MetaADEDB 2.0 @ LMMD
fosphenytoin
(XWLUWCNOOVRFPX-UHFFFAOYSA-N)
Structure
SMILES
O=C1N(COP(=O)(O)O)C(=O)NC1(c1ccccc1)c1ccccc1
Type(s)
Approved; Investigational
ATC code(s)
N03AB05
Molecular Formula:
C16H15N2O6P
Molecular Weight:
362.274
Log P:
1.8155
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
3
TPSA:
125.98
CAS Number(s):
93390-81-9
Synonym(s)
1.
fosphenytoin
2.
3-(hydroxymethyl)phenytoin disodium phosphate
3.
3-(hydroxymethyl)phenytoin phosphate ester
4.
ACC 9653
5.
ACC-9653
6.
Cerebyx
7.
HMPDP
8.
Prodilantin
9.
fosphenytoin sodium
10.
fosphenytoin, disodium salt
External Link(s)
MeSHC043114
PubChem Compound56339
ChEBI5165
CHEMBLCHEMBL1201336
DrugBankDB01320
DrugCentral1247
IUPHAR/BPS Guide to PHARMACOLOGY7190
KEGGcpd:C07840
dr:D07993
Therapeutic Target DatabaseD0J5YC
ZINC1530922
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1HypotensionFAERS: 1312500711
19854616		CTD
SIDER
US FAERS
2BradycardiaFAERS: 9OFFSIDES
SIDER
US FAERS
3Cardiac ArrestFAERS: 5SIDER
US FAERS
4Mental status changesFAERS: 4OFFSIDES
US FAERS
5AtaxiaFAERS: 3SIDER
US FAERS
6DizzinessFAERS: 3SIDER
US FAERS
7Accidental overdoseFAERS: 2US FAERS
8EosinophiliaFAERS: 2US FAERS
9NystagmusFAERS: 2OFFSIDES
SIDER
US FAERS
10PruritusFAERS: 212500711CTD
SIDER
US FAERS
11Unresponsive to stimuliFAERS: 2US FAERS
12Acute respiratory failureFAERS: 1OFFSIDES
US FAERS
13Administration site extravasationFAERS: 1US FAERS
14AgitationFAERS: 1SIDER
US FAERS
15Alanine Aminotransferase IncreasedFAERS: 1US FAERS
16Anticonvulsant drug level increasedFAERS: 1US FAERS
17AnxietyFAERS: 1OFFSIDES
US FAERS
18Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
19CholestasisFAERS: 1US FAERS
20ChoreoathetosisFAERS: 1US FAERS
21Cytolytic hepatitisFAERS: 1OFFSIDES
US FAERS
22DeliriumFAERS: 1SIDER
US FAERS
23Electromechanical dissociationFAERS: 1US FAERS
24Factor V deficiencyFAERS: 1US FAERS
25HeadacheFAERS: 1SIDER
US FAERS
26HepatitisFAERS: 1OFFSIDES
US FAERS
27HepatomegalyFAERS: 1US FAERS
28HyporeflexiaFAERS: 1SIDER
US FAERS
29HypoxiaFAERS: 1US FAERS
30IntussusceptionFAERS: 1US FAERS
31LethargyFAERS: 1OFFSIDES
US FAERS
32Lip swellingFAERS: 1US FAERS
33MydriasisFAERS: 1SIDER
US FAERS
34OverdoseFAERS: 1OFFSIDES
US FAERS
35PancytopeniaFAERS: 1US FAERS
36Product contamination physicalFAERS: 1US FAERS
37Product quality issueFAERS: 1US FAERS
38Product use in unapproved indicationFAERS: 1US FAERS
39RestlessnessFAERS: 1US FAERS
40Status EpilepticusFAERS: 116434340CTD
OFFSIDES
US FAERS
41Stevens-Johnson SyndromeFAERS: 125811541CTD
OFFSIDES
US FAERS
42TachycardiaFAERS: 1SIDER
US FAERS
43Throat irritationFAERS: 1US FAERS
44ThrombocytopeniaFAERS: 1SIDER
US FAERS
45TinnitusFAERS: 1SIDER
US FAERS
46Toxicity to various agentsFAERS: 1US FAERS
47TremorFAERS: 1SIDER
