MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Otosclerosis

(UMLS:C0029899)

Definition:: Formation of spongy bone in the labyrinth capsule which can progress toward the STAPES (stapedial fixation) or anteriorly toward the COCHLEA leading to conductive, sensorineural, or mixed HEARING LOSS. Several genes are associated with familial otosclerosis with varied clinical signs.
UMLS ID:: C0029899
MeSH ID:: D010040

Classification:

Name:

Otorhinolaryngologic Diseases
MeSH Tree Number(s):: C09.218.768

Synonym(s)

Otosclerosis

OTOSCLEROSIS

Otosclerosis syndrome

Otosclerosis, NOS

Otosclerosis, unspecified

Otospongiosis

Otospongiosis syndrome

Otospongiosis, NOS

Unspecified otosclerosis, unspecified ear

10.

otoscleroses

11.

otosclerosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Norgestrel	FAERS: 12 Canada Vigilance: 1	Canada Vigilance OFFSIDES US FAERS
2	Zoledronic Acid	FAERS: 3	US FAERS
3	Alendronate	FAERS: 2	US FAERS
4	Bromocriptine	FAERS: 2	US FAERS
5	Latanoprost	FAERS: 2	US FAERS
6	Teriparatide	FAERS: 2	US FAERS
7	Valsartan	FAERS: 2	US FAERS
8	Estradiol	FAERS: 1	US FAERS
9	Estrogens, Conjugated (USP)	FAERS: 1	US FAERS
10	Fluvoxamine	FAERS: 1	US FAERS
11	Lisinopril	FAERS: 1	US FAERS
12	Norethindrone acetate and ethinyl estradiol	FAERS: 1	US FAERS
13	Ortho Evra	FAERS: 1	US FAERS
14	Rivaroxaban	FAERS: 1	US FAERS
15	Rosuvastatin Calcium	FAERS: 1	US FAERS
16	acetaminophen, aspirin, caffeine drug combination	FAERS: 1	US FAERS
17	candesartan cilexetil	FAERS: 1	US FAERS
18	estradiol, norethindrone drug combination	FAERS: 1	US FAERS
19	norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination	FAERS: 1	US FAERS
20	sibutramine	FAERS: 1	US FAERS
21	Acebutolol		OFFSIDES
22	Bupropion		OFFSIDES
23	Chloroquine		OFFSIDES
24	Pantoprazole		OFFSIDES
25	Raloxifene Hydrochloride		OFFSIDES
26	rizatriptan		OFFSIDES
27	rizatriptan		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Tympanosclerosis	42.9%
2	Labyrinthitis	40.9%
3	Cochlear Diseases	31%
4	Otitis Externa	31%
5	Otitis Media	31%
6	Vestibular Diseases	31%
7	Endolymphatic Hydrops	31%
8	Tympanic Membrane Perforation	30%
9	Otomycosis	28.6%
10	Congenital Microtia	28.6%
11	Ear Neoplasms	27.8%
12	Meniere Disease	25.4%
13	Otitis Media with Effusion	25.4%
14	Vestibulocochlear Nerve Diseases	20.9%
15	Dysacusis	20.5%
16	Vestibular Neuronitis	16.9%
17	Herpes Zoster Oticus	16.3%
18	Laryngeal Diseases	15.8%
19	Nose Diseases	15.8%
20	Pharyngeal Diseases	15.8%
21	Hyperacusis	14.9%
22	Tinnitus	14.9%
23	Phonophobia	14.9%
24	Hearing Loss	14.9%
25	Vertigo	12.8%
26	Mastoiditis	12.4%
27	Petrositis	12.4%
28	Deafness	12.3%
29	Hearing Loss, Sudden	12.3%
30	Hearing Loss, Bilateral	12.3%
31	Hearing Loss, High-Frequency	12.3%
32	Hearing Loss, Mixed Conductive-Sensorineural	12.3%
33	Hearing Loss, Unilateral	12.3%
34	Complete Hearing Loss	12.3%
35	Deaf Mutism	12.3%
36	Pharyngeal Neoplasms	11.2%
37	Granuloma, Lethal Midline	9.5%
38	Laryngeal Edema	9.5%
39	Nose Deformities, Acquired	9.5%
40	Laryngeal neoplasm	9.4%
41	Deglutition Disorders	9.3%
42	Primary Ciliary Dyskinesia	8.8%
43	Nasopharyngeal Neoplasms	8.6%
44	Hypopharyngeal Neoplasms	8%
45	Hypopharyngeal Cancer	8%
46	Acoustic Neuroma	7.5%
47	Paranasal Sinus Neoplasms	7.5%
48	Laryngitis	7.1%
49	Pharyngitis	7.1%
50	Rhinitis	7.1%
51	Vocal Cord Dysfunction	7.1%
52	Auditory Perceptual Disorders	7.1%
53	Laryngostenosis	7%
54	Nasal Polyps	7%
55	Nose Neoplasms	6.9%
56	Croup	6.8%
57	Rhinitis, Vasomotor	6.8%
58	Nasopharyngitis	6.7%
59	Tonsillar Neoplasms	6.5%
60	Maxillary Sinus Neoplasms	6.1%
61	Nasopharyngeal carcinoma	6.1%
62	Choanal Atresia	5.6%
63	Voice Disorders	5.6%
64	Voice Disturbance	5.6%
65	Laryngocele	5.6%
66	Epistaxis	5.6%
67	Sinusitis	5.2%
68	Laryngospasm	5.1%
69	Tonsillitis	5.1%
70	Laryngomalacia	4.7%
71	Granuloma, Laryngeal	4.6%
72	Vocal Cord Paralysis	4.6%
73	Aphonia	4%
74	Retropharyngeal Abscess	4%
75	Dysphonia	4%
76	Lemierre Syndrome	3.8%
77	Rhinoscleroma	3.4%
78	Hay fever	3.3%
79	Rhinitis, Allergic, Perennial	3.3%
80	Peritonsillar Abscess	3.3%
81	Hoarseness	2.9%
82	Kartagener Syndrome	2.1%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120237