semaglutide
(DLSWIYLPEUIQAV-CCUURXOWSA-N)
Structure
- SMILES
- CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)O)CCCNC(=N)N)CCCNC(=N)N)C(C)C)CC(C)C)Cc1c[nH]c2c1cccc2)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@H]([C@H](O)C)NC(=O)CNC(=O)[C@@H](NC(=O)C(NC(=O)[C@H](Cc1[nH]cnc1)N)(C)C)CCC(=O)O)Cc1ccccc1)CO)CC(=O)O)CO)CO)Cc1ccc(cc1)O)CC(C)C)CCC(=O)O)CCC(=O)N)C)C)CCCCNC(=O)COCCOCCNC(=O)COCCOCCNC(=O)CC[C@H](C(=O)O)NC(=O)CCCCCCCCCCCCCCCCC(=O)O)CCC(=O)O)Cc1ccccc1)C
- Type(s)
- Approved; Investigational
- ATC code(s)
- A10BJ06
- Molecular Formula:
- C187H291N45O59
- Molecular Weight:
- 4113.580
- Log P:
- 5.4452
- Hydrogen Bond Acceptor:
- 102
- Hydrogen Bond Donor:
- 57
- TPSA:
- 1646.18
- CAS Number(s):
- 910463-68-2
Synonym(s)
1.
semaglutide
External Link(s)
| MeSH | C000591245 |
| PubChem Compound | 122189768 56843331 |
| BindingDB | 50121400 |
| CHEMBL | CHEMBL3616752 |
| DrugBank | DB13928 |
| IUPHAR/BPS Guide to PHARMACOLOGY | 9724 |
| Therapeutic Target Database | D02ULU |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Nausea | FAERS: 263 Canada Vigilance: 9 | Canada Vigilance US FAERS | |
| 2 | Vomiting | FAERS: 148 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 3 | Blood glucose increased | FAERS: 93 | US FAERS | |
| 4 | Constipation | FAERS: 47 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 5 | Headache | FAERS: 42 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 6 | Abdominal Pain | FAERS: 41 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 7 | Wrong technique in product usage process | FAERS: 37 | US FAERS | |
| 8 | Weight decreased | FAERS: 33 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 9 | Product dispensing error | FAERS: 32 | US FAERS | |
| 10 | Dehydration | FAERS: 26 | US FAERS | |
| 11 | Incorrect dose administered | FAERS: 26 | US FAERS | |
| 12 | Dyspepsia | FAERS: 25 | US FAERS | |
| 13 | Eructation | FAERS: 25 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 14 | Inappropriate schedule of drug administration | FAERS: 25 | US FAERS | |
| 15 | Inappropriate schedule of product administration | FAERS: 25 | US FAERS | |
| 16 | Dizziness | FAERS: 24 | US FAERS | |
| 17 | Pancreatitis | FAERS: 24 Canada Vigilance: 6 | Canada Vigilance US FAERS | |
| 18 | Blood glucose decreased | FAERS: 23 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 19 | Product use issue | FAERS: 23 | US FAERS | |
| 20 | Abdominal discomfort | FAERS: 22 | US FAERS | |
| 21 | Drug ineffective | FAERS: 21 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 22 | Malaise | FAERS: 21 | US FAERS | |
| 23 | Fatigue | FAERS: 19 | US FAERS | |
| 24 | Drug dispensing error | FAERS: 17 | US FAERS | |
| 25 | Drug titration error | FAERS: 17 | US FAERS | |
| 26 | Extra dose administered | FAERS: 17 | US FAERS | |
| 27 | Product use in unapproved indication | FAERS: 16 | US FAERS | |
| 28 | Drug dose titration not performed | FAERS: 15 | US FAERS | |
| 29 | Intercepted drug dispensing error | FAERS: 14 | US FAERS | |
