S-Adenosylmethionine
(MEFKEPWMEQBLKI-AIRLBKTGSA-N)
Structure
- SMILES
- C[S+](C[C@H]1O[C@H]([C@@H]([C@@H]1O)O)n1cnc2c1ncnc2N)CC[C@@H](C(=O)[O-])N
- Type(s)
- Approved; Investigational; Nutraceutical
- ATC code(s)
- A16AA02
- Molecular Formula:
- C15H22N6O5S
- Molecular Weight:
- 398.437
- Log P:
- -1.9754
- Hydrogen Bond Acceptor:
- 11
- Hydrogen Bond Donor:
- 4
- TPSA:
- 210.76
- CAS Number(s):
- 485-80-3; 17176-17-9; 24346-00-7; 29908-03-0; 78548-84-2; 91279-78-6
Synonym(s)
1.
S-Adenosylmethionine
2.
AdoMet
3.
Ademetionine
4.
FO-1561
5.
Gumbaral
6.
S Amet
7.
S-Adenosyl-L-Methionine
8.
S-Adenosylmethionine Sulfate Tosylate
9.
SAM-e
10.
Samyr
11.
FO 1561
12.
FO1561
13.
S Adenosyl L Methionine
14.
S Adenosylmethionine
15.
S Adenosylmethionine Sulfate Tosylate
External Link(s)
| MeSH | D012436 |
| PubChem Compound | 34755 |
| BindingDB | 50361999 28422 |
| ChEBI | 67040 |
| CHEMBL | CHEMBL1088977 |
| DrugBank | DB00118 |
| DrugCentral | 2414 |
| KEGG | cpd:C00019 |
| Therapeutic Target Database | D06PVL |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Crying | FAERS: 1 | US FAERS | |
| 2 | Product quality issue | FAERS: 1 | US FAERS | |
| 3 | Autistic Disorder | 16917939 19056591 | CTD | |
| 4 | Bipolar Disorder | 6367496 | CTD | |
| 5 | Chemical and Drug Induced Liver Injury | CTD | ||
| 6 | Cholestasis | CTD | ||
| 7 | Cognition Disorders | 7527320 | CTD | |
| 8 | Dementia | 7527320 | CTD | |
| 9 | Demyelinating Diseases | 7527320 | CTD | |
| 10 | Depressive disorder | 6367496 18824331 | CTD | |
| 11 | Dyskinesia, Drug-Induced | 14643842 | CTD | |
| 12 | Folic Acid Deficiency | 7527320 | CTD | |
| 13 | Hepatomegaly | 18068290 | CTD | |
| 14 | Hypokinesia | 1359575 8503824 10973524 | CTD | |
| 15 | Hypothyroidism | 18518811 | CTD | |
| 16 | Liver Cirrhosis, Experimental | 15983038 | CTD | |
| 17 | Liver Cirrhosis | 8878782 | CTD | |
| 18 | Liver Neoplasms, Experimental | 18404532 | CTD | |
| 19 | Liver diseases | 1327655 | CTD | |
| 20 | Liver neoplasms | 12163149 | CTD | |
| 21 | Mucocele | 18518811 | CTD | |
| 22 | Muscle Rigidity | 1359575 8503824 10973524 | CTD | |
| 23 | Necrosis | 11346894 18068290 | CTD | |
| 24 | Nerve Degeneration | 1359575 | CTD | |
| 25 | Paraparesis | 19821069 | CTD | |
| 26 | Renal Insufficiency | 8497444 | CTD | |
| 27 | Schizophrenia | 18824331 | CTD | |
| 28 | Spinal Cord Diseases | 19821069 | CTD | |
| 29 | Tremor | CTD | ||
| 30 | Vitamin B 12 Deficiency | 7527320 | CTD | |
| 31 | jaundice | 8497444 | CTD |
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