MetaADEDB 2.0 @ LMMD
Neostigmine
(ALWKGYPQUAPLQC-UHFFFAOYSA-N)
Structure
SMILES
O=C(N(C)C)Oc1cccc(c1)[N+](C)(C)C
Type(s)
Approved; Vet_approved
ATC code(s)
N07AA01; N07AA51; S01EB06
Molecular Formula:
C12H19N2O2+
Molecular Weight:
223.291
Log P:
1.9437
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
29.54
CAS Number(s):
59-99-4; 114-80-7
Synonym(s)
1.
Neostigmine
2.
Synstigmin
3.
Neostigmine Bromide
4.
Neostigmine Methylsulfate
5.
Polstigmine
6.
Proserine
7.
Prostigmin
8.
Prostigmine
9.
Prozerin
10.
Syntostigmine
11.
Bromide, Neostigmine
12.
Methylsulfate, Neostigmine
External Link(s)
MeSHD009388
PubChem Compound4456
BindingDB50022775
ChEBI7514
CHEMBLCHEMBL278020
DrugBankDB01400
DrugCentral1897
IUPHAR/BPS Guide to PHARMACOLOGY8993
KEGGdr:D08261
cpd:C07258
Therapeutic Target DatabaseD08USJ
ZINC1792
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 7US FAERS
2BradycardiaFAERS: 51989731
3434760
3767025		CTD
OFFSIDES
SIDER
US FAERS
3BronchospasmFAERS: 4SIDER
US FAERS
4TachycardiaFAERS: 46498577CTD
SIDER
US FAERS
5AstheniaFAERS: 3OFFSIDES
SIDER
US FAERS
6HypotensionFAERS: 3

View details

3434760
8010419
8712447
8895282
8956398
16113981
 		CTD
SIDER
US FAERS
7Post procedural complicationFAERS: 3OFFSIDES
SIDER
US FAERS
8Cardiac ArrestFAERS: 2SIDER
US FAERS
9Large intestine perforationFAERS: 2OFFSIDES
US FAERS
10Medication ErrorFAERS: 2US FAERS
11Procedural complicationFAERS: 2OFFSIDES
SIDER
US FAERS
12Respiratory arrestFAERS: 2SIDER
US FAERS
13SepsisFAERS: 2US FAERS
14Abdominal InfectionFAERS: 1US FAERS
15Abdominal PainFAERS: 112845923CTD
OFFSIDES
SIDER
US FAERS
16Blood pressure immeasurableFAERS: 1US FAERS
17Cardiac function disturbance postoperativeFAERS: 1US FAERS
18Chest PainFAERS: 1OFFSIDES
US FAERS
19Circumstance or information capable of leading to medication errorFAERS: 1US FAERS
20DiplopiaFAERS: 1US FAERS
21Diverticular perforationFAERS: 1US FAERS
22Drug effect incompleteFAERS: 1US FAERS
23FlatulenceFAERS: 1SIDER
US FAERS
24InflammationFAERS: 1US FAERS
25Labile blood pressureFAERS: 1US FAERS
26Metabolic acidosisFAERS: 1OFFSIDES
US FAERS
27NauseaFAERS: 1

