MetaADEDB 2.0 @ LMMD
Pentostatin
(FPVKHBSQESCIEP-JQCXWYLXSA-N)
Structure
SMILES
OC[C@H]1O[C@H](C[C@@H]1O)n1cnc2c1NC=NC[C@H]2O
Type(s)
Approved; Investigational
ATC code(s)
L01XX08
Molecular Formula:
C11H16N4O4
Molecular Weight:
268.269
Log P:
-1.4154
Hydrogen Bond Acceptor:
8
Hydrogen Bond Donor:
4
TPSA:
112.13
CAS Number(s):
53910-25-1
Synonym(s)
1.
Pentostatin
2.
2'-Deoxycoformycin
3.
CI-825
4.
Co-Vidarabine
5.
Deoxycoformycin
6.
Imidazo(4,5-d)(1,3)diazepin-8-ol, 3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydro-, (R)-
7.
NSC-218321
8.
Nipent
9.
2' Deoxycoformycin
10.
CI 825
11.
CI825
12.
NSC 218321
13.
NSC218321
External Link(s)
MeSHD015649
PubChem Compound439693
BindingDB223291
22925
CHEMBLCHEMBL1580
DrugBankDB00552
DrugCentral2098
IUPHAR/BPS Guide to PHARMACOLOGY4805
KEGGcpd:C02267
dr:D00155
Therapeutic Target DatabaseD0T3AD
ZINC3806262
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Abdominal PainFAERS: 5SIDER
US FAERS
2AstheniaFAERS: 5SIDER
US FAERS
3Respiratory FailureFAERS: 5US FAERS
4Septic ShockFAERS: 5US FAERS
5HeadacheFAERS: 4SIDER
US FAERS
6Respiratory distressFAERS: 4US FAERS
7Basal cell carcinomaFAERS: 3US FAERS
8Blood alkaline phosphatase increasedFAERS: 3US FAERS
9Bronchopulmonary AspergillosisFAERS: 3US FAERS
10CellulitisFAERS: 3SIDER
US FAERS
11CholelithiasisFAERS: 3US FAERS
12Diffuse Large B-Cell LymphomaFAERS: 3US FAERS
13General physical health deteriorationFAERS: 3US FAERS
14NauseaFAERS: 3SIDER
US FAERS
15AgranulocytosisFAERS: 2SIDER
US FAERS
16Alanine Aminotransferase IncreasedFAERS: 2US FAERS
17AnorexiaFAERS: 2SIDER
US FAERS
18AnxietyFAERS: 2SIDER
US FAERS
19Aspartate Aminotransferase IncreasedFAERS: 2US FAERS
20Atrial FibrillationFAERS: 2US FAERS
21Biopsy liver abnormalFAERS: 2US FAERS
22Chest PainFAERS: 2SIDER
US FAERS
23ChillsFAERS: 2SIDER
US FAERS
24DehydrationFAERS: 2US FAERS
25Diabetes mellitus inadequate controlFAERS: 2US FAERS
26Febrile NeutropeniaFAERS: 2US FAERS
27HepatomegalyFAERS: 2US FAERS
28Mental status changesFAERS: 2US FAERS
29MyalgiaFAERS: 2SIDER
US FAERS
30NeutropeniaFAERS: 2US FAERS
31PancytopeniaFAERS: 2US FAERS
32PneumoniaFAERS: 2SIDER
US FAERS
33SplenomegalyFAERS: 2US FAERS
34ThrombocytopeniaFAERS: 2SIDER
US FAERS
35VomitingFAERS: 2SIDER
US FAERS
36White blood cell count decreasedFAERS: 2US FAERS
37Acute kidney injuryFAERS: 111219485CTD
US FAERS
38AmnesiaFAERS: 1SIDER
US FAERS
39Ankylosing spondylitisFAERS: 1US FAERS
40Atrial FlutterFAERS: 1US FAERS
41Bacterial sepsisFAERS: 1US FAERS
42BlindnessFAERS: 1US FAERS
43Blood creatinine increasedFAERS: 1SIDER
US FAERS
44Blood glucose fluctuationFAERS: 1US FAERS
45Blood stem cell transplant failureFAERS: 1US FAERS
46Bone painFAERS: 1US FAERS
47Cerebrovascular accidentFAERS: 1US FAERS
48Complications of transplant surgeryFAERS: 1US FAERS
49Cytomegalovirus antigen positiveFAERS: 1US FAERS
50Cytomegalovirus test positiveFAERS: 1US FAERS
51Deep Vein ThrombosisFAERS: 1US FAERS
52Delayed engraftmentFAERS: 1US FAERS
53Depressed Level of ConsciousnessFAERS: 1US FAERS
54Disease ProgressionFAERS: 1US FAERS
55DisorientationFAERS: 1US FAERS
56Disseminated Intravascular CoagulationFAERS: 1US FAERS
57Epstein-Barr virus antibody positiveFAERS: 1US FAERS
58Erythema NodosumFAERS: 1US FAERS
59Failure to ThriveFAERS: 1US FAERS
60FolliculitisFAERS: 1US FAERS
61Glasgow coma scale abnormalFAERS: 1US FAERS
