MetaADEDB 2.0 @ LMMD
Procarbazine
(CPTBDICYNRMXFX-UHFFFAOYSA-N)
Structure
SMILES
CNNCc1ccc(cc1)C(=O)NC(C)C
Type(s)
Approved; Investigational
ATC code(s)
L01XB01
Molecular Formula:
C12H19N3O
Molecular Weight:
221.299
Log P:
2.2215
Hydrogen Bond Acceptor:
4
Hydrogen Bond Donor:
3
TPSA:
53.16
CAS Number(s):
366-70-1; 671-16-9
Synonym(s)
1.
Procarbazine
2.
Matulane
3.
Natulan
4.
Procarbazine Hydrochloride
5.
Procarbazine Monohydrobromide
6.
Procarbazine Monohydrochloride
7.
Hydrochloride, Procarbazine
8.
Monohydrobromide, Procarbazine
9.
Monohydrochloride, Procarbazine
External Link(s)
MeSHD011344
PubChem Compound4915
ChEBI71417
CHEMBLCHEMBL1321
DrugBankDB01168
DrugCentral2272
IUPHAR/BPS Guide to PHARMACOLOGY7278
KEGGcpd:C07402
dr:D08423
Therapeutic Target DatabaseD08GYO
ZINC19166988
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1PneumonitisFAERS: 1US FAERS
2Abdominal PainSIDER
3Abdominal symptomOFFSIDES
4AcneOFFSIDES
5Acute graft versus host disease in liverOFFSIDES
6Acute psychosisOFFSIDES
7Adenocarcinoma675898CTD
8AgeusiaOFFSIDES
9Alanine Aminotransferase IncreasedOFFSIDES
10AlopeciaSIDER
11Anemia18953065CTD
12Angina PectorisSIDER
13AnhidrosisOFFSIDES
14AnisocytosisSIDER
15AnorexiaSIDER
16AnosmiaOFFSIDES
17AnxietyOFFSIDES
SIDER
18ApoptosisOFFSIDES
19ArthralgiaSIDER
20AscitesOFFSIDES
SIDER
21Aspiration PneumoniaOFFSIDES
22AstheniaSIDER
23Astrocytoma185991
1312230
8186424		CTD
24AtaxiaOFFSIDES
SIDER
25AzoospermiaOFFSIDES
SIDER
26Bacterial sepsisOFFSIDES
27Bipolar Disorder6797665CTD
28Bleeding tendencySIDER
29Blood brain barrier defectOFFSIDES
30Blood parathyroid hormone increasedOFFSIDES
31Blood urea increasedCanada Vigilance: 1Canada Vigilance
32Bone painOFFSIDES
33Brain DeathOFFSIDES
34Brain Diseases7931469CTD
35Brain Neoplasms

View details

185991
1312230
7931469
8186424
 		CTD
36BronchitisOFFSIDES
37Bronchoalveolar LavageOFFSIDES
38Carcinoma of lungSIDER
39Carcinoma, Transitional Cell1949449CTD
40CardiotoxicitySIDER
41Cataract3352637CTD
42Catheter placementOFFSIDES
43Central Nervous System Neoplasms3359561
10963643
18953065		CTD
44Cerebellar Diseases18293384CTD
45Cerebral Hemorrhage7931469
18953065		CTD
46ChillsSIDER
47CholangiolitisOFFSIDES
48ChondrosarcomaOFFSIDES
49Completed SuicideOFFSIDES
50ConstipationSIDER
51Cytomegalovirus chorioretinitisOFFSIDES
52DeafnessSIDER
53DehydrationCanada Vigilance: 1Canada Vigilance
54DemyelinationOFFSIDES
55DermatitisSIDER
56DiarrheaOFFSIDES
57DiplopiaSIDER
58Disease ProgressionOFFSIDES
59DisorientationSIDER
60DizzinessOFFSIDES
SIDER
61DrowsinessSIDER
62Drug toxicityOFFSIDES
63Drug withdrawal headacheOFFSIDES
64DysarthriaSIDER
65DysphoniaSIDER
66EcthymaOFFSIDES
67Embryo Loss435078CTD
68EnteritisOFFSIDES
69EosinophiliaSIDER
70Ependymoma3359561CTD
71EpistaxisSIDER
72Erythema InfectiosumOFFSIDES
73Eye Neoplasms18953065CTD
74FatigueSIDER
75Febrile NeutropeniaOFFSIDES
SIDER
76Feeling abnormalSIDER
77FlushingSIDER
78FormicationOFFSIDES
79Fungus serology test positiveOFFSIDES
80Gastroenteritis4560767CTD
81Gastrointestinal Diseases6089632CTD
82Gastrointestinal PainSIDER
83Glioma1662522
19901110		CTD
84GranulocytosisOFFSIDES
85HeadacheSIDER
86Heart failure18953065CTD
87Hemangioblastoma3359561CTD
88Hematoma, Subdural7931469CTD
89HepatitisOFFSIDES
90HepatotoxicityOFFSIDES
91Herpes NOSSIDER
92Hip surgeryOFFSIDES
93HoarsenessSIDER
94Hodgkin Disease

