amitriptyline, chlordiazepoxide drug combination
(KFYRPLNVJVHZGT-UHFFFAOYSA-N)
Structure
- SMILES
- CN(CCC=C1c2ccccc2CCc2c1cccc2)C.Cl
- Molecular Formula:
- C20H24ClN
- Molecular Weight:
- 313.864
- Log P:
- 4.9706
- Hydrogen Bond Acceptor:
- 1
- Hydrogen Bond Donor:
- 1
- TPSA:
- 3.24
- CAS Number(s):
- 549-18-8
Synonym(s)
1.
amitriptyline, chlordiazepoxide drug combination
2.
Limbitrol
3.
Limbritol
4.
amitriptyline - chlordiazepoxide
5.
amitriptyline hydrochloride, chlordiazepoxide drug combination
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Completed Suicide | FAERS: 30 | US FAERS | |
| 2 | Drug ineffective | FAERS: 28 Canada Vigilance: 5 | Canada Vigilance US FAERS | |
| 3 | Tremor | FAERS: 20 | US FAERS | |
| 4 | Headache | FAERS: 19 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 5 | Overdose | FAERS: 17 | US FAERS | |
| 6 | Dizziness | FAERS: 16 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 7 | Somnolence | FAERS: 13 Canada Vigilance: 7 | Canada Vigilance US FAERS | |
| 8 | Drug ineffective for unapproved indication | FAERS: 11 | US FAERS | |
| 9 | Memory impairment | FAERS: 11 | US FAERS | |
| 10 | Fatigue | FAERS: 10 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 11 | Feeling abnormal | FAERS: 10 | US FAERS | |
| 12 | Drug dispensing error | FAERS: 9 | US FAERS | |
| 13 | Dysgeusia | FAERS: 9 | US FAERS | |
| 14 | Tachycardia | FAERS: 9 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 15 | Disorientation | FAERS: 8 | US FAERS | |
| 16 | Hypersensitivity | FAERS: 8 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 17 | Medication Error | FAERS: 8 | US FAERS | |
| 18 | Nausea | FAERS: 8 | US FAERS | |
| 19 | Tinnitus | FAERS: 8 | US FAERS | |
| 20 | Toxicity to various agents | FAERS: 8 | US FAERS | |
| 21 | Agitation | FAERS: 7 | US FAERS | |
| 22 | Anxiety | FAERS: 7 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 23 | Cardiac Arrest | FAERS: 7 | US FAERS | |
| 24 | Dysarthria | FAERS: 7 | US FAERS | |
| 25 | Hypotension | FAERS: 7 | US FAERS | |
| 26 | Suicide attempt | FAERS: 7 | US FAERS | |
| 27 | Vomiting | FAERS: 7 | US FAERS | |
| 28 | Wrong technique in product usage process | FAERS: 7 | US FAERS | |
| 29 | Abdominal Pain | FAERS: 6 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 30 | Crying | FAERS: 6 | US FAERS | |
| 31 | Depressed Level of Consciousness | FAERS: 6 | US FAERS | |
| 32 | Electrocardiogram abnormal | FAERS: 6 | US FAERS | |
| 33 | Abdominal discomfort | FAERS: 5 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 34 | Amnesia | FAERS: 5 | US FAERS | |
| 35 | Drug Dependence | FAERS: 5 | US FAERS | |
| 36 | Incorrect dose administered | FAERS: 5 | US FAERS | |
| 37 | Mental status changes | FAERS: 5 | US FAERS | |
| 38 | Status Epilepticus | FAERS: 5 | US FAERS | |
| 39 | Abasia | FAERS: 4 | US FAERS | |
| 40 | Anger | FAERS: 4 | US FAERS | |
| 41 | Back Pain | FAERS: 4 | US FAERS | |
| 42 | Blood glucose abnormal | FAERS: 4 | US FAERS | |
| 43 | Chest Pain | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 44 | Drug withdrawal syndrome | FAERS: 4 | US FAERS | |
