MetaADEDB 2.0 @ LMMD
Guanfacine
(INJOMKTZOLKMBF-UHFFFAOYSA-N)
Structure
SMILES
O=C(Cc1c(Cl)cccc1Cl)N=C(N)N
Type(s)
Approved; Investigational
ATC code(s)
C02AC02
Molecular Formula:
C9H9Cl2N3O
Molecular Weight:
246.093
Log P:
2.7365
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
2
TPSA:
81.47
CAS Number(s):
29110-47-2; 29110-48-3
Synonym(s)
1.
Guanfacine
2.
BS-100-141
3.
Estulic
4.
Guanfacine Hydrochloride
5.
Guanfacine Monohydrochloride
6.
Lon798
7.
Tenex
8.
BS 100 141
9.
BS100141
10.
Hydrochloride, Guanfacine
11.
Monohydrochloride, Guanfacine
External Link(s)
MeSHD016316
PubChem Compound137319710
3519
BindingDB50412316
81984
ChEBI5558
CHEMBLCHEMBL862
DrugBankDB01018
DrugCentral1343
IUPHAR/BPS Guide to PHARMACOLOGY522
KEGGcpd:C07037
dr:D08031
ZINC3872738
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 38US FAERS
2Product substitution issueFAERS: 25US FAERS
3SomnolenceFAERS: 15SIDER
US FAERS
4FatigueFAERS: 87042594
19179940
19395648		CTD
OFFSIDES
SIDER
US FAERS
5HeadacheFAERS: 619179940CTD
SIDER
US FAERS
6Product quality issueFAERS: 6OFFSIDES
US FAERS
7TremorFAERS: 5SIDER
US FAERS
8Adverse eventFAERS: 4OFFSIDES
US FAERS
9AgitationFAERS: 4SIDER
US FAERS
10AnxietyFAERS: 4SIDER
US FAERS
11BradycardiaFAERS: 41466475
2867958
6121810		CTD
OFFSIDES
SIDER
US FAERS
12HypotensionFAERS: 42867958
3541005
6121810		CTD
SIDER
US FAERS
13LethargyFAERS: 4OFFSIDES
SIDER
US FAERS
14NauseaFAERS: 4SIDER
US FAERS
15AngerFAERS: 3OFFSIDES
US FAERS
16Complex partial seizuresFAERS: 3OFFSIDES
US FAERS
17Depressed moodFAERS: 3US FAERS
18DizzinessFAERS: 33513530
6998487		CTD
SIDER
US FAERS
19DyspepsiaFAERS: 3SIDER
US FAERS
20Emotional disorderFAERS: 3OFFSIDES
US FAERS
21FormicationFAERS: 3US FAERS
22Medication residue presentFAERS: 3US FAERS
23Obsessive-Compulsive DisorderFAERS: 3US FAERS
24Oppositional Defiant DisorderFAERS: 3OFFSIDES
US FAERS
25PallorFAERS: 3OFFSIDES
SIDER
US FAERS
26PruritusFAERS: 3SIDER
US FAERS
27VomitingFAERS: 3SIDER
US FAERS
28Autonomic nervous system imbalanceFAERS: 2US FAERS
29CryingFAERS: 2US FAERS
30Drug dispensing errorFAERS: 2US FAERS
31Drug effect incompleteFAERS: 2US FAERS
32DysarthriaFAERS: 2US FAERS
33Educational problemFAERS: 2OFFSIDES
US FAERS
34EpistaxisFAERS: 2US FAERS
35Feeling abnormalFAERS: 2SIDER
US FAERS
36FlushingFAERS: 2US FAERS
37Food AllergyFAERS: 2US FAERS
38Intentional self-injuryFAERS: 2US FAERS
39MalaiseFAERS: 2SIDER
US FAERS
40Medication ErrorFAERS: 2US FAERS
41NegativismFAERS: 2US FAERS
42Product coating issueFAERS: 2US FAERS
43Product use in unapproved indicationFAERS: 2US FAERS
44Reaction to excipientFAERS: 2US FAERS
45Therapy changeFAERS: 2US FAERS
46Toxicity to various agentsFAERS: 2US FAERS
47Visual ImpairmentFAERS: 2SIDER
US FAERS
48treatment failureFAERS: 2US FAERS
49Abdominal discomfortFAERS: 1SIDER
US FAERS
50Accidental exposure to product by childFAERS: 1US FAERS
51Accidental overdoseFAERS: 1US FAERS
52Activities of daily living impairedFAERS: 1OFFSIDES
US FAERS
53AkathisiaFAERS: 1US FAERS
54BlepharospasmFAERS: 1OFFSIDES
US FAERS
55Blood glucose increasedFAERS: 1US FAERS
56BruxismFAERS: 1US FAERS
57Chest discomfortFAERS: 1US FAERS
58ChillsFAERS: 1US FAERS
59ChokingFAERS: 1US FAERS
