[(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;hydron;chloride;trihydrate
(KLEAIHJJLUAXIQ-JDRGBKBRSA-N)
Structure
- SMILES
- CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccc(cc4c(c3Cn1c2=O)CC)OC(=O)N1CCC(CC1)N1CCCCC1.O.O.O.Cl
- Molecular Formula:
- C33H45ClN4O9
- Molecular Weight:
- 677.185
- Log P:
- 4.5760
- Hydrogen Bond Acceptor:
- 13
- Hydrogen Bond Donor:
- 5
- TPSA:
- 141.89
- CAS Number(s):
- 136572-09-3
Synonym(s)
1.
[(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;hydron;chloride;trihydrate
2.
IRINOTECAN HYDROCHLORIDE Trihydrate
External Link(s)
| PubChem Compound | 46911859 60837 |
| ChEBI | 90881 |
| CHEMBL | CHEMBL3989514 |
| KEGG | dr:D01061 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Disease Progression | FAERS: 3 | US FAERS | |
| 2 | Malaise | FAERS: 3 | US FAERS | |
| 3 | Nausea | FAERS: 3 | US FAERS | |
| 4 | Neutropenia | FAERS: 3 | US FAERS | |
| 5 | Erythema | FAERS: 2 | US FAERS | |
| 6 | Posterior reversible encephalopathy syndrome | FAERS: 2 | US FAERS | |
| 7 | Septic Shock | FAERS: 2 | US FAERS | |
| 8 | Skin Ulcer | FAERS: 2 | US FAERS | |
| 9 | Adenocarcinoma | FAERS: 1 | US FAERS | |
| 10 | Atrioventricular Block | FAERS: 1 | US FAERS | |
| 11 | Back Pain | FAERS: 1 | US FAERS | |
| 12 | Biliary tract infection | FAERS: 1 | US FAERS | |
| 13 | Cellulitis | FAERS: 1 | US FAERS | |
| 14 | Choking | FAERS: 1 | US FAERS | |
| 15 | Drug dispensing error | FAERS: 1 | US FAERS | |
| 16 | Fatigue | FAERS: 1 | US FAERS | |
| 17 | Gastrointestinal toxicity | FAERS: 1 | US FAERS | |
| 18 | Glioblastoma | FAERS: 1 | US FAERS | |
| 19 | Lack of spontaneous speech | FAERS: 1 | US FAERS | |
| 20 | Pain | FAERS: 1 | US FAERS | |
| 21 | Panniculitis | FAERS: 1 | US FAERS | |
| 22 | Pneumonia | FAERS: 1 | US FAERS | |
| 23 | Product use issue | FAERS: 1 | US FAERS | |
| 24 | Streptococcus test positive | FAERS: 1 | US FAERS | |
| 25 | Tremor | FAERS: 1 | US FAERS | |
| 26 | Urinary Retention | FAERS: 1 | US FAERS | |
| 27 | Vomiting | FAERS: 1 | US FAERS | |
| 28 | Weight decreased | FAERS: 1 | US FAERS | |
| 29 | White blood cell count decreased | FAERS: 1 | US FAERS | |
| 30 | jaundice | FAERS: 1 | US FAERS |
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