MetaADEDB 2.0 @ LMMD
Methysergide
(KPJZHOPZRAFDTN-ZRGWGRIASA-N)
Structure
SMILES
CC[C@H](NC(=O)[C@H]1CN(C)[C@H]2C(=C1)c1cccc3c1c(C2)cn3C)CO
Molecular Formula:
C21H27N3O2
Molecular Weight:
353.458
Log P:
2.2639
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
57.5
CAS Number(s):
361-37-5
Synonym(s)
1.
Methysergide
2.
Dimethylergometrin
3.
Methylmethylergonovine
4.
Deseril
5.
Desril
6.
Désernil-Sandoz
7.
Methysergide Dimaleate
8.
Methysergide Maleate
9.
Sansert
10.
UML-491
11.
Dimaleate, Methysergide
12.
Désernil Sandoz
13.
Maleate, Methysergide
14.
UML 491
15.
UML491
External Link(s)
MeSHD008784
PubChem Compound9681
BindingDB30708
50031942
ChEBI92629
CHEMBLCHEMBL1065
DrugCentral1775
IUPHAR/BPS Guide to PHARMACOLOGY134
KEGGcpd:C07199
dr:D02357
Therapeutic Target DatabaseD0O6GC
ZINC53151228
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Colorectal cancer recurrentFAERS: 2US FAERS
2Creatinine renal clearance decreasedFAERS: 2US FAERS
3CyanosisFAERS: 2
Canada Vigilance: 2		Canada Vigilance
US FAERS
4Ejection Fraction DecreasedFAERS: 2US FAERS
5Femoral artery occlusionFAERS: 2US FAERS
6FibrosisFAERS: 2760308
4420941		CTD
US FAERS
7Jugular vein distensionFAERS: 2US FAERS
8Multiple SclerosisFAERS: 2US FAERS
9Retroperitoneal fibrosisFAERS: 2
Canada Vigilance: 6

View details

4226104
4393372
5042197
5467905
5695652
5953401
15151680
17099974
 		CTD
SIDER
Canada Vigilance
US FAERS
10Vascular bypass graftFAERS: 2US FAERS
11Abdominal PainFAERS: 1
Canada Vigilance: 3		6071145CTD
SIDER
Canada Vigilance
US FAERS
12Aortic bruitFAERS: 1US FAERS
13Blood creatine increasedFAERS: 1US FAERS
14CryingFAERS: 1US FAERS
15Deep Vein ThrombosisFAERS: 1US FAERS
16Erection increasedFAERS: 1US FAERS
17HeadacheFAERS: 1
Canada Vigilance: 1

View details

844003
5467905
5953309
6071145
6807440
 		CTD
Canada Vigilance
US FAERS
18HydronephrosisFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
19Iatrogenic injuryFAERS: 1US FAERS
20InflammationFAERS: 1US FAERS
21PeriarthritisFAERS: 1US FAERS
22Peripheral arterial occlusive diseaseFAERS: 1US FAERS
23Peripheral artery stenosisFAERS: 1US FAERS
24Physical assaultFAERS: 1US FAERS
25Right ventricular failureFAERS: 1US FAERS
26AlopeciaSIDER
27AmnesiaCanada Vigilance: 1Canada Vigilance
28Anemia, Hemolytic5467905CTD
29Aortic Valve Insufficiency912852
12848667		CTD
30Aortic embolusSIDER
31Arterial Occlusive Diseases844003
2212880		CTD
32Arteritis6790701
7220274		CTD
33ArthralgiaCanada Vigilance: 1Canada Vigilance
SIDER
34AstheniaSIDER
35AtaxiaCanada Vigilance: 1Canada Vigilance
SIDER
36Atrial FibrillationCanada Vigilance: 1Canada Vigilance
37Back PainSIDER
38Bipolar Disorder4179254CTD
39Blood urea increasedSIDER
40BradyphreniaCanada Vigilance: 1Canada Vigilance
41Catalepsy40649
108749
6771831		CTD
42Cataplexy164849CTD
43Chest PainCanada Vigilance: 2Canada Vigilance
SIDER
44Chest discomfortCanada Vigilance: 1Canada Vigilance
45ChillsCanada Vigilance: 1Canada Vigilance
46ConstipationSIDER
47Coronary Artery DiseaseCanada Vigilance: 1Canada Vigilance
48Deglutition Disorders6807440CTD
49DermatitisSIDER
50DiscomfortSIDER
51DisorientationCanada Vigilance: 3Canada Vigilance
52DissociationSIDER
53DizzinessCanada Vigilance: 2Canada Vigilance
SIDER
54DrowsinessSIDER
55DysarthriaCanada Vigilance: 1Canada Vigilance
56Dyskinesia, Drug-Induced8106150CTD
57DyspepsiaCanada Vigilance: 1Canada Vigilance
SIDER
58DysphemiaCanada Vigilance: 1Canada Vigilance
59Dystonia3470140CTD
60DysuriaSIDER
61Edema

