MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Mexiletine

(VLPIATFUUWWMKC-UHFFFAOYSA-N)

Structure

SMILES: CC(COc1c(C)cccc1C)N
Type(s): Approved; Investigational
ATC code(s): C01BB02
Molecular Formula:: C11H17NO
Molecular Weight:: 179.259
Log P:: 2.7297
Hydrogen Bond Acceptor:: 2
Hydrogen Bond Donor:: 1
TPSA:: 35.25
CAS Number(s):: 31828-71-4

Synonym(s)

Mexiletine

KO-1173

KO1173

KOE-1173

Mexiletene

Mexiletine Hydrochloride

Mexitil

Mexitil PL

Mexityl

10.

Novo-Mexiletine

11.

KO 1173

12.

KOE 1173

13.

KOE1173

14.

Novo Mexiletine

External Link(s)

MeSH	D008801
PubChem Compound	4178
BindingDB	50117271
ChEBI	6916
CHEMBL	CHEMBL558
DrugBank	DB00379
DrugCentral	1794
IUPHAR/BPS Guide to PHARMACOLOGY	2629
KEGG	cpd:C07220 dr:D08215
Therapeutic Target Database	D0X0RI

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Dizziness	FAERS: 4	11009231	CTD SIDER US FAERS
2	Eosinophilia	FAERS: 4	9414061	CTD US FAERS
3	Lymphadenopathy	FAERS: 4		US FAERS
4	Nausea	FAERS: 4	6641093 11009230 11009231	CTD OFFSIDES SIDER US FAERS
5	Drug screen false positive	FAERS: 3		US FAERS
6	Leukocytosis	FAERS: 3		US FAERS
7	Vomiting	FAERS: 3	3196380	CTD SIDER US FAERS
8	Autoimmune thyroiditis	FAERS: 2		US FAERS
9	Diplopia	FAERS: 2		OFFSIDES US FAERS
10	Fulminant type 1 diabetes mellitus	FAERS: 2		US FAERS
11	Hypersensitivity	FAERS: 2		SIDER US FAERS
12	Nystagmus	FAERS: 2		SIDER US FAERS
13	Overdose	FAERS: 2		US FAERS
14	Pruritus	FAERS: 2	11009231	CTD US FAERS
15	Tremor	FAERS: 2	View details 3196380 6209318 6641093 11009230 11009231	CTD SIDER US FAERS
16	Accidental overdose	FAERS: 1		US FAERS
17	Asthenia	FAERS: 1		SIDER US FAERS
18	Blood count abnormal	FAERS: 1		US FAERS
19	Cerebrovascular accident	FAERS: 1		US FAERS
20	Chills	FAERS: 1		US FAERS
21	Choking	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
22	Constipation	FAERS: 1		SIDER US FAERS
23	Cytomegalovirus enterocolitis	FAERS: 1		OFFSIDES US FAERS
24	Cytomegalovirus test positive	FAERS: 1		US FAERS
25	Drug ineffective	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
26	Dry skin	FAERS: 1		OFFSIDES SIDER US FAERS
27	Dysarthria	FAERS: 1		US FAERS
28	Dysgeusia	FAERS: 1		SIDER US FAERS
29	Dyspepsia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
30	Eczema	FAERS: 1		OFFSIDES US FAERS
31	Erythema	FAERS: 1		OFFSIDES US FAERS
32	Fatigue	FAERS: 1		SIDER US FAERS
33	Feeling abnormal	FAERS: 1		SIDER US FAERS
34	Flatulence	FAERS: 1		US FAERS
35	Flushing	FAERS: 1		US FAERS
36	Human herpes virus 6 serology positive	FAERS: 1		OFFSIDES US FAERS
37	Lupus-like syndrome	FAERS: 1		US FAERS
38	Lymphocytic infiltration	FAERS: 1		US FAERS
39	Medication tampering	FAERS: 1		US FAERS
40	Mucosal erosion	FAERS: 1		OFFSIDES US FAERS
41	Oropharyngeal pain	FAERS: 1		US FAERS
42	Pain	FAERS: 1	10445233 15215642	CTD SIDER US FAERS
43	Pharmaceutical product complaint	FAERS: 1		US FAERS
44	Pneumonia	FAERS: 1		US FAERS
45	Purpura	FAERS: 1		US FAERS
46	Rash erythematous	FAERS: 1		US FAERS
47	Respiratory Failure	FAERS: 1		OFFSIDES US FAERS
48	Retching	FAERS: 1		US FAERS
49	Shock	FAERS: 1		SIDER US FAERS
50	Skin lesion	FAERS: 1		US FAERS
51	Stevens-Johnson Syndrome	FAERS: 1		OFFSIDES SIDER US FAERS
52	Sudden death	FAERS: 1		OFFSIDES US FAERS
53	Toxicity to various agents	FAERS: 1		US FAERS
54	Urinary Retention	FAERS: 1		US FAERS
55	jaundice	FAERS: 1		US FAERS
56	Abdominal Pain			SIDER
