MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Caspofungin

(JYIKNQVWKBUSNH-OGZDCFRISA-N)

Structure

SMILES: NCCN[C@H]1NC(=O)[C@@H]2[C@@H](O)CCN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC(=O)[C@H](C[C@H]1O)NC(=O)CCCCCCCCC(CC(CC)C)C)[C@H](O)C)C[C@@H](C2)O)[C@@H]([C@H](c1ccc(cc1)O)O)O)[C@@H](CCN)O
Type(s): Approved
ATC code(s): J02AX04
Molecular Formula:: C52H88N10O15
Molecular Weight:: 1093.310
Log P:: 0.0615
Hydrogen Bond Acceptor:: 25
Hydrogen Bond Donor:: 16
TPSA:: 412.03
CAS Number(s):: 162808-62-0

Synonym(s)

Caspofungin

Cancidas

Caspofungin Acetate

Caspofungin MSD

L 743,872

L 743872

L-743,872

L-743872

MK 0991

10.

MK-0991

11.

L743,872

12.

L743872

13.

MK0991

External Link(s)

MeSH	D000077336
PubChem Compound	2826718 3035406
ChEBI	474180
CHEMBL	CHEMBL499808
DrugBank	DB00520
KEGG	dr:D07626

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drug ineffective	FAERS: 6		OFFSIDES US FAERS
2	Alanine Aminotransferase Increased	FAERS: 1		OFFSIDES US FAERS
3	Ascites	FAERS: 1		US FAERS
4	Aspartate Aminotransferase Increased	FAERS: 1		US FAERS
5	Blood alkaline phosphatase increased	FAERS: 1		OFFSIDES US FAERS
6	Clostridium difficile infection	FAERS: 1		US FAERS
7	Emotional disorder	FAERS: 1		US FAERS
8	Erythema	FAERS: 1		US FAERS
9	Hepatotoxicity	FAERS: 1		OFFSIDES US FAERS
10	Hypotension	FAERS: 1		US FAERS
11	Neutrophil count decreased	FAERS: 1		US FAERS
12	Abdominal Infection			OFFSIDES
13	Abscess fungal			OFFSIDES
14	Abscess			OFFSIDES
15	Acidosis			OFFSIDES
16	Acquired diaphragmatic eventration			OFFSIDES
17	Acute graft versus host disease in intestine			OFFSIDES
18	Acute graft versus host disease in liver			OFFSIDES
19	Adenitis			OFFSIDES
20	Adverse event			OFFSIDES
21	Ammonia increased			OFFSIDES
22	Anal Fistula			OFFSIDES
23	Anticholinergic Syndrome			OFFSIDES
24	Anticonvulsant drug level above therapeutic			OFFSIDES
25	Antithrombin III decreased			OFFSIDES
26	Anuria			OFFSIDES
27	Aspergilloma			OFFSIDES
28	Aspergillosis		18835682 20606829 26387063	CTD OFFSIDES
29	Asphyxia			OFFSIDES
30	Aspiration tracheal abnormal			OFFSIDES
31	Atrial thrombosis			OFFSIDES
32	Autoimmune hepatitis			OFFSIDES
33	B-cell lymphoma stage II			OFFSIDES
34	Bacteria stool identified			OFFSIDES
35	Bacterial sepsis			OFFSIDES
36	Basal ganglion degeneration			OFFSIDES
37	Bilirubin conjugated increased			OFFSIDES
38	Blast cell count increased			OFFSIDES
39	Blood bilirubin abnormal			OFFSIDES
40	Blood calcium abnormal			OFFSIDES
41	Blood chloride increased			OFFSIDES
42	Blood creatine phosphokinase abnormal			OFFSIDES
43	Blood electrolytes decreased			OFFSIDES
44	Blood lactate dehydrogenase increased			OFFSIDES
45	Blood magnesium decreased			OFFSIDES
46	Blood osmolarity decreased			OFFSIDES
47	Blood sodium increased			OFFSIDES
48	Blood stem cell transplant failure			OFFSIDES
49	Blood urea increased			OFFSIDES
