MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Diosmin

(GZSOSUNBTXMUFQ-YFAPSIMESA-N)

Structure

SMILES: COc1ccc(cc1O)c1cc(=O)c2c(o1)cc(cc2O)O[C@@H]1O[C@H](CO[C@@H]2O[C@@H](C)[C@@H]([C@H]([C@H]2O)O)O)[C@H]([C@@H]([C@H]1O)O)O
Type(s): Approved; Investigational
ATC code(s): C05CA03; C05CA53
Molecular Formula:: C28H32O15
Molecular Weight:: 608.545
Log P:: -1.0897
Hydrogen Bond Acceptor:: 15
Hydrogen Bond Donor:: 8
TPSA:: 238.2
CAS Number(s):: 520-27-4

Synonym(s)

Diosmin

Barosmin

Buchu Resin

Daflon

Venosmine

Resin, Buchu

External Link(s)

MeSH	D004145
PubChem Compound	5281613
BindingDB	153267
ChEBI	4631
CHEMBL	CHEMBL231884
DrugBank	DB08995
DrugCentral	3157
KEGG	cpd:C10039 dr:D07858
ZINC	4098512

Adverse Drug Event(s)

	Name	Reference(s)	Data Source
1	Acute Coronary Syndrome		OFFSIDES
2	Aldolase increased		OFFSIDES
3	Arteritis obliterans		OFFSIDES
4	Asthma		OFFSIDES
5	Blepharoptosis		OFFSIDES
6	Blood calcium abnormal		OFFSIDES
7	Blood creatine phosphokinase MB increased		OFFSIDES
8	Blood creatine phosphokinase increased		OFFSIDES
9	Blood fibrinogen increased		OFFSIDES
10	Blood lactate dehydrogenase increased		OFFSIDES
11	Blood phosphorus		OFFSIDES
12	Blood pressure inadequately controlled		OFFSIDES
13	Blood uric acid		OFFSIDES
14	Bone density increased		OFFSIDES
15	Brain Hypoxia		OFFSIDES
16	Calcinosis		OFFSIDES
17	Cardio-respiratory distress		OFFSIDES
18	Cerebral atrophy		OFFSIDES
19	Chemical and Drug Induced Liver Injury	2563116 23665045	CTD
20	Cholelithotomy		OFFSIDES
21	Cholestasis, Extrahepatic	30026087	CTD
22	Corneal Ulcer		OFFSIDES
23	Cytolytic hepatitis		OFFSIDES
24	Dehydration		OFFSIDES
25	Diabetes Mellitus, Experimental	22056647	CTD
26	Diarrhea		OFFSIDES
27	Diplopia		OFFSIDES
28	Epistaxis		OFFSIDES
29	Erectile dysfunction		OFFSIDES
30	Erysipelas		OFFSIDES
31	Escherichia urinary tract infection		OFFSIDES
32	Fatigue		OFFSIDES
33	General physical health deterioration		OFFSIDES
34	Granuloma		OFFSIDES
35	Hepatic Encephalopathy	2563116	CTD
36	Hepatic Insufficiency	30026087	CTD
37	Hepatitis		OFFSIDES
38	Hepatomegaly	30026087	CTD
39	Hyperkeratosis		OFFSIDES
40	Hyperreflexia		OFFSIDES
41	Hyporeflexia		OFFSIDES
42	Intention tremor		OFFSIDES
43	Intertrigo		OFFSIDES
44	Joint stiffness		OFFSIDES
45	Leukopenia neonatal		OFFSIDES
46	Limb injury		OFFSIDES
47	Lymphoma		OFFSIDES
48	Micronuclei, Chromosome-Defective	25499067	CTD
49	Multiple Sclerosis		OFFSIDES
50	Multiple drug overdose intentional		OFFSIDES
51	Multiple sclerosis relapse		OFFSIDES
52	Muscle hypertrophy		OFFSIDES
53	Necrosis	25499067	CTD
54	Nephrolithiasis		OFFSIDES
55	Pancreatic Insufficiency		OFFSIDES
56	Parotitis		OFFSIDES
57	Peripheral arterial occlusive disease		OFFSIDES
58	Perirectal abscess		OFFSIDES
59	Phlebitis		OFFSIDES
60	Popliteal pulse decreased		OFFSIDES
61	Respiratory Failure		OFFSIDES
62	Rhabdomyolysis		OFFSIDES
63	Sigmoiditis		OFFSIDES
64	Silent myocardial infarction		OFFSIDES
65	Transaminases increased		OFFSIDES
66	Urethral Stenosis		OFFSIDES
67	Vitamin B 12 Deficiency		OFFSIDES
68	effusion		OFFSIDES
69	jaundice	2563116	CTD

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