defibrotide
(JNWFIPVDEINBAI-UHFFFAOYSA-N)
Structure
- SMILES
- Oc1cc(OP(=O)(O)O)c(cc1c1n[nH]c(=O)n1c1ccc2c(c1)ccn2C)C(C)C
- Molecular Formula:
- C20H21N4O6P
- Molecular Weight:
- 444.378
- Log P:
- 3.0198
- Hydrogen Bond Acceptor:
- 9
- Hydrogen Bond Donor:
- 4
- TPSA:
- 152.41
- CAS Number(s):
- 83712-60-1; 1118915-78-8
Synonym(s)
1.
defibrotide
2.
Defitelio
3.
JZP-381
4.
JZP381
5.
defibrinotide
6.
defibrotide (bovine)
7.
defibrotide sodium
External Link(s)
| MeSH | C036901 |
| PubChem Compound | 135565962 |
| BindingDB | 176684 |
| CHEMBL | CHEMBL3674153 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Blood creatinine increased | FAERS: 1 | US FAERS | |
| 2 | Bradycardia | FAERS: 1 | US FAERS | |
| 3 | Feeling jittery | FAERS: 1 | US FAERS | |
| 4 | Nausea | FAERS: 1 | US FAERS | |
| 5 | Proteinuria | FAERS: 1 | US FAERS | |
| 6 | Venoocclusive disease | FAERS: 1 | US FAERS | |
| 7 | Vomiting | FAERS: 1 | US FAERS | |
| 8 | Antiphospholipid Syndrome | 12233899 | CTD | |
| 9 | Hepatic Veno-Occlusive Disease | 18696182 | CTD | |
| 10 | Intermittent Claudication | 10823260 | CTD | |
| 11 | Shock, Hemorrhagic | 3063971 | CTD | |
| 12 | Vascular Diseases | 12750969 | CTD |
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