MetaADEDB 2.0 @ LMMD
Topotecan
(UCFGDBYHRUNTLO-QHCPKHFHSA-N)
Structure
SMILES
CC[C@@]1(O)C(=O)OCc2c1cc1c3nc4ccc(c(c4cc3Cn1c2=O)CN(C)C)O
Type(s)
Approved; Investigational
ATC code(s)
L01XX17
Molecular Formula:
C23H23N3O5
Molecular Weight:
421.446
Log P:
1.8468
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
2
TPSA:
104.89
CAS Number(s):
123948-87-8
Synonym(s)
1.
Topotecan
2.
9-Dimethylaminomethyl-10-hydroxycamptothecin
3.
Hycamtamine
4.
Hycamtin
5.
NSC-609699
6.
Nogitecan Hydrochloride
7.
SK&F-104864-A
8.
SKF-104864-A
9.
Topotecan Hydrochloride
10.
Topotecan Monohydrochloride, (S)-Isomer
11.
9 Dimethylaminomethyl 10 hydroxycamptothecin
12.
Hydrochloride, Nogitecan
13.
Hydrochloride, Topotecan
14.
NSC 609699
15.
NSC609699
16.
SK&F 104864 A
17.
SK&F104864A
18.
SKF 104864 A
19.
SKF104864A
External Link(s)
MeSHD019772
PubChem Compound60700
BindingDB50034026
50008935
ChEBI63632
CHEMBLCHEMBL84
DrugBankDB01030
DrugCentral2707
IUPHAR/BPS Guide to PHARMACOLOGY7101
KEGGcpd:C11158
dr:D08618
Therapeutic Target DatabaseD02PMO
ZINC1611274
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1VomitingFAERS: 289660538
10741709		CTD
SIDER
US FAERS
2Malignant neoplasm progressionFAERS: 26US FAERS
3NauseaFAERS: 269660538
10741709		CTD
OFFSIDES
SIDER
US FAERS
4DehydrationFAERS: 22OFFSIDES
US FAERS
5FatigueFAERS: 19

View details

9660538
11721172
14760117
17399850
19808951
 		CTD
OFFSIDES
SIDER
US FAERS
6Disease ProgressionFAERS: 17OFFSIDES
US FAERS
7AstheniaFAERS: 1511557123CTD
OFFSIDES
SIDER
US FAERS
8General physical health deteriorationFAERS: 15OFFSIDES
US FAERS
9PancytopeniaFAERS: 15SIDER
US FAERS
10LymphopeniaFAERS: 1419139825CTD
US FAERS
11ThrombocytopeniaFAERS: 14

View details

10741709
10955863
11264156
11557123
11721172
12204671
14760117
15150579
15501959
16273254
17399850
19808951
21795476
 		CTD
SIDER
US FAERS
12AscitesFAERS: 1120935474CTD
US FAERS
13GenotoxicityFAERS: 11US FAERS
14NeutropeniaFAERS: 11
Canada Vigilance: 1

