MetaADEDB 2.0 @ LMMD
Ketotifen
(ZCVMWBYGMWKGHF-UHFFFAOYSA-N)
Structure
SMILES
CN1CCC(=C2c3ccccc3CC(=O)c3c2ccs3)CC1
Type(s)
Approved
ATC code(s)
R06AX17; S01GX08
Molecular Formula:
C19H19NOS
Molecular Weight:
309.425
Log P:
3.9523
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
48.55
CAS Number(s):
34580-13-7; 34580-14-8
Synonym(s)
1.
Ketotifen
2.
4,9-Dihydro-4-(1-methyl-4-piperidylidene)-10H-benzo(4,5)-cyclohepta(1,2-b)thiophen-10-one
3.
Ketotifen Fumarate
4.
Ketotifene
5.
Ketotiphen
6.
Ketotiphene
7.
Zaditen
8.
Fumarate, Ketotifen
External Link(s)
MeSHD007665
PubChem Compound3827
BindingDB94597
50002087
ChEBI92511
CHEMBLCHEMBL534
DrugBankDB00920
DrugCentral1530
IUPHAR/BPS Guide to PHARMACOLOGY7206
KEGGdr:D01332
dr:D08105
Therapeutic Target DatabaseD0YG7M
ZINC4351
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 4
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
2Eye irritationFAERS: 3US FAERS
3Contraindicated product administeredFAERS: 2US FAERS
4Eye painFAERS: 2OFFSIDES
US FAERS
5FlushingFAERS: 2US FAERS
6PainFAERS: 2SIDER
US FAERS
7PhotophobiaFAERS: 2US FAERS
8Product use in unapproved indicationFAERS: 2US FAERS
9BradycardiaFAERS: 1US FAERS
10Burning sensationFAERS: 1US FAERS
11CyanosisFAERS: 1OFFSIDES
US FAERS
12Device ineffectiveFAERS: 1US FAERS
13DystoniaFAERS: 1US FAERS
14Eye inflammationFAERS: 1OFFSIDES
US FAERS
15General physical health deteriorationFAERS: 1US FAERS
16HypersensitivityFAERS: 116536907CTD
US FAERS
17HypotensionFAERS: 1US FAERS
18Respiratory distressFAERS: 1US FAERS
19Swelling of eyelidFAERS: 1SIDER
US FAERS
20Therapeutic product ineffectiveFAERS: 1US FAERS
21Therapy non-responderFAERS: 1US FAERS
22Abdominal PainSIDER
23Accidental overdoseOFFSIDES
24AcidosisOFFSIDES
25Adenoidal disorderOFFSIDES
26Alanine Aminotransferase IncreasedOFFSIDES
27Alcoholic IntoxicationOFFSIDES
28AnorexiaOFFSIDES
29Aphthous StomatitisOFFSIDES
30Asthma1479763CTD
OFFSIDES
31Atrioventricular BlockOFFSIDES
32BasophiliaOFFSIDES
33Bladder discomfortOFFSIDES
34Bladder painSIDER
35BlepharitisOFFSIDES
36Blood GlucoseOFFSIDES
37Blood albumin decreasedOFFSIDES
38Blood alkaline phosphatase increasedOFFSIDES
39Blood antidiuretic hormone increasedOFFSIDES
40Blood creatine phosphokinase increasedOFFSIDES
41Blood creatinine decreasedOFFSIDES
42Blood glucose decreasedOFFSIDES
43Blood in stoolSIDER
44Blood lactate dehydrogenase decreasedOFFSIDES
45Blood lactate dehydrogenase increasedOFFSIDES
46Blood osmolarity decreasedOFFSIDES
47Blood pressure immeasurableOFFSIDES
48Blood triglycerides increasedOFFSIDES
49Blood uric acid decreasedOFFSIDES
50Body HeightOFFSIDES
51Body TemperatureOFFSIDES
52Bone density decreasedOFFSIDES
53Cardiac function test abnormalOFFSIDES
54Cardiomegaly18520950CTD
55Carnitine decreasedOFFSIDES
56Cataract operationOFFSIDES
57CheilitisOFFSIDES
58Chemical and Drug Induced Liver Injury22166485
22331495
24085192		CTD
59Choroidal dystrophyOFFSIDES
60Colitis15794416CTD
61Concomitant disease aggravatedOFFSIDES
62Congenital heart diseaseOFFSIDES
63Conjunctival depositOFFSIDES
