MetaADEDB 2.0 @ LMMD
flunisolide
(XSFJVAJPIHIPKU-XWCQMRHXSA-N)
Structure
SMILES
OCC(=O)[C@@]12OC(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1C[C@@H](C1=CC(=O)C=C[C@]21C)F)(C)C
Type(s)
Approved; Investigational
ATC code(s)
R01AD04; R03BA03
Molecular Formula:
C24H31FO6
Molecular Weight:
434.498
Log P:
2.2747
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
2
TPSA:
93.06
CAS Number(s):
3385-03-3; 77326-96-6; 542449
Synonym(s)
1.
flunisolide
2.
6 alpha-fluorodihydroxy-16 alpha,17 alpha-isopropylidenedioxy-1,4-pregnadiene-3,20- dione
3.
AeroBid
4.
Apo-Flunisolide
5.
Inhacort
6.
Nasalide
7.
Nasarel
8.
RS-3999
9.
Rhinalar
10.
Syntaris
11.
flunisolide HFA
12.
flunisolide hemihydrate, (6alpha,11beta,16alpha)-isomer
13.
flunisolide hydrofluoroalkane
14.
flunisolide, (6beta,11beta,16alpha)-isomer
15.
ratio-Flunisolide
External Link(s)
MeSHC007734
PubChem Compound82153
BindingDB50248007
ChEBI5106
CHEMBLCHEMBL1512
DrugBankDB00180
DrugCentral1201
IUPHAR/BPS Guide to PHARMACOLOGY7076
KEGGcpd:C07005
ZINC4097305
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Nasal discomfortFAERS: 25OFFSIDES
SIDER
US FAERS
2EpistaxisFAERS: 18SIDER
US FAERS
3Drug ineffectiveFAERS: 10US FAERS
4AnosmiaFAERS: 7SIDER
US FAERS
5DysgeusiaFAERS: 5
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
6Product quality issueFAERS: 5US FAERS
7AgeusiaFAERS: 4SIDER
US FAERS
8RhinalgiaFAERS: 4US FAERS
9Application site painFAERS: 3US FAERS
10Burning sensationFAERS: 3US FAERS
11MalaiseFAERS: 3SIDER
US FAERS
12Product container issueFAERS: 3US FAERS
13Product contaminationFAERS: 3US FAERS
14Product substitution issueFAERS: 3US FAERS
15BronchospasmFAERS: 2SIDER
US FAERS
16CandidiasisFAERS: 2US FAERS
17CataractFAERS: 2SIDER
US FAERS
18Drug ineffective for unapproved indicationFAERS: 2US FAERS
19Eye irritationFAERS: 2US FAERS
20HeadacheFAERS: 2SIDER
US FAERS
21PainFAERS: 2SIDER
US FAERS
22Pharmaceutical product complaintFAERS: 2US FAERS
23SwellingFAERS: 2US FAERS
24UrticariaFAERS: 2SIDER
US FAERS
25VomitingFAERS: 2SIDER
US FAERS
26WheezingFAERS: 2SIDER
US FAERS
27Abdominal discomfortFAERS: 1OFFSIDES
SIDER
US FAERS
28AlopeciaFAERS: 1US FAERS
29AphasiaFAERS: 1US FAERS
30Application site irritationFAERS: 1US FAERS
31ArthralgiaFAERS: 1US FAERS
32AstheniaFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
33AsthmaFAERS: 116696591CTD
OFFSIDES
US FAERS
34Breath alcohol test positiveFAERS: 1US FAERS
35Cerebrovascular accidentFAERS: 1US FAERS
36Chest PainFAERS: 1OFFSIDES
SIDER
US FAERS
37Chest discomfortFAERS: 1SIDER
US FAERS
38ChokingFAERS: 1US FAERS
39DizzinessFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
40Drug dose omissionFAERS: 1US FAERS
41Drug effect incompleteFAERS: 1US FAERS
42Drug withdrawal syndromeFAERS: 1US FAERS
43Dry skinFAERS: 1OFFSIDES
US FAERS
44DysphoniaFAERS: 1SIDER
US FAERS
45Educational problemFAERS: 1US FAERS
46Emotional distressFAERS: 1OFFSIDES
US FAERS
47ErythemaFAERS: 1US FAERS
48Eye painFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
US FAERS
49GlaucomaFAERS: 1SIDER
US FAERS
50HypersensitivityFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
51Incorrect dose administeredFAERS: 1US FAERS
52Instillation site painFAERS: 1US FAERS
