MetaADEDB 2.0 @ LMMD
Nebivolol
(KOHIRBRYDXPAMZ-UHFFFAOYSA-N)
Structure
SMILES
OC(C1CCc2c(O1)ccc(c2)F)CNCC(C1CCc2c(O1)ccc(c2)F)O
Type(s)
Approved; Investigational
ATC code(s)
C07AB12; C07BB12; C07FB12; C09DX05
Molecular Formula:
C22H25F2NO4
Molecular Weight:
405.435
Log P:
2.7545
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
3
TPSA:
70.95
CAS Number(s):
99200-09-6; 118457-14-0; 118457-16-2; 119365-25-2
Synonym(s)
1.
Nebivolol
2.
Alpha,Alpha'-(Iminobis(Methylene))bis(6-Fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol
3.
Bystolic
4.
Lobivon
5.
Nebilet
6.
Nebivolol Hydrochloride
7.
R 67555
8.
R-67555
9.
Silostar
10.
67555, R
11.
Hydrochloride, Nebivolol
12.
R67555
External Link(s)
MeSHD000068577
PubChem Compound71301
BindingDB84735
ChEBI64019
CHEMBLCHEMBL434394
DrugBankDB04861
DrugCentral1887
IUPHAR/BPS Guide to PHARMACOLOGY7246
KEGGdr:D05127
Therapeutic Target DatabaseD0Z1UA
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1DizzinessFAERS: 8SIDER
US FAERS
2HeadacheFAERS: 6SIDER
US FAERS
3Hypertensive crisisFAERS: 4US FAERS
4MalaiseFAERS: 4US FAERS
5SyncopeFAERS: 4SIDER
US FAERS
6Angina PectorisFAERS: 3US FAERS
7BradycardiaFAERS: 317323786CTD
OFFSIDES
SIDER
US FAERS
8BronchospasmFAERS: 3SIDER
US FAERS
9Drug ineffectiveFAERS: 3US FAERS
10HepatotoxicityFAERS: 3US FAERS
11HypotensionFAERS: 3US FAERS
12PresyncopeFAERS: 3US FAERS
13TinnitusFAERS: 3US FAERS
14TremorFAERS: 3US FAERS
15Abnormal weight gainFAERS: 2US FAERS
16Accidental exposure to product by childFAERS: 2US FAERS
17AnxietyFAERS: 2US FAERS
18Burning sensationFAERS: 2US FAERS
19Drug administration errorFAERS: 2US FAERS
20Ear discomfortFAERS: 2US FAERS
21EpistaxisFAERS: 2OFFSIDES
US FAERS
22Head discomfortFAERS: 2US FAERS
23Hypertrophic CardiomyopathyFAERS: 2US FAERS
24Pulmonary congestionFAERS: 2US FAERS
25Sinus bradycardiaFAERS: 2US FAERS
26SomnolenceFAERS: 2SIDER
US FAERS
27Sudden deathFAERS: 2OFFSIDES
US FAERS
28Suicide attemptFAERS: 2US FAERS
29VomitingFAERS: 2SIDER
US FAERS
30WheezingFAERS: 2US FAERS
31Acute respiratory failureFAERS: 1US FAERS
32Altered state of consciousnessFAERS: 1US FAERS
33AphasiaFAERS: 1US FAERS
34AstheniaFAERS: 1OFFSIDES
SIDER
US FAERS
35Bifascicular blockFAERS: 1US FAERS
36Blood creatine phosphokinase increasedFAERS: 1US FAERS
37BronchitisFAERS: 1US FAERS
38CapillaritisFAERS: 1US FAERS
39Chest PainFAERS: 1SIDER
US FAERS
40CyanosisFAERS: 1US FAERS
41Erectile dysfunctionFAERS: 1SIDER
US FAERS
42FatigueFAERS: 1OFFSIDES
SIDER
US FAERS
43Feeling abnormalFAERS: 1US FAERS
44GlaucomaFAERS: 1US FAERS
45Granulomatosis with polyangiitisFAERS: 1US FAERS
46Lipase increasedFAERS: 1US FAERS
47NauseaFAERS: 1SIDER
US FAERS
48NephrolithiasisFAERS: 1US FAERS
49OverdoseFAERS: 1US FAERS
50PancreatitisFAERS: 1US FAERS
51PsoriasisFAERS: 1OFFSIDES
SIDER
US FAERS
52Sjogren's SyndromeFAERS: 1US FAERS
53Status AsthmaticusFAERS: 1US FAERS
54TachycardiaFAERS: 11383620CTD
US FAERS
55Therapy non-responderFAERS: 1US FAERS
56ThrombocytopeniaFAERS: 1SIDER
US FAERS
57Toxic Epidermal NecrolysisFAERS: 1US FAERS
58VertigoFAERS: 1SIDER
US FAERS
59jaundiceFAERS: 1US FAERS
60Abdominal PainSIDER
61Abdominal symptomOFFSIDES
62Abdominal wall cystOFFSIDES
63Abnormal visionOFFSIDES
64Accidental overdoseOFFSIDES
65Acute Coronary SyndromeSIDER
66Acute prerenal failureOFFSIDES
67AgeusiaOFFSIDES
68AngerOFFSIDES
69AngioedemaOFFSIDES
SIDER
70AngioplastyOFFSIDES
71AnisocoriaOFFSIDES
72Ankle FractureOFFSIDES
73AnorexiaOFFSIDES
74Antithrombin III decreasedOFFSIDES