50	Bone marrow toxicity			OFFSIDES
51	Brain Abscess			OFFSIDES
52	Brain natriuretic peptide increased			OFFSIDES
53	Bronchial Fistula			OFFSIDES
54	Bronchoalveolar Lavage			OFFSIDES
55	CYTOMEGALOVIRUS ANTIGEN			OFFSIDES
56	Candida sepsis			OFFSIDES
57	Candidemia		16117996 20606829	CTD
58	Candidiasis of vagina			OFFSIDES
59	Candidiasis		View details 15917516 16283214 16757500 18627469 18835682 20606829	CTD
60	Capillary Leak Syndrome			OFFSIDES
61	Cardiac Death			OFFSIDES
62	Cardioactive drug level			OFFSIDES
63	Carnitine deficiency			OFFSIDES
64	Catheter bacteraemia			OFFSIDES
65	Catheter related infection			OFFSIDES
66	Catheter site erythema			OFFSIDES
67	Catheter site infection			OFFSIDES
68	Catheter site inflammation			OFFSIDES
69	Central line infection			OFFSIDES
70	Cerebral aspergillosis			OFFSIDES
71	Cerebral hypoperfusion			OFFSIDES
72	Cervical laser therapy			OFFSIDES
73	Cholangiolitis			OFFSIDES
74	Chorioretinitis			OFFSIDES
75	Chronic granulomatous disease			OFFSIDES
76	Circumstance or information capable of leading to medication error			OFFSIDES
77	Clostridium colitis			OFFSIDES
78	Coagulation factor V level decreased			OFFSIDES
79	Corneal Infection			OFFSIDES
80	Culture positive			OFFSIDES
81	Cytolytic hepatitis			OFFSIDES
82	Delayed engraftment			OFFSIDES
83	Device related infection			OFFSIDES
84	Diffuse alveolar damage			OFFSIDES
85	Dilatation intrahepatic duct acquired			OFFSIDES
86	Drug resistance			OFFSIDES
87	Electromechanical dissociation			OFFSIDES
88	Embolic stroke			OFFSIDES
89	Endocarditis enterococcal			OFFSIDES
90	Endocarditis		16283214	CTD OFFSIDES
91	Enterococcal infection			OFFSIDES
92	Enterococcal sepsis			OFFSIDES
93	Eosinophilic myocarditis			OFFSIDES
94	Escherichia infection			OFFSIDES
95	Exophthalmos			OFFSIDES
96	Failure to anastomose			OFFSIDES
97	Familial Mediterranean Fever			OFFSIDES
98	Febrile Neutropenia			OFFSIDES
99	Fluid overload			OFFSIDES
100	Focal Nodular Hyperplasia			OFFSIDES
101	Fungus serology test positive			OFFSIDES
102	Gamma-Glutamyltransferase Increased			OFFSIDES
103	Gastrointestinal obstruction			OFFSIDES
104	General physical health deterioration			OFFSIDES
105	Genital rash			OFFSIDES
106	Haptoglobin Decreased			OFFSIDES
107	Hemiplegia			OFFSIDES
108	Hepatic artery thrombosis			OFFSIDES
109	Hepatic infection fungal			OFFSIDES
110	Hepatic necrosis			OFFSIDES
111	Hepatic siderosis			OFFSIDES
112	Hepatitis B positive			OFFSIDES
113	Hepatitis			OFFSIDES
114	Hepatosplenic candidiasis			OFFSIDES
115	Hepatosplenomegaly			OFFSIDES
116	Hydropneumothorax			OFFSIDES
117	Hypocoagulable state			OFFSIDES
118	Impaired gastric emptying			OFFSIDES
119	Incoherent			OFFSIDES
120	Incorrect drug dosage form administered			OFFSIDES
121	Infection			OFFSIDES
122	Infusion site rash			OFFSIDES
123	Intestinal Fistula			OFFSIDES
124	Invasive Pulmonary Aspergillosis		19011270	CTD