53LacerationFAERS: 1US FAERS
54Nasal inflammationFAERS: 1US FAERS
55Nasal mucosal disorderFAERS: 1US FAERS
56No adverse eventFAERS: 1US FAERS
57Oropharyngeal painFAERS: 1
Canada Vigilance: 1
Canada Vigilance
OFFSIDES
SIDER
US FAERS
58PalpitationsFAERS: 1SIDER
US FAERS
59PharyngitisFAERS: 1SIDER
US FAERS
60Product identification number issueFAERS: 1US FAERS
61Product taste abnormalFAERS: 1US FAERS
62Pulmonary congestionFAERS: 1OFFSIDES
SIDER
US FAERS
63RetchingFAERS: 1US FAERS
64SnoringFAERS: 1US FAERS
65SomnambulismFAERS: 1US FAERS
66SyncopeFAERS: 1SIDER
US FAERS
67TachycardiaFAERS: 1SIDER
US FAERS
68Throat irritationFAERS: 1SIDER
US FAERS
69Visual ImpairmentFAERS: 1
Canada Vigilance: 1
Canada Vigilance
US FAERS
70treatment failureFAERS: 1US FAERS
71Abdominal PainOFFSIDES
SIDER
72Abdominal tendernessOFFSIDES
73AbscessOFFSIDES
74Acid refluxOFFSIDES
75Actinic keratosisOFFSIDES
76Acute myocardial infarctionOFFSIDES
77Acute otitis mediaOFFSIDES
78AgitationSIDER
79AgoraphobiaOFFSIDES
80AgraphiaOFFSIDES
81Alcohol consumptionOFFSIDES
82Allergy test positiveOFFSIDES
83AlveolitisOFFSIDES
84AngerOFFSIDES
85AngioedemaOFFSIDES
86AnhedoniaOFFSIDES
87AnorexiaOFFSIDES
88AnxietyOFFSIDES
SIDER
89Aortic AneurysmOFFSIDES
90ArteriosclerosisOFFSIDES
91ArthritisOFFSIDES
92ArthroscopyOFFSIDES
93AtelectasisOFFSIDES
94Atrial tachycardiaOFFSIDES
95AuraOFFSIDES
96Back PainSIDER
97Blood GlucoseOFFSIDES
98Blood cholesterolOFFSIDES
99Blood glucose decreasedOFFSIDES
100Blood thyroid stimulating hormoneOFFSIDES
101Blurred visionOFFSIDES
102Bone lesionOFFSIDES
103Bone painOFFSIDES
104BradycardiaOFFSIDES
105Brain natriuretic peptide increasedOFFSIDES
106BronchitisOFFSIDES
SIDER
107BronchopneumoniaOFFSIDES
108BursitisOFFSIDES
109Capillary FragilitySIDER
110Cardioactive drug level below therapeuticOFFSIDES
111Cardioactive drug level increasedOFFSIDES
112Cataract operationOFFSIDES
113Cerebral atrophyOFFSIDES
114Cerebral hypoperfusionOFFSIDES
115Cervicobrachial syndromeOFFSIDES
116Chemotherapeutic drug level increasedOFFSIDES
117Chest tightnessSIDER
118ChillsSIDER
119Choking sensationOFFSIDES
120CholecystitisOFFSIDES
121Choroidal DetachmentOFFSIDES
122ChromaturiaOFFSIDES
123Chronic Obstructive Airway DiseaseOFFSIDES
124Chronic left ventricular failureOFFSIDES
125ClaustrophobiaOFFSIDES
126Clostridium colitisOFFSIDES
127Clostridium difficile colitisOFFSIDES
128Cold symptomsSIDER
129ConfabulationOFFSIDES
130Conjunctival depositOFFSIDES
131ConjunctivitisSIDER
132ConstipationSIDER
133Contact DermatitisOFFSIDES
134Cytomegalovirus antibody positiveOFFSIDES
135DehydrationOFFSIDES
136Dental abscessOFFSIDES
137Depressed moodOFFSIDES
138DermatitisSIDER
139DiabetesOFFSIDES
140DiarrheaOFFSIDES
141DiscomfortSIDER
142DiverticulitisOFFSIDES
143DrowsinessOFFSIDES
144Drug effect delayedOFFSIDES
145Drug toxicityOFFSIDES
146DyspepsiaSIDER
147DysuriaOFFSIDES
148Economic problemOFFSIDES
149EczemaSIDER
150Ejection Fraction DecreasedOFFSIDES
151Electrocardiogram poor R-wave progressionOFFSIDES
152Electromechanical dissociationOFFSIDES
153Endodontic procedureOFFSIDES
154Eosinophilia16111148CTD
155Erythema MultiformeSIDER
156Esophageal StenosisOFFSIDES
157Eustachian tube disorderOFFSIDES