57	Abdominal discomfort			SIDER
58	Accelerated Idioventricular Rhythm			OFFSIDES
59	Ageusia			OFFSIDES
60	Agranulocytosis			SIDER
61	Alanine Aminotransferase Increased			OFFSIDES
62	Alcohol consumption			OFFSIDES
63	Alcohol interaction			OFFSIDES
64	Alcohol poisoning			OFFSIDES
65	Alopecia			SIDER
66	Altered state of consciousness			OFFSIDES
67	Amnesia			SIDER
68	Angina Pectoris			SIDER
69	Anorexia			OFFSIDES
70	Arteriosclerosis			OFFSIDES
71	Arteriovenous fistula			OFFSIDES
72	Arthralgia			SIDER
73	Arthrodesis			OFFSIDES
74	Ascites			OFFSIDES
75	Aspiration Pneumonia			OFFSIDES
76	Ataxia			SIDER
77	Atrial arrhythmia			SIDER
78	Atrioventricular Block			SIDER
79	Blood alkaline phosphatase increased			OFFSIDES
80	Blood chloride decreased			OFFSIDES
81	Blood cholinesterase decreased			OFFSIDES
82	Blood creatine phosphokinase increased			OFFSIDES
83	Blood glucose decreased			OFFSIDES
84	Blood immunoglobulin E			OFFSIDES
85	Blood lactate dehydrogenase increased			OFFSIDES
86	Blood phosphorus increased			OFFSIDES
87	Blood potassium increased			OFFSIDES
88	Blood pressure inadequately controlled			OFFSIDES
89	Blood urea increased			OFFSIDES
90	Blood uric acid			OFFSIDES
91	Bradycardia			OFFSIDES SIDER
92	Brain natriuretic peptide increased			OFFSIDES
93	Breast discomfort			OFFSIDES
94	Cancer Pain			OFFSIDES
95	Cardiac Hypertrophy			OFFSIDES
96	Cardiac ablation			OFFSIDES
97	Cardioactive drug level			OFFSIDES
98	Cardioactive drug level increased			OFFSIDES
99	Cardiotoxicity		26259608	CTD
100	Cell marker increased			OFFSIDES
101	Cerebral Thrombosis			OFFSIDES
102	Cerebral disorder			OFFSIDES
103	Cervicobrachial syndrome			OFFSIDES
104	Chemical and Drug Induced Liver Injury		9414061	CTD
105	Chemotherapeutic drug level increased			OFFSIDES
106	Chest Pain			SIDER
107	Choking sensation			OFFSIDES
108	Congenital tricuspid valve incompetence			OFFSIDES
109	Conversion disorder			OFFSIDES
110	Depressed Level of Consciousness			OFFSIDES
111	Dermatitis			SIDER
112	Device malfunction			OFFSIDES
113	Diabetic Autonomic Neuropathy			OFFSIDES
114	Diabetic Retinopathy			OFFSIDES
115	Diarrhea			OFFSIDES
116	Discomfort			SIDER
117	Disease recurrence			OFFSIDES
118	Disseminated Intravascular Coagulation			OFFSIDES
119	Distress gastrointestinal			SIDER
120	Disturbance in sexual arousal			SIDER
121	Drowsiness			OFFSIDES SIDER
122	Drug Eruptions		9414061	CTD
123	Drug toxicity			OFFSIDES
124	Dysgraphia			OFFSIDES
125	Economic problem			OFFSIDES
126	Ejection Fraction Decreased			OFFSIDES
127	Erectile dysfunction			SIDER
128	Erythema Multiforme			SIDER
129	Erythromelalgia		19162012 22170168	CTD
130	Fever		9414061	CTD
131	Gamma-Glutamyltransferase Increased			OFFSIDES
132	Gastric ulcer			OFFSIDES
133	Gastrointestinal Diseases		3318368	CTD
134	Gastrointestinal Pain			SIDER
135	Gaze palsy			OFFSIDES
136	General physical health deterioration			OFFSIDES
137	Glossitis			OFFSIDES
138	Granulocytosis			OFFSIDES
139	Headache		11009230 11009231	CTD SIDER
140	Heart failure		2509529	CTD
141	Heartburn			SIDER
142	Helicobacter pylori identification test positive			OFFSIDES
143	Hepatitis			SIDER
144	Hepatomegaly		28108177	CTD
145	Hyperalgesia		View details 11124013 16556439 18400411 18777607 19591853	CTD
146	Hypercapnia			OFFSIDES
147	Hypertrophic Cardiomyopathy			OFFSIDES
148	Hyperventilation			OFFSIDES
149	Hypotension			SIDER
150	Ileal Stenosis			OFFSIDES