60ConstipationFAERS: 13281788CTD
SIDER
US FAERS
61Dark circles under eyesFAERS: 1US FAERS
62Diabetes mellitus inadequate controlFAERS: 1US FAERS
63Drug abuserFAERS: 1US FAERS
64Drug dose omissionFAERS: 1US FAERS
65Drug effect variableFAERS: 1US FAERS
66Drug prescribing errorFAERS: 1US FAERS
67DysphemiaFAERS: 1US FAERS
68Excessive eye blinkingFAERS: 1US FAERS
69Feeling ColdFAERS: 1US FAERS
70Fight in schoolFAERS: 1US FAERS
71Gastrointestinal PainFAERS: 1SIDER
US FAERS
72HostilityFAERS: 1US FAERS
73HypersensitivityFAERS: 1SIDER
US FAERS
74Hypertensive crisisFAERS: 1US FAERS
75Intercepted drug prescribing errorFAERS: 1US FAERS
76Joint Range of Motion DecreasedFAERS: 1US FAERS
77Lip swellingFAERS: 1US FAERS
78Loss of personal independence in daily activitiesFAERS: 1US FAERS
79MalabsorptionFAERS: 1US FAERS
80Mood swingsFAERS: 1US FAERS
81Physical assaultFAERS: 1OFFSIDES
US FAERS
82Poor quality sleepFAERS: 1OFFSIDES
US FAERS
83Product administered to patient of inappropriate ageFAERS: 1US FAERS
84Product formulation issueFAERS: 1US FAERS
85Product packaging quantity issueFAERS: 1US FAERS
86Product physical consistency issueFAERS: 1US FAERS
87Product use issueFAERS: 1US FAERS
88RetchingFAERS: 1US FAERS
89ScreamingFAERS: 1OFFSIDES
US FAERS
90Sinus bradycardiaFAERS: 1OFFSIDES
US FAERS
91SluggishnessFAERS: 1US FAERS
92SyncopeFAERS: 1SIDER
US FAERS
93Therapeutic product effect decreasedFAERS: 1US FAERS
94TinnitusFAERS: 1SIDER
US FAERS
95Unevaluable eventFAERS: 1OFFSIDES
US FAERS
96Urinary IncontinenceFAERS: 1SIDER
US FAERS
97UrticariaFAERS: 1US FAERS
98Wrong doseFAERS: 1US FAERS
99nervous system disorderFAERS: 1US FAERS
100Abdominal PainOFFSIDES
SIDER
101Acute Coronary SyndromeSIDER
102Adrenal massOFFSIDES
103AgeusiaOFFSIDES
104Agonal rhythmOFFSIDES
105Alanine Aminotransferase IncreasedSIDER
106AlopeciaSIDER
107Altered state of consciousnessOFFSIDES
108AmnesiaOFFSIDES
SIDER
109AmphetaminesOFFSIDES
110AnhedoniaOFFSIDES
111Anticholinergic SyndromeOFFSIDES
112Anticonvulsant drug level below therapeuticOFFSIDES
113Aortic AneurysmOFFSIDES
114ArthralgiaSIDER
115ArthropathyOFFSIDES
116AstheniaSIDER
117AsthmaOFFSIDES
SIDER
118Atrioventricular BlockSIDER
119Autistic Disorder19232924CTD
120Bacterial sepsisOFFSIDES
121Bipolar Disorder10467976CTD
OFFSIDES
122Blood GlucoseOFFSIDES
123Blood albumin decreasedOFFSIDES
124Blood creatinine increasedOFFSIDES
125Blood pressure inadequately controlledOFFSIDES
126Blood pressure orthostatic increasedOFFSIDES
127Blood urea increasedOFFSIDES
128Blunted affectOFFSIDES
129Bone SarcomaOFFSIDES
130Brain AbscessOFFSIDES
131Breast MicrocalcificationOFFSIDES
132Cataract operationOFFSIDES
133Cerebrovascular accidentSIDER
134Chest PainOFFSIDES
SIDER
135Choking sensationOFFSIDES
136Chronic sinusitisOFFSIDES
137Circumstance or information capable of leading to medication errorOFFSIDES
138Completed SuicideOFFSIDES
139ConfabulationOFFSIDES
140Congenital tricuspid valve incompetenceOFFSIDES
141ConjunctivitisSIDER
142Cramps of lower extremitiesSIDER
143Creatinine renal clearance increasedOFFSIDES
144DeafnessOFFSIDES
145DemyelinationOFFSIDES
146DermatitisSIDER
147Developmental Disabilities18552703CTD