| 45 | Intentional product misuse | FAERS: 4 | US FAERS | |
| 46 | Lethargy | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 47 | Malaise | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 48 | Metabolic acidosis | FAERS: 4 | US FAERS | |
| 49 | Muscle Rigidity | FAERS: 4 | US FAERS | |
| 50 | Muscle tightness | FAERS: 4 | US FAERS | |
| 51 | Mydriasis | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 52 | Nephrolithiasis | FAERS: 4 | US FAERS | |
| 53 | Pain | FAERS: 4 | US FAERS | |
| 54 | Palpitations | FAERS: 4 | US FAERS | |
| 55 | Pharmaceutical product complaint | FAERS: 4 | US FAERS | |
| 56 | Product quality issue | FAERS: 4 | US FAERS | |
| 57 | Product use issue | FAERS: 4 | US FAERS | |
| 58 | Reaction to drug excipients | FAERS: 4 | US FAERS | |
| 59 | Throat irritation | FAERS: 4 | US FAERS | |
| 60 | Urinary Retention | FAERS: 4 | US FAERS | |
| 61 | Ventricular Fibrillation | FAERS: 4 | US FAERS | |
| 62 | Accidental overdose | FAERS: 3 | US FAERS | |
| 63 | Activities of daily living impaired | FAERS: 3 | US FAERS | |
| 64 | Adverse event | FAERS: 3 | US FAERS | |
| 65 | Alopecia | FAERS: 3 | US FAERS | |
| 66 | Altered state of consciousness | FAERS: 3 | US FAERS | |
| 67 | Asthenia | FAERS: 3 | US FAERS | |
| 68 | Burning sensation | FAERS: 3 | US FAERS | |
| 69 | Chills | FAERS: 3 | US FAERS | |
| 70 | Cholecystitis | FAERS: 3 | US FAERS | |
| 71 | Constipation | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 72 | Depressed mood | FAERS: 3 | US FAERS | |
| 73 | Drug abuser | FAERS: 3 | US FAERS | |
| 74 | Drug screen positive | FAERS: 3 | US FAERS | |
| 75 | Drug toxicity | FAERS: 3 | US FAERS | |
| 76 | Dysphonia | FAERS: 3 | US FAERS | |
| 77 | Flatulence | FAERS: 3 | US FAERS | |
| 78 | Gastroenteritis | FAERS: 3 | US FAERS | |
| 79 | Hypersomnia | FAERS: 3 | US FAERS | |
| 80 | Menorrhagia | FAERS: 3 | US FAERS | |
| 81 | Nervousness | FAERS: 3 | US FAERS | |
| 82 | Paranoia | FAERS: 3 | US FAERS | |
| 83 | Poor quality sleep | FAERS: 3 | US FAERS | |
| 84 | Product substitution issue | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 85 | Pruritus | FAERS: 3 | US FAERS | |
| 86 | Shock | FAERS: 3 | US FAERS | |
| 87 | Syncope | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 88 | Tooth Loss | FAERS: 3 | US FAERS | |
| 89 | Unevaluable event | FAERS: 3 | US FAERS | |
| 90 | Unresponsive to stimuli | FAERS: 3 | US FAERS | |
| 91 | Acne | FAERS: 2 | US FAERS | |
| 92 | Alanine Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 93 | Anaphylactic shock | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 94 | Anticholinergic Syndrome | FAERS: 2 | US FAERS | |
| 95 | Aspartate Aminotransferase Increased | FAERS: 2 | US FAERS | |
| 96 | Blood electrolytes abnormal | FAERS: 2 | US FAERS | |
| 97 | Blood glucose increased | FAERS: 2 | US FAERS | |
| 98 | Blood sodium decreased | FAERS: 2 | US FAERS | |
| 99 | Bradycardia | FAERS: 2 | US FAERS | |
| 100 | Chest discomfort | FAERS: 2 | US FAERS | |
| 101 | Chromaturia | FAERS: 2 | US FAERS | |
