MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

nimesulide

(HYWYRSMBCFDLJT-UHFFFAOYSA-N)

Structure

SMILES: [O-][N+](=O)c1ccc(c(c1)Oc1ccccc1)NS(=O)(=O)C
Type(s): Approved; Investigational; Withdrawn
ATC code(s): M01AX17; M02AA26
Molecular Formula:: C13H12N2O5S
Molecular Weight:: 308.310
Log P:: 4.4356
Hydrogen Bond Acceptor:: 4
Hydrogen Bond Donor:: 1
TPSA:: 109.6
CAS Number(s):: 51803-78-2

Synonym(s)

nimesulide

4-nitro-2-phenoxymethanesulfonanilide

Antifloxil

Aulin

Eskaflam

Guaxan

Mesulid

Nexen

Nimesil

10.

R 805

11.

R-805

12.

Redaflam

13.

lizepat

External Link(s)

MeSH	C012655
PubChem Compound	4495
BindingDB	50056999
ChEBI	44445
CHEMBL	CHEMBL56367
DrugBank	DB04743
DrugCentral	1935
IUPHAR/BPS Guide to PHARMACOLOGY	7401
KEGG	dr:D01049
Therapeutic Target Database	D03SJA D0C0JT
ZINC	4617749

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Erythema Nodosum	FAERS: 1		OFFSIDES US FAERS
2	Abdominal Pain		14655069	CTD OFFSIDES
3	Abdominal discomfort			OFFSIDES
4	Abnormal vision			OFFSIDES
5	Acidosis			OFFSIDES
6	Acute bronchitis			OFFSIDES
7	Acute psychosis			OFFSIDES
8	Acute respiratory failure			OFFSIDES
9	Adenocarcinoma		12717830	CTD
10	Airway Remodeling		21873451	CTD
11	Alanine Aminotransferase Increased			OFFSIDES
12	Altered bowel function			OFFSIDES
13	Alveolitis			OFFSIDES
14	Amphetamines			OFFSIDES
15	Anal abscess			OFFSIDES
16	Analgesia			OFFSIDES
17	Angioedema		10609620 11694026	CTD
18	Anti-SS-A antibody positive			OFFSIDES
19	Anti-SS-B antibody positive			OFFSIDES
20	Anticholinergic Syndrome			OFFSIDES
21	Apathy			OFFSIDES
22	Aphonia			OFFSIDES
23	Application site pain			OFFSIDES
24	Arrest of spermatogenesis		17624748	CTD
25	Arthritis			OFFSIDES
26	Asphyxia			OFFSIDES
27	Asthenia			OFFSIDES
28	Atrial tachycardia			OFFSIDES
29	Autoimmune hepatitis			OFFSIDES
30	Blood glucose abnormal			OFFSIDES
31	Blood iron decreased			OFFSIDES
32	Blood iron increased			OFFSIDES
33	Blood uric acid			OFFSIDES
34	Body Temperature			OFFSIDES
35	Bone erosion			OFFSIDES
36	Bone fistula			OFFSIDES
37	Bone lesion			OFFSIDES
38	Bone neoplasms		16489006	CTD
39	Bradycardia			OFFSIDES
40	Brain Abscess			OFFSIDES
41	Brain Ischemia		17564305	CTD
42	Bronchoalveolar Lavage			OFFSIDES
43	Butterfly rash			OFFSIDES
44	Cachexia		17878525	CTD
45	Cardiovascular insufficiency			OFFSIDES
46	Catalepsy		12369252	CTD
47	Cataract			OFFSIDES
48	Catatonia		19666045	CTD
49	Cervical laser therapy			OFFSIDES
50	Cervical myelopathy			OFFSIDES
51	Chemical and Drug Induced Liver Injury		View details 9696502 10731303 11126038 11549211 11573855 14655069 18049158 18524759 18558794 19053182 19362101 19772912 20405857 20457212 22107987 22509279 24136188 28437613	CTD
52	Choking sensation			OFFSIDES
53	Cholangiolitis			OFFSIDES
54	Cholestasis		View details 9696502 10220748 11126038 16720710 18672579	CTD
55	Chromaturia			OFFSIDES
56	Coagulation factor V level decreased			OFFSIDES
57	Cognition Disorders		12110471 12410334	CTD
58	Colitis		11137876	CTD
59	Colonic Neoplasms		View details 15359292 15892897 16774945 17893232	CTD
60	Colonic Stenosis			OFFSIDES
61	Colorectal Neoplasms		18349538	CTD
62	Conjunctivitis		16476901	CTD
63	Corneal dystrophy			OFFSIDES
64	Cyanosis			OFFSIDES
65	Dental prosthesis placement			OFFSIDES
66	Diarrhea		17631696	CTD
67	Disease Progression			OFFSIDES
68	Diverticulitis			OFFSIDES
69	Diverticulum			OFFSIDES
70	Drug Eruptions		10400483 11792017 15859361	CTD
71	Duodenal Ulcer			OFFSIDES
72	Duodenogastric Reflux			OFFSIDES
73	Dyschezia			OFFSIDES
74	Dysmenorrhea		20457212	CTD
75	Dyspnea		10609620	CTD
76	Edema		View details 11820457 18534634 19212002 20046705 22509279 27188793	CTD
77	Endocarditis			OFFSIDES
78	Endoscopy abnormal			OFFSIDES
79	Eosinophilia		9696502	CTD
80	Epilepsy		17604186	CTD
81	Erythema			OFFSIDES
82	Erythrodermic psoriasis			OFFSIDES
83	Eye pain			OFFSIDES
84	Facial Neuralgia			OFFSIDES
85	Fever		15859361 17345100	CTD
86	Fibrosis		11872629 21873451	CTD