148Diastolic dysfunctionOFFSIDES
149DiscomfortSIDER
150Disorders of Excessive Somnolence19179940CTD
151Disseminated Intravascular CoagulationOFFSIDES
152DiverticulitisOFFSIDES
153DiverticulumOFFSIDES
154DrowsinessOFFSIDES
SIDER
155Drug screen positiveOFFSIDES
156DysgeusiaSIDER
157DysphasiaOFFSIDES
158DysphoniaOFFSIDES
159Dysthymic DisorderOFFSIDES
160Dystonia10405494CTD
OFFSIDES
161DysuriaOFFSIDES
162Economic problemOFFSIDES
163Emotional distressOFFSIDES
164Enterovesical FistulaOFFSIDES
165EnuresisSIDER
166Erectile dysfunctionSIDER
167Ethmoid sinus surgeryOFFSIDES
168Failure to ThriveOFFSIDES
169Fatty LiverOFFSIDES
170Foaming at mouthOFFSIDES
171Food cravingOFFSIDES
172Gaze palsyOFFSIDES
173GlobulinuriaOFFSIDES
174GoiterOFFSIDES
175Hallucinations10630462
14627872		CTD
176HypersomniaSIDER
177Hypertensive heart diseaseOFFSIDES
178HypokinesiaOFFSIDES
SIDER
179Hypotension, Orthostatic6998487CTD
180IncontinenceOFFSIDES
181Initial insomniaSIDER
182Injection site erythemaOFFSIDES
183Injection site stingingOFFSIDES
184Intention tremorOFFSIDES
185Intentional misuseOFFSIDES
186IritisSIDER
187Lung AbscessOFFSIDES
188MastectomyOFFSIDES
189Medication tamperingOFFSIDES
190Mental status changesOFFSIDES
191Metamyelocyte count increasedOFFSIDES
192Middle insomniaSIDER
193Mitral valve sclerosisOFFSIDES
194Mononucleosis syndromeOFFSIDES
195MonoplegiaOFFSIDES
196Multiple MyelomaOFFSIDES
197Multiple drug overdoseOFFSIDES
198Musculoskeletal discomfortSIDER
199Musculoskeletal stiffnessOFFSIDES
200MyalgiaSIDER
201Myocardiac abscessOFFSIDES
202Myocardial InfarctionSIDER
203NephrolithiasisOFFSIDES
204Nephrotic SyndromeOFFSIDES
205NervousnessSIDER
206Neurobehavioral Manifestations12432978CTD
207Neurotransmitter level alteredOFFSIDES
208Neutrophil count decreasedOFFSIDES
209NocturiaOFFSIDES
SIDER
210OculogyrationOFFSIDES
211Optic Disc EdemaOFFSIDES
212OsteopeniaOFFSIDES
213Osteosarcoma localisedOFFSIDES
214OverdoseOFFSIDES
215PalpitationsSIDER
216Paranasal sinus hypersecretionOFFSIDES
217ParesisSIDER
218Pharmaceutical product complaintOFFSIDES
219Pharyngolaryngeal PainOFFSIDES
220Postmenopausal bleedingOFFSIDES
221Postural Orthostatic Tachycardia SyndromeOFFSIDES
222PurpuraSIDER
223Pyoderma GangrenosumOFFSIDES
224Reaction to medical agent preservativesOFFSIDES
225Renal Artery StenosisOFFSIDES
226Renal abscessOFFSIDES
227Renal cystOFFSIDES
228Respiratory tract congestionOFFSIDES
229RetinitisOFFSIDES
230RetrocollisOFFSIDES
231Retrosternal painSIDER
232RhinitisSIDER
233Self MutilationOFFSIDES
234ShockSIDER
235Sinus ArrhythmiaSIDER
236Sinus antrostomyOFFSIDES
237SinusitisOFFSIDES
238Skin lacerationOFFSIDES
239StaringOFFSIDES
240Stenotrophomonas infectionOFFSIDES
241Substance Withdrawal Syndrome

View details

2867958
3887593
6360692
7050735
7869468
 		CTD
242SweatingSIDER
243Tachycardia, Ventricular2665757CTD
244Tachycardia2665757CTD
SIDER
245TachyphylaxisOFFSIDES
246Tardive DyskinesiaOFFSIDES
247TensionSIDER
248Thought insertionOFFSIDES
249Upset stomachSIDER
250Vascular purpuraSIDER
251Ventricular Dysfunction, Left3520085CTD
252VertigoSIDER
253Weight GainOFFSIDES
254Xerostomia2037703
3281788
3513530		CTD
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