| 30 | Product prescribing error | FAERS: 14 | US FAERS | |
| 31 | Back Pain | FAERS: 13 | US FAERS | |
| 32 | Injection site pain | FAERS: 13 | US FAERS | |
| 33 | Dysgeusia | FAERS: 12 | US FAERS | |
| 34 | Pain | FAERS: 12 | US FAERS | |
| 35 | Chest Pain | FAERS: 11 | US FAERS | |
| 36 | Intercepted product dispensing error | FAERS: 11 | US FAERS | |
| 37 | Arthralgia | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 38 | Asthenia | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 39 | Flatulence | FAERS: 10 | US FAERS | |
| 40 | Diabetes mellitus inadequate control | FAERS: 9 | US FAERS | |
| 41 | Injection site mass | FAERS: 9 | US FAERS | |
| 42 | Palpitations | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 43 | Drug dose omission | FAERS: 8 | US FAERS | |
| 44 | Injection Site Reaction | FAERS: 8 | US FAERS | |
| 45 | Injection site erythema | FAERS: 7 | US FAERS | |
| 46 | Myalgia | FAERS: 7 | US FAERS | |
| 47 | Urticaria | FAERS: 7 | US FAERS | |
| 48 | Device malfunction | FAERS: 6 | US FAERS | |
| 49 | Diabetic Ketoacidosis | FAERS: 6 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 50 | Drug prescribing error | FAERS: 6 | US FAERS | |
| 51 | Feeling abnormal | FAERS: 6 | US FAERS | |
| 52 | Impaired gastric emptying | FAERS: 6 | US FAERS | |
| 53 | Lipase increased | FAERS: 6 | US FAERS | |
| 54 | Neck Pain | FAERS: 6 | US FAERS | |
| 55 | Product label confusion | FAERS: 6 | US FAERS | |
| 56 | Tremor | FAERS: 6 | US FAERS | |
| 57 | Visual Impairment | FAERS: 6 | US FAERS | |
| 58 | Accidental overdose | FAERS: 5 | US FAERS | |
| 59 | Acute kidney injury | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 60 | Anxiety | FAERS: 5 | US FAERS | |
| 61 | Diabetic Retinopathy | FAERS: 5 | US FAERS | |
| 62 | Intentional product misuse | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 63 | Intercepted product prescribing error | FAERS: 5 | US FAERS | |
| 64 | Product communication issue | FAERS: 5 | US FAERS | |
| 65 | Product quality issue | FAERS: 5 | US FAERS | |
| 66 | Pruritus | FAERS: 5 | US FAERS | |
| 67 | Retching | FAERS: 5 | US FAERS | |
| 68 | Urinary tract infection | FAERS: 5 | US FAERS | |
| 69 | Chest discomfort | FAERS: 4 | US FAERS | |
| 70 | Chills | FAERS: 4 | US FAERS | |
| 71 | Hyperchlorhydria | FAERS: 4 | US FAERS | |
| 72 | Influenza | FAERS: 4 | US FAERS | |
| 73 | Injection site extravasation | FAERS: 4 | US FAERS | |
| 74 | Injury associated with device | FAERS: 4 | US FAERS | |
| 75 | Myocardial Infarction | FAERS: 4 | US FAERS | |
| 76 | Overdose | FAERS: 4 | US FAERS | |
| 77 | Product dose omission | FAERS: 4 | US FAERS | |
| 78 | Alopecia | FAERS: 3 | US FAERS | |
| 79 | Angioedema | FAERS: 3 | US FAERS | |
| 80 | Chromaturia | FAERS: 3 | US FAERS | |
| 81 | Cold sweat | FAERS: 3 | US FAERS | |
| 82 | Device Failure | FAERS: 3 | US FAERS | |
| 83 | Device leakage | FAERS: 3 | US FAERS | |
| 84 | Discomfort | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 85 | Diverticulitis | FAERS: 3 | US FAERS | |
| 86 | Hunger | FAERS: 3 | US FAERS | |
