MetaADEDB 2.0 @ LMMD
zileuton
(MWLSOWXNZPKENC-UHFFFAOYSA-N)
Structure
SMILES
ON(C(c1cc2c(s1)cccc2)C)C(=O)N
Type(s)
Approved; Investigational; Withdrawn
Molecular Formula:
C11H12N2O2S
Molecular Weight:
236.290
Log P:
3.4325
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
94.8
CAS Number(s):
111406-87-2
Synonym(s)
1.
zileuton
2.
A 64077
3.
A-64077
4.
Abbot 64077
5.
N-(1-benzo(b)thien-2-ylethyl)-N-hydroxyurea
6.
Zyflo
External Link(s)
MeSHC063449
PubChem Compound60490
BindingDB50000541
ChEBI10112
CHEMBLCHEMBL93
DrugBankDB00744
DrugCentral2862
IUPHAR/BPS Guide to PHARMACOLOGY5297
KEGGdr:D00414
Therapeutic Target DatabaseD09JUG
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Alanine Aminotransferase IncreasedFAERS: 9OFFSIDES
US FAERS
2HeadacheFAERS: 8SIDER
US FAERS
3NauseaFAERS: 5OFFSIDES
SIDER
US FAERS
4Aspartate Aminotransferase IncreasedFAERS: 4US FAERS
5PruritusFAERS: 417827870
19657356		CTD
SIDER
US FAERS
6Chest PainFAERS: 3SIDER
US FAERS
7Drug ineffectiveFAERS: 3US FAERS
8AnxietyFAERS: 2US FAERS
9Burning sensationFAERS: 2US FAERS
10Feeling abnormalFAERS: 2SIDER
US FAERS
11FlatulenceFAERS: 2SIDER
US FAERS
12Gamma-Glutamyltransferase IncreasedFAERS: 2US FAERS
13MalaiseFAERS: 2SIDER
US FAERS
14PalpitationsFAERS: 2US FAERS
15Pharmaceutical product complaintFAERS: 2US FAERS
16Product quality issueFAERS: 2US FAERS
17Unevaluable eventFAERS: 2OFFSIDES
US FAERS
18UrticariaFAERS: 2SIDER
US FAERS
19White blood cell count decreasedFAERS: 2SIDER
US FAERS
20AcneFAERS: 1US FAERS
21Activities of daily living impairedFAERS: 1US FAERS
22Adverse eventFAERS: 1US FAERS
23AgitationFAERS: 1US FAERS
24AngioedemaFAERS: 1US FAERS
25Anti-platelet antibodyFAERS: 1US FAERS
26ArthralgiaFAERS: 1SIDER
US FAERS
27Aspiration bone marrow abnormalFAERS: 1US FAERS
28Aspiration joint abnormalFAERS: 1US FAERS
29AstheniaFAERS: 1US FAERS
30AsthmaFAERS: 1

