 9 | Inflammation | 21640813 | CTD | |
| 10 | Kidney Diseases | 19879934 | CTD | |
| 11 | Leprosy | 23639586 | CTD | |
| 12 | Lupus Erythematosus, Systemic | 23639586 | CTD | |
| 13 | Multiple Myeloma | 19330649 | CTD | |
| 14 | Multiple Organ Failure | 21596114 | CTD | |
| 15 | Necrosis | 24949944 | CTD | |
| 16 | Neoplasm Invasiveness | 26420756 | CTD | |
| 17 | Neoplasm Metastasis | 12533674 | CTD | |
| 18 | Neoplasms, Experimental | 12533674 24842335 | CTD | |
| 19 | Neoplasms | 21640813 | CTD | |
| 20 | Nephritis | 23639586 | CTD | |
| 21 | Oligospermia | 26219505 30836114 | CTD | |
| 22 | Ovarian Diseases | 20223271 | CTD | |
| 23 | Pneumonia | 20348278 | CTD | |
| 24 | Proteinuria | 18509322 | CTD | |
| 25 | Splenomegaly | 20223271 | CTD | |
| 26 | Teratozoospermia | 30836114 | CTD | |
| 27 | Testicular Diseases | 30836114 | CTD |
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