| 87 | Hypersensitivity | FAERS: 3 | US FAERS | |
| 88 | Hypophagia | FAERS: 3 | US FAERS | |
| 89 | Hypotension | FAERS: 3 | US FAERS | |
| 90 | Lethargy | FAERS: 3 | US FAERS | |
| 91 | Needle issue | FAERS: 3 | US FAERS | |
| 92 | Nephrolithiasis | FAERS: 3 | US FAERS | |
| 93 | Pain of skin | FAERS: 3 | US FAERS | |
| 94 | Photophobia | FAERS: 3 | US FAERS | |
| 95 | Product storage error | FAERS: 3 | US FAERS | |
| 96 | Somnolence | FAERS: 3 | US FAERS | |
| 97 | Amylase increased | FAERS: 2 | US FAERS | |
| 98 | Anhedonia | FAERS: 2 | US FAERS | |
| 99 | Arthritis | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 100 | Atrial Fibrillation | FAERS: 2 | US FAERS | |
| 101 | Blindness | FAERS: 2 | US FAERS | |
| 102 | Blood creatine increased | FAERS: 2 | US FAERS | |
| 103 | Blood creatinine increased | FAERS: 2 | US FAERS | |
| 104 | Burning sensation | FAERS: 2 | US FAERS | |
| 105 | Cholangitis | FAERS: 2 | US FAERS | |
| 106 | Cholecystitis | FAERS: 2 | US FAERS | |
| 107 | Cholelithiasis | FAERS: 2 | US FAERS | |
| 108 | Conjunctivitis | FAERS: 2 | US FAERS | |
| 109 | Dry skin | FAERS: 2 | US FAERS | |
| 110 | Erythema | FAERS: 2 | US FAERS | |
| 111 | Feeling jittery | FAERS: 2 | US FAERS | |
| 112 | Gastric pH decreased | FAERS: 2 | US FAERS | |
| 113 | Gastroenteritis | FAERS: 2 | US FAERS | |
| 114 | Glaucoma | FAERS: 2 | US FAERS | |
| 115 | Hyperacusis | FAERS: 2 | US FAERS | |
| 116 | Incorrect dose administered by device | FAERS: 2 | US FAERS | |
| 117 | Injection site bruising | FAERS: 2 | US FAERS | |
| 118 | Injection site hypersensitivity | FAERS: 2 | US FAERS | |
| 119 | Injection site urticaria | FAERS: 2 | US FAERS | |
| 120 | Intercepted drug prescribing error | FAERS: 2 | US FAERS | |
| 121 | Limb discomfort | FAERS: 2 | US FAERS | |
| 122 | Mesenteric Panniculitis | FAERS: 2 | US FAERS | |
| 123 | Musculoskeletal Pain | FAERS: 2 | US FAERS | |
| 124 | Musculoskeletal chest pain | FAERS: 2 | US FAERS | |
| 125 | Oropharyngeal pain | FAERS: 2 | US FAERS | |
| 126 | Pancreatic carcinoma | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 127 | Peripheral swelling | FAERS: 2 | US FAERS | |
| 128 | Pneumonia | FAERS: 2 | US FAERS | |
| 129 | Product dosage form confusion | FAERS: 2 | US FAERS | |
| 130 | Product packaging confusion | FAERS: 2 | US FAERS | |
| 131 | Renal pain | FAERS: 2 | US FAERS | |
| 132 | Retinal Detachment | FAERS: 2 | US FAERS | |
| 133 | Sexual Dysfunction | FAERS: 2 | US FAERS | |
| 134 | Skin discomfort | FAERS: 2 | US FAERS | |
| 135 | Syncope | FAERS: 2 | US FAERS | |
| 136 | Thirst | FAERS: 2 | US FAERS | |
| 137 | Vertigo | FAERS: 2 | US FAERS | |
| 138 | Accidental exposure to product | FAERS: 1 | US FAERS | |
| 139 | Acne | FAERS: 1 | US FAERS | |
| 140 | Acute myocardial infarction | FAERS: 1 | US FAERS | |
| 141 | Ageusia | FAERS: 1 | US FAERS | |
| 142 | Agitation | FAERS: 1 | US FAERS | |
| 143 | Amnesia | FAERS: 1 | US FAERS | |
| 144 | Angina Pectoris | FAERS: 1 | US FAERS | |