View details

9778009
10691221
12845923
19377050
 		CTD
OFFSIDES
SIDER
US FAERS
28Neonatal disorderFAERS: 1US FAERS
29PallorFAERS: 1US FAERS
30PancreatitisFAERS: 1US FAERS
31PeritonitisFAERS: 1OFFSIDES
US FAERS
32PoisoningFAERS: 1US FAERS
33Respiratory FailureFAERS: 1OFFSIDES
US FAERS
34Seizure like phenomenaFAERS: 1US FAERS
35UrticariaFAERS: 1SIDER
US FAERS
36Wrong drug administeredFAERS: 1US FAERS
37Abdominal Compartment SyndromeOFFSIDES
38Abdominal CrampsSIDER
39Abdominal discomfortOFFSIDES
40AbscessOFFSIDES
41AcidosisOFFSIDES
42Actinic keratosisOFFSIDES
43Acute otitis mediaOFFSIDES
44Adnexa uteri massOFFSIDES
45AdnexitisOFFSIDES
46AgitationSIDER
47AgraphiaOFFSIDES
48Airway Obstruction18559352CTD
49AkinesiaOFFSIDES
50Alanine Aminotransferase IncreasedOFFSIDES
51AlopeciaOFFSIDES
52Altered state of consciousnessOFFSIDES
53Amnesia9268086CTD
54Anaphylactic shockSIDER
55Angle Closure GlaucomaOFFSIDES
56AnhedoniaOFFSIDES
57AnisocoriaOFFSIDES
58AnxietyOFFSIDES
59Aortic bruitOFFSIDES
60Aphthous StomatitisOFFSIDES
61Apnea4326672
18399847		CTD
OFFSIDES
62ArthralgiaSIDER
63ArthritisOFFSIDES
64AspergillosisOFFSIDES
65AsphyxiaOFFSIDES
66Atrial tachycardiaOFFSIDES
67Atrioventricular BlockSIDER
68Autologous bone marrow transplantation therapyOFFSIDES
69AutomatismOFFSIDES
70BedriddenOFFSIDES
71Blepharoptosis122656CTD
72Blood GlucoseOFFSIDES
73Blood chloride decreasedOFFSIDES
74Blood glucose abnormalOFFSIDES
75Blood glucose decreasedOFFSIDES
76Blood phosphorus decreasedOFFSIDES
77Blood sodiumOFFSIDES
78Bone lesionOFFSIDES
79Bone painOFFSIDES
80BronchitisOFFSIDES
81Cardiomegaly17872965CTD
82Carotid bruitOFFSIDES
83Cataract operationOFFSIDES
84CellulitisOFFSIDES
85Cerebral atrophyOFFSIDES
86Cervicobrachial syndromeOFFSIDES
87Chest discomfortSIDER
88Chest tightnessSIDER
89Chronic Obstructive Airway DiseaseOFFSIDES
90Chronic ulcerative colitisOFFSIDES
91ClonusOFFSIDES
92Constipation12845923CTD
93Contact DermatitisOFFSIDES
94Conversion disorderOFFSIDES
95CystOFFSIDES
96DebridementOFFSIDES
97DehydrationOFFSIDES
98DemyelinationOFFSIDES
99Dental abscessOFFSIDES
100Dental cariesOFFSIDES
101Depressed moodOFFSIDES
102Dermatitis, Irritant21319177CTD
103DermatitisSIDER
104DiabetesOFFSIDES
105Diarrhea20350559CTD
OFFSIDES
106DiverticulitisOFFSIDES
107DiverticulosisOFFSIDES
108DiverticulumOFFSIDES
109Dizziness12845923CTD
OFFSIDES
SIDER
110DrowsinessSIDER
111Drug resistanceOFFSIDES
112DysarthriaSIDER
113DysuriaOFFSIDES
114EmpyemaOFFSIDES
115EncephalitisOFFSIDES
116Endodontic procedureOFFSIDES
117Erectile dysfunctionOFFSIDES
118ExcoriationOFFSIDES
119Failure to anastomoseOFFSIDES
120FatigueOFFSIDES
121FlushingSIDER
122FormicationOFFSIDES
123Gamma-Glutamyltransferase IncreasedOFFSIDES
124Gastrointestinal PainSIDER
125Gingival erythemaOFFSIDES
126Global AmnesiaOFFSIDES
127GranulocytosisOFFSIDES
128HeadacheSIDER
129Heart Block2742112
18323319		CTD
130Hepatic necrosisOFFSIDES
131HepatosplenomegalyOFFSIDES
132Histiocytosis haematophagicOFFSIDES
133Hyperalgesia10551598CTD
134HypercapniaOFFSIDES
135Hyperglycemia1350317CTD
136HypersensitivitySIDER
137HypokinesiaOFFSIDES
138Hypotension, Orthostatic1665057CTD
139HypoxiaOFFSIDES
140HysterectomyOFFSIDES
141Iliac artery occlusionOFFSIDES
142Impaired gastric emptyingOFFSIDES
143Incision site complicationSIDER
144InfectionOFFSIDES
145Intervertebral Disc DegenerationOFFSIDES
146Intestinal ObstructionOFFSIDES
147Intestinal crampsSIDER
148Joint sprainOFFSIDES
149Labor Pain10691221
19377050		CTD
150LacrimationSIDER
151Long QT Syndrome18323319CTD
OFFSIDES
152Lymphocyte stimulation test positiveOFFSIDES
153Malignant neoplasm progressionOFFSIDES
154MediastinoscopyOFFSIDES
155Metastases to adrenalsOFFSIDES
156Mood disorder due to a general medical conditionOFFSIDES
157Multiple MyelomaOFFSIDES
158Muscle Weakness122656CTD
OFFSIDES
159Muscle necrosisOFFSIDES
160Musculoskeletal PainOFFSIDES
161Musculoskeletal discomfortOFFSIDES
SIDER
162Myasthenia Gravis

