MetaADEDB 2.0 @ LMMD
Troglitazone
(GXPHKUHSUJUWKP-UHFFFAOYSA-N)
Structure
SMILES
O=C1NC(=O)C(S1)Cc1ccc(cc1)OCC1(C)CCc2c(O1)c(C)c(c(c2C)O)C
Type(s)
Investigational; Withdrawn
ATC code(s)
A10BG01
Molecular Formula:
C24H27NO5S
Molecular Weight:
441.540
Log P:
4.7030
Hydrogen Bond Acceptor:
7
Hydrogen Bond Donor:
2
TPSA:
110.16
CAS Number(s):
97322-87-7
Synonym(s)
1.
Troglitazone
2.
5-(4-((6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl-methoxy)benzyl)-2,4-thiazolidinedione) - T
3.
CS 045
4.
CS-045
5.
Prelay
6.
Rezulin
7.
CS045
External Link(s)
MeSHD000077288
PubChem Compound5591
BindingDB50088494
50101974
ChEBI9753
CHEMBLCHEMBL408
DrugBankDB00197
DrugCentral2767
IUPHAR/BPS Guide to PHARMACOLOGY2693
KEGGdr:D00395
Therapeutic Target DatabaseD06XZW
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1MalaiseFAERS: 4SIDER
US FAERS
2jaundiceFAERS: 49652998
10795774
11194222		CTD
SIDER
US FAERS
3NauseaFAERS: 3SIDER
US FAERS
4Mental status changesFAERS: 2US FAERS
5Abdominal PainFAERS: 1OFFSIDES
SIDER
US FAERS
6Abdominal symptomFAERS: 1US FAERS
7ArthralgiaFAERS: 1US FAERS
8Abdominal discomfortOFFSIDES
9AbscessOFFSIDES
10Accidental overdoseOFFSIDES
11Acidosis14506076
15501982		CTD
12Acute Lung Injury21153920CTD
13AdenocarcinomaOFFSIDES
14Alanine Aminotransferase IncreasedSIDER
15Albuminuria11912544CTD
16AngioplastyOFFSIDES
17Anorexia15824971CTD
OFFSIDES
SIDER
18ApathyOFFSIDES
19Apparent deathOFFSIDES
20ArteriosclerosisOFFSIDES
21AstheniaOFFSIDES
SIDER
22Atherosclerosis8878442
11231916		CTD
23Atrioventricular BlockOFFSIDES
24Autoimmune hepatitisOFFSIDES
25Blood GlucoseOFFSIDES
26Blood cholesterolOFFSIDES
27Blood glucose decreasedOFFSIDES
28BradycardiaOFFSIDES
29Brain ConcussionOFFSIDES
30Breast MicrocalcificationOFFSIDES
31CataractOFFSIDES
32CellulitisOFFSIDES
33Chemical and Drug Induced Liver Injury

View details

9652998
10749332
10989325
11281188
12963435
14986274
15525695
16115720
17150972
17975114
18495193
18524759
19631733
19632256
20709092
20860658
21315101
22166485
22331495
22902350
23397584
23956101
24014644
24085192
25663337
25934330
26643070
26921665
27485346
27765674
28437613
28762043
29407385
 		CTD
34Chest PainOFFSIDES
35Choking sensationOFFSIDES
36CholangiolitisOFFSIDES
37Cholestasis

View details

9839107
11179459
11374713
24713091
25663337
 		CTD
38Circumstance or information capable of leading to medication errorOFFSIDES
39Cold sweatOFFSIDES
40Colitis11346461CTD
41Colonic Neoplasms

View details

11346461
12475986
15818612
15892897
16899971
20540935
 		CTD
42ConfabulationOFFSIDES
43DehydrationOFFSIDES
44DemyelinationOFFSIDES
45DiabetesOFFSIDES
46Diabetes Mellitus, Experimental