62HyperpyrexiaFAERS: 1US FAERS
63HypotensionFAERS: 1SIDER
US FAERS
64Impaired driving abilityFAERS: 1US FAERS
65InfectionFAERS: 1SIDER
US FAERS
66Intentional self-injuryFAERS: 1US FAERS
67LethargyFAERS: 1US FAERS
68Lobar PneumoniaFAERS: 1US FAERS
69Lung consolidationFAERS: 1US FAERS
70Lung squamous cell carcinoma stage IFAERS: 1US FAERS
71LymphadenopathyFAERS: 1US FAERS
72MalaiseFAERS: 1US FAERS
73Malignant neoplasm progressionFAERS: 1US FAERS
74Mantle cell lymphomaFAERS: 1US FAERS
75Memory impairmentFAERS: 1US FAERS
76Metabolic acidosisFAERS: 1US FAERS
77MetastasisFAERS: 1US FAERS
78Multiple MyelomaFAERS: 1US FAERS
79MyelitisFAERS: 1US FAERS
80Nephritis allergicFAERS: 1US FAERS
81Neutrophil count decreasedFAERS: 1US FAERS
82Nonspecific reactionFAERS: 1US FAERS
83PainFAERS: 1SIDER
US FAERS
84PalpitationsFAERS: 1US FAERS
85Pancreatic InsufficiencyFAERS: 1US FAERS
86Pericardial effusionFAERS: 1SIDER
US FAERS
87PseudosarcomaFAERS: 1US FAERS
88Respiratory arrestFAERS: 1US FAERS
89SarcoidosisFAERS: 1US FAERS
90SepsisFAERS: 1SIDER
US FAERS
91Squamous cell carcinomaFAERS: 1US FAERS
92Stem cell transplantFAERS: 1US FAERS
93Subacute combined cord degenerationFAERS: 1US FAERS
94Superinfection bacterialFAERS: 1US FAERS
95SuperinfectionFAERS: 1US FAERS
96Therapy non-responderFAERS: 1US FAERS
97Thrombocytopenic purpuraFAERS: 1US FAERS
98Unresponsive to stimuliFAERS: 1US FAERS
99VasculitisFAERS: 1SIDER
US FAERS
100Visual disturbanceFAERS: 1US FAERS
101Weight decreasedFAERS: 1US FAERS
102White matter lesionFAERS: 1US FAERS
103jaundiceFAERS: 1US FAERS
104Abnormal visionSIDER
105AbscessSIDER
106AcneSIDER
107AgitationSIDER
108AlopeciaSIDER
109AmblyopiaSIDER
110Angina PectorisSIDER
111ArthralgiaSIDER
112ArthritisSIDER
113AsthmaSIDER
114AtaxiaSIDER
115Atrioventricular BlockSIDER
116BradycardiaSIDER
117BronchitisSIDER
118BronchospasmSIDER
119CNS toxicitySIDER
120Cardiac ArrestSIDER
121ConjunctivitisSIDER
122ConstipationSIDER
123Creatinine increasedSIDER
124DeafnessSIDER
125DermatitisSIDER
126DizzinessSIDER
127Dry skinSIDER
128DysarthriaSIDER
129DyspepsiaSIDER
130EczemaSIDER
131EncephalitisSIDER
132Erectile dysfunctionSIDER
133FatigueSIDER
134Feeling abnormalSIDER
135FlatulenceSIDER
136FurunculosisSIDER
137Gastrointestinal PainSIDER
138GingivitisSIDER
139GlossitisSIDER
140GoutSIDER
141Heart Diseases8241979CTD
142HostilitySIDER
143HyperkinesiaSIDER
144HypersensitivitySIDER
145IleusSIDER
146Influenza-like symptomsSIDER
147LabyrinthitisSIDER
148Lacrimal structural disorderSIDER
149LeukopeniaSIDER
150MeningismSIDER
151Mood swingsSIDER
152Musculoskeletal discomfortSIDER
153NephrolithiasisSIDER
154NervousnessSIDER
155NeuralgiaSIDER
156NeuritisSIDER
157NeuropathySIDER
158OsteomyelitisSIDER
159PetechiaeSIDER
160PharyngitisSIDER
161PhlebitisSIDER
162PhotophobiaSIDER
163PruritusSIDER
164Pulmonary EmbolismSIDER
165RhinitisSIDER
166ShockSIDER
167SinusitisSIDER
168SomnolenceSIDER
169StomatitisSIDER
170SweatingSIDER
171SyncopeSIDER
172TachycardiaSIDER
173TensionSIDER
174ThrombophlebitisSIDER
175TinnitusSIDER
176Urinary tract infectionSIDER
177UrticariaSIDER
178UveitisSIDER
179VertigoSIDER
180Visual ImpairmentSIDER
181furuncleSIDER
182nervous system disorderSIDER
Powered by :

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234

Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.