US FAERS
48UrticariaFAERS: 1SIDER
US FAERS
49Viral myocarditisFAERS: 1US FAERS
50nervous system disorderFAERS: 1US FAERS
51Abdominal discomfortOFFSIDES
52AcidosisSIDER
53AdenitisOFFSIDES
54AgeusiaSIDER
55AgraphiaOFFSIDES
56AkathisiaSIDER
57AlbuminuriaSIDER
58AlkalosisSIDER
59AlveolitisOFFSIDES
60AmblyopiaSIDER
61Ammonia increasedOFFSIDES
62AmnesiaSIDER
63AmphetaminesOFFSIDES
64Anaphylactic shockSIDER
65Anaphylactoid ReactionSIDER
66AngioedemaOFFSIDES
67AnhedoniaOFFSIDES
68AnisocytosisOFFSIDES
69Anorectal discomfortSIDER
70AnorexiaSIDER
71AnoxiaOFFSIDES
72Anticonvulsant drug level abnormalOFFSIDES
73Anticonvulsant drug level below therapeuticOFFSIDES
74Antiviral drug level above therapeuticOFFSIDES
75AnuriaOFFSIDES
76AphasiaSIDER
77ApneaOFFSIDES
78ArthralgiaSIDER
79ArthropathyOFFSIDES
80AscitesOFFSIDES
81AstheniaSIDER
82AsthmaSIDER
83AstrocytomaOFFSIDES
84AtelectasisOFFSIDES
SIDER
85AtherosclerosisOFFSIDES
86AthetosisOFFSIDES
87Atrial FlutterSIDER
88Atrial tachycardiaOFFSIDES
89Atrioventricular Block16434340CTD
90Back PainSIDER
91Blood GlucoseOFFSIDES
92Blood count abnormalOFFSIDES
93Blood potassium increasedOFFSIDES
94Blood sodium increasedOFFSIDES
95Blood sodiumOFFSIDES
96Blood triglycerides increasedOFFSIDES
97Blood urine presentOFFSIDES
98Bone lesionOFFSIDES
99Bone painOFFSIDES
100Bone trimmingOFFSIDES
101BronchitisSIDER
102CachexiaSIDER
103CardiomegalySIDER
104CellulitisOFFSIDES
105Cerebral InfarctionSIDER
106ChillsSIDER
107CholangiolitisOFFSIDES
108Circumoral paresthesiaSIDER
109Circumstance or information capable of leading to medication errorOFFSIDES
110Cognitive deteriorationOFFSIDES
111ConfabulationOFFSIDES
112ConjunctivitisSIDER
113ConstipationSIDER
114Cramps of lower extremitiesSIDER
115Culture positiveOFFSIDES
116Culture wound positiveOFFSIDES
117CyanosisSIDER
118DeafnessSIDER
119DehydrationSIDER
120DemyelinationOFFSIDES
121Depressed Level of ConsciousnessSIDER
122DermatitisSIDER
123Device interactionOFFSIDES
124Diabetes InsipidusOFFSIDES
SIDER
125DiplopiaOFFSIDES
SIDER
126DiscomfortSIDER
127Disseminated Intravascular CoagulationOFFSIDES
128Drug dispensing errorOFFSIDES
129DysarthriaSIDER
130DysgeusiaSIDER
131DyspepsiaSIDER
132DysuriaSIDER
133EcchymosisSIDER
134Emotional distressOFFSIDES
135EncephalitisOFFSIDES
SIDER
136Enterococcal infectionOFFSIDES
137EpilepsyOFFSIDES
138EpistaxisSIDER
139Erythema MultiformeOFFSIDES
140Eye painSIDER
141Failure to ThriveOFFSIDES
142Feeling ColdOFFSIDES
143Feeling abnormalSIDER
144FlatulenceSIDER
145Fluid overloadOFFSIDES
146FolliculitisOFFSIDES
147GastritisSIDER
148Gastrointestinal sounds abnormalOFFSIDES
149General physical health deteriorationOFFSIDES
150Hallucinations11118803CTD
151HemiparesisOFFSIDES
152HemiplegiaOFFSIDES
SIDER
153Hepatic necrosisOFFSIDES