View details

9387049
10741709
10955863
11264156
11557123
11721172
14760117
15150579
16273254
19139825
21795476
 		CTD
SIDER
Canada Vigilance
US FAERS
15Abdominal PainFAERS: 10OFFSIDES
SIDER
US FAERS
16Febrile NeutropeniaFAERS: 10OFFSIDES
SIDER
US FAERS
17Drug ineffectiveFAERS: 8US FAERS
18Urinary tract infectionFAERS: 8US FAERS
19Weight decreasedFAERS: 8US FAERS
20IleusFAERS: 7US FAERS
21Neutrophil count decreasedFAERS: 7OFFSIDES
US FAERS
22Respiratory FailureFAERS: 7OFFSIDES
SIDER
US FAERS
23AnorexiaFAERS: 6OFFSIDES
SIDER
US FAERS
24ConstipationFAERS: 6SIDER
US FAERS
25LethargyFAERS: 6SIDER
US FAERS
26LeukopeniaFAERS: 610955863
19808951		CTD
SIDER
US FAERS
27MalaiseFAERS: 6SIDER
US FAERS
28Malignant ascitesFAERS: 6OFFSIDES
US FAERS
29PainFAERS: 6OFFSIDES
SIDER
US FAERS
30PneumoniaFAERS: 6SIDER
US FAERS
31Product use in unapproved indicationFAERS: 6US FAERS
32SubileusFAERS: 6OFFSIDES
US FAERS
33White blood cell count decreasedFAERS: 6US FAERS
34ConjunctivitisFAERS: 5US FAERS
35DermatitisFAERS: 5SIDER
US FAERS
36DiplopiaFAERS: 5US FAERS
37DizzinessFAERS: 5SIDER
US FAERS
38HaematotoxicityFAERS: 5
Canada Vigilance: 7		Canada Vigilance
OFFSIDES
US FAERS
39HypotensionFAERS: 514760117CTD
US FAERS
40Neutropenic sepsisFAERS: 5US FAERS
41Blood glucose increasedFAERS: 4US FAERS
42Brain Stem GliomaFAERS: 4US FAERS
43CachexiaFAERS: 4US FAERS
44Cerebral cystFAERS: 4US FAERS
45ChillsFAERS: 4SIDER
US FAERS
46Eye irritationFAERS: 4US FAERS
47GastritisFAERS: 4US FAERS
48HypersensitivityFAERS: 4
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
49PallorFAERS: 4US FAERS
50Pulmonary toxicityFAERS: 4US FAERS
51Toxicity to various agentsFAERS: 4US FAERS
52Chest PainFAERS: 3SIDER
US FAERS
53Drug administered to patient of inappropriate ageFAERS: 3US FAERS
54Escherichia infectionFAERS: 3OFFSIDES
US FAERS
55HeadacheFAERS: 3SIDER
US FAERS
56PapuleFAERS: 3US FAERS
57PruritusFAERS: 3SIDER
US FAERS
58SepsisFAERS: 311557123CTD
SIDER
US FAERS
59Septic ShockFAERS: 3US FAERS
60Stent occlusionFAERS: 3OFFSIDES
US FAERS
61Acute kidney injuryFAERS: 2US FAERS
62AphasiaFAERS: 2US FAERS
63BedriddenFAERS: 2OFFSIDES
US FAERS
64CholestasisFAERS: 2US FAERS
65Culture urine positiveFAERS: 2US FAERS
66CystFAERS: 2US FAERS
67Drug dose omissionFAERS: 2US FAERS
68Drug toxicityFAERS: 2OFFSIDES
US FAERS
69DysgeusiaFAERS: 2OFFSIDES
US FAERS
70EncephalitisFAERS: 2US FAERS
71EndophthalmitisFAERS: 2OFFSIDES
US FAERS
72Enterovesical FistulaFAERS: 2OFFSIDES
US FAERS
73Feeling abnormalFAERS: 2SIDER
US FAERS
74HemiparesisFAERS: 2US FAERS
75ImpetigoFAERS: 2US FAERS
76Mental status changesFAERS: 2OFFSIDES
US FAERS
77Metastatic NeoplasmFAERS: 2SIDER
US FAERS
78Neutrophilic dermatosisFAERS: 2US FAERS
79ObstructionFAERS: 2OFFSIDES
US FAERS
80Performance status decreasedFAERS: 2OFFSIDES
US FAERS
81Posterior reversible encephalopathy syndromeFAERS: 2US FAERS
82PseudophakiaFAERS: 2OFFSIDES
US FAERS
83Pulmonary EmbolismFAERS: 2SIDER
US FAERS
84Retrograde amnesiaFAERS: 2OFFSIDES
US FAERS
85Skin ErosionFAERS: 2US FAERS
86SomnolenceFAERS: 2US FAERS
87Urinary RetentionFAERS: 2US FAERS
