MetaADEDB 2.0 @ LMMD
Mitotane
(JWBOIMRXGHLCPP-UHFFFAOYSA-N)
Structure
SMILES
ClC(C(c1ccccc1Cl)c1ccc(cc1)Cl)Cl
Type(s)
Approved
ATC code(s)
L01XX23
Molecular Formula:
C14H10Cl4
Molecular Weight:
320.041
Log P:
5.9290
Hydrogen Bond Acceptor:
0
Hydrogen Bond Donor:
0
TPSA:
0
CAS Number(s):
53-19-0
Synonym(s)
1.
Mitotane
2.
o,p-DDD
3.
ortho,para-DDD
4.
Chloditan
5.
Chlodithane
6.
Khloditan
7.
Lysodren
8.
Mytotan
9.
ortho,para DDD
External Link(s)
MeSHD008939
PubChem Compound4211
ChEBI6954
CHEMBLCHEMBL1670
DrugBankDB00648
DrugCentral1820
IUPHAR/BPS Guide to PHARMACOLOGY6957
KEGGdr:D00420
Therapeutic Target DatabaseD0Z5OE
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Accidental exposure to productFAERS: 14US FAERS
2DizzinessFAERS: 10OFFSIDES
SIDER
US FAERS
3NauseaFAERS: 912015757CTD
OFFSIDES
SIDER
US FAERS
4AstheniaFAERS: 8OFFSIDES
SIDER
US FAERS
5Drug level above therapeuticFAERS: 8US FAERS
6OverdoseFAERS: 8OFFSIDES
US FAERS
7SomnolenceFAERS: 8SIDER
US FAERS
8Adverse eventFAERS: 6US FAERS
9Gastrointestinal toxicityFAERS: 6SIDER
US FAERS
10HypothyroidismFAERS: 6
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
11Weight decreasedFAERS: 6US FAERS
12Accidental exposureFAERS: 5OFFSIDES
US FAERS
13Malignant neoplasm progressionFAERS: 5OFFSIDES
US FAERS
14Maternal exposure during pregnancyFAERS: 5US FAERS
15PregnancyFAERS: 5US FAERS
16VomitingFAERS: 5SIDER
US FAERS
17Depressed Level of ConsciousnessFAERS: 4US FAERS
18Respiratory distressFAERS: 4US FAERS
19Altered state of consciousnessFAERS: 3US FAERS
20AnorexiaFAERS: 3OFFSIDES
SIDER
US FAERS
21Cytolytic hepatitisFAERS: 3OFFSIDES
US FAERS
22Drug administration errorFAERS: 3US FAERS
23Drug level increasedFAERS: 3US FAERS
24FatigueFAERS: 312015757CTD
US FAERS
25HypogonadismFAERS: 3
Canada Vigilance: 1		3441014CTD
OFFSIDES
Canada Vigilance
US FAERS
26PruritusFAERS: 3US FAERS
27SepsisFAERS: 3US FAERS
28VertigoFAERS: 3SIDER
US FAERS
29AmnesiaFAERS: 2OFFSIDES
SIDER
US FAERS
30Blood alkaline phosphatase increasedFAERS: 2OFFSIDES
US FAERS
31CholestasisFAERS: 2US FAERS
32Cholestatic liver injuryFAERS: 2US FAERS
33Circumstance or information capable of leading to medication errorFAERS: 2US FAERS
34DehydrationFAERS: 2US FAERS
35Drug level below therapeuticFAERS: 2OFFSIDES
US FAERS
36Endometrial HyperplasiaFAERS: 2US FAERS
37Gamma-Glutamyltransferase IncreasedFAERS: 2US FAERS
38HepatitisFAERS: 2SIDER
US FAERS
39Lichen PlanusFAERS: 2US FAERS
40Medication ErrorFAERS: 2US FAERS
41MenorrhagiaFAERS: 2US FAERS
42NeutropeniaFAERS: 212015757CTD
SIDER
US FAERS
43Neutrophil count decreasedFAERS: 2OFFSIDES
US FAERS
44No adverse eventFAERS: 2US FAERS
45Parapharyngeal abscessFAERS: 2OFFSIDES
US FAERS
46Pelvic venous thrombosisFAERS: 2OFFSIDES
US FAERS
47Septic ShockFAERS: 2US FAERS
48TremorFAERS: 23798445CTD
SIDER
US FAERS
49White blood cell count decreasedFAERS: 2US FAERS
50Wrong technique in drug usage processFAERS: 2US FAERS
