Tiopronin
(YTGJWQPHMWSCST-UHFFFAOYSA-N)
Structure
- SMILES
- CC(C(=O)NCC(=O)O)S
- Type(s)
- Approved; Investigational
- ATC code(s)
- G04BX16
- Molecular Formula:
- C5H9NO3S
- Molecular Weight:
- 163.195
- Log P:
- -0.1036
- Hydrogen Bond Acceptor:
- 5
- Hydrogen Bond Donor:
- 3
- TPSA:
- 105.2
- CAS Number(s):
- 1953-02-2; 3625-85-2; 19392
Synonym(s)
1.
Tiopronin
2.
Mercaptopropionylglycine
3.
Thiopronine
4.
2-Mercaptopropionylglycine
5.
2-Thiol-propionamido-acetic Acid
6.
2-Thiolpropionamidoacetic Acid
7.
Acadione
8.
Captimer
9.
Meprin
10.
Thiola
11.
Tiopronine
12.
alpha-Mercaptopropionylglycine
13.
2 Mercaptopropionylglycine
14.
2 Thiol propionamido acetic Acid
15.
2 Thiolpropionamidoacetic Acid
16.
Acid, 2-Thiol-propionamido-acetic
17.
Acid, 2-Thiolpropionamidoacetic
18.
alpha Mercaptopropionylglycine
External Link(s)
| MeSH | D008625 |
| PubChem Compound | 5483 |
| BindingDB | 50020805 |
| ChEBI | 32229 |
| CHEMBL | CHEMBL1314 |
| DrugBank | DB06823 |
| DrugCentral | 2676 |
| KEGG | cpd:C12876 dr:D01430 |
| Therapeutic Target Database | D0A8CJ |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug ineffective | FAERS: 376 | US FAERS | |
| 2 | Drug dose omission | FAERS: 203 | US FAERS | |
| 3 | Nausea | FAERS: 110 | SIDER US FAERS | |
| 4 | Pain | FAERS: 79 | US FAERS | |
| 5 | Fatigue | FAERS: 57 | SIDER US FAERS | |
| 6 | Nephrolithiasis | FAERS: 55 | US FAERS | |
| 7 | Arthralgia | FAERS: 44 | SIDER US FAERS | |
| 8 | Headache | FAERS: 41 | US FAERS | |
| 9 | Vomiting | FAERS: 36 | SIDER US FAERS | |
| 10 | Abdominal discomfort | FAERS: 32 | US FAERS | |
| 11 | Pruritus | FAERS: 31 | SIDER US FAERS | |
| 12 | Dysgeusia | FAERS: 28 | US FAERS | |
| 13 | Myalgia | FAERS: 28 | SIDER US FAERS | |
| 14 | Malaise | FAERS: 26 | US FAERS | |
| 15 | Dizziness | FAERS: 23 | US FAERS | |
| 16 | Renal pain | FAERS: 21 | US FAERS | |
| 17 | Abdominal Pain | FAERS: 18 | SIDER US FAERS | |
| 18 | Ageusia | FAERS: 18 | US FAERS | |
| 19 | Dyspepsia | FAERS: 18 | US FAERS | |
| 20 | Incorrect dose administered | FAERS: 18 | US FAERS | |
| 21 | Asthenia | FAERS: 14 | SIDER US FAERS | |
| 22 | Back Pain | FAERS: 13 | US FAERS | |
| 23 | Flatulence | FAERS: 12 | SIDER US FAERS | |
| 24 | Lymphadenopathy | FAERS: 12 | SIDER US FAERS | |
| 25 | Peripheral swelling | FAERS: 12 | US FAERS | |
| 26 | Urticaria | FAERS: 12 | US FAERS | |
| 27 | Proteinuria | FAERS: 11 | SIDER US FAERS | |
| 28 | Dry skin | FAERS: 10 | US FAERS | |
| 29 | Hypersensitivity | FAERS: 10 | US FAERS | |
| 30 | Weight decreased | FAERS: 10 | US FAERS | |
| 31 | Blood urine present | FAERS: 8 | US FAERS | |
| 32 | Chest Pain | FAERS: 8 | US FAERS | |