88AbasiaFAERS: 1US FAERS
89Activities of daily living impairedFAERS: 1US FAERS
90AgitationFAERS: 1US FAERS
91AmnesiaFAERS: 1US FAERS
92AnxietyFAERS: 1US FAERS
93Back PainFAERS: 1SIDER
US FAERS
94Blood albumin decreasedFAERS: 1OFFSIDES
US FAERS
95Blood alkaline phosphatase increasedFAERS: 1US FAERS
96Blood creatinine increasedFAERS: 1OFFSIDES
US FAERS
97Blood lactate dehydrogenase increasedFAERS: 1OFFSIDES
US FAERS
98Blood phosphorus increasedFAERS: 1OFFSIDES
US FAERS
99Blood potassium decreasedFAERS: 1OFFSIDES
US FAERS
100Blood urea increasedFAERS: 1OFFSIDES
US FAERS
101Bone marrow depressionFAERS: 1OFFSIDES
US FAERS
102BronchitisFAERS: 1OFFSIDES
US FAERS
103Cerebral disorderFAERS: 1OFFSIDES
US FAERS
104Clostridium difficile infectionFAERS: 1US FAERS
105Colloid brain cystFAERS: 1US FAERS
106Deep Vein ThrombosisFAERS: 1US FAERS
107DeliriumFAERS: 1US FAERS
108Depressed Level of ConsciousnessFAERS: 1OFFSIDES
US FAERS
109DiscomfortFAERS: 1SIDER
US FAERS
110DisorientationFAERS: 1US FAERS
111Disseminated Intravascular CoagulationFAERS: 1US FAERS
112Drug administration errorFAERS: 1US FAERS
113Ear discomfortFAERS: 1OFFSIDES
US FAERS
114Electrolyte imbalanceFAERS: 1US FAERS
115ErythemaFAERS: 1US FAERS
116Failure to ThriveFAERS: 1OFFSIDES
US FAERS
117Full blood count decreasedFAERS: 1US FAERS
118Gastrointestinal sounds abnormalFAERS: 1US FAERS
119Gastrointestinal toxicityFAERS: 1OFFSIDES
US FAERS
120HydronephrosisFAERS: 1OFFSIDES
US FAERS
121HypoxiaFAERS: 1OFFSIDES
US FAERS
122Laboratory test interferenceFAERS: 1US FAERS
123Large intestine perforationFAERS: 1US FAERS
124MaculeFAERS: 1US FAERS
125MeningitisFAERS: 1US FAERS
126Metastases to perineumFAERS: 1US FAERS
127MetastasisFAERS: 1US FAERS
128Muscle SpasticityFAERS: 1US FAERS
129MyalgiaFAERS: 1SIDER
US FAERS
130Neutropenic colitisFAERS: 1SIDER
US FAERS
131Ocular ToxicityFAERS: 1US FAERS
132PancreatitisFAERS: 1US FAERS
133PetechiaeFAERS: 1US FAERS
134Pharyngolaryngeal PainFAERS: 1US FAERS
135Pneumocystis jiroveci pneumoniaFAERS: 1US FAERS
136PneumothoraxFAERS: 1US FAERS
137Product use issueFAERS: 1US FAERS
138Protein total decreasedFAERS: 1OFFSIDES
US FAERS
139Radiation PneumonitisFAERS: 1OFFSIDES
US FAERS
140Renal painFAERS: 1US FAERS
141Respiratory distressFAERS: 1US FAERS
142RetchingFAERS: 1US FAERS
143Sinus TachycardiaFAERS: 1US FAERS
144Small cell lung cancer recurrentFAERS: 1US FAERS
145Staphylococcus test positiveFAERS: 1US FAERS
146Sudden Cardiac DeathFAERS: 1US FAERS
147TachycardiaFAERS: 1US FAERS
148ThrombosisFAERS: 1US FAERS
149Transaminases increasedFAERS: 1US FAERS
150TremorFAERS: 1US FAERS
151Unevaluable eventFAERS: 1US FAERS
152Visual ImpairmentFAERS: 1US FAERS
153Vitreous floatersFAERS: 1US FAERS
154Wheelchair userFAERS: 1US FAERS
155WheezingFAERS: 1US FAERS
156White matter lesionFAERS: 1US FAERS
157Wound infection staphylococcalFAERS: 1US FAERS
158Adenocarcinoma21795476CTD
159Alanine Aminotransferase IncreasedOFFSIDES
SIDER
160Alopecia17399850CTD
OFFSIDES
SIDER
161Amaurosis FugaxOFFSIDES
162Anal discomfortOFFSIDES
163Anaphylactic shockSIDER
164Anaphylactoid ReactionSIDER
165Anemia

