MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Pancuronium

(GVEAYVLWDAFXET-XGHATYIMSA-N)

Structure

SMILES: CC(=O)O[C@H]1C[C@@H]2CC[C@@H]3[C@@H]([C@]2(C[C@@H]1[N+]1(C)CCCCC1)C)CC[C@]1([C@H]3C[C@@H]([C@@H]1OC(=O)C)[N+]1(C)CCCCC1)C
Type(s): Approved
ATC code(s): M03AC01
Molecular Formula:: C35H60N2O4++
Molecular Weight:: 572.862
Log P:: 6.0281
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 0
TPSA:: 52.6
CAS Number(s):: 15500-66-0; 16974-53-1

Synonym(s)

Pancuronium

Pancuronium Bromide

Pancuronium Curamed

Pancuronium Organon

Pavulon

Bromide, Pancuronium

External Link(s)

MeSH	D010197
PubChem Compound	441289
ChEBI	7907
CHEMBL	CHEMBL185073
DrugBank	DB01337
DrugCentral	2052
IUPHAR/BPS Guide to PHARMACOLOGY	4001
KEGG	cpd:C07551
Therapeutic Target Database	D0AA0L
ZINC	4097383

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Medication Error	FAERS: 6		US FAERS
2	Respiratory Failure	FAERS: 1		OFFSIDES SIDER US FAERS
3	Wrong drug administered	FAERS: 1		OFFSIDES US FAERS
4	Abdominal rigidity			OFFSIDES
5	Acute prerenal failure			OFFSIDES
6	Acute respiratory failure			OFFSIDES
7	Anaphylactic shock			SIDER
8	Anaphylactoid Reaction			SIDER
9	Anuria			OFFSIDES
10	Anxiety			OFFSIDES
11	Apnea		View details 1186977 2058358 4249575 6147155	CTD
12	Arterial thrombosis			OFFSIDES
13	Asthma			OFFSIDES
14	Atrial thrombosis			OFFSIDES
15	Bilirubin conjugated increased			OFFSIDES
16	Blood creatine phosphokinase increased			OFFSIDES
17	Blood creatinine increased			OFFSIDES
18	Blood immunoglobulin E abnormal			OFFSIDES
19	Blood pH decreased			OFFSIDES
20	Blood potassium increased			OFFSIDES
21	Blood triglycerides increased			OFFSIDES
22	Blood urea increased			OFFSIDES
23	Bradycardia		1239221 4247670 7293700	CTD OFFSIDES
24	Bronchopneumonia			OFFSIDES
25	Bronchospasm			SIDER
26	Choking			OFFSIDES
27	Chromaturia			OFFSIDES
28	Circumstance or information capable of leading to medication error			OFFSIDES
29	Clostridium colitis			OFFSIDES
30	Completed Suicide			OFFSIDES
31	Cyanosis			OFFSIDES
32	Deafness Neurosensory			OFFSIDES
33	Deafness			OFFSIDES
34	Decreased Libido			OFFSIDES
35	Dermatitis			SIDER
36	Diplopia		16192781	CTD
37	Disseminated Intravascular Coagulation			OFFSIDES
38	Diverticulitis			OFFSIDES
39	Diverticulosis			OFFSIDES
40	Drug Overdose		1405022	CTD
41	Duodenal Ulcer			OFFSIDES
42	Dysphasia			OFFSIDES
43	Dystonia			OFFSIDES
44	Electromechanical dissociation			OFFSIDES
45	Embolism			OFFSIDES
46	Empyema			OFFSIDES
47	Endocarditis			OFFSIDES
48	Enterobacter pneumonia			OFFSIDES
49	Epistaxis			OFFSIDES
50	Erosive gastritis			OFFSIDES
51	Erythema			SIDER
52	Fluid overload			OFFSIDES
53	Flushing			SIDER
54	Gamma-Glutamyltransferase Increased			OFFSIDES
55	Gangrene			OFFSIDES
56	Gastric ulcer			OFFSIDES
57	Gastroduodenitis			OFFSIDES
58	General physical health deterioration			OFFSIDES
59	Granulocytosis			OFFSIDES
60	Hearing aid user			OFFSIDES
61	Hepatic Infarction			OFFSIDES
62	Hepatic congestion			OFFSIDES
