MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Acenocoumarol

(VABCILAOYCMVPS-UHFFFAOYSA-N)

Structure

SMILES: CC(=O)CC(c1c(=O)oc2c(c1O)cccc2)c1ccc(cc1)[N+](=O)[O-]
Type(s): Approved; Investigational
ATC code(s): B01AA07
Molecular Formula:: C19H15NO6
Molecular Weight:: 353.325
Log P:: 4.0410
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 113.33
CAS Number(s):: 152-72-7; 70897-81-3

Synonym(s)

Acenocoumarol

Acenocoumarin

Nicoumalone

Mini-Sintrom

Sinkumar

Sinthrome

Sintrom

Syncoumar

Syncumar

10.

Synthrom

11.

Mini Sintrom

12.

MiniSintrom

External Link(s)

MeSH	D000074
PubChem Compound	54676537
ChEBI	53766
CHEMBL	CHEMBL397420
DrugBank	DB01418
IUPHAR/BPS Guide to PHARMACOLOGY	9015
KEGG	dr:D07064
Therapeutic Target Database	D05HFY

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Abdominal symptom			SIDER
2	Abscess			OFFSIDES
3	Acanthosis			OFFSIDES
4	Acute Coronary Syndrome			OFFSIDES
5	Acute kidney injury		15327563	CTD
6	Acute left ventricular failure			OFFSIDES
7	Adenocarcinoma			OFFSIDES
8	Agraphia			OFFSIDES
9	Alopecia			SIDER
10	Alveolitis			OFFSIDES
11	Angiodysplasia			OFFSIDES
12	Angioedema			OFFSIDES
13	Anogenital dysplasia			OFFSIDES
14	Anoxic Encephalopathy			OFFSIDES
15	Anticholinergic Syndrome			OFFSIDES
16	Anticoagulation drug level below therapeutic	Canada Vigilance: 1		Canada Vigilance
17	Antiviral drug level above therapeutic			OFFSIDES
18	Anuria			OFFSIDES
19	Aortic Diseases		8171941	CTD
20	Apathy			OFFSIDES
21	Arteritis			OFFSIDES
22	Ataxia			OFFSIDES
23	Atrial Fibrillation		1682588 16981216	CTD
24	Atrial Flutter			OFFSIDES
25	Aura			OFFSIDES
26	Bacterial Endocarditis			OFFSIDES
27	Bilirubin conjugated increased			OFFSIDES
28	Blood glucose decreased			OFFSIDES
29	Blood lactate dehydrogenase increased			OFFSIDES
30	Blood sodium			OFFSIDES
31	Blood uric acid			OFFSIDES
32	Bone marrow depression			OFFSIDES
33	Bradycardia			OFFSIDES
34	Brain Infarction		1682588	CTD
35	Bronchial Obstruction			OFFSIDES
36	Bronchopneumonia			OFFSIDES
37	Cardiac enzymes increased			OFFSIDES
38	Cardiac ventricular disorder			OFFSIDES
39	Catheter placement			OFFSIDES
40	Cerebral atrophy			OFFSIDES
41	Chemical and Drug Induced Liver Injury		1479182 9499683 12743448	CTD
42	Chemotherapeutic drug level increased			OFFSIDES
43	Cholangiolitis			OFFSIDES
44	Cholestasis		9499683	CTD
45	Clumsiness			OFFSIDES
46	Coagulation test abnormal			OFFSIDES
47	Complications of transplant surgery			OFFSIDES
48	Confabulation			OFFSIDES
49	Corneal Ulcer			OFFSIDES
50	Corneal abscess			OFFSIDES
51	Cytolytic hepatitis			OFFSIDES
52	Dermatitis			SIDER
53	Diplopia			OFFSIDES
54	Disseminated Intravascular Coagulation		10822766	CTD
55	Drowsiness			OFFSIDES
56	Drug ineffective	Canada Vigilance: 3		Canada Vigilance
57	Drug level below therapeutic			OFFSIDES
58	Drug toxicity			OFFSIDES
59	Dry skin			OFFSIDES
60	Duodenitis			OFFSIDES
61	Eczema			OFFSIDES
62	Embolism		19225864	CTD
63	Endophthalmitis			OFFSIDES
64	Epistaxis	Canada Vigilance: 1		Canada Vigilance OFFSIDES
65	Erosive gastritis			OFFSIDES
