MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Polymerase Chain Reaction

(UMLS:C0032520)

Definition:: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
UMLS ID:: C0032520
MeSH ID:: D016133

Classification:

Name:

Synonym(s)

Polymerase Chain Reaction

PCR

PCR - Polymerase chain reaction

POLYMERASE CHAIN REACTION

Polymerase chain reaction

polymerase chain reaction

polymerase chain reaction (PCR)

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Imatinib Mesylate	FAERS: 7 Canada Vigilance: 1	Canada Vigilance US FAERS
2	Lamivudine	FAERS: 4	US FAERS
3	Baclofen	FAERS: 3	US FAERS
4	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
5	Citalopram	FAERS: 1	US FAERS
6	Deferasirox	FAERS: 1	OFFSIDES US FAERS
7	Gefitinib	FAERS: 1	US FAERS
8	Lamotrigine	FAERS: 1	US FAERS
9	Minocycline	FAERS: 1	US FAERS
10	Ruxolitinib phosphate	FAERS: 1	US FAERS
11	Valacyclovir	FAERS: 1	US FAERS
12	Isoniazid		OFFSIDES
13	Meloxicam		OFFSIDES
14	deflazacort		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Cytogenetic Analysis	19%
2	Device Failure	18.5%
3	Electrophoresis	14%
4	Intubation	12.8%
5	Gastric Lavage	10.3%
6	Peritoneal lavage	10.3%
7	Bronchoalveolar Lavage	10.3%
8	Autopsy	8.8%
9	Microscopy	8.8%
10	Prosthesis Failure	6.8%
11	Immunosuppression	6.7%
12	Glasgow coma scale	5.4%
13	Tuberculin Test	4.9%
14	Neoplasms, Experimental	4.8%
15	Biopsy	4.6%
16	Liver Cirrhosis, Experimental	4.4%
17	Ovulation Induction	4.4%
18	Arthritis, Experimental	4.4%
19	Blood culture	4.4%
20	Immunoglobulin Therapy	4.4%
21	Angioplasty	4.1%
22	Amniocentesis	4.1%
23	Diabetes Mellitus, Experimental	3.4%
24	Leukapheresis	3%
25	Atherectomy	2.6%
26	Body mass index	2.6%
27	Leukemia, Experimental	2.5%
28	Mammary Neoplasms, Experimental	2.5%
29	Sarcoma, Experimental	2.5%
30	PROTHROMBIN TIME	2.5%
31	Glucose tolerance test	2.4%
32	Superovulation	2.4%
33	Clot retraction	2.4%
34	Radiation Injuries, Experimental	2.2%
35	venipuncture	2%
36	Paracentesis	2%
37	Neuritis, Autoimmune, Experimental	2%
38	Body Height	1.9%
39	Liver Neoplasms, Experimental	1.7%
40	Body Weight	1.6%
41	Melanoma, Experimental	1.6%
42	Myasthenia Gravis, Autoimmune, Experimental	1.4%
43	Birth Weight	1.3%
44	Fetal Weight	1%

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