MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Caspofungin

(OGUJBRYAAJYXQP-IJFZAWIJSA-N)

Structure

SMILES: CC(=O)O.CC(=O)O.NCCN[C@H]1NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@H](C[C@H]1O)NC(=O)CCCCCCCC[C@H](C[C@H](CC)C)C)[C@H](O)C)C[C@@H](C2)O)[C@@H]([C@H](c1ccc(cc1)O)O)O)[C@@H](CCN)O
Molecular Formula:: C56H96N10O19
Molecular Weight:: 1213.420
Log P:: 0.2433
Hydrogen Bond Acceptor:: 29
Hydrogen Bond Donor:: 18
TPSA:: 486.63
CAS Number(s):: 179463-17-3

Synonym(s)

Caspofungin

Cancidas

Caspofungin Acetate

Caspofungin MSD

L 743,872

L 743872

L-743,872

L-743872

MK 0991

10.

MK-0991

11.

L743,872

12.

L743872

13.

MK0991

External Link(s)

MeSH	D000077336
PubChem Compound	117065245 16119813

Adverse Drug Event(s)

	Name	Data Source
1	Acidosis	OFFSIDES
2	Acute graft versus host disease in intestine	OFFSIDES
3	Acute graft versus host disease in liver	OFFSIDES
4	Acute respiratory failure	OFFSIDES
5	Adenitis	OFFSIDES
6	Adverse event	OFFSIDES
7	Alanine Aminotransferase Increased	OFFSIDES
8	Ammonia increased	OFFSIDES
9	Anticholinergic Syndrome	OFFSIDES
10	Antithrombin III decreased	OFFSIDES
11	Anuria	OFFSIDES
12	Aspergilloma	OFFSIDES
13	Aspergillosis	OFFSIDES
14	Atrial thrombosis	OFFSIDES
15	B-cell lymphoma stage II	OFFSIDES
16	Bacterial sepsis	OFFSIDES
17	Biliary Fistula	OFFSIDES
18	Bilirubin conjugated increased	OFFSIDES
19	Blast cell count increased	OFFSIDES
20	Blood alkaline phosphatase increased	OFFSIDES
21	Blood calcium abnormal	OFFSIDES
22	Blood creatine phosphokinase abnormal	OFFSIDES
23	Blood lactate dehydrogenase increased	OFFSIDES
24	Blood magnesium decreased	OFFSIDES
25	Blood osmolarity decreased	OFFSIDES
26	Blood pH decreased	OFFSIDES
27	Blood sodium increased	OFFSIDES
28	Blood urea increased	OFFSIDES
29	Blood uric acid decreased	OFFSIDES
30	Body Temperature	OFFSIDES
31	Brain Abscess	OFFSIDES
32	Bronchoalveolar Lavage	OFFSIDES
33	Candida sepsis	OFFSIDES
34	Candidiasis of vagina	OFFSIDES
35	Capillary Leak Syndrome	OFFSIDES
36	Cardioactive drug level	OFFSIDES
37	Carnitine deficiency	OFFSIDES
38	Catheter bacteraemia	OFFSIDES
39	Catheter site inflammation	OFFSIDES
40	Cerebral aspergillosis	OFFSIDES
41	Cerebral hypoperfusion	OFFSIDES
42	Cervical laser therapy	OFFSIDES
43	Cheilitis	OFFSIDES
44	Cholangiolitis	OFFSIDES
45	Chronic granulomatous disease	OFFSIDES
46	Chronic respiratory failure	OFFSIDES
47	Circumstance or information capable of leading to medication error	OFFSIDES
48	Clostridium difficile colitis	OFFSIDES
49	Coagulation factor V level decreased	OFFSIDES
50	Culture positive	OFFSIDES
51	Cytolytic hepatitis	OFFSIDES
52	Delayed engraftment	OFFSIDES
53	Device related infection	OFFSIDES
54	Dilatation intrahepatic duct acquired	OFFSIDES
55	Disease Progression	OFFSIDES
56	Drug ineffective	OFFSIDES
57	Drug resistance	OFFSIDES
58	Electromechanical dissociation	OFFSIDES
59	Embolic stroke	OFFSIDES
60	Endocarditis enterococcal	OFFSIDES
61	Endocarditis	OFFSIDES
62	Endometriosis	OFFSIDES
63	Enterococcal infection	OFFSIDES
64	Enterococcal sepsis	OFFSIDES
65	Enterocolitis	OFFSIDES
66	Eosinophilic myocarditis	OFFSIDES