View details

9389757
9452481
10900012
11947963
14563825
14697232
 		CTD
47Diabetes Mellitus15525695
20860658		CTD
48Diabetes mellitus inadequate controlOFFSIDES
49Diabetic Angiopathies12601628CTD
50Diabetic FootOFFSIDES
51Diabetic foot infectionOFFSIDES
52Diabetic ulcerOFFSIDES
53DiarrheaOFFSIDES
54DiscomfortSIDER
55DiverticulitisOFFSIDES
56DiverticulosisOFFSIDES
57DiverticulumOFFSIDES
58DizzinessSIDER
59Drug dispensing errorOFFSIDES
60Drug toxicityOFFSIDES
61Dysthymic DisorderOFFSIDES
62Economic problemOFFSIDES
63Electromechanical dissociationOFFSIDES
64Escherichia urinary tract infectionOFFSIDES
65Esophageal StenosisOFFSIDES
66FatigueOFFSIDES
SIDER
67Fatty Liver11281188CTD
68Feeling abnormalSIDER
69Fibrosis15211114CTD
70Gastrointestinal PainSIDER
71General physical health deteriorationOFFSIDES
72Glioma16820965CTD
73Glomerulonephritis11318962CTD
74Glucose Metabolism Disorders9589670
10726906		CTD
75Heart Diseases22166485CTD
76Hemangiosarcoma

View details

17569031
18465119
19285096
21684317
21937740
28973697
 		CTD
77Hepatic Encephalopathy9652998CTD
78Hepatitis10795774
11194222
11374713		CTD
OFFSIDES
SIDER
79HepatotoxicityOFFSIDES
80Hyperbilirubinemia15824971CTD
81Hyperglycemia

View details

8786734
9389757
9502777
11231916
11768731
11918743
14697232
20846491
 		CTD
82Hyperinsulinism

View details

8786734
9389757
9502777
11889176
11909685
12661920
 		CTD
83Hyperplasia8878442CTD
84Hypertriglyceridemia

View details

9452481
9502777
9727893
11768731
15824971
 		CTD
85HypophagiaOFFSIDES
86Idiosyncratic drug reactionSIDER
87Impaired gastric emptyingOFFSIDES
88IncontinenceOFFSIDES
89Inflammation21617575CTD
90Insulin Resistance

View details

8772734
9502777
9544743
9727893
9920142
11118623
11947963
20846491
 		CTD
91Intention tremorOFFSIDES
92Ischemia12468449CTD
93Kidney FailureOFFSIDES
94Leukostasis12468449CTD
95Liver Cirrhosis11281188CTD
96Liver Failure, Acute

View details

10685776
10749332
10989325
12639207
12681458
 		CTD
97Liver Failure9652998
10068399
10685643		CTD
98Liver Neoplasms, Experimental15526359CTD
99Liver neoplasms10503899CTD
100Lung Neoplasms16149072CTD
101Mammary Neoplasms, Experimental9671760CTD
102Massive Hepatic Necrosis9839107CTD
103Muscle WeaknessOFFSIDES
104Muscle necrosisOFFSIDES
105Myositis11281188CTD
106Necrosis

View details

17150972
17569031
18495193
18956761
 		CTD
107Neoplasm Invasiveness14618613
19285010		CTD
108Neuroblastoma16820965CTD
109Neurotoxicity Syndromes11750908CTD
110Pancreatitis, Chronic15211114CTD
111Paranasal sinus hypersecretionOFFSIDES
112Pericardial effusionOFFSIDES
113PericarditisOFFSIDES
114Peritoneal Fibrosis17199790CTD
115Pharmaceutical product complaintOFFSIDES
116Polycystic Ovary Syndrome10814527
11889176		CTD
117Postoperative infectionOFFSIDES
118Precancerous Conditions11346461CTD
119Prescribed overdoseOFFSIDES
120Proteinuria11318962CTD
121Pruritus10795774CTD
122Psoriasis10815854CTD
123Pulmonary Fibrosis18162602CTD
124Renal Insufficiency22166485CTD
125Renal cystOFFSIDES
126Renal tubular atrophyOFFSIDES
127Renal tubular necrosisOFFSIDES
128Reperfusion Injury12468449CTD
129ShockSIDER
130Skin Neoplasms15610522CTD
131Splenic Neoplasms17569031
18465119		CTD
132Stevens-Johnson SyndromeOFFSIDES
133Stomach Neoplasms15930296
19140230
21461570		CTD
134SyncopeSIDER
135Unevaluable eventOFFSIDES
136Vascular Neoplasms10198275
17569031		CTD
137VomitingSIDER
138Weight Gain

View details

9727893
11118623
11909685
16483873
 		CTD
OFFSIDES
139Wound abscessOFFSIDES
140liposarcoma10097144CTD
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120239

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.