| 33 | Epigastric discomfort | FAERS: 8 | US FAERS | |
| 34 | Nephrotic Syndrome | FAERS: 8 | 2250412 | CTD SIDER US FAERS |
| 35 | Stomatitis | FAERS: 8 | SIDER US FAERS | |
| 36 | Chills | FAERS: 7 | SIDER US FAERS | |
| 37 | Dehydration | FAERS: 7 | US FAERS | |
| 38 | Flank Pain | FAERS: 7 | US FAERS | |
| 39 | Infection | FAERS: 7 | US FAERS | |
| 40 | Protein urine present | FAERS: 7 | SIDER US FAERS | |
| 41 | Somnolence | FAERS: 7 | US FAERS | |
| 42 | Constipation | FAERS: 6 | US FAERS | |
| 43 | Erythema | FAERS: 6 | US FAERS | |
| 44 | Feeling abnormal | FAERS: 6 | US FAERS | |
| 45 | Influenza | FAERS: 6 | US FAERS | |
| 46 | Oropharyngeal pain | FAERS: 6 | US FAERS | |
| 47 | Pneumonia | FAERS: 6 | US FAERS | |
| 48 | Abnormal weight gain | FAERS: 5 | US FAERS | |
| 49 | Acne | FAERS: 5 | US FAERS | |
| 50 | Anxiety | FAERS: 5 | US FAERS | |
| 51 | Sepsis | FAERS: 5 | US FAERS | |
| 52 | Alopecia | FAERS: 4 | US FAERS | |
| 53 | Blood glucose increased | FAERS: 4 | US FAERS | |
| 54 | Burning sensation | FAERS: 4 | US FAERS | |
| 55 | Chest discomfort | FAERS: 4 | US FAERS | |
| 56 | Eructation | FAERS: 4 | US FAERS | |
| 57 | Joint swelling | FAERS: 4 | US FAERS | |
| 58 | Myocardial Infarction | FAERS: 4 | US FAERS | |
| 59 | Nasopharyngitis | FAERS: 4 | US FAERS | |
| 60 | Skin Wrinkling | FAERS: 4 | SIDER US FAERS | |
| 61 | Swelling | FAERS: 4 | US FAERS | |
| 62 | Thrombocytopenia | FAERS: 4 | SIDER US FAERS | |
| 63 | Urinary tract infection | FAERS: 4 | US FAERS | |
| 64 | Amnesia | FAERS: 3 | US FAERS | |
| 65 | Blood creatinine increased | FAERS: 3 | US FAERS | |
| 66 | Bone pain | FAERS: 3 | US FAERS | |
| 67 | Cholelithiasis | FAERS: 3 | US FAERS | |
| 68 | Depressed mood | FAERS: 3 | US FAERS | |
| 69 | Hypogeusia | FAERS: 3 | SIDER US FAERS | |
| 70 | Increased tendency to bruise | FAERS: 3 | US FAERS | |
| 71 | Joint stiffness | FAERS: 3 | US FAERS | |
| 72 | Renal Colic | FAERS: 3 | US FAERS | |
| 73 | Stress | FAERS: 3 | US FAERS | |
| 74 | Throat irritation | FAERS: 3 | US FAERS | |
| 75 | Thrombosis | FAERS: 3 | US FAERS | |
| 76 | Abasia | FAERS: 2 | US FAERS | |
| 77 | Anosmia | FAERS: 2 | US FAERS | |
| 78 | Blood albumin decreased | FAERS: 2 | US FAERS | |
| 79 | Cystine urine present | FAERS: 2 | US FAERS | |
| 80 | Cystitis | FAERS: 2 | US FAERS | |
| 81 | Discomfort | FAERS: 2 | US FAERS | |
| 82 | Drug administration error | FAERS: 2 | US FAERS | |
| 83 | Ear discomfort | FAERS: 2 | US FAERS | |
| 84 | Erectile dysfunction | FAERS: 2 | US FAERS | |
| 85 | Hydronephrosis | FAERS: 2 | US FAERS | |
| 86 | Inappropriate schedule of drug administration | FAERS: 2 | US FAERS | |