66	Femoral Neuropathy		6186784	CTD
67	Fluid overload			OFFSIDES
68	Gamma-Glutamyltransferase Increased			OFFSIDES
69	Gangrene			OFFSIDES
70	Gastroenteritis			OFFSIDES
71	General physical health deterioration			OFFSIDES
72	Globulinuria			OFFSIDES
73	Headache		12944455	CTD
74	Hematoma, Subdural		12944455	CTD
75	Hematoma		6186784	CTD
76	Hemisensory Neglect			OFFSIDES
77	Hemorrhage		15826524 19225864	CTD
78	Hepatitis B DNA increased			OFFSIDES
79	Hepatosplenomegaly			OFFSIDES
80	Hiccough			OFFSIDES
81	Hidradenitis			OFFSIDES
82	Hydrothorax			OFFSIDES
83	Hypersensitivity			SIDER
84	Hypertensive heart disease			OFFSIDES
85	Hypesthesia		12944455	CTD
86	Hypokinesia			OFFSIDES
87	Iatrogenic injury			OFFSIDES
88	Infection			OFFSIDES
89	Injection site phlebitis			OFFSIDES
90	Kidney Failure			OFFSIDES
91	Left atrial dilatation			OFFSIDES
92	Leukoaraiosis			OFFSIDES
93	Listeria encephalitis			OFFSIDES
94	Livedo Reticularis			OFFSIDES
95	Lymphocytosis			OFFSIDES
96	Menorrhagia			SIDER
97	Metrorrhagia			SIDER
98	Microscopic hematuria			SIDER
99	Mixed liver injury			OFFSIDES
100	Nausea			SIDER
101	Neck Pain		12944455	CTD
102	Necrosis		15327563	CTD
103	Nystagmus			OFFSIDES
104	Oral fungal infection			OFFSIDES
105	Oral mucosal exfoliation			OFFSIDES
106	Overdose			OFFSIDES
107	PROTHROMBIN TIME			OFFSIDES
108	Pain		6186784	CTD
109	Pallor			OFFSIDES
110	Parapsoriasis			OFFSIDES
111	Performance status decreased			OFFSIDES
112	Peritonitis			OFFSIDES
113	Phlebitis			OFFSIDES
114	Pleurisy			OFFSIDES
115	Pneumothorax			OFFSIDES
116	Polymyalgia Rheumatica			OFFSIDES
117	Poor personal hygiene			OFFSIDES
118	Post procedural complication			OFFSIDES
119	Product quality issue	Canada Vigilance: 1		Canada Vigilance
120	Protein C Deficiency			SIDER
121	Prothrombin level decreased			OFFSIDES
122	Pulmonary Hypertension			OFFSIDES
123	Pulmonary arterial hypertension			OFFSIDES
124	Rales			OFFSIDES
125	Respiratory Failure			OFFSIDES
126	Respiratory tract irritation			OFFSIDES
127	Reticulocyte count increased			OFFSIDES
128	Retinal exudates			OFFSIDES
129	Rheumatic Heart Disease		10878885	CTD
130	Rupture, Spontaneous		8430022	CTD
131	Scotoma			OFFSIDES
132	Septic Shock			OFFSIDES
133	Skin necrosis			SIDER
134	Status Epilepticus			OFFSIDES
135	Sudden death			OFFSIDES
136	Supraventricular tachycardia			OFFSIDES
137	Terminal state			OFFSIDES
138	Therapeutic response unexpected	Canada Vigilance: 1		Canada Vigilance
139	Therapy non-responder			OFFSIDES
140	Thrombocytopenia		8171941	CTD
141	Thromboembolism		8171941 18698879 19225864	CTD
142	Tracheobronchitis			OFFSIDES
143	Transaminases increased			OFFSIDES
144	Ulcer			SIDER
145	Urinary Retention		12944455	CTD
146	Urticaria			SIDER
147	Vasculitis, Leukocytoclastic, Cutaneous		8490477 10329927 16981216	CTD
148	Venous Insufficiency			OFFSIDES
149	Venous Thromboembolism		12755667	CTD
150	Venous Thrombosis		8171941 20473075 28867752	CTD
151	Ventricular Fibrillation			OFFSIDES
152	Visual disturbance			OFFSIDES
153	Vomiting			SIDER

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234