View details

7508328
7990266
9274987
11554618
15748628
 		CTD
62Endomyocardial Fibrosis912852
6736450		CTD
63EosinophiliaSIDER
64Erectile dysfunctionCanada Vigilance: 1Canada Vigilance
65ErythemaCanada Vigilance: 1Canada Vigilance
66Euphoric moodSIDER
67FatigueCanada Vigilance: 1Canada Vigilance
SIDER
68Feeling abnormalSIDER
69Flank PainSIDER
70FlushingSIDER
71Friction rubSIDER
72Gastrointestinal PainSIDER
73General symptomSIDER
74Hallucinations5024073CTD
75Heart Diseases377933
4420941
6028242		CTD
76HeartburnSIDER
77Hoarseness6807440CTD
78Horner Syndrome6807440CTD
79Hyperalgesia9151293
12727271		CTD
80Hyperemesis Gravidarum4741813CTD
81HypotensionCanada Vigilance: 1Canada Vigilance
82Intermittent Claudication464813
5694374
5953401		CTD
83Ischemia1663389
6807440		CTD
84Joint swellingCanada Vigilance: 1Canada Vigilance
85Leg edemaSIDER
86Leriche SyndromeSIDER
87LightheadednessSIDER
88MalaiseSIDER
89Mental impairmentCanada Vigilance: 1Canada Vigilance
90Mesenteric Vascular Occlusion5694374
5953309		CTD
91Migraine Disorders

View details

464813
626452
646367
760308
912852
2944904
4226104
4393372
4835843
5024073
5348490
5953401
6028242
10074961
12848667
15197703
16029366
17099974
 		CTD
92Mitral Valve Insufficiency

View details

912852
5348490
5467905
7353368
12848667
 		CTD
93Mitral Valve Stenosis17099974CTD
94Musculoskeletal discomfortSIDER
95MyalgiaCanada Vigilance: 1Canada Vigilance
SIDER
96MydriasisSIDER
97Myocardial Infarction10074961CTD
98Myocardial Ischemia11198591CTD
99Myoclonus1079721
2986413		CTD
100NauseaCanada Vigilance: 8Canada Vigilance
SIDER
101Necrosis6632CTD
102NeuritisCanada Vigilance: 1Canada Vigilance
103NeutropeniaSIDER
104OliguriaSIDER
105PainCanada Vigilance: 11663389CTD
SIDER
Canada Vigilance
106PalpitationsCanada Vigilance: 1Canada Vigilance
107Penile Diseases2872065CTD
108Pericardial effusion15151680CTD
109Pericarditis, Constrictive626452
982213
6736450		CTD
110PericarditisCanada Vigilance: 1Canada Vigilance
111Peripheral Nervous System Diseases1663389CTD
112Peripheral Vascular Diseases1006471CTD
113Pleural Diseases1196890CTD
114PolyuriaSIDER
115Psychoses, Substance-Induced2485859
5024073		CTD
116Pulmonary FibrosisCanada Vigilance: 11196890
6028242
17099974		CTD
Canada Vigilance
117PurpuraCanada Vigilance: 1Canada Vigilance
118Reflex, Abnormal6807440CTD
119Sclerosis6727469
16029366		CTD
120Serotonin Syndrome3711372
8869767		CTD
121Somatosensory Disorders6807440CTD
122SomnolenceCanada Vigilance: 1Canada Vigilance
SIDER
123TachycardiaSIDER
124ThrombocytopeniaSIDER
125ThrombophlebitisSIDER
126Tricuspid Valve Insufficiency912852CTD
127UreterolithiasisCanada Vigilance: 1Canada Vigilance
128Urinary tract obstructionSIDER
129Urine output increasedSIDER
130UrticariaCanada Vigilance: 1Canada Vigilance
131Vascular Diseases2944904
3300918		CTD
132Vascular Headaches5694374CTD
133Vascular insufficiencySIDER
134VasculitisCanada Vigilance: 1Canada Vigilance
135Vertigo6807440CTD
136VomitingCanada Vigilance: 4Canada Vigilance
SIDER
137Weight decreasedSIDER
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