Mefloquine
(WESWYMRNZNDGBX-YLCXCWDSSA-N)
Structure
- SMILES
- O[C@@H](c1cc(nc2c1cccc2C(F)(F)F)C(F)(F)F)[C@H]1CCCCN1.Cl
- Molecular Formula:
- C17H17ClF6N2O
- Molecular Weight:
- 414.773
- Log P:
- 5.5787
- Hydrogen Bond Acceptor:
- 3
- Hydrogen Bond Donor:
- 3
- TPSA:
- 45.15
- CAS Number(s):
- 51742-86-0; 51773-92-3
Synonym(s)
1.
Mefloquine
2.
Lariam
3.
Mefloquine Hydrochloride
4.
Mephloquine
5.
Ro-21-5998-001
6.
WR-142,490
7.
WR-177,602
8.
Ro 21 5998 001
9.
Ro215998001
10.
WR 142,490
11.
WR 177,602
12.
WR142,490
13.
WR177,602
External Link(s)
| MeSH | D015767 |
| PubChem Compound | 65329 |
| ChEBI | 6719 |
| CHEMBL | CHEMBL1606 |
| KEGG | dr:D00831 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Anxiety | FAERS: 32 Canada Vigilance: 7 | Canada Vigilance US FAERS | |
| 2 | Dizziness | FAERS: 16 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 3 | Headache | FAERS: 16 | US FAERS | |
| 4 | Paranoia | FAERS: 15 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 5 | Nausea | FAERS: 12 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 6 | Amnesia | FAERS: 10 | US FAERS | |
| 7 | Tinnitus | FAERS: 9 | US FAERS | |
| 8 | Delirium | FAERS: 8 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 9 | Mood swings | FAERS: 8 | US FAERS | |
| 10 | Palpitations | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 11 | Personality Change | FAERS: 7 | US FAERS | |
| 12 | Agitation | FAERS: 6 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 13 | Emotional disorder | FAERS: 6 | US FAERS | |
| 14 | Fatigue | FAERS: 6 | US FAERS | |
| 15 | Feeling abnormal | FAERS: 6 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 16 | Nephrotic Syndrome | FAERS: 6 | US FAERS | |
| 17 | Vertigo | FAERS: 6 | US FAERS | |
| 18 | Anger | FAERS: 5 | US FAERS | |
| 19 | Memory impairment | FAERS: 5 | US FAERS | |
| 20 | Restlessness | FAERS: 5 | US FAERS | |
| 21 | Tremor | FAERS: 5 | US FAERS | |
| 22 | Visual Impairment | FAERS: 5 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 23 | Vomiting | FAERS: 5 | US FAERS | |
| 24 | Asthenia | FAERS: 4 | US FAERS | |
| 25 | Blood creatinine increased | FAERS: 4 | US FAERS | |
| 26 | Crying | FAERS: 4 | US FAERS | |
| 27 | Lethargy | FAERS: 4 | US FAERS | |
| 28 | Toxicity to various agents | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 29 | Weight decreased | FAERS: 4 | US FAERS | |
| 30 | Abasia | FAERS: 3 | US FAERS | |
| 31 | Arthralgia | FAERS: 3 | US FAERS | |
| 32 | Chest discomfort | FAERS: 3 | US FAERS | |
| 33 | Chills | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 34 | Deafness | FAERS: 3 | US FAERS | |
| 35 | Disorientation | FAERS: 3 | US FAERS | |
| 36 | Flight of ideas | FAERS: 3 | US FAERS | |
| 37 | Impaired work ability | FAERS: 3 | US FAERS | |
| 38 | Malaise | FAERS: 3 | US FAERS | |
| 39 | Pain | FAERS: 3 | US FAERS | |
| 40 | Poisoning | FAERS: 3 | US FAERS | |
| 41 | Postural Orthostatic Tachycardia Syndrome | FAERS: 3 | US FAERS | |
| 42 | Apathy | FAERS: 2 | US FAERS | |
| 43 | Aphasia | FAERS: 2 | US FAERS | |
| 44 | Depressed Level of Consciousness | FAERS: 2 | US FAERS | |
| 45 | Depressed mood | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 46 | Drug ineffective | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 47 | Drug toxicity | FAERS: 2 | US FAERS | |
| 48 | Emotional poverty | FAERS: 2 | US FAERS | |
| 49 | Feeling jittery | FAERS: 2 | US FAERS | |
| 50 | Flushing | FAERS: 2 | US FAERS | |
| 51 | Hallucinations, mixed | FAERS: 2 | US FAERS | |
| 52 | Hypersomnia | FAERS: 2 | US FAERS | |
| 53 | Hypomania | FAERS: 2 | US FAERS | |
| 54 | Leukocytosis | FAERS: 2 | US FAERS | |
| 55 | Medication Error | FAERS: 2 | US FAERS | |
| 56 | Musculoskeletal Pain | FAERS: 2 | US FAERS | |
| 57 | Photophobia | FAERS: 2 | US FAERS | |
| 58 | Plasmodium falciparum infection | FAERS: 2 | US FAERS | |
| 59 | Pregnancy | FAERS: 2 | US FAERS | |
| 60 | Pruritus | FAERS: 2 | US FAERS | |
| 61 | Sinus Tachycardia | FAERS: 2 | US FAERS | |
| 62 | Stillbirth | FAERS: 2 | US FAERS | |
| 63 | Abdominal Pain | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 64 | Activities of daily living impaired | FAERS: 1 | US FAERS | |
| 65 | Acute psychosis | FAERS: 1 | US FAERS | |