64Conjunctival erosionOFFSIDES
65Conversion disorderOFFSIDES
66Corneal InfectionOFFSIDES
67Cystitis1479763CTD
SIDER
68Deafness NeurosensoryOFFSIDES
69Dental abscessOFFSIDES
70Depressed Level of ConsciousnessOFFSIDES
71DermatitisSIDER
72DiabetesOFFSIDES
73DiscomfortCanada Vigilance: 1Canada Vigilance
74DizzinessSIDER
75DrowsinessOFFSIDES
SIDER
76DysphoniaOFFSIDES
77Echocardiogram abnormalOFFSIDES
78Edema9274987CTD
79Electrocardiogram repolarisation abnormalityOFFSIDES
80EpilepsyOFFSIDES
81EpistaxisOFFSIDES
SIDER
82Erythema MultiformeOFFSIDES
SIDER
83ErythemaOFFSIDES
84ErythropeniaOFFSIDES
85Expired drug administeredOFFSIDES
86Failure to ThriveOFFSIDES
87Fat redistributionOFFSIDES
88Gamma-Glutamyltransferase IncreasedOFFSIDES
89Gastric LavageOFFSIDES
90GastroenteritisOFFSIDES
91Gastrointestinal PainSIDER
92Gaze palsyOFFSIDES
93HeadacheSIDER
94Heart Diseases22166485CTD
95HemiplegiaOFFSIDES
96HepatitisSIDER
97Hyperalgesia15265675CTD
98HypophagiaOFFSIDES
99Immunosuppressant drug levelOFFSIDES
100ImpetigoOFFSIDES
101Implant site indurationOFFSIDES
102InfectionSIDER
103Inflammatory painOFFSIDES
104Instillation site irritationOFFSIDES
105Instillation site painOFFSIDES
106Intervertebral disc disorderOFFSIDES
107Life expectancy shortenedOFFSIDES
108Lip erosionOFFSIDES
109Lymphocyte count decreasedOFFSIDES
110Lymphocyte stimulation test positiveOFFSIDES
111Lymphocyte transformation test positiveOFFSIDES
112Malaria23129054CTD
113Malignant neoplasm progressionOFFSIDES
114Mental retardation severity unspecifiedOFFSIDES
115Multiple MyelomaOFFSIDES
116MumpsOFFSIDES
117Muscle WeaknessOFFSIDES
118NauseaSIDER
119Necrosis16117696CTD
120Nerve Root CompressionOFFSIDES
121NervousnessSIDER
122Neutrophil count decreasedOFFSIDES
123ObstructionOFFSIDES
124Ocular discomfortOFFSIDES
125Ophthalmic fluid drainageOFFSIDES
126Oral mucosal erythemaOFFSIDES
127OsteopeniaOFFSIDES
128OverdoseOFFSIDES
129PallorOFFSIDES
130Pancreatic enzymes increasedOFFSIDES
131PleurisyOFFSIDES
132Product substitution issueCanada Vigilance: 1Canada Vigilance
133PruritusSIDER
134PseudarthrosisOFFSIDES
135PyelonephritisOFFSIDES
136Renal Insufficiency22166485CTD
137Renal tubular necrosisOFFSIDES
138Rheumatic FeverOFFSIDES
139Rhinitis, Allergic, Perennial10822083CTD
140RhinitisOFFSIDES
141Seizures

View details

8101246
9339868
14575901
20012267
 		CTD
142ShockSIDER
143Skin ErosionOFFSIDES
144Sneezing8100058CTD
145SomnolenceSIDER
146Spinal column stenosisOFFSIDES
147Sputum retentionOFFSIDES
148Staphylococcal osteomyelitisOFFSIDES
149Stevens-Johnson SyndromeOFFSIDES
SIDER
150SyncopeSIDER
151Synovial CystOFFSIDES
152Tachycardia10073741CTD
153TensionSIDER
154Therapy responderOFFSIDES
155ThrombocytopeniaSIDER
156Tinea crurisOFFSIDES
157Tolosa-Hunt SyndromeOFFSIDES
158Tooth ExtractionOFFSIDES
159Tympanic Membrane PerforationOFFSIDES
160Upper respiratory tract inflammationOFFSIDES
161Urine osmolarity increasedOFFSIDES
162Urticaria2420246
12121561		CTD
SIDER
163VomitingSIDER
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