View details

9660538
10741709
10955863
11264156
11557123
11721172
14760117
15150579
16273254
17399850
19808951
 		CTD
166AngioedemaSIDER
167AnhidrosisOFFSIDES
168Arterial InjuryOFFSIDES
169ArthralgiaSIDER
170Aspartate Aminotransferase IncreasedSIDER
171Aspartate aminotransferase decreasedOFFSIDES
172AspergillosisOFFSIDES
173AtelectasisOFFSIDES
174Atrial FlutterOFFSIDES
175Atrial tachycardiaOFFSIDES
176Bacterial test positiveOFFSIDES
177Bile duct stent insertionOFFSIDES
178Blood albumin increasedOFFSIDES
179Blood alkaline phosphatase decreasedOFFSIDES
180Blood amylase increasedOFFSIDES
181Blood and lymphatic system disordersSIDER
182Blood chloride decreasedOFFSIDES
183Blood chloride increasedOFFSIDES
184Blood creatine increasedOFFSIDES
185Blood creatinine decreasedOFFSIDES
186Blood electrolytes abnormalOFFSIDES
187Blood gases abnormalOFFSIDES
188Blood lactate dehydrogenase decreasedOFFSIDES
189Blood magnesium decreasedOFFSIDES
190Blood phosphorusOFFSIDES
191Blood potassium increasedOFFSIDES
192Blood sodium increasedOFFSIDES
193Blood sodiumOFFSIDES
194Bone painSIDER
195Bone scan abnormalOFFSIDES
196Bone trimmingOFFSIDES
197Bronchial secretion retentionOFFSIDES
198BronchiectasisOFFSIDES
199Bullous eruptionSIDER
200C1 esterase inhibitor decreasedOFFSIDES
201Cardiac ArrestSIDER
202Catheter site erythemaOFFSIDES
203Catheter site infectionOFFSIDES
204Cerumen removalOFFSIDES
205Cervix carcinoma recurrentOFFSIDES
206Choking sensationOFFSIDES
207ChokingOFFSIDES
208CholecystitisOFFSIDES
209Chromosome Breakage24345465CTD
210Chronic tonsillitisOFFSIDES
211Circumstance or information capable of leading to medication errorOFFSIDES
212ColitisSIDER
213Colonic Neoplasms21388138
21795476		CTD
214ConfabulationOFFSIDES
215Culture positiveOFFSIDES
216DeafnessOFFSIDES
217DebridementOFFSIDES
218Diarrhea9660538CTD
OFFSIDES
219Differential white blood cell count abnormalOFFSIDES
220Dilatation intrahepatic duct acquiredOFFSIDES
221DiverticulumOFFSIDES
222Drug dispensing errorOFFSIDES
223DyspareuniaSIDER
224DyspepsiaSIDER
225Dyspnoea exacerbatedOFFSIDES
226EczemaOFFSIDES
227Engraftment syndromeOFFSIDES
228Enterocutaneous FistulaOFFSIDES
229EpistaxisOFFSIDES
SIDER
230ErysipelasOFFSIDES
231Escherichia urinary tract infectionOFFSIDES
232Esophagitis14760117CTD
233Exfoliative rashOFFSIDES
234Exploratory operationOFFSIDES
235ExtravasationSIDER
236Eyelid Function DisorderOFFSIDES
237Febrile bone marrow aplasiaOFFSIDES
238Febrile infectionOFFSIDES
239Fever11557123
14760117		CTD
240Flank PainOFFSIDES
241GangreneOFFSIDES
242Gastrointestinal Diseases17399850CTD
243Gastrointestinal PainSIDER
244Gastrointestinal motility disorderOFFSIDES
245Genital burning sensationOFFSIDES
246Glioblastoma19139825CTD
247HeartburnSIDER
248Hepatic cancer metastaticOFFSIDES
249Hepatitis B positiveOFFSIDES
250HiccoughOFFSIDES
251HypophagiaOFFSIDES
252IleitisOFFSIDES
253Impaired self-careOFFSIDES
254Infection15501959CTD
SIDER
255InfestationSIDER
256Infrequent bowel movementsOFFSIDES
257Intestinal ObstructionSIDER
258Intestinal mucosal hypertrophyOFFSIDES
259Left Ventricular HypertrophyOFFSIDES
260Leukopenia neonatalOFFSIDES
261LipaseOFFSIDES
262Lymphocyte count decreasedOFFSIDES
263Lymphoma, Non-Hodgkin10786197CTD
264MalnutritionSIDER
265Mechanical ventilationOFFSIDES
266Metastatic CarcinomaSIDER
267Mixed liver injuryOFFSIDES
268MonoplegiaOFFSIDES
269Multiple Myeloma10786197CTD
OFFSIDES
270Musculoskeletal discomfortSIDER
271MyelosuppressionSIDER
272Neoplasms15150579CTD
273NeuralgiaSIDER
274Neuroblastoma15176712CTD
275NeuropathySIDER
276Neutropenic infectionOFFSIDES
277Neutrophil count abnormalOFFSIDES
278Optic NeuropathyOFFSIDES
279Oral fungal infectionOFFSIDES
280OsteoporosisOFFSIDES
281PO2 decreasedOFFSIDES
282Pancreatic duct dilatationOFFSIDES
283ParesisSIDER
284Pelvic PainSIDER
285PeritonitisOFFSIDES
286PharyngitisSIDER
287Platelet count abnormalOFFSIDES
288Pleuritic painSIDER
289Pulmonary thrombosisOFFSIDES
290PyelonephritisOFFSIDES
291Radiation skin injuryOFFSIDES
292Rash erythematousSIDER
293Respiratory depth decreasedOFFSIDES
294RhabdomyosarcomaOFFSIDES
295RhinitisOFFSIDES
SIDER
296Sinus rhythmOFFSIDES
297Stomatitis14760117CTD
SIDER
298SweatingSIDER
299TetanyOFFSIDES
300Thrombocytopenia aggravatedSIDER
301Tongue bitingOFFSIDES
302Tooth InfectionOFFSIDES
303Ureteral stent insertionOFFSIDES
304UrethritisOFFSIDES
305Urge IncontinenceOFFSIDES
306Urinary sediment presentOFFSIDES
307Urobilin urine presentOFFSIDES
308UrticariaSIDER
309Venous thrombosis limbOFFSIDES
310Very low density lipoprotein increasedOFFSIDES
311White blood cell count abnormalOFFSIDES
312leukemia15501959
16684125		CTD
313melanoma11264156
21795476		CTD
314nervous system disorderSIDER
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.