View details

1139195
3256814
4739612
4987393
 		CTD
163NasopharyngitisOFFSIDES
164NephrolithiasisOFFSIDES
165Nutritional condition abnormalOFFSIDES
166NystagmusOFFSIDES
SIDER
167OliguriaOFFSIDES
168Oral Cavity FistulaOFFSIDES
169Oral polypectomyOFFSIDES
170Oroantral FistulaOFFSIDES
171OsteolysisOFFSIDES
172OsteomyelitisOFFSIDES
173OsteopeniaOFFSIDES
174OsteoporosisOFFSIDES
175Pain, Postoperative5625011
20716080		CTD
176Pain

View details

2417918
8712447
8895282
9778009
 		CTD
OFFSIDES
177Pelvic InfectionOFFSIDES
178Pericardial effusionOFFSIDES
179Pharyngolaryngeal PainSIDER
180Polymyalgia RheumaticaOFFSIDES
181Post procedural nauseaSIDER
182Postoperative Complications3434760
18399847		CTD
183Postoperative shiveringSIDER
184Primary sequestrumOFFSIDES
185Procedural hypotensionOFFSIDES
186Procedural nauseaSIDER
187Prostate cancer recurrentOFFSIDES
188Protein total increasedOFFSIDES
189PruritusSIDER
190Pulmonary HypertensionOFFSIDES
191Pulmonary InfarctionOFFSIDES
192Pulmonary function test decreasedSIDER
193Pulmonary thrombosisOFFSIDES
194Purulent dischargeOFFSIDES
195Renal artery occlusionOFFSIDES
196Respiratory DepressionSIDER
197Respiratory Paralysis2573388CTD
198Seizures12198388CTD
199Septic ShockOFFSIDES
200ShockSIDER
201Sick Sinus SyndromeOFFSIDES
202Sinus operationOFFSIDES
203Sinus rhythmOFFSIDES
204SinusitisOFFSIDES
205Sjogren's SyndromeOFFSIDES
206Skin IndurationOFFSIDES
207Slurred speechSIDER
208SomnolenceSIDER
209Spasm9431903CTD
210Sphincter of Oddi Dysfunction9431903CTD
211Spinal column stenosisOFFSIDES
212SpondylolisthesisOFFSIDES
213Stem cell transplantOFFSIDES
214StridorOFFSIDES
215SubileusOFFSIDES
216SyncopeSIDER
217Synovial CystOFFSIDES
218TendinitisOFFSIDES
219ThoracotomyOFFSIDES
220Tinea crurisOFFSIDES
221Tooth ExtractionOFFSIDES
222Tremor623676CTD
223Trismus15096252CTD
224Unresponsive to stimuliOFFSIDES
225Urinary IncontinenceSIDER
226Urinary Retention12903414CTD
227Urine flow decreasedOFFSIDES
228Uterine atrophyOFFSIDES
229Venous InsufficiencyOFFSIDES
230Ventricular FibrillationOFFSIDES
231VomitingSIDER
232WheezingSIDER
233nervous system disorderSIDER
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