| 102 | Cold sweat | FAERS: 2 | US FAERS | |
| 103 | Drug screen negative | FAERS: 2 | US FAERS | |
| 104 | Dyspepsia | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 105 | Euphoric mood | FAERS: 2 | US FAERS | |
| 106 | Expired product administered | FAERS: 2 | US FAERS | |
| 107 | False positive investigation result | FAERS: 2 | US FAERS | |
| 108 | Feeling jittery | FAERS: 2 | US FAERS | |
| 109 | Inflammation | FAERS: 2 | US FAERS | |
| 110 | Intentional misuse | FAERS: 2 | US FAERS | |
| 111 | Intercepted drug dispensing error | FAERS: 2 | US FAERS | |
| 112 | Mood swings | FAERS: 2 | US FAERS | |
| 113 | Myalgia | FAERS: 2 | US FAERS | |
| 114 | Oropharyngeal pain | FAERS: 2 | US FAERS | |
| 115 | Peripheral swelling | FAERS: 2 | US FAERS | |
| 116 | Pharmaceutical product counterfeit | FAERS: 2 | US FAERS | |
| 117 | Photophobia | FAERS: 2 | US FAERS | |
| 118 | Poisoning | FAERS: 2 | US FAERS | |
| 119 | Product taste abnormal | FAERS: 2 | US FAERS | |
| 120 | Product use in unapproved indication | FAERS: 2 | US FAERS | |
| 121 | Pulmonary Embolism | FAERS: 2 | US FAERS | |
| 122 | Respiratory arrest | FAERS: 2 | US FAERS | |
| 123 | Restlessness | FAERS: 2 | US FAERS | |
| 124 | Sinus Tachycardia | FAERS: 2 | US FAERS | |
| 125 | Swelling | FAERS: 2 | US FAERS | |
| 126 | Tardive Dyskinesia | FAERS: 2 | US FAERS | |
| 127 | Transaminases increased | FAERS: 2 | US FAERS | |
| 128 | White blood cell count decreased | FAERS: 2 | US FAERS | |
| 129 | Abdominal symptom | FAERS: 1 | US FAERS | |
| 130 | Accidental drug intake by child | FAERS: 1 | US FAERS | |
| 131 | Accidental exposure to product | FAERS: 1 | US FAERS | |
| 132 | Acute Lung Injury | FAERS: 1 | US FAERS | |
| 133 | Alcohol poisoning | FAERS: 1 | US FAERS | |
| 134 | Antidepressant drug level above therapeutic | FAERS: 1 | US FAERS | |
| 135 | Apathy | FAERS: 1 | US FAERS | |
| 136 | Arthralgia | FAERS: 1 | US FAERS | |
| 137 | Arthropathy | FAERS: 1 | US FAERS | |
| 138 | Ascites | FAERS: 1 | US FAERS | |
| 139 | Atrial Fibrillation | FAERS: 1 | US FAERS | |
| 140 | Autoimmune hepatitis | FAERS: 1 | US FAERS | |
| 141 | Bipolar I disorder | FAERS: 1 | US FAERS | |
| 142 | Blood alkaline phosphatase increased | FAERS: 1 | US FAERS | |
| 143 | Blood alkaline phosphatase normal | FAERS: 1 | US FAERS | |
| 144 | Blood chloride increased | FAERS: 1 | US FAERS | |
| 145 | Blood creatine phosphokinase increased | FAERS: 1 | US FAERS | |
| 146 | Blood creatinine increased | FAERS: 1 | US FAERS | |
| 147 | Blood magnesium decreased | FAERS: 1 | US FAERS | |
| 148 | Blood magnesium increased | FAERS: 1 | US FAERS | |
| 149 | Blood pH increased | FAERS: 1 | US FAERS | |
| 150 | Blood potassium decreased | FAERS: 1 | US FAERS | |
| 151 | Blood sodium increased | FAERS: 1 | US FAERS | |
| 152 | Blood urea increased | FAERS: 1 | US FAERS | |
| 153 | Cerebral Infarction | FAERS: 1 | US FAERS | |
| 154 | Cerebrovascular accident | FAERS: 1 | US FAERS | |
| 155 | Consciousness fluctuating | FAERS: 1 | US FAERS | |
| 156 | Deafness | FAERS: 1 | US FAERS | |