| 145 | Anorectal discomfort | FAERS: 1 | US FAERS | |
| 146 | Arthropod sting | FAERS: 1 | US FAERS | |
| 147 | Back disorder | FAERS: 1 | US FAERS | |
| 148 | Blood glucose abnormal | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 149 | Blood glucose fluctuation | FAERS: 1 | US FAERS | |
| 150 | Blood magnesium decreased | FAERS: 1 | US FAERS | |
| 151 | Blood potassium decreased | FAERS: 1 | US FAERS | |
| 152 | Blood pressure fluctuation | FAERS: 1 | US FAERS | |
| 153 | Blood sodium decreased | FAERS: 1 | US FAERS | |
| 154 | Blood triglycerides increased | FAERS: 1 | US FAERS | |
| 155 | Blood urine present | FAERS: 1 | US FAERS | |
| 156 | Bone pain | FAERS: 1 | US FAERS | |
| 157 | Cardiac Arrest | FAERS: 1 | US FAERS | |
| 158 | Cataract | FAERS: 1 | US FAERS | |
| 159 | Cellulitis | FAERS: 1 | US FAERS | |
| 160 | Cerebrovascular accident | FAERS: 1 | US FAERS | |
| 161 | Cheilitis | FAERS: 1 | US FAERS | |
| 162 | Chemical burn of skin | FAERS: 1 | US FAERS | |
| 163 | Circumstance or information capable of leading to medication error | FAERS: 1 | US FAERS | |
| 164 | Clostridium difficile infection | FAERS: 1 | US FAERS | |
| 165 | Dark circles under eyes | FAERS: 1 | US FAERS | |
| 166 | Deafness | FAERS: 1 | US FAERS | |
| 167 | Depressed Level of Consciousness | FAERS: 1 | US FAERS | |
| 168 | Device breakage | FAERS: 1 | US FAERS | |
| 169 | Device dispensing error | FAERS: 1 | US FAERS | |
| 170 | Device use issue | FAERS: 1 | US FAERS | |
| 171 | Diplopia | FAERS: 1 | US FAERS | |
| 172 | Drug dose omission by device | FAERS: 1 | US FAERS | |
| 173 | Dyschezia | FAERS: 1 | US FAERS | |
| 174 | Dysuria | FAERS: 1 | US FAERS | |
| 175 | Enzyme level increased | FAERS: 1 | US FAERS | |
| 176 | Epigastric discomfort | FAERS: 1 | US FAERS | |
| 177 | Eye irritation | FAERS: 1 | US FAERS | |
| 178 | Eye pain | FAERS: 1 | US FAERS | |
| 179 | Feeling Cold | FAERS: 1 | US FAERS | |
| 180 | Feelings of worthlessness | FAERS: 1 | US FAERS | |
| 181 | Fibromyalgia | FAERS: 1 | US FAERS | |
| 182 | Gastritis | FAERS: 1 | US FAERS | |
| 183 | Gastrointestinal sounds abnormal | FAERS: 1 | US FAERS | |
| 184 | Grip strength decreased | FAERS: 1 | US FAERS | |
| 185 | Hair growth rate abnormal | FAERS: 1 | US FAERS | |
| 186 | Hepatitis C | FAERS: 1 | US FAERS | |
| 187 | Hypothyroidism | FAERS: 1 | US FAERS | |
| 188 | Ileus | FAERS: 1 | US FAERS | |
| 189 | Incorrect route of drug administration | FAERS: 1 | US FAERS | |
| 190 | Injection related reaction | FAERS: 1 | US FAERS | |
| 191 | Injection site injury | FAERS: 1 | US FAERS | |
| 192 | Injection site pruritus | FAERS: 1 | US FAERS | |
| 193 | Intentional product use issue | FAERS: 1 | US FAERS | |
| 194 | Intercepted product administration error | FAERS: 1 | US FAERS | |
| 195 | Intestinal Obstruction | FAERS: 1 | US FAERS | |
| 196 | Intra-abdominal fluid collection | FAERS: 1 | US FAERS | |
| 197 | Intraductal papillary mucinous neoplasm | FAERS: 1 | US FAERS | |