151	Injury asphyxiation			OFFSIDES
152	Kidney Failure			OFFSIDES
153	Leukopenia neonatal			OFFSIDES
154	Leukopenia			SIDER
155	Lightheadedness			SIDER
156	Lip erosion			OFFSIDES
157	Lipase			OFFSIDES
158	Long QT Syndrome		11001179 12969756 18848812	CTD
159	Lymph node palpable			OFFSIDES
160	Lymphocyte count decreased			OFFSIDES
161	Lymphocyte stimulation test positive			OFFSIDES
162	Lymphocytosis		9414061	CTD OFFSIDES
163	Malaise			SIDER
164	Malignant neoplasm progression			OFFSIDES
165	Markedly reduced dietary intake			OFFSIDES
166	Mesenteric vascular insufficiency			OFFSIDES
167	Mucocutaneous rash			OFFSIDES
168	Multiple sclerosis relapse			OFFSIDES
169	Muscle Weakness		11009231	CTD
170	Musculoskeletal discomfort			SIDER
171	Myelitis			OFFSIDES
172	Myelodysplasia			OFFSIDES
173	Myelofibrosis			SIDER
174	Myeloid Metaplasia			SIDER
175	Myoclonic Epilepsy			OFFSIDES
176	Myoclonus		8250327	CTD
177	Nasopharyngitis			OFFSIDES
178	Nervousness			SIDER
179	Neuralgia		18777607 20097124	CTD
180	Neurologic Manifestations		18400411	CTD
181	Neutropenia			SIDER
182	No reaction on previous exposure to drug			OFFSIDES
183	Numbness			SIDER
184	Oculomucocutaneous syndrome			OFFSIDES
185	Optic Neuritis			OFFSIDES
186	Orthopnea			OFFSIDES
187	Osteochondrodysplasias		12238912	CTD
188	PROTHROMBIN TIME			OFFSIDES
189	Palpitations			SIDER
190	Pancreatitis			SIDER
191	Pemphigus			OFFSIDES
192	Peptic Ulcer			SIDER
193	Periodontitis			OFFSIDES
194	Peritoneal Dialysis			OFFSIDES
195	Pharyngitis			SIDER
196	Physical disability			OFFSIDES
197	Pneumatosis Cystoides Intestinalis			OFFSIDES
198	Poor peripheral circulation			OFFSIDES
199	Post procedural pain			OFFSIDES
200	Protein total decreased			OFFSIDES
201	Prothrombin level decreased			OFFSIDES
202	Psychiatric symptom			OFFSIDES
203	Psychomotor Agitation		11009230	CTD
204	Pulmonary Fibrosis			SIDER
205	Pulmonary congestion			OFFSIDES
206	Pulmonary toxicity			SIDER
207	Pyelectasia			OFFSIDES
208	Pyelonephritis			OFFSIDES
209	Seizures		1612103 3196380	CTD
210	Signs and Symptoms, Digestive		6209318	CTD
211	Skin Erosion			OFFSIDES
212	Skin test positive			OFFSIDES
213	Sleep Initiation and Maintenance Disorders		11009230	CTD
214	Snoring			OFFSIDES
215	Soliloquy			OFFSIDES
216	Somnolence			SIDER
217	Spinal column stenosis			OFFSIDES
218	Sputum culture positive			OFFSIDES
219	Sputum retention			OFFSIDES
220	Staring			OFFSIDES
221	Syncope			SIDER
222	Syphilis			OFFSIDES
223	Tachycardia, Ventricular		2480708 8154423	CTD
224	Tachycardia		2972491 6486026 7160572	CTD
225	Tension			SIDER
226	Therapy non-responder			OFFSIDES
227	Thrombocytopenia			SIDER
228	Thrombophlebitis			OFFSIDES
229	Thrombotic stroke			OFFSIDES
230	Tinnitus			SIDER
231	Toe operation			OFFSIDES
232	Torsades de Pointes		6137140 7446392	CTD
233	Trismus		11009230	CTD
234	Unresponsive to stimuli			OFFSIDES
235	Urinary hesitation			SIDER
236	Urinary sediment abnormal			OFFSIDES
237	Ventricular Dysfunction, Left		1861579	CTD
238	Ventricular Fibrillation		1612103 2726785	CTD OFFSIDES
239	Ventricular Flutter			OFFSIDES
240	Ventricular arrhythmia			SIDER
241	Virus serology test positive			OFFSIDES
242	Vision Disorders		11009231	CTD
243	Visual Impairment			SIDER
244	Visual disturbance			SIDER
245	Vitreous Detachment			OFFSIDES
246	Waist circumference increased			OFFSIDES
247	Wound Infection			OFFSIDES

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