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1329697
5013538
6089632
15922437
16135485
17606976
18293384
 		CTD
95Hodgkin's disease mixed cellularity recurrentOFFSIDES
96HypersensitivitySIDER
97HyporeflexiaSIDER
98HypotensionSIDER
99IncontinenceOFFSIDES
100InfectionOFFSIDES
SIDER
101InfertilitySIDER
102LethargySIDER
103Leukopenia18953065CTD
SIDER
104LymphocytosisSIDER
105Lymphoma, Non-Hodgkin8780746CTD
106Lymphoma10963643
18953065
24038727		CTD
107Malignant GliomaOFFSIDES
108Malignant neoplasm of spinal cordOFFSIDES
109Malignant neoplasm progressionOFFSIDES
110Mammary Neoplasms, Experimental11921183CTD
111Medulloblastoma3359561CTD
112MenopauseSIDER
113MetaplasiaOFFSIDES
114Metastatic NeoplasmSIDER
115MicrolithiasisOFFSIDES
116Microsporum infectionOFFSIDES
117Multiple Myeloma183029CTD
118Muscle strainOFFSIDES
119Musculoskeletal discomfortSIDER
120MyalgiaSIDER
121MyelodysplasiaOFFSIDES
122NauseaCanada Vigilance: 1Canada Vigilance
SIDER
123Neoplasms, Neuroepithelial12325066
21710625		CTD
124Neoplasms4340255CTD
125NephritisSIDER
126NervousnessSIDER
127NeuropathySIDER
128Neutropenia18953065CTD
129Neutrophil count abnormalOFFSIDES
130NocturiaSIDER
131Nose Neoplasms9385384CTD
132NystagmusSIDER
133Optic Nerve Glioma16936459CTD
134Optic Neuritis625262CTD
SIDER
135OrchitisOFFSIDES
136Oropharyngeal painOFFSIDES
137Ovarian failureSIDER
138PainOFFSIDES
SIDER
139PancreatitisSIDER
140PancytopeniaSIDER
141ParaparesisOFFSIDES
142PericarditisSIDER
143Peripheral arterial occlusive diseaseOFFSIDES
144PeritonitisOFFSIDES
145PetechiaeSIDER
146PhotophobiaSIDER
147Pilonidal CystOFFSIDES
148PleocytosisOFFSIDES
149Pneumocystis jiroveci pneumoniaOFFSIDES
150PneumoniaSIDER
151PoikilocytosisSIDER
152Protein total abnormalOFFSIDES
153PruritusCanada Vigilance: 2Canada Vigilance
SIDER
154PseudolymphomaCanada Vigilance: 1Canada Vigilance
155PubertyOFFSIDES
156Pulmonary toxicitySIDER
157PurpuraSIDER
158Renal Insufficiency3359561
18953065		CTD
159ReticulocytopeniaOFFSIDES
160Retinitis625262CTD
161ScotomaOFFSIDES
162ShockSIDER
163Sinus operationOFFSIDES
164SinusitisOFFSIDES
165Skin lacerationOFFSIDES
166Slurred speechSIDER
167SomnolenceSIDER
168Stem cell transplantOFFSIDES
169StomatitisSIDER
170Subcutaneous noduleOFFSIDES
171SweatingSIDER
172SyncopeSIDER
173Systemic mycosisOFFSIDES
174TachycardiaSIDER
175TensionSIDER
176Thrombocytopenia18953065CTD
SIDER
177Thrombosis4560767CTD
SIDER
178ThyroiditisOFFSIDES
179Toxic Epidermal NecrolysisSIDER
180Treatment related secondary malignancyOFFSIDES
181TremorSIDER
182UrticariaSIDER
183Vascular purpuraSIDER
184VomitingCanada Vigilance: 1Canada Vigilance
SIDER
185apprehensionSIDER
186jaundiceSIDER
187liposarcomaOFFSIDES
188oligodendroglioma

View details

7931469
15015656
19901104
20842591
21246521
 		CTD
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