MetaADEDB 2.0 @ LMMD
Dihydroergotamine
(LUZRJRNZXALNLM-JGRZULCMSA-N)
Structure
SMILES
CN1C[C@@H](C[C@H]2[C@H]1Cc1c[nH]c3c1c2ccc3)C(=O)N[C@]1(C)O[C@@]2(N(C1=O)[C@@H](Cc1ccccc1)C(=O)N1[C@H]2CCC1)O
Type(s)
Approved; Investigational
ATC code(s)
N02CA01; N02CA51
Molecular Formula:
C33H37N5O5
Molecular Weight:
583.677
Log P:
2.2857
Hydrogen Bond Acceptor:
9
Hydrogen Bond Donor:
3
TPSA:
118.21
CAS Number(s):
511-12-6
Synonym(s)
1.
Dihydroergotamine
2.
Agit
3.
Angionorm
4.
Clavigrenin
5.
D-Tamin Retard L.U.T.
6.
D.H.E. 45
7.
DET MS
8.
DHE-45
9.
DHE-Puren
10.
DHE-Ratiopharm
11.
Dihydergot
12.
Dihydroergotamin AL
13.
Dihydroergotamine Mesylate
14.
Dihydroergotamine Methanesulfonate
15.
Dihydroergotamine-Sandoz
16.
Dihytamin
17.
Erganton
18.
Ergomimet
19.
Ergont
20.
Ergotam Von Ct
21.
Ikaran
22.
Migranal
23.
Orstanorm
24.
Seglor
25.
Tamik
26.
Verladyn
27.
D Tamin Retard L.U.T.
28.
DHE 45
29.
DHE Puren
30.
DHE Ratiopharm
31.
DHE45
32.
Dihydroergotamine Sandoz
33.
Mesylate, Dihydroergotamine
34.
Methanesulfonate, Dihydroergotamine
35.
Von Ct, Ergotam
External Link(s)
MeSHD004087
PubChem Compound10531
BindingDB50295557
ChEBI4562
CHEMBLCHEMBL1732
DrugBankDB00320
DrugCentral888
IUPHAR/BPS Guide to PHARMACOLOGY121
KEGGcpd:C07798
dr:D07837
Therapeutic Target DatabaseD0V3ZA
D0O4CV
ZINC3978005
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 6
Canada Vigilance: 8
Canada Vigilance
US FAERS
2Product quality issueFAERS: 5US FAERS
3DizzinessFAERS: 4SIDER
US FAERS
4Chest PainFAERS: 3US FAERS
5Feeling abnormalFAERS: 3SIDER
US FAERS
6Drug dose omissionFAERS: 2US FAERS
7FatigueFAERS: 2SIDER
US FAERS
8MyalgiaFAERS: 2
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
9NauseaFAERS: 2
Canada Vigilance: 2
8682669CTD
SIDER
Canada Vigilance
US FAERS
10No adverse eventFAERS: 2US FAERS
11Angina PectorisFAERS: 18308831CTD
SIDER
US FAERS
12Atrioventricular BlockFAERS: 1US FAERS
13Blood cholesterol increasedFAERS: 1US FAERS
14Blood pressure inadequately controlledFAERS: 1US FAERS
15Cerebrovascular accidentFAERS: 1SIDER
US FAERS
16Deep Vein ThrombosisFAERS: 1US FAERS
17DehydrationFAERS: 1US FAERS
18Drug DependenceFAERS: 1US FAERS
19EpistaxisFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
20ErythemaFAERS: 1US FAERS
21Expired product administeredFAERS: 1US FAERS
22HeadacheFAERS: 1
Canada Vigilance: 2