| 157 | Dehydration | FAERS: 1 | US FAERS | |
| 158 | Delirium | FAERS: 1 | US FAERS | |
| 159 | Dementia | FAERS: 1 | US FAERS | |
| 160 | Dermatitis | FAERS: 1 | US FAERS | |
| 161 | Dextrocardia | FAERS: 1 | US FAERS | |
| 162 | Diabetic Ketoacidosis | FAERS: 1 | US FAERS | |
| 163 | Diplopia | FAERS: 1 | US FAERS | |
| 164 | Dissociation | FAERS: 1 | US FAERS | |
| 165 | Drug administration error | FAERS: 1 | US FAERS | |
| 166 | Drug dispensed to wrong patient | FAERS: 1 | US FAERS | |
| 167 | Drug dose omission | FAERS: 1 | US FAERS | |
| 168 | Drug level below therapeutic | FAERS: 1 | US FAERS | |
| 169 | Dry skin | FAERS: 1 | US FAERS | |
| 170 | Dystonia | FAERS: 1 | US FAERS | |
| 171 | Dysuria | FAERS: 1 | US FAERS | |
| 172 | Ear discomfort | FAERS: 1 | US FAERS | |
| 173 | Echocardiogram abnormal | FAERS: 1 | US FAERS | |
| 174 | Electrocardiogram change | FAERS: 1 | US FAERS | |
| 175 | Epigastric discomfort | FAERS: 1 | US FAERS | |
| 176 | Epilepsy | FAERS: 1 | US FAERS | |
| 177 | Erythema | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 178 | Exposure during breast feeding | FAERS: 1 | US FAERS | |
| 179 | Eye pain | FAERS: 1 | US FAERS | |
| 180 | Feeling Cold | FAERS: 1 | US FAERS | |
| 181 | Fibromyalgia | FAERS: 1 | US FAERS | |
| 182 | Foaming at mouth | FAERS: 1 | US FAERS | |
| 183 | Food Allergy | FAERS: 1 | US FAERS | |
| 184 | Formication | FAERS: 1 | US FAERS | |
| 185 | Gastrointestinal inflammation | FAERS: 1 | US FAERS | |
| 186 | General physical health deterioration | FAERS: 1 | US FAERS | |
| 187 | Glaucoma | FAERS: 1 | US FAERS | |
| 188 | Glossitis | FAERS: 1 | US FAERS | |
| 189 | Head discomfort | FAERS: 1 | US FAERS | |
| 190 | Hemiparesis | FAERS: 1 | US FAERS | |
| 191 | Hepatomegaly | FAERS: 1 | US FAERS | |
| 192 | Hostility | FAERS: 1 | US FAERS | |
| 193 | Hunger | FAERS: 1 | US FAERS | |
| 194 | Hyporeflexia | FAERS: 1 | US FAERS | |
| 195 | Hypoventilation | FAERS: 1 | US FAERS | |
| 196 | Impaired driving ability | FAERS: 1 | US FAERS | |
| 197 | Impaired gastric emptying | FAERS: 1 | US FAERS | |
| 198 | Inappropriate affect | FAERS: 1 | US FAERS | |
| 199 | Incoherent | FAERS: 1 | US FAERS | |
| 200 | Incorrect drug dosage form administered | FAERS: 1 | US FAERS | |
| 201 | Intentional drug misuse | FAERS: 1 | US FAERS | |
| 202 | Intentional product use issue | FAERS: 1 | US FAERS | |
| 203 | Internal injury | FAERS: 1 | US FAERS | |
| 204 | Joint stiffness | FAERS: 1 | US FAERS | |
| 205 | Laceration | FAERS: 1 | US FAERS | |
| 206 | Lactose Intolerance | FAERS: 1 | US FAERS | |
| 207 | Leukocytosis | FAERS: 1 | US FAERS | |
| 208 | Long QT Syndrome | FAERS: 1 | US FAERS | |
| 209 | Loose tooth | FAERS: 1 | US FAERS | |
| 210 | Lymphadenopathy | FAERS: 1 | US FAERS | |
| 211 | Middle insomnia | FAERS: 1 | US FAERS | |
| 212 | Musculoskeletal stiffness | FAERS: 1 | US FAERS | |
| 213 | Myocarditis | FAERS: 1 | US FAERS | |
| 214 | Nasopharyngitis | FAERS: 1 | US FAERS | |
| 215 | Neck Pain | FAERS: 1 | US FAERS | |
| 216 | Negative thoughts | FAERS: 1 | US FAERS | |