View details

8598621
9620945
10181070
10764316
17944539
19214143
20332717
22059882
 		CTD
US FAERS
31Atrial FibrillationFAERS: 1US FAERS
32Blood alkaline phosphatase increasedFAERS: 1OFFSIDES
US FAERS
33Blood iron decreasedFAERS: 1US FAERS
34BursitisFAERS: 1US FAERS
35Cerebrovascular accidentFAERS: 1US FAERS
36ColitisFAERS: 1US FAERS
37Completed SuicideFAERS: 1US FAERS
38DehydrationFAERS: 1US FAERS
39Drug abuseFAERS: 1US FAERS
40Drug screen positiveFAERS: 1US FAERS
41EructationFAERS: 1US FAERS
42Facial PainFAERS: 1US FAERS
43FatigueFAERS: 1OFFSIDES
US FAERS
44Hepatitis CFAERS: 1US FAERS
45HypersensitivityFAERS: 1SIDER
US FAERS
46Impaired work abilityFAERS: 1US FAERS
47Joint swellingFAERS: 1US FAERS
48LacerationFAERS: 1US FAERS
49LaryngospasmFAERS: 1US FAERS
50Mental status changesFAERS: 1US FAERS
51Metabolic acidosisFAERS: 1US FAERS
52Middle insomniaFAERS: 1US FAERS
53Myocardial InfarctionFAERS: 1US FAERS
54PCO2 increasedFAERS: 1US FAERS
55PainFAERS: 115935457CTD
SIDER
US FAERS
56PhotophobiaFAERS: 1US FAERS
57Product formulation issueFAERS: 1US FAERS
58Product use issueFAERS: 1US FAERS
59Renal Cell CarcinomaFAERS: 1US FAERS
60Respiratory distressFAERS: 1US FAERS
61SchizophreniaFAERS: 1US FAERS
62ShockFAERS: 1US FAERS
63Skin PapillomaFAERS: 1US FAERS
64SplenomegalyFAERS: 1US FAERS
65Sputum culture positiveFAERS: 1US FAERS
66Suicide attemptFAERS: 1US FAERS
67Supraventricular tachycardiaFAERS: 1US FAERS
68TachycardiaFAERS: 1US FAERS
69Troponin increasedFAERS: 1US FAERS
70Venous ThrombosisFAERS: 1US FAERS
71VomitingFAERS: 1SIDER
US FAERS
72WheezingFAERS: 1US FAERS
73jaundiceFAERS: 1SIDER
US FAERS
74treatment failureFAERS: 1US FAERS
75Abdominal discomfortOFFSIDES
76Acne Vulgaris20436887CTD
77Acute Coronary SyndromeOFFSIDES
78Acute Lung Injury17118201CTD
79Acute myocardial infarctionOFFSIDES
80AgraphiaOFFSIDES
81Asthma, Exercise-Induced10984370CTD
82Atrial tachycardiaOFFSIDES
83Blurred visionOFFSIDES
84Brain Edema19309543CTD
85Bronchial Hyperreactivity12388339
12654629
12794006		CTD
86Chemical and Drug Induced Liver Injury

View details

17944539
18524759
24085192
28487374
 		CTD
87Choking sensationOFFSIDES
88Chronic liver diseaseSIDER
89Colonic Neoplasms18927292CTD
90ConjunctivitisSIDER
91ConstipationSIDER
92Decompression Sickness18309904CTD
93DermatitisSIDER
94DiscomfortSIDER
95DizzinessSIDER
96DyspepsiaSIDER
97DysphoniaOFFSIDES
98Edema

View details

7812673
7990266
8273558
9831321
11698051
17118201
19703484
 		CTD
99Endotoxemia15328337CTD
100Eosinophil percentage increasedOFFSIDES
101Eosinophilia8621850
10764316		CTD
102Fractures, Closed19544365CTD
103HepatitisSIDER
104Hepatomegaly8661344CTD
105HepatotoxicitySIDER
106Infarction, Middle Cerebral Artery19309543CTD
107Inflammation

View details

7812673
8621850
8960868
9831321
17118201
18059327
18295198
18309904
 		CTD
108Inflammatory Bowel Diseases15339030CTD
109Intention tremorOFFSIDES
110Large intestine perforationOFFSIDES
111LymphadenopathySIDER
112Muscle RigiditySIDER
113Musculoskeletal discomfortSIDER
114MyalgiaSIDER
115Nasal Polyps10665187CTD
116Neck PainSIDER
117Necrosis23211037CTD
118NervousnessSIDER
119Oropharyngeal discomfortOFFSIDES
120Peritonitis17371808CTD
121Pharyngolaryngeal PainSIDER
122Pulmonary Edema18309904CTD
123Pulmonary congestionOFFSIDES
124Reperfusion Injury9865762
15266012		CTD
125Rhinitis20332717CTD
126Sinusitis10665187CTD
SIDER
127Sleep Apnea, Obstructive19118273CTD
128SomnolenceSIDER
129Spinal Cord Injuries18059327CTD
130TensionSIDER
131Traumatic liver injurySIDER
132Urinary tract infectionSIDER
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