63	Hepatic necrosis			OFFSIDES
64	Hepatitis A			OFFSIDES
65	Hydrocephalus			OFFSIDES
66	Hypercapnia		11072806	CTD
67	Hypersensitivity			SIDER
68	Hypotension		View details 1239221 2020101 2862454 7293700 8322571	CTD SIDER
69	Hypoxia		11072806	CTD
70	Increased upper airway secretion			OFFSIDES
71	Intentional misuse			OFFSIDES
72	Intestinal infarction			OFFSIDES
73	Kidney Failure			OFFSIDES
74	Labile blood pressure			OFFSIDES
75	Lethargy			OFFSIDES
76	Mental disorders		4061705	CTD
77	Metabolic acidosis			OFFSIDES
78	Metatarsalgia			OFFSIDES
79	Motor Neuron Disease		8403681	CTD
80	Muscle Rigidity		6859587 7294381	CTD
81	Muscle Spasticity		900439	CTD
82	Muscle Weakness		View details 2398288 3987137 8020274 8403681 11212041 11873034 16192781	CTD
83	Muscle enzyme			OFFSIDES
84	Muscular Atrophy		View details 1959379 3420309 3987137 8403681	CTD
85	Myocardial Ischemia		3873880	CTD
86	Necrosis		1352749 8020274	CTD
87	Nerve Degeneration		8403681 8572410	CTD
88	Neuromuscular Diseases		2666960 3987137 8020274	CTD
89	Oliguria			OFFSIDES
90	Ophthalmoplegia		2046941	CTD
91	PCO2 decreased			OFFSIDES
92	PO2 decreased			OFFSIDES
93	Pain, Postoperative		View details 143062 3281700 7362724 8214718 16192781	CTD
94	Pain		466557 6112998 8317643	CTD
95	Paresis		7952572 8020274 11873034	CTD
96	Peripheral Nervous System Diseases		8572410	CTD
97	Peritonitis			OFFSIDES
98	Peroneal Neuropathies		8020274	CTD
99	Pneumopericardium			OFFSIDES
100	Post procedural complication			OFFSIDES
101	Postoperative Complications		View details 3289771 4264152 11072806 11873034	CTD
102	Postoperative fever			OFFSIDES
103	Procedural complication			OFFSIDES
104	Pulmonary Hypertension			OFFSIDES
105	Pulmonary congestion			OFFSIDES
106	Quadriplegia		View details 1352749 8023076 8572410 10979426	CTD OFFSIDES
107	Red blood cell schistocytes present			OFFSIDES
108	Redness			SIDER
109	Reflex, Abnormal		3987137 8572410	CTD
110	Renal Insufficiency		9549427	CTD
111	Renal tubular necrosis			OFFSIDES
112	Respiratory Insufficiency			SIDER
113	Respiratory Paralysis		1405022	CTD
114	Rhabdomyolysis			OFFSIDES
115	Seizures		7912481	CTD
116	Sinoatrial Block			OFFSIDES
117	Sinus bradycardia			OFFSIDES
118	Skeletal muscle paralysis			SIDER
119	Skin test positive			OFFSIDES
120	Somatosensory Disorders		1352749	CTD
121	Status Asthmaticus		1763262 7427548 8023076	CTD
122	Stem cell transplant			OFFSIDES
123	Supraventricular tachycardia			OFFSIDES
124	Tachycardia, Ventricular		6943946	CTD
125	Tachycardia		View details 426993 2604091 3873880 4544391 6475690	CTD SIDER
126	Tetanus		4257689	CTD
127	Therapy non-responder			OFFSIDES
128	Toxoplasmosis			OFFSIDES
129	Trismus		6250420	CTD
130	Ulcer			OFFSIDES
131	Urea urine increased			OFFSIDES
132	Urinary Retention		9549427	CTD
133	Venous thrombosis limb			OFFSIDES
134	Ventricular Fibrillation		1239221	CTD OFFSIDES
135	Weight decrease neonatal			OFFSIDES
136	anaphylaxis		9785081	CTD

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