154HostilitySIDER
155HydrocephalusOFFSIDES
156HyperacusisSIDER
157HyperkinesiaSIDER
158HyperreflexiaSIDER
159Hypertensive heart diseaseOFFSIDES
160HyperventilationSIDER
161HypokinesiaSIDER
162HypophagiaOFFSIDES
163IleusSIDER
164Incorrect dose administeredOFFSIDES
165Increased bronchial secretionSIDER
166InfectionOFFSIDES
SIDER
167InfluenzaSIDER
168Infusion site erythemaOFFSIDES
169Infusion site infectionOFFSIDES
170Infusion site painOFFSIDES
171Infusion site reactionOFFSIDES
172Infusion site swellingOFFSIDES
173Injection Site ReactionSIDER
174Injection site inflammationSIDER
175Injection site painSIDER
176Intervertebral Disc DegenerationOFFSIDES
177Intervertebral disc disorderOFFSIDES
178KetosisSIDER
179Kidney FailureOFFSIDES
180Laboratory test interferenceOFFSIDES
181LacerationOFFSIDES
182LeukocytosisSIDER
183Leukopenia neonatalOFFSIDES
184LeukopeniaSIDER
185Lichen PlanusOFFSIDES
186Life expectancy shortenedOFFSIDES
187LymphadenopathySIDER
188MacrocytosisOFFSIDES
189MalaiseSIDER
190Malignant neoplasm progressionOFFSIDES
191Mastication disorderOFFSIDES
192MastoiditisOFFSIDES
193MeningitisSIDER
194Metabolic acidosisOFFSIDES
195Metastases to abdominal cavityOFFSIDES
196Mood swingsSIDER
197Muscle relaxant therapySIDER
198Musculoskeletal discomfortSIDER
199MyalgiaSIDER
200MyoclonusSIDER
201MyopathySIDER
202NauseaSIDER
203Neonatal aspirationOFFSIDES
204NervousnessSIDER
205Occult blood positiveOFFSIDES
206OliguriaSIDER
207Open woundOFFSIDES
208OsteolysisOFFSIDES
209PainOFFSIDES
210PalpitationsSIDER
211Paresthesia12500711CTD
212Pelvic PainSIDER
213PeriarthritisOFFSIDES
214PetechiaeSIDER
215PharyngitisSIDER
216Phlebitis8159601CTD
OFFSIDES
217PhotophobiaSIDER
218PneumoniaSIDER
219PneumothoraxSIDER
220PolyuriaSIDER
221Post procedural complicationOFFSIDES
222Post procedural painOFFSIDES
223Pulmonary EmbolismSIDER
224Pulmonary congestionOFFSIDES
225RalesOFFSIDES
226Rectal tenesmusSIDER
227Red blood cell schistocytes presentOFFSIDES
228Renal tubular necrosisOFFSIDES
229Respiratory FailureOFFSIDES
230RhinitisSIDER
231ScotomaSIDER
232Seizures19854616CTD
233SepsisSIDER
234Serum SicknessOFFSIDES
235ShockSIDER
236Sinus Arrest, Cardiac16434340CTD
237Sinus bradycardiaSIDER
238SinusitisSIDER
239Skin discomfortOFFSIDES
240Skin noduleSIDER
241SomnolenceSIDER
242StuporSIDER
243SweatingSIDER
244SyncopeSIDER
245Tachycardia, Ventricular2767010CTD
246TensionSIDER
247ThrombophlebitisSIDER
248Tooth ExtractionOFFSIDES
249Urinary IncontinenceSIDER
250Urinary RetentionSIDER
251Urinary tract infection pseudomonalOFFSIDES
252Urine output increasedSIDER
253Venous stenosisOFFSIDES
254VertigoSIDER
255Vitamin B 12 DeficiencyOFFSIDES
256VomitingSIDER
257Vulvovaginal mycotic infectionSIDER
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