67	Epilepsy	OFFSIDES
68	Familial Mediterranean Fever	OFFSIDES
69	Febrile Neutropenia	OFFSIDES
70	Febrile bone marrow aplasia	OFFSIDES
71	Focal Nodular Hyperplasia	OFFSIDES
72	Fungus culture positive	OFFSIDES
73	Gamma-Glutamyltransferase Increased	OFFSIDES
74	Gastrointestinal stoma complication	OFFSIDES
75	General physical health deterioration	OFFSIDES
76	Granulocytosis	OFFSIDES
77	Haptoglobin Decreased	OFFSIDES
78	Hemiplegia	OFFSIDES
79	Hepatic infection fungal	OFFSIDES
80	Hepatic necrosis	OFFSIDES
81	Hepatic siderosis	OFFSIDES
82	Hepatitis B positive	OFFSIDES
83	Hepatitis	OFFSIDES
84	Hepatosplenic candidiasis	OFFSIDES
85	Hepatosplenomegaly	OFFSIDES
86	Hepatotoxicity	OFFSIDES
87	Histiocytosis haematophagic	OFFSIDES
88	Hydropneumothorax	OFFSIDES
89	Hypocoagulable state	OFFSIDES
90	Immunosuppressant drug level decreased	OFFSIDES
91	Incorrect drug dosage form administered	OFFSIDES
92	Infection	OFFSIDES
93	Infusion site rash	OFFSIDES
94	Intestinal Fistula	OFFSIDES
95	JC virus infection	OFFSIDES
96	Kidney Failure	OFFSIDES
97	Klebsiella sepsis	OFFSIDES
98	Large intestine perforation	OFFSIDES
99	Leukopenia neonatal	OFFSIDES
100	Liver Abscess	OFFSIDES
101	Lung infection pseudomonal	OFFSIDES
102	Lymphocyte percentage decreased	OFFSIDES
103	Mixed liver injury	OFFSIDES
104	Mucormycosis	OFFSIDES
105	Multi-organ disorder	OFFSIDES
106	Muscle necrosis	OFFSIDES
107	Myocarditis mycotic	OFFSIDES
108	Myoclonic Epilepsy	OFFSIDES
109	Myoglobin urine present	OFFSIDES
110	Myositis Ossificans	OFFSIDES
111	Neurological decompensation	OFFSIDES
112	Neurological examination abnormal	OFFSIDES
113	Oliguria	OFFSIDES
114	Pancreatitis	OFFSIDES
115	Paroxysmal arrhythmia	OFFSIDES
116	Pathogen resistance	OFFSIDES
117	Peritonitis	OFFSIDES
118	Phlebitis	OFFSIDES
119	Platelet count abnormal	OFFSIDES
120	Pneumopericardium	OFFSIDES
121	Polyneuropathy	OFFSIDES
122	Prescribed overdose	OFFSIDES
123	Prothrombin time abnormal	OFFSIDES
124	Pseudomonal sepsis	OFFSIDES
125	Red blood cell schistocytes present	OFFSIDES
126	Refusal of treatment by relative	OFFSIDES
127	Renal abscess	OFFSIDES
128	Renal tubular disorder	OFFSIDES
129	Respiratory Failure	OFFSIDES
130	Retinitis	OFFSIDES
131	Retroperitoneal abscess	OFFSIDES
132	Salpingo-oophorectomy	OFFSIDES
133	Scedosporium infection	OFFSIDES
134	Septic Shock	OFFSIDES
135	Septic embolus	OFFSIDES
136	Sinus bradycardia	OFFSIDES
137	Sopor	OFFSIDES
138	Splenic Infarction	OFFSIDES
139	Status Epilepticus	OFFSIDES
140	Stenotrophomonas infection	OFFSIDES
141	Stevens-Johnson Syndrome	OFFSIDES
142	Superinfection bacterial	OFFSIDES
143	Systemic mycosis	OFFSIDES
144	T-cell lymphoma stage III	OFFSIDES
145	Therapy non-responder	OFFSIDES
146	Therapy responder	OFFSIDES
147	Torulopsis infection	OFFSIDES
148	Toxoplasmosis	OFFSIDES
149	Transaminases increased	OFFSIDES
150	Trichosporon infection	OFFSIDES
151	Unresponsive to stimuli	OFFSIDES
152	Vasospasm	OFFSIDES
153	Venoocclusive disease	OFFSIDES
154	Venous occlusion	OFFSIDES
155	Venous stent insertion	OFFSIDES
156	Ventricular Fibrillation	OFFSIDES
157	treatment failure	OFFSIDES

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