158ExcoriationOFFSIDES
159Eye InfectionSIDER
160Eye inflammationOFFSIDES
161Eye laser surgeryOFFSIDES
162Factor V deficiencyOFFSIDES
163FatigueOFFSIDES
SIDER
164Fatty LiverOFFSIDES
165Feeling abnormalSIDER
166Fluid overloadOFFSIDES
167FormicationOFFSIDES
168Fullness abdominalSIDER
169GamblingOFFSIDES
170Gastric ulcerOFFSIDES
171GastroduodenitisOFFSIDES
172GastroenteritisSIDER
173Gastrointestinal Diseases21885873CTD
174Gastrointestinal PainSIDER
175GlomerulonephritisOFFSIDES
176GlossitisSIDER
177Growth retardationSIDER
178HeartburnSIDER
179Hepatic necrosisOFFSIDES
180HepatitisOFFSIDES
181HerniaOFFSIDES
182Herpes simplex serology positiveOFFSIDES
183HoarsenessSIDER
184HydronephrosisOFFSIDES
185HyperkinesiaSIDER
186HypokinesiaSIDER
187HypophagiaOFFSIDES
188Immune reconstitution syndromeOFFSIDES
189Impaired gastric emptyingOFFSIDES
190Incision site complicationOFFSIDES
191InfectionSIDER
192Inflammation16111148CTD
193Intermittent ClaudicationOFFSIDES
194Intervertebral Disc DegenerationOFFSIDES
195LaryngitisSIDER
196LethargyOFFSIDES
197Leukopenia neonatalOFFSIDES
198Lichen PlanusOFFSIDES
199Life expectancy shortenedOFFSIDES
200Limb operationOFFSIDES
201Loose toothOFFSIDES
202LymphadenopathySIDER
203MalnutritionSIDER
204Mental status changesOFFSIDES
205Monoclonal immunoglobulin presentOFFSIDES
206Mouth irritationSIDER
207Multiple MyelomaOFFSIDES
208Multiple sclerosis relapseOFFSIDES
209Musculoskeletal discomfortSIDER
210MyalgiaSIDER
211Myoglobin blood increasedOFFSIDES
212Nasal burningSIDER
213NasopharyngitisOFFSIDES
SIDER
214NauseaOFFSIDES
SIDER
215Neck PainSIDER
216Nephrotic SyndromeOFFSIDES
217Neutrophil count decreasedOFFSIDES
218NumbnessSIDER
219Occult blood positiveOFFSIDES
220Ocular discomfortSIDER
221Optic Disc EdemaOFFSIDES
222Oral candidiasisSIDER
223Oral torusOFFSIDES
224Oropharyngeal discomfortSIDER
225Oropharyngeal swellingOFFSIDES
226OsteopeniaOFFSIDES
227OsteoporosisOFFSIDES
228PO2 decreasedOFFSIDES
229ParanoiaOFFSIDES
230PleurisySIDER
231PneumoniaSIDER
232Productive CoughOFFSIDES
233PruritusSIDER
234PseudocystOFFSIDES
235Psychiatric symptomOFFSIDES
236Pulmonary HypertensionOFFSIDES
237Rectal polypOFFSIDES
238Respiratory FailureOFFSIDES
239Respiratory tract congestionSIDER
240RhinitisCanada Vigilance: 1Canada Vigilance
SIDER
241Risus sardonicusOFFSIDES
242SchizophreniaOFFSIDES
243ShockSIDER
244SinusitisSIDER
245Skin lacerationOFFSIDES
246Skin toxicityOFFSIDES
247SneezingSIDER
248Soft tissue inflammationOFFSIDES
249SpondylosisOFFSIDES
250Squamous cell carcinoma of skinOFFSIDES
251Stem cell transplantOFFSIDES
252StomatitisSIDER
253Supraventricular tachycardiaOFFSIDES
254SweatingSIDER
255Tachycardia nervousSIDER
256ThymomaOFFSIDES
257TinnitusOFFSIDES
258TracheitisOFFSIDES
259Transfusion-Related Acute Lung InjuryOFFSIDES
260TremorSIDER
261Umbilical herniaOFFSIDES
262Upset stomachSIDER
263Urinary tract infectionSIDER
264Venous InsufficiencyOFFSIDES
265Ventricular FibrillationOFFSIDES
266VertebroplastyOFFSIDES
267VertigoSIDER
268Violence-related symptomOFFSIDES
269Weight GainOFFSIDES
270Wound dehiscenceOFFSIDES
271colonoscopyOFFSIDES
272kyphosisOFFSIDES
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