| 198 | Ketoacidosis | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 199 | Ketosis | FAERS: 1 | US FAERS | |
| 200 | Laryngitis | FAERS: 1 | US FAERS | |
| 201 | Limb injury | FAERS: 1 | US FAERS | |
| 202 | Lyme Disease | FAERS: 1 | US FAERS | |
| 203 | Lymphadenopathy | FAERS: 1 | US FAERS | |
| 204 | Macular degeneration | FAERS: 1 | US FAERS | |
| 205 | Memory impairment | FAERS: 1 | US FAERS | |
| 206 | Metrorrhagia | FAERS: 1 | US FAERS | |
| 207 | Monoplegia | FAERS: 1 | US FAERS | |
| 208 | Muscle Rigidity | FAERS: 1 | US FAERS | |
| 209 | Nasopharyngitis | FAERS: 1 | US FAERS | |
| 210 | Necrotising myositis | FAERS: 1 | US FAERS | |
| 211 | Nervousness | FAERS: 1 | US FAERS | |
| 212 | Neuralgia | FAERS: 1 | US FAERS | |
| 213 | Pallor | FAERS: 1 | US FAERS | |
| 214 | Pancreatic Cyst | FAERS: 1 | US FAERS | |
| 215 | Pancreatic Pseudocyst | FAERS: 1 | US FAERS | |
| 216 | Pancytopenia | FAERS: 1 | US FAERS | |
| 217 | Presyncope | FAERS: 1 | US FAERS | |
| 218 | Product complaint | FAERS: 1 | US FAERS | |
| 219 | Product design confusion | FAERS: 1 | US FAERS | |
| 220 | Pulmonary congestion | FAERS: 1 | US FAERS | |
| 221 | Radiotherapy to brain | FAERS: 1 | US FAERS | |
| 222 | Regurgitation | FAERS: 1 | US FAERS | |
| 223 | Renal mass | FAERS: 1 | US FAERS | |
| 224 | Retroperitoneal mass | FAERS: 1 | US FAERS | |
| 225 | Saliva altered | FAERS: 1 | US FAERS | |
| 226 | Scab | FAERS: 1 | US FAERS | |
| 227 | Sinus headache | FAERS: 1 | US FAERS | |
| 228 | Skin weeping | FAERS: 1 | US FAERS | |
| 229 | Stent malfunction | FAERS: 1 | US FAERS | |
| 230 | Stomatitis | FAERS: 1 | US FAERS | |
| 231 | Stress | FAERS: 1 | US FAERS | |
| 232 | Sudden onset of sleep | FAERS: 1 | US FAERS | |
| 233 | Swelling | FAERS: 1 | US FAERS | |
| 234 | Therapy cessation | FAERS: 1 | US FAERS | |
| 235 | Therapy change | FAERS: 1 | US FAERS | |
| 236 | Therapy non-responder | FAERS: 1 | US FAERS | |
| 237 | Thirst decreased | FAERS: 1 | US FAERS | |
| 238 | Thrombosis | FAERS: 1 | US FAERS | |
| 239 | Thyroid hormones increased | FAERS: 1 | US FAERS | |
| 240 | Unintentional use for unapproved indication | FAERS: 1 | US FAERS | |
| 241 | Upper-airway cough syndrome | FAERS: 1 | US FAERS | |
| 242 | Urinary Incontinence | FAERS: 1 | US FAERS | |
| 243 | Urinary Retention | FAERS: 1 | US FAERS | |
| 244 | Urine flow decreased | FAERS: 1 | US FAERS | |
| 245 | Urine ketone body present | FAERS: 1 | US FAERS | |
| 246 | Wrong technique in device usage process | FAERS: 1 | US FAERS | |
| 247 | colonoscopy | FAERS: 1 | US FAERS | |
| 248 | jaundice | FAERS: 1 | US FAERS | |
| 249 | Drug withdrawal syndrome | Canada Vigilance: 1 | Canada Vigilance | |
| 250 | Gastrointestinal carcinoma | Canada Vigilance: 1 | Canada Vigilance | |
| 251 | Lip swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 252 | Osteomyelitis | Canada Vigilance: 1 | Canada Vigilance | |
| 253 | Ulcer | Canada Vigilance: 1 | Canada Vigilance | |
| 254 | intensive care | Canada Vigilance: 1 | Canada Vigilance |
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