afuresertib
(AFJRDFWMXUECEW-LBPRGKRZSA-N)
Structure
- SMILES
- NC[C@@H](NC(=O)c1sc(c(c1)c1c(Cl)cnn1C)Cl)Cc1cccc(c1)F
- Type(s)
- Investigational
- Molecular Formula:
- C18H17Cl2FN4OS
- Molecular Weight:
- 427.323
- Log P:
- 4.9855
- Hydrogen Bond Acceptor:
- 6
- Hydrogen Bond Donor:
- 2
- TPSA:
- 101.18
- CAS Number(s):
- 1047644-62-1
Synonym(s)
1.
afuresertib
External Link(s)
| MeSH | C000593263 |
| PubChem Compound | 46843057 |
| ChEBI | 131168 |
| CHEMBL | CHEMBL2219422 |
| DrugBank | DB11648 |
| IUPHAR/BPS Guide to PHARMACOLOGY | 7890 |
| KEGG | dr:D10381 |
| ZINC | 43197674 |
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Acneiform Eruptions | 25417902 | CTD | |
| 2 | Alopecia | 30563934 | CTD | |
| 3 | Diarrhea | CTD | ||
| 4 | Dyspepsia | 25075128 27804235 | CTD | |
| 5 | Dyspnea | 25417902 | CTD | |
| 6 | Exanthema | 25417902 30563934 | CTD | |
| 7 | Fatigue | 25417902 27804235 30563934 | CTD | |
| 8 | Histiocytosis, Langerhans-Cell | 25075128 27804235 29768711 | CTD | |
| 9 | Hodgkin Disease | 25075128 | CTD | |
| 10 | Lymphoma, Non-Hodgkin | 25075128 | CTD | |
| 11 | Multiple Myeloma | 25075128 | CTD | |
| 12 | Nausea | CTD | ||
| 13 | Necrosis | 27804235 | CTD | |
| 14 | Neutropenia | 30563934 | CTD | |
| 15 | Pain | 27804235 | CTD | |
| 16 | Skin Manifestations | 25417902 | CTD | |
| 17 | Vomiting | 27804235 30563934 | CTD |
Powered by :
Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120262
Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.