125	Kidney Failure			OFFSIDES
126	Large intestine perforation			OFFSIDES
127	Leukopenia neonatal			OFFSIDES
128	Lip erosion			OFFSIDES
129	Liver Abscess			OFFSIDES
130	Lung Abscess			OFFSIDES
131	Lung Injury			OFFSIDES
132	Lung infection pseudomonal			OFFSIDES
133	Lymphangitis			OFFSIDES
134	Lymphocyte percentage decreased			OFFSIDES
135	Malabsorption			OFFSIDES
136	Mechanical ventilation complication			OFFSIDES
137	Metabolic acidosis			OFFSIDES
138	Mixed liver injury			OFFSIDES
139	Monocyte percentage decreased			OFFSIDES
140	Mucormycosis			OFFSIDES
141	Multi-organ disorder			OFFSIDES
142	Mycoses		15459300	CTD
143	Myocarditis mycotic			OFFSIDES
144	Myoglobin urine present			OFFSIDES
145	Myositis Ossificans			OFFSIDES
146	Neurological examination abnormal			OFFSIDES
147	Neutropenia		20606829	CTD
148	Orbital infection			OFFSIDES
149	Pancreatitis			OFFSIDES
150	Parophthalmia			OFFSIDES
151	Paroxysmal arrhythmia			OFFSIDES
152	Pathogen resistance			OFFSIDES
153	Pericarditis			OFFSIDES
154	Periostitis			OFFSIDES
155	Peritonitis			OFFSIDES
156	Phlebitis			OFFSIDES
157	Platelet count abnormal			OFFSIDES
158	Pneumopericardium			OFFSIDES
159	Post procedural complication			OFFSIDES
160	Prescribed overdose			OFFSIDES
161	Pseudomonal sepsis			OFFSIDES
162	Red blood cell schistocytes present			OFFSIDES
163	Renal abscess			OFFSIDES
164	Renal cyst			OFFSIDES
165	Renal tubular disorder			OFFSIDES
166	Respiratory Failure			OFFSIDES
167	Retinitis			OFFSIDES
168	Retroperitoneal abscess			OFFSIDES
169	Salpingo-oophorectomy			OFFSIDES
170	Septic Shock			OFFSIDES
171	Septic embolus			OFFSIDES
172	Sinus bradycardia			OFFSIDES
173	Sinus operation			OFFSIDES
174	Sopor			OFFSIDES
175	Splenic Infarction			OFFSIDES
176	Sputum culture positive			OFFSIDES
177	Status Epilepticus			OFFSIDES
178	Stem cell transplant			OFFSIDES
179	Stenotrophomonas infection			OFFSIDES
180	Stevens-Johnson Syndrome		25811541	CTD OFFSIDES
181	Superinfection bacterial			OFFSIDES
182	Systemic mycosis			OFFSIDES
183	T-Cell Lymphoma			OFFSIDES
184	T-cell lymphoma stage III			OFFSIDES
185	Therapeutic response unexpected			OFFSIDES
186	Therapy non-responder			OFFSIDES
187	Therapy responder			OFFSIDES
188	Torulopsis infection			OFFSIDES
189	Toxoplasmosis			OFFSIDES
190	Trichosporon infection			OFFSIDES
191	Ultrasound abdomen abnormal			OFFSIDES
192	Unresponsive to pain stimuli			OFFSIDES
193	Ureterostomy site discomfort			OFFSIDES
194	Urinary tract infection enterococcal			OFFSIDES
195	Urine sodium abnormal			OFFSIDES
196	Vaccination failure			OFFSIDES
197	Vasospasm			OFFSIDES
198	Venoocclusive disease			OFFSIDES
199	Venous occlusion			OFFSIDES
200	Venous stent insertion			OFFSIDES
201	Ventricular Fibrillation			OFFSIDES
202	Wound dehiscence			OFFSIDES
203	treatment failure			OFFSIDES

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