| 87 | Lip swelling | FAERS: 2 | US FAERS | |
| 88 | Menorrhagia | FAERS: 2 | US FAERS | |
| 89 | Middle insomnia | FAERS: 2 | US FAERS | |
| 90 | Musculoskeletal stiffness | FAERS: 2 | US FAERS | |
| 91 | Neck Pain | FAERS: 2 | US FAERS | |
| 92 | Nephritis | FAERS: 2 | 3084782 | CTD US FAERS |
| 93 | Nervousness | FAERS: 2 | US FAERS | |
| 94 | Pain of skin | FAERS: 2 | US FAERS | |
| 95 | Palpitations | FAERS: 2 | US FAERS | |
| 96 | Pancreatitis | FAERS: 2 | US FAERS | |
| 97 | Sinusitis | FAERS: 2 | US FAERS | |
| 98 | Sudden death | FAERS: 2 | US FAERS | |
| 99 | Syncope | FAERS: 2 | US FAERS | |
| 100 | Therapy change | FAERS: 2 | US FAERS | |
| 101 | Tremor | FAERS: 2 | US FAERS | |
| 102 | Vertigo | FAERS: 2 | US FAERS | |
| 103 | White blood cell count decreased | FAERS: 2 | US FAERS | |
| 104 | Abdominal mass | FAERS: 1 | US FAERS | |
| 105 | Alanine Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 106 | Alcohol Intolerance | FAERS: 1 | US FAERS | |
| 107 | Altered visual depth perception | FAERS: 1 | US FAERS | |
| 108 | Arthritis | FAERS: 1 | US FAERS | |
| 109 | Aspartate Aminotransferase Increased | FAERS: 1 | US FAERS | |
| 110 | Atypical pneumonia | FAERS: 1 | US FAERS | |
| 111 | Bladder discomfort | FAERS: 1 | US FAERS | |
| 112 | Blood alkaline phosphatase increased | FAERS: 1 | US FAERS | |
| 113 | Blood creatine increased | FAERS: 1 | US FAERS | |
| 114 | Blood creatine phosphokinase increased | FAERS: 1 | US FAERS | |
| 115 | Blood glucose abnormal | FAERS: 1 | US FAERS | |
| 116 | Blood glucose decreased | FAERS: 1 | US FAERS | |
| 117 | Brain Hypoxia | FAERS: 1 | US FAERS | |
| 118 | Cardiac Flutter | FAERS: 1 | US FAERS | |
| 119 | Cataract | FAERS: 1 | US FAERS | |
| 120 | Cerebrovascular accident | FAERS: 1 | US FAERS | |
| 121 | Cheilitis | FAERS: 1 | US FAERS | |
| 122 | Choking sensation | FAERS: 1 | US FAERS | |
| 123 | Choking | FAERS: 1 | US FAERS | |
| 124 | Crying | FAERS: 1 | US FAERS | |
| 125 | Crystal urine present | FAERS: 1 | US FAERS | |
| 126 | Dacryostenosis acquired | FAERS: 1 | US FAERS | |
| 127 | Diplopia | FAERS: 1 | US FAERS | |
| 128 | Disorientation | FAERS: 1 | US FAERS | |
| 129 | Drug dispensing error | FAERS: 1 | US FAERS | |
| 130 | Dyschezia | FAERS: 1 | US FAERS | |
| 131 | Educational problem | FAERS: 1 | US FAERS | |
| 132 | Epistaxis | FAERS: 1 | US FAERS | |
| 133 | Febrile Neutropenia | FAERS: 1 | US FAERS | |
| 134 | Feeling Cold | FAERS: 1 | US FAERS | |
| 135 | Fibromyalgia | FAERS: 1 | US FAERS | |
| 136 | Fingerprint loss | FAERS: 1 | US FAERS | |
| 137 | Flat affect | FAERS: 1 | US FAERS | |