51Abdominal discomfortFAERS: 1US FAERS
52AdrenalectomyFAERS: 1US FAERS
53Adrenocortical carcinomaFAERS: 1

View details

1320517
1517795
2954144
3441014
4739370
6094274
8098948
11106117
11572034
12015757
17675396
18854392
22156929
23179081
23330457
23585556
25542188
 		CTD
OFFSIDES
US FAERS
54Alanine Aminotransferase IncreasedFAERS: 1US FAERS
55Aspartate Aminotransferase IncreasedFAERS: 1US FAERS
56Back PainFAERS: 1US FAERS
57BlindnessFAERS: 1US FAERS
58Blood bilirubin abnormalFAERS: 1US FAERS
59Blood cholesterol increasedFAERS: 1SIDER
US FAERS
60Blood glucose increasedFAERS: 1US FAERS
61Blood thyroid stimulating hormone decreasedFAERS: 1US FAERS
62Blood triglycerides increasedFAERS: 1SIDER
US FAERS
63Cardiac ArrestFAERS: 1US FAERS
64DementiaFAERS: 1US FAERS
65Diabetes mellitus inadequate controlFAERS: 1US FAERS
66DiplopiaFAERS: 1SIDER
US FAERS
67DiscomfortFAERS: 1US FAERS
68Disease ProgressionFAERS: 1US FAERS
69Drug exposure during pregnancyFAERS: 1US FAERS
70Drug ineffectiveFAERS: 1US FAERS
71Drug level decreasedFAERS: 1US FAERS
72Drug prescribing errorFAERS: 1US FAERS
73DysuriaFAERS: 1US FAERS
74Expired drug administeredFAERS: 1US FAERS
75Exposure via direct contactFAERS: 1US FAERS
76Gastrointestinal infectionFAERS: 1US FAERS
77General physical health deteriorationFAERS: 1OFFSIDES
US FAERS
78Growth retardationFAERS: 1SIDER
US FAERS
79HeadacheFAERS: 1SIDER
US FAERS
80HepatotoxicityFAERS: 1US FAERS
81HyperparathyroidismFAERS: 1US FAERS
82HypotensionFAERS: 1SIDER
US FAERS
83HypotrichosisFAERS: 1US FAERS
84InfectionFAERS: 1SIDER
US FAERS
85Inflammatory marker increasedFAERS: 1US FAERS
86Intestinal FistulaFAERS: 1US FAERS
87LethargyFAERS: 1SIDER
US FAERS
88LeukopeniaFAERS: 1US FAERS
89Low density lipoprotein increasedFAERS: 1US FAERS
90MalaiseFAERS: 1US FAERS
91Maternal exposure timing unspecifiedFAERS: 1US FAERS
92Medication residueFAERS: 1US FAERS
93Memory impairmentFAERS: 1US FAERS
94MetrorrhagiaFAERS: 1US FAERS
95MyoclonusFAERS: 1US FAERS
96NephrectomyFAERS: 1US FAERS
97Neurological examination abnormalFAERS: 1OFFSIDES
US FAERS
98Non-high-density lipoprotein cholesterol increasedFAERS: 1US FAERS
99Occupational exposure to productFAERS: 1US FAERS
100Optic NeuritisFAERS: 1US FAERS
101Ovarian cyst torsionFAERS: 1US FAERS
102PancreatitisFAERS: 1US FAERS
103Performance status decreasedFAERS: 1OFFSIDES
US FAERS
104PneumoniaFAERS: 1US FAERS
105Prescribed underdoseFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
106Product quality issueFAERS: 1US FAERS
107Product substitution issueFAERS: 1US FAERS
108Product use in unapproved indicationFAERS: 1US FAERS
109Product use issueFAERS: 1US FAERS
110ProteinuriaFAERS: 1SIDER
US FAERS
111Psychomotor skills impairedFAERS: 1US FAERS
112Respiratory FailureFAERS: 1US FAERS
113ScotomaFAERS: 1US FAERS
114TachycardiaFAERS: 1US FAERS
115Therapy cessationFAERS: 1US FAERS
116Therapy changeFAERS: 1US FAERS
