apalutamide
(HJBWBFZLDZWPHF-UHFFFAOYSA-N)
Structure
- SMILES
- CNC(=O)c1ccc(cc1F)N1C(=S)N(C(=O)C21CCC2)c1cnc(c(c1)C(F)(F)F)C#N
- Type(s)
- Approved; Investigational
- ATC code(s)
- L02BB05
- Molecular Formula:
- C21H15F4N5O2S
- Molecular Weight:
- 477.435
- Log P:
- 4.0525
- Hydrogen Bond Acceptor:
- 8
- Hydrogen Bond Donor:
- 1
- TPSA:
- 121.42
- CAS Number(s):
- 956104-40-8
Synonym(s)
1.
apalutamide
2.
ARN-509
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Fatigue | FAERS: 68 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 2 | Dizziness | FAERS: 20 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 3 | Nausea | FAERS: 20 | US FAERS | |
| 4 | Therapy cessation | FAERS: 19 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 5 | Arthralgia | FAERS: 17 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 6 | Weight decreased | FAERS: 17 | US FAERS | |
| 7 | Asthenia | FAERS: 15 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 8 | Drug ineffective | FAERS: 15 | US FAERS | |
| 9 | Pruritus | FAERS: 13 | US FAERS | |
| 10 | Disease Progression | FAERS: 11 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 11 | Dysgeusia | FAERS: 9 | US FAERS | |
| 12 | Constipation | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 13 | Peripheral swelling | FAERS: 7 | US FAERS | |
| 14 | Product dose omission | FAERS: 7 | US FAERS | |
| 15 | Cerebrovascular accident | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 16 | Myocardial Infarction | FAERS: 6 | US FAERS | |
| 17 | Alopecia | FAERS: 5 | US FAERS | |
| 18 | Chest Pain | FAERS: 5 | US FAERS | |
| 19 | Dry skin | FAERS: 5 | US FAERS | |
| 20 | Headache | FAERS: 5 | US FAERS | |
| 21 | Pain | FAERS: 5 | US FAERS | |
| 22 | Product use complaint | FAERS: 5 | US FAERS | |
| 23 | Vomiting | FAERS: 5 | US FAERS | |
| 24 | Anxiety | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 25 | Back Pain | FAERS: 4 | US FAERS | |
| 26 | Flatulence | FAERS: 4 | US FAERS | |
| 27 | Hypothyroidism | FAERS: 4 | US FAERS | |
| 28 | Somnolence | FAERS: 4 | US FAERS | |
| 29 | Swelling | FAERS: 4 | US FAERS | |
| 30 | Therapy change | FAERS: 4 | US FAERS | |
| 31 | Tremor | FAERS: 4 | US FAERS | |
| 32 | Urinary tract infection | FAERS: 4 | US FAERS | |
| 33 | Abdominal discomfort | FAERS: 3 | US FAERS | |
| 34 | Dementia | FAERS: 3 | US FAERS | |
| 35 | Feeling abnormal | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 36 | Gait inability | FAERS: 3 | US FAERS | |
| 37 | Hospice Care | FAERS: 3 | US FAERS | |
| 38 | Inappropriate schedule of product administration | FAERS: 3 | US FAERS | |
| 39 | Malaise | FAERS: 3 | US FAERS | |
| 40 | Nasopharyngitis | FAERS: 3 | US FAERS | |
| 41 | Pneumonia | FAERS: 3 | US FAERS | |
| 42 | Urticaria | FAERS: 3 | US FAERS | |
| 43 | Abdominal Pain | FAERS: 2 | US FAERS | |
| 44 | Antiandrogen therapy | FAERS: 2 | US FAERS | |
| 45 | Blood testosterone increased | FAERS: 2 | US FAERS | |
| 46 | Bone pain | FAERS: 2 | US FAERS | |
| 47 | Cellulitis | FAERS: 2 | US FAERS | |
| 48 | Dehydration | FAERS: 2 | US FAERS | |
| 49 | Diverticulitis | FAERS: 2 | US FAERS | |
| 50 | Dyspepsia | FAERS: 2 | US FAERS | |
| 51 | Dysuria | FAERS: 2 | US FAERS | |
| 52 | Epistaxis | FAERS: 2 | US FAERS | |
| 53 | Hypersensitivity | FAERS: 2 | 31538772 | CTD US FAERS |
| 54 | Hypertensive crisis | FAERS: 2 | US FAERS | |
| 55 | Hypotension | FAERS: 2 | US FAERS | |
| 56 | Hypotrichosis | FAERS: 2 | US FAERS | |
| 57 | Incorrect dose administered | FAERS: 2 | US FAERS | |
| 58 | Lethargy | FAERS: 2 | US FAERS | |
| 59 | Lip swelling | FAERS: 2 | US FAERS | |
| 60 | Low density lipoprotein increased | FAERS: 2 | US FAERS | |
| 61 | Memory impairment | FAERS: 2 | US FAERS | |
| 62 | Metastasis | FAERS: 2 | US FAERS | |
| 63 | Myalgia | FAERS: 2 | US FAERS | |
| 64 | Pelvic Pain | FAERS: 2 | US FAERS | |
| 65 | Product lot number issue | FAERS: 2 | US FAERS | |
| 66 | Product size issue | FAERS: 2 | US FAERS | |
| 67 | Product solubility abnormal | FAERS: 2 | US FAERS | |
| 68 | Stevens-Johnson Syndrome | FAERS: 2 | US FAERS | |
| 69 | Throat irritation | FAERS: 2 | US FAERS | |
| 70 | Thrombosis | FAERS: 2 | US FAERS | |
| 71 | Urinary Retention | FAERS: 2 | US FAERS | |
| 72 | Acute kidney injury | FAERS: 1 | US FAERS | |