| 138 | Flushing | FAERS: 1 | US FAERS | |
| 139 | Food Allergy | FAERS: 1 | US FAERS | |
| 140 | Foreign body in respiratory tract | FAERS: 1 | US FAERS | |
| 141 | Formication | FAERS: 1 | US FAERS | |
| 142 | Gastric ulcer | FAERS: 1 | US FAERS | |
| 143 | Gastritis | FAERS: 1 | US FAERS | |
| 144 | Gastrointestinal sounds abnormal | FAERS: 1 | US FAERS | |
| 145 | Gastrointestinal ulcer | FAERS: 1 | US FAERS | |
| 146 | Genital discomfort | FAERS: 1 | US FAERS | |
| 147 | Gingivitis | FAERS: 1 | US FAERS | |
| 148 | Head discomfort | FAERS: 1 | US FAERS | |
| 149 | Hunger | FAERS: 1 | US FAERS | |
| 150 | Hypophagia | FAERS: 1 | US FAERS | |
| 151 | Hypothyroidism | FAERS: 1 | US FAERS | |
| 152 | Iatrogenic injury | FAERS: 1 | US FAERS | |
| 153 | Incontinence | FAERS: 1 | US FAERS | |
| 154 | Incorrect drug administration rate | FAERS: 1 | US FAERS | |
| 155 | Incorrect route of drug administration | FAERS: 1 | US FAERS | |
| 156 | Inflammation | FAERS: 1 | US FAERS | |
| 157 | Intentional product use issue | FAERS: 1 | US FAERS | |
| 158 | Intestinal Obstruction | FAERS: 1 | US FAERS | |
| 159 | Ketonuria | FAERS: 1 | US FAERS | |
| 160 | Laryngitis | FAERS: 1 | US FAERS | |
| 161 | Leukopenia | FAERS: 1 | SIDER US FAERS | |
| 162 | Lichen Planus | FAERS: 1 | US FAERS | |
| 163 | Limb discomfort | FAERS: 1 | US FAERS | |
| 164 | Lithotripsy | FAERS: 1 | US FAERS | |
| 165 | Lower respiratory tract congestion | FAERS: 1 | US FAERS | |
| 166 | Lyme Disease | FAERS: 1 | US FAERS | |
| 167 | Lymphoma | FAERS: 1 | US FAERS | |
| 168 | Macular degeneration | FAERS: 1 | US FAERS | |
| 169 | Memory impairment | FAERS: 1 | US FAERS | |
| 170 | Metamorphopsia | FAERS: 1 | US FAERS | |
| 171 | Multiple allergies | FAERS: 1 | US FAERS | |
| 172 | Nerve injury | FAERS: 1 | US FAERS | |
| 173 | Neuralgia | FAERS: 1 | US FAERS | |
| 174 | Neutropenia | FAERS: 1 | US FAERS | |
| 175 | Night sweats | FAERS: 1 | US FAERS | |
| 176 | Non-cardiac chest pain | FAERS: 1 | US FAERS | |
| 177 | Ocular vascular disorder | FAERS: 1 | US FAERS | |
| 178 | Oral mucosal eruption | FAERS: 1 | US FAERS | |
| 179 | Oral mucosal erythema | FAERS: 1 | US FAERS | |
| 180 | Pallor | FAERS: 1 | US FAERS | |
| 181 | Pharyngitis | FAERS: 1 | SIDER US FAERS | |
| 182 | Photophobia | FAERS: 1 | US FAERS | |
| 183 | Pneumonitis | FAERS: 1 | US FAERS | |
| 184 | Pneumothorax | FAERS: 1 | US FAERS | |
| 185 | Product use issue | FAERS: 1 | US FAERS | |
| 186 | Psoriasis | FAERS: 1 | US FAERS | |
| 187 | Pulmonary Embolism | FAERS: 1 | US FAERS | |
| 188 | Pulmonary Fibrosis | FAERS: 1 | US FAERS | |
