MetaADEDB 2.0 @ LMMD
ecallantide
(VBGWSQKGUZHFPS-FHVLXVBRSA-N)
Structure
SMILES
NCCCC[C@@H]1NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]4CCCN4C(=O)[C@H](Cc4cnc[nH]4)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CCC(=O)O)CCC(=O)O)Cc3ccccc3)[C@H](CC)C)Cc3ccc(cc3)O)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2)CCC(=O)O)CCC(=O)O)CC(C)C)CO)CCC(=O)O)Cc2ccccc2)CCCNC(=N)N)CC(=O)N)CCC(=O)N)CC(=O)N)NC(=O)[C@H]2N(C(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)CCCCN)CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(=O)O)CCCNC(=N)N)[C@H](O)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)N)C)CCSC)Cc1cnc[nH]1)CO)Cc1ccccc1)C)Cc1ccccc1)CCCCN)C)CC(=O)O)CC(=O)O)CCC2)CCCNC(=N)N)C)C)Cc1c[nH]c2c1cccc2)[C@H](CC)C)[C@H](O)C
Molecular Formula:
C305H442N88O91S8
Molecular Weight:
7053.830
Log P:
3.2894
Hydrogen Bond Acceptor:
184
Hydrogen Bond Donor:
100
TPSA:
3115.35
CAS Number(s):
460738-38-9
Synonym(s)
1.
ecallantide
2.
DX 88
3.
DX-88
4.
DX-88 cpd
5.
EPI-KAL-2
6.
kalbitor
External Link(s)
MeSHC511194
PubChem Compound118984459
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 26US FAERS
2HypersensitivityFAERS: 20SIDER
US FAERS
3MalaiseFAERS: 18US FAERS
4Drug administration errorFAERS: 11US FAERS
5HeadacheFAERS: 11SIDER
US FAERS
6UrticariaFAERS: 11SIDER
US FAERS
7ErythemaFAERS: 9SIDER
US FAERS
8PainFAERS: 9SIDER
US FAERS
9VomitingFAERS: 8SIDER
US FAERS
10Extra dose administeredFAERS: 7US FAERS
11Injection site painFAERS: 7US FAERS
12PruritusFAERS: 7SIDER
US FAERS
13Abdominal PainFAERS: 6US FAERS
14BronchitisFAERS: 6US FAERS
15DizzinessFAERS: 6US FAERS
16NauseaFAERS: 6SIDER
US FAERS
17SinusitisFAERS: 6US FAERS
18AnxietyFAERS: 5US FAERS
19FatigueFAERS: 5SIDER
US FAERS
20Feeling abnormalFAERS: 5US FAERS
21PneumoniaFAERS: 5US FAERS
22SwellingFAERS: 5US FAERS
23AstheniaFAERS: 4SIDER
US FAERS
24CryingFAERS: 4US FAERS
25No adverse eventFAERS: 4US FAERS
26PallorFAERS: 4US FAERS
27Abdominal discomfortFAERS: 3US FAERS
28AppendicitisFAERS: 3US FAERS
29Chest PainFAERS: 3US FAERS
30DehydrationFAERS: 3US FAERS
31Drug ineffective for unapproved indicationFAERS: 3US FAERS
32Emotional distressFAERS: 3US FAERS
33InfluenzaFAERS: 3US FAERS
34Injection Site ReactionFAERS: 3SIDER
US FAERS
35Injection site urticariaFAERS: 3US FAERS
36Lip swellingFAERS: 3US FAERS
37Oropharyngeal painFAERS: 3US FAERS
38PancreatitisFAERS: 3US FAERS
39Peripheral swellingFAERS: 3US FAERS
40PregnancyFAERS: 3US FAERS
41StressFAERS: 3US FAERS
42SyncopeFAERS: 3US FAERS
43Throat irritationFAERS: 3US FAERS
44Adverse eventFAERS: 2US FAERS
45Anaphylactic shockFAERS: 2SIDER
US FAERS
46AphoniaFAERS: 2US FAERS
47Chest discomfortFAERS: 2US FAERS
48Device related infectionFAERS: 2US FAERS
49DysphoniaFAERS: 2US FAERS
50Expired product administeredFAERS: 2US FAERS
51Feeding disorder neonatalFAERS: 2US FAERS
52FlushingFAERS: 2US FAERS
53HysterectomyFAERS: 2US FAERS
54Inappropriate schedule of product administrationFAERS: 2US FAERS
55Incorrect route of drug administrationFAERS: 2US FAERS
56InfectionFAERS: 2US FAERS
57Injection site erythemaFAERS: 2US FAERS
58Joint swellingFAERS: 2US FAERS
59Large cell lung cancer metastaticFAERS: 2US FAERS
60Myocardial InfarctionFAERS: 2US FAERS
61Product use issueFAERS: 2US FAERS
62Pulmonary EmbolismFAERS: 2US FAERS
63SomnolenceFAERS: 2US FAERS
64AbasiaFAERS: 1US FAERS
65AbscessFAERS: 1US FAERS
66Acute endocarditisFAERS: 1US FAERS
67AgitationFAERS: 1US FAERS
68Alcohol poisoningFAERS: 1US FAERS
69AmnesiaFAERS: 1US FAERS
70AnencephalyFAERS: 1US FAERS
71Animal biteFAERS: 1US FAERS
72Apparent deathFAERS: 1US FAERS
73ArthralgiaFAERS: 1US FAERS
74ArthropathyFAERS: 1US FAERS