87	Folliculitis			OFFSIDES
88	Formication			OFFSIDES
89	Gamma-Glutamyltransferase Increased			OFFSIDES
90	Gastrointestinal Diseases		12017396 18604318	CTD
91	Gastrointestinal Neoplasms		12717830	CTD
92	Genital Herpes			OFFSIDES
93	Globulinuria			OFFSIDES
94	Goiter		22387750	CTD
95	Head and Neck Neoplasms		15482327	CTD
96	Hepatitis B positive			OFFSIDES
97	Hepatitis		View details 10220748 11573855 14655069 17538762	CTD OFFSIDES
98	Hepatomegaly		28108177	CTD
99	Hernia			OFFSIDES
100	Hyperalgesia		View details 12208318 14506907 14506908 15799002 17377112 18534634 20601862	CTD
101	Hyperkeratosis			OFFSIDES
102	Hyperplasia		22387750	CTD
103	Hypopharyngeal Neoplasms		21176579	CTD
104	Immobile			OFFSIDES
105	Incorrect drug dosage form administered			OFFSIDES
106	Inflammation		View details 11438310 14753029 15859361 17631696 17921331 22387750	CTD
107	Infusion site mobility decreased			OFFSIDES
108	Intestinal Polyps		12189188 14991580	CTD
109	Intestinal infarction			OFFSIDES
110	Jejunal ulcer			OFFSIDES
111	Joint prosthesis user			OFFSIDES
112	Kidney Failure			OFFSIDES
113	Lethargy			OFFSIDES
114	Liver Failure, Acute		View details 10731303 11549211 17538762 18821716	CTD
115	Liver Failure		18049158	CTD
116	Liver diseases		16867024	CTD
117	Lower respiratory tract infection viral			OFFSIDES
118	Memory Disorders		16258590	CTD
119	Metabolic acidosis			OFFSIDES
120	Microalbuminuria			OFFSIDES
121	Movement Disorders		12586733 16258590 20043943	CTD
122	Multiple Sclerosis			OFFSIDES
123	Myasthenia Gravis			OFFSIDES
124	Myocardial Infarction		18426087	CTD
125	Nasal discomfort			OFFSIDES
126	Nasal inflammation			OFFSIDES
127	Necrosis		9696502 22107987	CTD
128	Neoplasm Metastasis		16489006	CTD
129	Nerve Degeneration		18481165	CTD
130	Oligohydramnios			OFFSIDES
131	Oral fungal infection			OFFSIDES
132	Osteoarthritis, Knee		12166616	CTD
133	Osteopenia			OFFSIDES
134	Overdose			OFFSIDES
135	Pain, Postoperative		14753029	CTD
136	Pain		View details 11438310 12017396 12166616 12208318 12269398 14506909 16205617 17631696 19617648 20046705	CTD OFFSIDES
137	Papilloma		19748995	CTD
138	Periarthritis			OFFSIDES
139	Peritonitis			OFFSIDES
140	Pharyngeal lesion			OFFSIDES
141	Pharyngolaryngeal Pain			OFFSIDES
142	Pneumothorax			OFFSIDES
143	Poor quality sleep			OFFSIDES
144	Post procedural complication			OFFSIDES
145	Pregnancy, Prolonged		18450957	CTD
146	Prenatal Exposure Delayed Effects		14648334 16205617	CTD
147	Pseudarthrosis			OFFSIDES
148	Pulmonary radiation injury			OFFSIDES
149	Pyuria			OFFSIDES
150	Radiotherapy to bone			OFFSIDES
151	Red blood cell rouleaux formation present			OFFSIDES
152	Reflux gastritis			OFFSIDES
153	Renal Colic			OFFSIDES
154	Renal Insufficiency		14648334	CTD
155	Renal failure neonatal			OFFSIDES
156	Respiratory Failure			OFFSIDES
157	Respiratory Tract Infections		16720710	CTD
158	Rhabdomyolysis			OFFSIDES
159	Salmonella sepsis			OFFSIDES
160	Secretion discharge			OFFSIDES
161	Seizures		View details 8872509 12618123 16629370 17139192 18178179	CTD
162	Skin Neoplasms		21159610	CTD
163	Skin lesion			OFFSIDES
164	Skin test positive			OFFSIDES
165	Soft Tissue Infection			OFFSIDES
166	Splenic Infarction			OFFSIDES
167	Spondylitis		20457212	CTD
168	Sputum culture positive			OFFSIDES
169	Stevens-Johnson Syndrome			OFFSIDES
170	Substance Withdrawal Syndrome		11976266	CTD
171	Thrombosis		15626595	CTD
172	Thyroxine free abnormal			OFFSIDES
173	Tongue Neoplasms		20043093	CTD
174	Tonsillitis			OFFSIDES
175	Tooth Avulsion			OFFSIDES
176	Tooth Extraction			OFFSIDES
177	Traumatic fracture			OFFSIDES
178	Troponin increased			OFFSIDES
179	Urinary sediment present			OFFSIDES
180	Urticaria		View details 9236499 10400483 10982225 11792017 12121561 15969659	CTD
181	Vision Disorders		16476901	CTD
182	Weight Gain			OFFSIDES
183	White blood cell count abnormal			OFFSIDES
184	Wound Debridement			OFFSIDES
185	Yawning			OFFSIDES
186	jaundice		9696502 11549211 14655069	CTD

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