117Therapy non-responderFAERS: 1US FAERS
118ThrombosisFAERS: 1US FAERS
119Transaminases increasedFAERS: 1OFFSIDES
US FAERS
120Urine leukocyte esterase positiveFAERS: 1US FAERS
121Wrong technique in product usage processFAERS: 1US FAERS
122jaundiceFAERS: 116822769CTD
US FAERS
123AcheSIDER
124Adrenal Cortex Diseases3798445
17675396		CTD
125Adrenal Gland Neoplasms8453685CTD
126Adrenal gland cancer metastaticOFFSIDES
127Alanine aminotransferase abnormalOFFSIDES
128AlbuminuriaSIDER
129Alopecia3798445CTD
OFFSIDES
130Antiviral drug level above therapeuticOFFSIDES
131AtaxiaSIDER
132Autoimmune hepatitisSIDER
133Blood Coagulation Disorders16822769CTD
134Blood alkaline phosphatase abnormalOFFSIDES
135Blood and lymphatic system disordersSIDER
136Blood cortisol increasedOFFSIDES
137Blood count abnormalOFFSIDES
138Blood lactate dehydrogenase increasedOFFSIDES
139Blood potassium decreasedOFFSIDES
140Blood uric acid decreasedSIDER
141Bone density increasedOFFSIDES
142CataractSIDER
143Cerebellar AtaxiaOFFSIDES
144Cerebral ThrombosisOFFSIDES
145Chemical and Drug Induced Liver Injury16822769CTD
146Chemotherapeutic drug level increasedOFFSIDES
147ConfabulationOFFSIDES
148Cushing Syndrome2963295
19153526		CTD
149Cutaneous hypersensitivitySIDER
150Dehydroepiandrosterone decreasedOFFSIDES
151DemyelinationOFFSIDES
152DermatitisSIDER
153Diarrhea3798445
12015757		CTD
154DrowsinessOFFSIDES
SIDER
155DysarthriaSIDER
156DysgeusiaSIDER
157DyspepsiaSIDER
158Epigastric discomfortSIDER
159Erectile dysfunction3441014CTD
160Exanthema1517795CTD
161Febrile NeutropeniaOFFSIDES
162Feeling abnormalSIDER
163FlushingSIDER
164FormicationOFFSIDES
165Gastrointestinal Diseases1517795CTD
166GlobulinuriaOFFSIDES
167Hemorrhage8453685CTD
168Hepatitis B positiveOFFSIDES
169Hypercholesterolemia1480741CTD
170HyperpyrexiaSIDER
171HypersensitivitySIDER
172InfestationSIDER
173Kidney FailureOFFSIDES
174Language Disorders1517795CTD
175Leukopenia neonatalOFFSIDES
176Long QT SyndromeOFFSIDES
177MalnutritionSIDER
178Memory Disorders1517795CTD
179Memory LossSIDER
180Mental RetardationSIDER
181Mental disorders1517795
12015757		CTD
182Mineralocorticoid deficiencySIDER
183Muscle Weakness3798445CTD
184Necrosis8453685CTD
185Neuromuscular Manifestations1517795CTD
186Neuropathic painOFFSIDES
187Opportunistic mycosisSIDER
188Orthostatic hypertensionSIDER
189PainSIDER
190Peripheral Nervous System Diseases2954144CTD
191Plasma cholesterol increasedSIDER
192Plasma triglycerides increasedSIDER
193PolyneuropathySIDER
194Premature Birth27748297CTD
195Protein urine presentSIDER
196Pseudotumor Cerebri2963295CTD
197Retinal toxicitySIDER
198ShockSIDER
199Skin toxicitySIDER
200Stevens-Johnson SyndromeOFFSIDES
201Sudden deathOFFSIDES
202ThrombocytopeniaSIDER
203Traumatic fractureOFFSIDES
204TraumaSIDER
205Visual ImpairmentSIDER
206Visual disturbanceOFFSIDES
207nervous system disorderSIDER
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