| 73 | Adverse event | FAERS: 1 | US FAERS | |
| 74 | Ageusia | FAERS: 1 | US FAERS | |
| 75 | Akinesia | FAERS: 1 | US FAERS | |
| 76 | Amnesia | FAERS: 1 | US FAERS | |
| 77 | Anger | FAERS: 1 | US FAERS | |
| 78 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 79 | Aphonia | FAERS: 1 | US FAERS | |
| 80 | Ascites | FAERS: 1 | US FAERS | |
| 81 | Ataxia | FAERS: 1 | US FAERS | |
| 82 | Bedridden | FAERS: 1 | US FAERS | |
| 83 | Blood creatinine increased | FAERS: 1 | US FAERS | |
| 84 | Blood glucose fluctuation | FAERS: 1 | US FAERS | |
| 85 | Blood glucose increased | FAERS: 1 | US FAERS | |
| 86 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 87 | Blood sodium decreased | FAERS: 1 | US FAERS | |
| 88 | Blood thyroid stimulating hormone increased | FAERS: 1 | US FAERS | |
| 89 | Blood urine present | FAERS: 1 | US FAERS | |
| 90 | Breast tenderness | FAERS: 1 | US FAERS | |
| 91 | Chills | FAERS: 1 | US FAERS | |
| 92 | Choking | FAERS: 1 | US FAERS | |
| 93 | Cholelithiasis | FAERS: 1 | US FAERS | |
| 94 | Chromaturia | FAERS: 1 | US FAERS | |
| 95 | Colitis | FAERS: 1 | US FAERS | |
| 96 | Dermatitis | FAERS: 1 | US FAERS | |
| 97 | Device occlusion | FAERS: 1 | US FAERS | |
| 98 | Drug administration error | FAERS: 1 | US FAERS | |
| 99 | Dysphonia | FAERS: 1 | US FAERS | |
| 100 | Ear discomfort | FAERS: 1 | US FAERS | |
| 101 | Elbow operation | FAERS: 1 | US FAERS | |
| 102 | Emergency Care | FAERS: 1 | US FAERS | |
| 103 | Eructation | FAERS: 1 | US FAERS | |
| 104 | Erythema | FAERS: 1 | US FAERS | |
| 105 | Extra dose administered | FAERS: 1 | US FAERS | |
| 106 | Eye inflammation | FAERS: 1 | US FAERS | |
| 107 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 108 | Hypersomnia | FAERS: 1 | US FAERS | |
| 109 | Hypophagia | FAERS: 1 | US FAERS | |
| 110 | Impaired driving ability | FAERS: 1 | US FAERS | |
| 111 | Impaired quality of life | FAERS: 1 | US FAERS | |
| 112 | Inappropriate schedule of drug administration | FAERS: 1 | US FAERS | |
| 113 | Insurance issue | FAERS: 1 | US FAERS | |
| 114 | Intentional product misuse | FAERS: 1 | US FAERS | |
| 115 | Intentional product use issue | FAERS: 1 | US FAERS | |
| 116 | Intraocular pressure test | FAERS: 1 | US FAERS | |
| 117 | Leukopenia | FAERS: 1 | US FAERS | |
| 118 | Lymphopenia | FAERS: 1 | US FAERS | |
| 119 | Malignant neoplasm progression | FAERS: 1 | US FAERS | |
| 120 | Mental impairment | FAERS: 1 | US FAERS | |
| 121 | Middle insomnia | FAERS: 1 | US FAERS | |
| 122 | Miliaria | FAERS: 1 | US FAERS | |
| 123 | Musculoskeletal Pain | FAERS: 1 | US FAERS | |
| 124 | Musculoskeletal stiffness | FAERS: 1 | US FAERS | |
| 125 | Nephrolithiasis | FAERS: 1 | US FAERS | |
| 126 | Neutropenia | FAERS: 1 | US FAERS | |
| 127 | Oropharyngeal pain | FAERS: 1 | US FAERS | |
| 128 | Pancreatitis | FAERS: 1 | US FAERS | |
| 129 | Presyncope | FAERS: 1 | US FAERS | |
| 130 | Product impurity | FAERS: 1 | US FAERS | |
| 131 | Product intolerance | FAERS: 1 | US FAERS | |
| 132 | Productive Cough | FAERS: 1 | US FAERS | |
| 133 | Psoriasis | FAERS: 1 | US FAERS | |
| 134 | Quality of life decreased | FAERS: 1 | US FAERS | |
| 135 | Rectal discharge | FAERS: 1 | US FAERS | |
| 136 | Rehabilitation therapy | FAERS: 1 | US FAERS | |
| 137 | Restless Legs Syndrome | FAERS: 1 | US FAERS | |
| 138 | Skin Ulcer | FAERS: 1 | US FAERS | |
| 139 | Squamous cell carcinoma | FAERS: 1 | US FAERS | |
| 140 | Stomatitis | FAERS: 1 | US FAERS | |
| 141 | Stress | FAERS: 1 | US FAERS | |
| 142 | Therapy non-responder | FAERS: 1 | US FAERS | |
| 143 | Thrombocytopenia | FAERS: 1 | US FAERS | |
| 144 | Tinnitus | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 145 | Toxicity to various agents | FAERS: 1 | US FAERS | |
| 146 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 147 | Visual Impairment | FAERS: 1 | US FAERS | |
| 148 | White blood cell count decreased | FAERS: 1 | US FAERS | |
| 149 | Wrong schedule | FAERS: 1 | US FAERS | |
| 150 | cancer surgery | FAERS: 1 | US FAERS | |
| 151 | Joint swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 152 | Personality Change | Canada Vigilance: 1 | Canada Vigilance | |
| 153 | Prostatic Neoplasms, Castration-Resistant | 25062956 | CTD |
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