| 217 | Nerve injury | FAERS: 1 | US FAERS | |
| 218 | Neuralgia | FAERS: 1 | US FAERS | |
| 219 | Neuropathy | FAERS: 1 | US FAERS | |
| 220 | No adverse event | FAERS: 1 | US FAERS | |
| 221 | No reaction on previous exposure to drug | FAERS: 1 | US FAERS | |
| 222 | Nocturia | FAERS: 1 | US FAERS | |
| 223 | Oral pain | FAERS: 1 | US FAERS | |
| 224 | Osteopenia | FAERS: 1 | US FAERS | |
| 225 | Pallor | FAERS: 1 | US FAERS | |
| 226 | Pancreatitis | FAERS: 1 | US FAERS | |
| 227 | Personality Change | FAERS: 1 | US FAERS | |
| 228 | Polyuria | FAERS: 1 | US FAERS | |
| 229 | Poor quality drug administered | FAERS: 1 | US FAERS | |
| 230 | Post procedural complication | FAERS: 1 | US FAERS | |
| 231 | Prescribed overdose | FAERS: 1 | US FAERS | |
| 232 | Presyncope | FAERS: 1 | US FAERS | |
| 233 | Product packaging issue | FAERS: 1 | US FAERS | |
| 234 | Product physical issue | FAERS: 1 | US FAERS | |
| 235 | Reaction to azo-dyes | FAERS: 1 | US FAERS | |
| 236 | Reaction to excipient | FAERS: 1 | US FAERS | |
| 237 | Renal pain | FAERS: 1 | US FAERS | |
| 238 | Respiratory Depression | FAERS: 1 | US FAERS | |
| 239 | Respiratory Failure | FAERS: 1 | US FAERS | |
| 240 | Retching | FAERS: 1 | US FAERS | |
| 241 | Sinus bradycardia | FAERS: 1 | US FAERS | |
| 242 | Skin lesion | FAERS: 1 | US FAERS | |
| 243 | Somnambulism | FAERS: 1 | US FAERS | |
| 244 | Sopor | FAERS: 1 | US FAERS | |
| 245 | Supraventricular tachycardia | FAERS: 1 | US FAERS | |
| 246 | Teeth brittle | FAERS: 1 | US FAERS | |
| 247 | Temperature regulation disorder | FAERS: 1 | US FAERS | |
| 248 | Therapeutic response unexpected | FAERS: 1 | US FAERS | |
| 249 | Therapeutic response unexpected with drug substitution | FAERS: 1 | US FAERS | |
| 250 | Therapy change | FAERS: 1 | US FAERS | |
| 251 | Thrombophlebitis | FAERS: 1 | US FAERS | |
| 252 | Tongue discomfort | FAERS: 1 | US FAERS | |
| 253 | Tooth Erosion | FAERS: 1 | US FAERS | |
| 254 | Transcription medication error | FAERS: 1 | US FAERS | |
| 255 | Trigeminal Neuralgia | FAERS: 1 | US FAERS | |
| 256 | Trismus | FAERS: 1 | US FAERS | |
| 257 | Urinary tract infection | FAERS: 1 | US FAERS | |
| 258 | Urticaria | FAERS: 1 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 259 | Vaginal burning sensation | FAERS: 1 | US FAERS | |
| 260 | Vertigo | FAERS: 1 | US FAERS | |
| 261 | Victim of child abuse | FAERS: 1 | US FAERS | |
| 262 | Violence-related symptom | FAERS: 1 | US FAERS | |
| 263 | Visceral congestion | FAERS: 1 | US FAERS | |
| 264 | Visual Impairment | FAERS: 1 | US FAERS | |
| 265 | Weight decreased | FAERS: 1 | US FAERS | |
| 266 | Wheelchair user | FAERS: 1 | US FAERS | |
| 267 | Wrong drug administered | FAERS: 1 | US FAERS | |
| 268 | furuncle | FAERS: 1 | US FAERS | |
| 269 | nervous system disorder | FAERS: 1 | US FAERS | |
| 270 | Drug level increased | Canada Vigilance: 1 | Canada Vigilance | |
| 271 | Oculogyric crisis | Canada Vigilance: 1 | Canada Vigilance | |
| 272 | jaundice | Canada Vigilance: 1 | Canada Vigilance |
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