MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Yohimbine

(BLGXFZZNTVWLAY-SCYLSFHTSA-N)

Structure

SMILES: COC(=O)[C@H]1[C@@H](O)CC[C@@H]2[C@@H]1C[C@@H]1N(C2)CCc2c1[nH]c1c2cccc1
Type(s): Approved; Investigational; Vet_approved
ATC code(s): G04BE04
Molecular Formula:: C21H26N2O3
Molecular Weight:: 354.443
Log P:: 2.5850
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 2
TPSA:: 65.56
CAS Number(s):: 146-48-5; 37247-87-3

Synonym(s)

Yohimbine

Rauwolscine

Aphrodine Hydrochloride

Aphrodyne

Corynanthine

Corynanthine Tartrate

Pluriviron

Rauhimbine

Yocon

10.

Yohimbin Spiegel

11.

Yohimbine Houdé

12.

Yohimbine Hydrochloride

13.

Yohimex

14.

Hydrochloride, Aphrodine

15.

Hydrochloride, Yohimbine

16.

Tartrate, Corynanthine

External Link(s)

MeSH	D015016
PubChem Compound	8969
BindingDB	50203564 50013515
ChEBI	10093
CHEMBL	CHEMBL15245
DrugBank	DB01392
DrugCentral	3659
IUPHAR/BPS Guide to PHARMACOLOGY	102
KEGG	cpd:C09256 dr:D08685
Therapeutic Target Database	D0H4JM
ZINC	3860825

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Akathisia, Drug-Induced		3372705	CTD
2	Alcoholic Intoxication		7617798	CTD
3	Amnesia		15265636 20064624	CTD
4	Anxiety Disorders		View details 1506013 2867497 3372705 6505121 7617798 7950687 8340584 8744988	CTD
5	Bipolar Disorder		6091464	CTD
6	Bone Resorption		27028940	CTD
7	Bradycardia		View details 978195 1527734 2157035 3039113 3505923 3720002 6117801 6121810 8623973	CTD
8	Cartilage Diseases		27028940	CTD
9	Catalepsy		View details 9723970 12970091 15448976 19429072	CTD
10	Chemical and Drug Induced Liver Injury		2886651	CTD
11	Chills		3153710	CTD
12	Cocaine-Related Disorders		14872205 18824018	CTD
13	Disorders of Excessive Somnolence		8318322	CTD
14	Drug Eruptions		8470320	CTD
15	Dyskinesia, Drug-Induced		8106150 10495035	CTD
16	Edema		27028940	CTD
17	Erectile dysfunction		View details 3352059 10337904 11896474 17874315	CTD
18	Erythema		27028940	CTD
19	Exotropia		3153710	CTD
20	Feeling abnormal	Canada Vigilance: 1		Canada Vigilance
21	Headache	Canada Vigilance: 1		Canada Vigilance
22	Hyperalgesia		View details 2128375 8987795 12727271 18799818	CTD
23	Hyperemia		2841874 7949234	CTD
24	Hyperglycemia		17195055	CTD
25	Hyperprolactinemia		1678730	CTD
26	Hypokinesia		19429072	CTD
27	Hypotension, Orthostatic		View details 503823 2708559 2920499 3799828 3953875 7224460 10369619	CTD
28	Hypotension		View details 978195 2157035 2565755 2594901 2767128 2879903 3039113 3421530 3720846 6111465 6117801 6121810 6256140 7250202 8816361	CTD
29	Inflammation		27028940	CTD
30	Malaise	Canada Vigilance: 1		Canada Vigilance
31	Mental disorders		2594901 19821221	CTD
32	Movement Disorders		17306893	CTD
33	Muscle Rigidity		3670563	CTD
34	Myocardial Infarction		2350327	CTD
35	Myocardial Ischemia		2429111 3768070	CTD
36	Myocardial Reperfusion Injury		2350327	CTD
37	Myoclonus		37558	CTD
38	Nausea	Canada Vigilance: 1	3021082	CTD Canada Vigilance
39	Neurobehavioral Manifestations		499336	CTD
40	Obesity		2877928	CTD
41	Opioid-Related Disorders		11955464	CTD
42	Palpitations	Canada Vigilance: 1		Canada Vigilance
43	Panic Disorder		View details 3153710 8080348 10367182 10435213 14656453	CTD
44	Polyuria		3505923	CTD
45	Reflex, Abnormal		20394767	CTD
46	Renal Insufficiency		8470320	CTD
47	Seizures		View details 1326092 1527734 2566944 3040437 11685388 12180996 17728537 19640235	CTD
48	Substance Withdrawal Syndrome		11955464	CTD
49	Substance-Related Disorders		3153710	CTD
50	Tachycardia, Ventricular		8720421 17852790	CTD
51	Tachycardia		View details 2864424 3007177 6323192 8340584 19640235	CTD
52	Tremor	Canada Vigilance: 1	View details 3021082 3153710 3372705 3670563	CTD Canada Vigilance
53	Ventricular Fibrillation		2350327 8720421	CTD
54	Vomiting		19640235	CTD
55	Xerostomia		9272401	CTD

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