| 189 | Pulmonary congestion | FAERS: 1 | US FAERS | |
| 190 | Pulmonary thrombosis | FAERS: 1 | US FAERS | |
| 191 | Quality of life decreased | FAERS: 1 | US FAERS | |
| 192 | Rash erythematous | FAERS: 1 | US FAERS | |
| 193 | Reaction to preservatives | FAERS: 1 | US FAERS | |
| 194 | Reduced facial expression | FAERS: 1 | US FAERS | |
| 195 | Reflux gastritis | FAERS: 1 | US FAERS | |
| 196 | Renal cyst | FAERS: 1 | US FAERS | |
| 197 | Renal mass | FAERS: 1 | US FAERS | |
| 198 | Respiratory Failure | FAERS: 1 | US FAERS | |
| 199 | Restless Legs Syndrome | FAERS: 1 | US FAERS | |
| 200 | Retching | FAERS: 1 | US FAERS | |
| 201 | Rheumatoid Arthritis | FAERS: 1 | US FAERS | |
| 202 | Sinus operation | FAERS: 1 | US FAERS | |
| 203 | Skin Papilloma | FAERS: 1 | SIDER US FAERS | |
| 204 | Skin hypertrophy | FAERS: 1 | US FAERS | |
| 205 | Splenomegaly | FAERS: 1 | US FAERS | |
| 206 | Stenosis | FAERS: 1 | US FAERS | |
| 207 | Sunburn | FAERS: 1 | US FAERS | |
| 208 | Systemic lupus erythematosus rash | FAERS: 1 | US FAERS | |
| 209 | Tachycardia | FAERS: 1 | US FAERS | |
| 210 | Therapeutic procedure | FAERS: 1 | US FAERS | |
| 211 | Therapy cessation | FAERS: 1 | US FAERS | |
| 212 | Tinnitus | FAERS: 1 | US FAERS | |
| 213 | Trichorrhexis | FAERS: 1 | US FAERS | |
| 214 | Unevaluable event | FAERS: 1 | US FAERS | |
| 215 | Ureterolithiasis | FAERS: 1 | US FAERS | |
| 216 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 217 | Urine flow decreased | FAERS: 1 | US FAERS | |
| 218 | Urine ketone body present | FAERS: 1 | US FAERS | |
| 219 | Vulvovaginal discomfort | FAERS: 1 | US FAERS | |
| 220 | Vulvovaginal pruritus | FAERS: 1 | US FAERS | |
| 221 | White blood cell count abnormal | FAERS: 1 | US FAERS | |
| 222 | furuncle | FAERS: 1 | US FAERS | |
| 223 | Abdominal bloating | SIDER | ||
| 224 | Anorexia | SIDER | ||
| 225 | Bronchiolitis | SIDER | ||
| 226 | Chemical and Drug Induced Liver Injury | 19683030 | CTD | |
| 227 | Cystinuria | 808002 6811078 | CTD | |
| 228 | Dermatitis | 3084782 | CTD SIDER | |
| 229 | Ecchymosis | SIDER | ||
| 230 | Eosinophilia | SIDER | ||
| 231 | Gastrointestinal Pain | SIDER | ||
| 232 | Lupus Erythematosus | SIDER | ||
| 233 | Muscle Weakness | 6811078 | CTD | |
| 234 | Musculoskeletal discomfort | SIDER | ||
| 235 | Myasthenic Syndrome | SIDER | ||
| 236 | Myocardial Reperfusion Injury | 8124816 | CTD | |
| 237 | Pemphigus | SIDER | ||
| 238 | Polymyositis | 10360187 | CTD | |
| 239 | Respiratory distress | SIDER | ||
| 240 | Urinary Calculi | 808002 | CTD | |
| 241 | Warts | SIDER | ||
| 242 | jaundice | SIDER |
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