MetaADEDB 2.0 @ LMMD
Lomustine
(GQYIWUVLTXOXAJ-UHFFFAOYSA-N)
Structure
SMILES
ClCCN(C(=O)NC1CCCCC1)N=O
Type(s)
Approved; Investigational
ATC code(s)
L01AD02
Molecular Formula:
C9H16ClN3O2
Molecular Weight:
233.695
Log P:
2.6418
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
1
TPSA:
61.77
CAS Number(s):
13010-47-4
Synonym(s)
1.
Lomustine
2.
CCNU
3.
Belustine
4.
Cecenu
5.
CeeNU
6.
NSC-79037
7.
NSC 79037
8.
NSC79037
External Link(s)
MeSHD008130
PubChem Compound3950
BindingDB50247919
ChEBI6520
CHEMBLCHEMBL514
DrugBankDB01206
DrugCentral1596
IUPHAR/BPS Guide to PHARMACOLOGY7214
KEGGcpd:C07079
dr:D00363
Therapeutic Target DatabaseD04JPJ
ZINC3831006
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1OverdoseFAERS: 7US FAERS
2Pulmonary toxicityFAERS: 7SIDER
US FAERS
3Mental status changesFAERS: 6US FAERS
4Abdominal PainFAERS: 5US FAERS
5Accidental overdoseFAERS: 5US FAERS
6Medication ErrorFAERS: 5US FAERS
7Disease ProgressionFAERS: 4US FAERS
8HepatotoxicityFAERS: 4SIDER
US FAERS
9NauseaFAERS: 4SIDER
US FAERS
10Therapy cessationFAERS: 4US FAERS
11White blood cell count decreasedFAERS: 4US FAERS
12Drug dispensing errorFAERS: 3US FAERS
13HeadacheFAERS: 3US FAERS
14IleitisFAERS: 3US FAERS
15Malignant neoplasm progressionFAERS: 3US FAERS
16PancytopeniaFAERS: 3SIDER
US FAERS
17Accidental exposure to product by childFAERS: 2US FAERS
18Circumstance or information capable of leading to medication errorFAERS: 2US FAERS
19Incorrect dose administeredFAERS: 2US FAERS
20NeutropeniaFAERS: 2
Canada Vigilance: 1

View details

11305414
15762370
18953065
21418164
24659727
 		CTD
Canada Vigilance
US FAERS
21No adverse eventFAERS: 2US FAERS
22PainFAERS: 2US FAERS
23PneumoniaFAERS: 2US FAERS
24Product use issueFAERS: 2US FAERS
25ThrombocytopeniaFAERS: 2

View details

11305414
15762370
18953065
21418164
 		CTD
SIDER
US FAERS
26VomitingFAERS: 221418164CTD
SIDER
US FAERS
27Blood count abnormalFAERS: 1US FAERS
28Bone marrow depressionFAERS: 1US FAERS
29CandidiasisFAERS: 1US FAERS
30ConstipationFAERS: 1US FAERS
31DeafnessFAERS: 1US FAERS
32Disease complicationFAERS: 1US FAERS
33DisorientationFAERS: 1SIDER
US FAERS
34Drug administration errorFAERS: 1US FAERS
35Drug ineffectiveFAERS: 1US FAERS
36FatigueFAERS: 16293321CTD
US FAERS
37Full blood count decreasedFAERS: 1US FAERS
38GlioblastomaFAERS: 118089819CTD
US FAERS
39Head discomfortFAERS: 1US FAERS
40Inappropriate schedule of drug administrationFAERS: 1US FAERS
41Manufacturing product shipping issueFAERS: 1US FAERS
42Neurological examination abnormalFAERS: 1US FAERS
43Neutrophil count decreasedFAERS: 1US FAERS
44Optic AtrophyFAERS: 1SIDER
US FAERS
45Platelet count abnormalFAERS: 1US FAERS
46Prescribed underdoseFAERS: 1US FAERS
47Product distribution issueFAERS: 1US FAERS
48Product dose omissionFAERS: 1US FAERS
49ScotomaFAERS: 1US FAERS
50SwellingFAERS: 1US FAERS
51Urinary tract infectionFAERS: 1US FAERS
52Visual ImpairmentFAERS: 1SIDER
US FAERS
53White blood cell count abnormalFAERS: 1US FAERS
54AlopeciaSIDER
55Anemia18953065
21418164		CTD
56AnorexiaSIDER
57Astrocytoma185991
4017166
8186424		CTD
58AtaxiaSIDER
59Blindness3028594CTD
SIDER
60Bone Marrow Diseases3040918CTD
61Brain Diseases7931469CTD
62Brain Edema2500219CTD
63Brain Neoplasms

View details

185991
4017166
7931469
8186424
21418164
21842312
 		CTD
64Central Nervous System Neoplasms18953065CTD
65Cerebral Hemorrhage7931469
18953065		CTD
66Chemical and Drug Induced Liver Injury3105904CTD
67Cholestasis3105904
3377683		CTD
68Depressive disorder6293321CTD
69Drug Overdose15762370CTD
70DysarthriaSIDER
71DysplasiaSIDER
72Eye Neoplasms18953065CTD
73FibrosisSIDER
74Gastrointestinal Diseases21418164CTD
75Gastrointestinal toxicitySIDER
76Glioma15762370
19901110		CTD
77Hearing Loss11305414CTD
78Heart Diseases7466925CTD
79Heart failure18953065CTD
80Hematoma, Subdural7931469CTD
81Histiocytic Disorders, Malignant21418164CTD
82Hodgkin Disease16135485CTD
83Hyperplasia16005536CTD
84InfectionSIDER
85Kidney Diseases

View details

221116
4017166
11305414
19761811
21418164
 		CTD
86Kidney Failure, Chronic7443446CTD
87LethargySIDER
88Leukopenia18953065CTD
SIDER
89Liver Failure21418164CTD
90Liver neoplasms28108177CTD
91Lung Neoplasms3040918CTD
92Lymphoma18953065
21418164		CTD
93MyelosuppressionSIDER
94Myocardial Infarction3984047CTD
95Neoplasms, Experimental175631
6849803
17878523		CTD
96Neoplasms, Neuroepithelial21710625CTD
97Neoplasms3698015CTD
98Nephritis, Interstitial7272960CTD
99Neurologic reactionSIDER
100Oropharyngeal discomfortSIDER
101Oropharyngeal painSIDER
102Pulmonary FibrosisSIDER
103Refractory cytopenia with unilineage dysplasiaSIDER
104Renal Insufficiency18953065CTD
105Sarcoma, Experimental6831472
7107385
7150475		CTD
106StomatitisSIDER
107Vipoma2868874CTD
108Visual disturbanceSIDER
109melanoma15577320
18315784		CTD
110oligodendroglioma

View details

7931469
15015656
19901104
20842591
21246521
 		CTD
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