| 66 | Ageusia | FAERS: 1 | US FAERS | |
| 67 | Alanine aminotransferase decreased | FAERS: 1 | US FAERS | |
| 68 | Anorexia | FAERS: 1 | US FAERS | |
| 69 | Belligerence | FAERS: 1 | US FAERS | |
| 70 | Bipolar Disorder | FAERS: 1 | US FAERS | |
| 71 | Blood albumin decreased | FAERS: 1 | US FAERS | |
| 72 | Blood potassium decreased | FAERS: 1 | US FAERS | |
| 73 | Blood sodium decreased | FAERS: 1 | US FAERS | |
| 74 | Blood urine present | FAERS: 1 | US FAERS | |
| 75 | Brain stem syndrome | FAERS: 1 | US FAERS | |
| 76 | Burning sensation | FAERS: 1 | US FAERS | |
| 77 | Chest Pain | FAERS: 1 | US FAERS | |
| 78 | Cold sweat | FAERS: 1 | US FAERS | |
| 79 | Deep Vein Thrombosis | FAERS: 1 | US FAERS | |
| 80 | Diffuse alveolar damage | FAERS: 1 | US FAERS | |
| 81 | Dissociation | FAERS: 1 | US FAERS | |
| 82 | Dissociative disorder | FAERS: 1 | US FAERS | |
| 83 | Ear discomfort | FAERS: 1 | US FAERS | |
| 84 | Educational problem | FAERS: 1 | US FAERS | |
| 85 | Emotional distress | FAERS: 1 | US FAERS | |
| 86 | Encephalocele | FAERS: 1 | US FAERS | |
| 87 | Feeling of body temperature change | FAERS: 1 | US FAERS | |
| 88 | Fibrin D dimer increased | FAERS: 1 | US FAERS | |
| 89 | Flatulence | FAERS: 1 | US FAERS | |
| 90 | Global Amnesia | FAERS: 1 | US FAERS | |
| 91 | Hepatitis | FAERS: 1 | US FAERS | |
| 92 | Hepatomegaly | FAERS: 1 | US FAERS | |
| 93 | Histamine intolerance | FAERS: 1 | US FAERS | |
| 94 | Homicide | FAERS: 1 | US FAERS | |
| 95 | Hypervigilance | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 96 | Impaired driving ability | FAERS: 1 | US FAERS | |
| 97 | Impetigo | FAERS: 1 | US FAERS | |
| 98 | Inappropriate schedule of drug administration | FAERS: 1 | US FAERS | |
| 99 | Inappropriate schedule of product administration | FAERS: 1 | US FAERS | |
| 100 | Lentigo | FAERS: 1 | US FAERS | |
| 101 | Malaria | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 102 | Maternal exposure during pregnancy | FAERS: 1 | US FAERS | |
| 103 | Metamorphopsia | FAERS: 1 | US FAERS | |
| 104 | Middle insomnia | FAERS: 1 | US FAERS | |
| 105 | Migraine with Aura | FAERS: 1 | US FAERS | |
| 106 | Multiple allergies | FAERS: 1 | US FAERS | |
| 107 | Myalgia | FAERS: 1 | US FAERS | |
| 108 | Myocardial Infarction | FAERS: 1 | US FAERS | |
| 109 | Neck Pain | FAERS: 1 | US FAERS | |
| 110 | Nervousness | FAERS: 1 | US FAERS | |
| 111 | Neuropsychiatric syndrome | FAERS: 1 | US FAERS | |
| 112 | Night sweats | FAERS: 1 | US FAERS | |
| 113 | No adverse event | FAERS: 1 | US FAERS | |
| 114 | Nonspecific reaction | FAERS: 1 | US FAERS | |
| 115 | Obsessive thoughts | FAERS: 1 | US FAERS | |
| 116 | Optic Neuritis | FAERS: 1 | US FAERS | |
| 117 | Overdose | FAERS: 1 | US FAERS | |
| 118 | Partner stress | FAERS: 1 | US FAERS | |
| 119 | Poor quality sleep | FAERS: 1 | US FAERS | |
| 120 | Post-Traumatic Stress Disorder | FAERS: 1 | US FAERS | |
| 121 | Product label issue | FAERS: 1 | US FAERS | |
| 122 | Protein urine present | FAERS: 1 | US FAERS | |
| 123 | Psychiatric symptom | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 124 | Pulmonary toxicity | FAERS: 1 | US FAERS | |
| 125 | Respiratory arrest | FAERS: 1 | US FAERS | |
| 126 | Sinusitis | FAERS: 1 | US FAERS | |
| 127 | Somnambulism | FAERS: 1 | US FAERS | |
| 128 | Stomatitis | FAERS: 1 | US FAERS | |
| 129 | Tachycardia | FAERS: 1 | US FAERS | |
| 130 | Thirst | FAERS: 1 | US FAERS | |
| 131 | Unevaluable event | FAERS: 1 | US FAERS | |
| 132 | Urticaria | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 133 | Violence-related symptom | FAERS: 1 | US FAERS | |
| 134 | Wrong drug administered | FAERS: 1 | US FAERS | |
| 135 | nervous system disorder | FAERS: 1 | US FAERS | |
| 136 | Illogical thinking | Canada Vigilance: 2 | Canada Vigilance | |
| 137 | Lichen Planus | Canada Vigilance: 1 | Canada Vigilance | |
| 138 | Screaming | Canada Vigilance: 1 | Canada Vigilance | |
| 139 | Somnolence | Canada Vigilance: 1 | Canada Vigilance | |
| 140 | Stevens-Johnson Syndrome | Canada Vigilance: 1 | Canada Vigilance | |
| 141 | Suicide attempt | Canada Vigilance: 2 | Canada Vigilance |
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