75AsthmaFAERS: 1US FAERS
76Atrial FibrillationFAERS: 1US FAERS
77Back PainFAERS: 1US FAERS
78Bacterial disease carrierFAERS: 1US FAERS
79Blood creatinine increasedFAERS: 1US FAERS
80Blood potassium decreasedFAERS: 1US FAERS
81Bowel movement irregularityFAERS: 1US FAERS
82Bronchial HyperreactivityFAERS: 1US FAERS
83BronchospasmFAERS: 1US FAERS
84Burning sensationFAERS: 1US FAERS
85CalcinosisFAERS: 1US FAERS
86CardiomegalyFAERS: 1US FAERS
87Cataract operationFAERS: 1US FAERS
88Catheter site infectionFAERS: 1US FAERS
89ChillsFAERS: 1US FAERS
90Compression fractureFAERS: 1US FAERS
91CyanosisFAERS: 1US FAERS
92DeliriumFAERS: 1US FAERS
93Dental cariesFAERS: 1US FAERS
94Device FailureFAERS: 1US FAERS
95Device breakageFAERS: 1US FAERS
96Device related sepsisFAERS: 1US FAERS
97DroolingFAERS: 1US FAERS
98Drug administered to patient of inappropriate ageFAERS: 1US FAERS
99Drug effect incompleteFAERS: 1US FAERS
100Drug resistanceFAERS: 1US FAERS
101DysgeusiaFAERS: 1US FAERS
102Exposure during breast feedingFAERS: 1US FAERS
103Eye laser surgeryFAERS: 1US FAERS
104FormicationFAERS: 1US FAERS
105GastritisFAERS: 1US FAERS
106GastroenteritisFAERS: 1US FAERS
107Gastrointestinal viral infectionFAERS: 1US FAERS
108General physical health deteriorationFAERS: 1US FAERS
109Inappropriate schedule of drug administrationFAERS: 1US FAERS
110IncontinenceFAERS: 1US FAERS
111Incorrect product storageFAERS: 1US FAERS
112Injection site pruritusFAERS: 1US FAERS
113Injection site warmthFAERS: 1US FAERS
114Intestinal scarringFAERS: 1US FAERS
115Joint injuryFAERS: 1US FAERS
116Ligament ruptureFAERS: 1US FAERS
117Limb discomfortFAERS: 1US FAERS
118Limb injuryFAERS: 1US FAERS
119Lip exfoliationFAERS: 1US FAERS
120Localised intraabdominal fluid collectionFAERS: 1US FAERS
121Lower respiratory tract infection fungalFAERS: 1US FAERS
122MastocytosisFAERS: 1US FAERS
123Maternal exposure during pregnancyFAERS: 1US FAERS
124Mechanical ventilationFAERS: 1US FAERS
125Mouth swellingFAERS: 1US FAERS
126MultimorbidityFAERS: 1US FAERS
127Multiple SclerosisFAERS: 1US FAERS
128Myasthenia GravisFAERS: 1US FAERS
129NephrolithiasisFAERS: 1US FAERS
130NervousnessFAERS: 1US FAERS
131NoduleFAERS: 1US FAERS
132Nonspecific reactionFAERS: 1US FAERS
133Ocular discomfortFAERS: 1US FAERS
134OsteomyelitisFAERS: 1US FAERS
135PalpitationsFAERS: 1US FAERS
136PetechiaeFAERS: 1US FAERS
137PhotophobiaFAERS: 1US FAERS
138PlasmapheresisFAERS: 1US FAERS
139PneumothoraxFAERS: 1US FAERS
140Radical hysterectomyFAERS: 1US FAERS
141Rash erythematousFAERS: 1US FAERS
142Rectal fissureFAERS: 1US FAERS
143Respiratory distressFAERS: 1US FAERS
144Respiratory tract congestionFAERS: 1US FAERS
145Retinal migraineFAERS: 1US FAERS
146Rheumatoid ArthritisFAERS: 1US FAERS
147Rotator cuff syndromeFAERS: 1US FAERS
148Septic embolusFAERS: 1US FAERS
149ShockFAERS: 1US FAERS
150Soft Tissue InfectionFAERS: 1US FAERS
151Thermal burnFAERS: 1US FAERS
152ThrombosisFAERS: 1US FAERS
153Tinea PedisFAERS: 1US FAERS
154TinnitusFAERS: 1US FAERS
155Tooth ExtractionFAERS: 1US FAERS
156Tooth repairFAERS: 1US FAERS
157TremorFAERS: 1US FAERS
158Urinary RetentionFAERS: 1US FAERS
159VIIth nerve paralysisFAERS: 1US FAERS
160Vaginal DischargeFAERS: 1US FAERS
161Visual ImpairmentFAERS: 1US FAERS
162Vital functions abnormalFAERS: 1US FAERS
163Vulvovaginal swellingFAERS: 1US FAERS
164Wrong patient received medicationFAERS: 1US FAERS
165Acquired angioedema23406939CTD
166Angioedemas, Hereditary

View details

17559913
23406939
23634741
23662043
23844784
23866957
23878046
 		CTD
167Hereditary Angioedema Type III22192969CTD
168NasopharyngitisSIDER
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