75Aphthous StomatitisOFFSIDES
76Arterial bypass operationOFFSIDES
77Arteriogram coronary abnormalOFFSIDES
78ArteriosclerosisOFFSIDES
79Arteriovenous fistula site infectionOFFSIDES
80Arteriovenous fistula thrombosisOFFSIDES
81Arteriovenous graft thrombosisOFFSIDES
82Aspartate Aminotransferase IncreasedSIDER
83AtaxiaOFFSIDES
84Atherosclerosis18435936CTD
85Atrioventricular BlockSIDER
86Axonal neuropathyOFFSIDES
87BiopsyOFFSIDES
88Blood creatinine increasedOFFSIDES
89Blood potassium decreasedOFFSIDES
90Blood pressure fluctuationOFFSIDES
91Blood pressure inadequately controlledOFFSIDES
92Blood sodiumOFFSIDES
93Blood urea increasedOFFSIDES
94Brain natriuretic peptide increasedOFFSIDES
95BronchiectasisOFFSIDES
96Capillary Leak SyndromeOFFSIDES
97Cardio-respiratory distressOFFSIDES
98Cardiovascular insufficiencyOFFSIDES
99Cerebellar infarctionOFFSIDES
100Cerebral disorderOFFSIDES
101CholangiolitisOFFSIDES
102ChromaturiaOFFSIDES
103Chronic left ventricular failureOFFSIDES
104Clostridium difficile colitisOFFSIDES
105Coagulation time abnormalOFFSIDES
106ColitisOFFSIDES
107Coronary angioplastyOFFSIDES
108Depressed moodOFFSIDES
109DermatitisSIDER
110Diabetic FootOFFSIDES
111Diastolic dysfunctionOFFSIDES
112DiplopiaOFFSIDES
113Drug withdrawal headacheOFFSIDES
114Echography abnormalOFFSIDES
115Escherichia infectionOFFSIDES
116Failure of implantOFFSIDES
117Fatty LiverOFFSIDES
118Feeling ColdOFFSIDES
119Femoral arterial stenosisOFFSIDES
120Gamma-Glutamyltransferase IncreasedOFFSIDES
121Gastrointestinal PainSIDER
122General physical health deteriorationOFFSIDES
123GlobulinuriaOFFSIDES
124GoiterOFFSIDES
125GranulocytosisOFFSIDES
126Heart Failure, Systolic17323786CTD
127Hepatic necrosisOFFSIDES
128Hepatic siderosisOFFSIDES
129HepatosplenomegalyOFFSIDES
130HostilityOFFSIDES
131HypersensitivitySIDER
132Idiosyncratic drug reactionOFFSIDES
133Iliac artery stenosisOFFSIDES
134IncontinenceOFFSIDES
135Infusion site mobility decreasedOFFSIDES
136Intermittent ClaudicationSIDER
137Keratitis siccaOFFSIDES
138Kidney FailureOFFSIDES
139Leukocytoclastic vasculitisSIDER
140Lip erosionOFFSIDES
141LividityOFFSIDES
142LymphocytosisOFFSIDES
143MalnutritionSIDER
144Motor retardationOFFSIDES
145Muscle necrosisOFFSIDES
146Mycosis FungoidesOFFSIDES
147Myocardial InfarctionSIDER
148Myocardial fibrosisOFFSIDES
149Neointima17310107CTD
150Nephrotic SyndromeOFFSIDES
151NystagmusOFFSIDES
152Oropharyngeal painOFFSIDES
153Osteoporosis30291735CTD
154Pelvic venous thrombosisOFFSIDES
155Perineal fistulaOFFSIDES
156Peripheral arterial occlusive diseaseOFFSIDES
157Phrenic nerve paralysisOFFSIDES
158Pneumococcal sepsisOFFSIDES
159PolyuriaOFFSIDES
160Portal HypertensionOFFSIDES
161PruritusSIDER
162Pupillary light reflex tests abnormalOFFSIDES
163Renal AdenomaOFFSIDES
164Renal Artery StenosisOFFSIDES
165Retinal Vein OcclusionOFFSIDES
166RhabdomyolysisOFFSIDES
167ScotomaOFFSIDES
168Sensorimotor disorderOFFSIDES
169ShockSIDER
170Status EpilepticusOFFSIDES
171Stevens-Johnson SyndromeOFFSIDES
172Supraventricular tachycardiaOFFSIDES
173TracheobronchitisOFFSIDES
174Transaminases increasedOFFSIDES
175Ultrasound abdomen abnormalOFFSIDES
176Ultrasound scan abnormalOFFSIDES
177Urine output increasedOFFSIDES
178Urine potassium increasedOFFSIDES
179UrticariaSIDER
180Ventricular Dysfunction, Left18194856CTD
181Ventricular FibrillationOFFSIDES
182Vulvovaginal pruritusOFFSIDES
183nervous system disorderSIDER
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