View details

CTD
SIDER
Canada Vigilance
US FAERS
23Incorrect drug administration durationFAERS: 1US FAERS
24Injection site extravasationFAERS: 1US FAERS
25LacerationFAERS: 1US FAERS
26Musculoskeletal stiffnessFAERS: 1SIDER
US FAERS
27MyopiaFAERS: 1US FAERS
28Pharmaceutical product complaintFAERS: 1US FAERS
29PhlebitisFAERS: 1US FAERS
30Product complaintFAERS: 1US FAERS
31Product dose omissionFAERS: 1US FAERS
32Product substitution issueFAERS: 1US FAERS
33Pulmonary HypertensionFAERS: 1US FAERS
34TachycardiaFAERS: 1SIDER
US FAERS
35Troponin increasedFAERS: 1US FAERS
36VomitingFAERS: 1
Canada Vigilance: 1
Canada Vigilance
SIDER
US FAERS
37Wrong technique in product usage processFAERS: 1US FAERS
38Abdominal PainSIDER
39Abnormal visionSIDER
40AbuseOFFSIDES
41Acute Coronary SyndromeSIDER
42AgitationSIDER
43Amnesia, Transient Global15573308CTD
44AnorexiaSIDER
45AnxietySIDER
46AphoniaSIDER
47Application site reactionSIDER
48ArthralgiaSIDER
49AstheniaOFFSIDES
SIDER
50Bladder painSIDER
51Blood GlucoseOFFSIDES
52Blood albumin decreasedOFFSIDES
53Blood electrolytes abnormalOFFSIDES
54Blood fibrinogen increasedOFFSIDES
55Blood iron decreasedOFFSIDES
56Brain Diseases18547264CTD
57Bronchial ObstructionOFFSIDES
58BronchitisSIDER
59BronchospasmSIDER
60Bulbar palsyOFFSIDES
61Burning sensationCanada Vigilance: 2Canada Vigilance
OFFSIDES
62Cerebral Infarction8777772CTD
63ChillsSIDER
64CholangiolitisOFFSIDES
65Circumstance or information capable of leading to medication errorOFFSIDES
66Cluster HeadacheOFFSIDES
67Coagulation factor VIII level increasedOFFSIDES
68Cold sweatSIDER
69ConjunctivitisSIDER
70Coronary Artery Disease9665056CTD
71CyanosisCanada Vigilance: 1Canada Vigilance
72CystitisSIDER
73DeafnessOFFSIDES
74Decreased LibidoOFFSIDES
75DependenceOFFSIDES
76Depressed Level of ConsciousnessSIDER
77DermatitisSIDER
78DiscomfortSIDER
79DiverticulumOFFSIDES
80Drug abuserOFFSIDES
81Drug withdrawal headacheOFFSIDES
82DysgeusiaCanada Vigilance: 1Canada Vigilance
83DyspepsiaSIDER
84Dysphonia12864762CTD
85Electromyogram abnormalOFFSIDES
86Erectile dysfunctionOFFSIDES
87Euphoric moodSIDER
88Eye painSIDER
89Fluid overloadOFFSIDES
90FlushingSIDER
91FormicationOFFSIDES
92Gamma-Glutamyltransferase IncreasedOFFSIDES
93Gangrene8721476CTD
94Gastrointestinal PainSIDER
95Head discomfortCanada Vigilance: 1Canada Vigilance
96Hepatic congestionOFFSIDES
97Hepatitis BOFFSIDES
98HepatosplenomegalyOFFSIDES
99Hip surgeryOFFSIDES
100HyperkinesiaSIDER
101HypersensitivitySIDER
102Hypotension, Orthostatic4433212CTD
103Hypotension135643
788908
3874423
CTD
SIDER
104Influenza-like symptomsSIDER
105Intentional self-injuryOFFSIDES
106Intermittent Claudication2050518CTD
OFFSIDES
107Intracranial Hypertension8777772CTD
108Ischemia3139897
3402234
CTD
109Kidney Papillary Necrosis8782036CTD
110Lacrimation abnormal NOSSIDER
111Latex allergyOFFSIDES
112Leukopenia neonatalOFFSIDES
113Livedo ReticularisCanada Vigilance: 1Canada Vigilance
114MalaiseSIDER
115Mesenteric Vascular Occlusion1751820CTD
116Migraine Disorders

View details

CTD
117Migraine aggravatedSIDER
118MonoplegiaOFFSIDES
119Muscle Cramp8682669CTD
120Muscle RigiditySIDER
121Musculoskeletal discomfortSIDER
122Myocardial Infarction3810102CTD
SIDER
123Myocardial Ischemia8312801CTD
124Necrosis9794162CTD
125Nerve BlockOFFSIDES
126NervousnessSIDER
127Neurologic Manifestations8777772CTD
128Open woundOFFSIDES
129PainCanada Vigilance: 1Canada Vigilance
OFFSIDES
SIDER
130PallorOFFSIDES
131PalpitationsSIDER
132Pelvic Inflammatory DiseaseSIDER
133PetechiaeSIDER
134PharyngitisSIDER
135PhotophobiaSIDER
136Pleuritic painSIDER
137Popliteal pulse decreasedOFFSIDES
138Postoperative Complications3874423CTD
139Prinzmetal's variant angina6425662CTD
140PruritusSIDER
141Radial pulse decreasedOFFSIDES
142RalesOFFSIDES
143Renal Insufficiency8721476CTD
144Retroperitoneal fibrosisSIDER
145RhinitisSIDER
146ScreamingOFFSIDES
147Serotonin Syndrome8869767CTD
148ShockSIDER
149SinusitisSIDER
150Skin cold clammySIDER
151SomnolenceSIDER
152StiffnessSIDER
153StuporSIDER
154SwellingSIDER
155TensionSIDER
156Throat irritationCanada Vigilance: 1Canada Vigilance
157Thrombosis1751820
3874423
CTD
158TinnitusSIDER
159Tongue bitingOFFSIDES
160Transaminases increasedOFFSIDES
161Transferrin decreasedOFFSIDES
162TraumaSIDER
163TremorSIDER
164UrticariaSIDER
165Vascular Diseases4601018
5651950
CTD
166VasospasmCanada Vigilance: 1Canada Vigilance
SIDER
167Venous Thrombosis3139897
3402234
3698718
CTD
168Ventricular FibrillationSIDER
169Ventricular hypokinesiaOFFSIDES
170VertigoSIDER
171Visual ImpairmentSIDER
172Wound eviscerationOFFSIDES
173YawningSIDER
174effusionOFFSIDES
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