MetaADEDB 2.0 @ LMMD
avanafil
(WEAJZXNPAWBCOA-INIZCTEOSA-N)
Structure
SMILES
OC[C@@H]1CCCN1c1ncc(c(n1)NCc1ccc(c(c1)Cl)OC)C(=O)NCc1ncccn1
Type(s)
Approved
ATC code(s)
G04BE10
Molecular Formula:
C23H26ClN7O3
Molecular Weight:
483.951
Log P:
2.9607
Hydrogen Bond Acceptor:
10
Hydrogen Bond Donor:
3
TPSA:
125.39
CAS Number(s):
330784-47-9
Synonym(s)
1.
avanafil
2.
4-((3-chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)-1-pyrrolidinyl)-N-(2-pyrimidinylmethyl)-5-pyrimidinecarboxamide
3.
stendra
External Link(s)
MeSHC553414
PubChem Compound9869929
BindingDB50036629
235766
ChEBI66876
CHEMBLCHEMBL1963681
DrugBankDB06237
DrugCentral4305
IUPHAR/BPS Guide to PHARMACOLOGY7448
KEGGdr:D03217
Therapeutic Target DatabaseD0Y5JC
ZINC11677857
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 154US FAERS
2HeadacheFAERS: 13SIDER
US FAERS
3Wrong technique in product usage processFAERS: 13US FAERS
4Erectile dysfunctionFAERS: 11US FAERS
5FlushingFAERS: 10SIDER
US FAERS
6TinnitusFAERS: 6US FAERS
7Intentional product misuseFAERS: 5US FAERS
8Drug effect incompleteFAERS: 4US FAERS
9Erection increasedFAERS: 4SIDER
US FAERS
10Inappropriate schedule of drug administrationFAERS: 4US FAERS
11Chest discomfortFAERS: 3US FAERS
12DeafnessFAERS: 3US FAERS
13DizzinessFAERS: 3SIDER
US FAERS
14Drug effect delayedFAERS: 3US FAERS
15DyspepsiaFAERS: 3SIDER
US FAERS
16Expired product administeredFAERS: 3US FAERS
17SyncopeFAERS: 3US FAERS
18Abdominal discomfortFAERS: 2SIDER
US FAERS
19Drug ineffective for unapproved indicationFAERS: 2US FAERS
20Incorrect dose administeredFAERS: 2US FAERS
21Incorrect route of drug administrationFAERS: 2US FAERS
22MalaiseFAERS: 2US FAERS
23Visual ImpairmentFAERS: 2US FAERS
24Vitreous DetachmentFAERS: 2US FAERS
25Accidental overdoseFAERS: 1US FAERS
26Amaurosis FugaxFAERS: 1US FAERS
27AngioedemaFAERS: 1US FAERS
28Back PainFAERS: 1SIDER
US FAERS
29BlindnessFAERS: 1US FAERS
30Cold sweatFAERS: 1US FAERS
31Deep Vein ThrombosisFAERS: 1SIDER
US FAERS
32Disturbance in sexual arousalFAERS: 1US FAERS
33Drug dose titration not performedFAERS: 1US FAERS
34Drug effect variableFAERS: 1US FAERS
35Drug prescribing errorFAERS: 1US FAERS
36ErythemaFAERS: 1US FAERS
37Foreign body sensation in eyesFAERS: 1US FAERS
38Head discomfortFAERS: 1US FAERS
39Incorrect product storageFAERS: 1US FAERS
40Intentional product use issueFAERS: 1US FAERS
41Muscle tightnessFAERS: 1SIDER
US FAERS
42NauseaFAERS: 1SIDER
US FAERS
43No adverse eventFAERS: 1US FAERS
44Ocular discomfortFAERS: 1US FAERS
45OverdoseFAERS: 1US FAERS
46Premature EjaculationFAERS: 1SIDER
US FAERS
47PresyncopeFAERS: 1US FAERS
48PriapismFAERS: 1SIDER
US FAERS
49Product measured potency issueFAERS: 1US FAERS
50Product quality issueFAERS: 1US FAERS
51Product storage errorFAERS: 1US FAERS
52Product taste abnormalFAERS: 1US FAERS
53Product use in unapproved indicationFAERS: 1US FAERS
54Product use issueFAERS: 1US FAERS
55PruritusFAERS: 1SIDER
US FAERS
56Retinal DetachmentFAERS: 1US FAERS
57Semen viscosity abnormalFAERS: 1US FAERS
58Semen volume increasedFAERS: 1US FAERS
59Spontaneous penile erectionFAERS: 1SIDER
US FAERS
60Therapeutic product effect decreasedFAERS: 1US FAERS
61Unevaluable eventFAERS: 1US FAERS
62VomitingFAERS: 1SIDER
US FAERS
63Wrong patient received medicationFAERS: 1US FAERS
64Wrong technique in drug usage processFAERS: 1US FAERS
65AgitationSIDER
66Alanine Aminotransferase IncreasedSIDER
67Angina PectorisSIDER
68ArthralgiaSIDER
69AstheniaSIDER
70BalanitisSIDER
71Blood creatinine increasedSIDER
72Blood glucose increasedSIDER
73Blood urine presentSIDER
74BronchitisSIDER
75Chest PainSIDER
76ConstipationSIDER
77DermatitisSIDER
78Diabetes MellitusSIDER
79Electrocardiogram abnormalSIDER
80EpistaxisSIDER
81FatigueSIDER
82Flank PainSIDER
83GastritisSIDER
84GoutSIDER
85HypotensionSIDER
86Inappropriate affectSIDER
87InfectionSIDER
88InfestationSIDER
89InfluenzaSIDER
90MalnutritionSIDER
91Musculoskeletal PainSIDER
92Musculoskeletal discomfortSIDER
93MyalgiaSIDER
94NasopharyngitisSIDER
95NephrolithiasisSIDER
96Oropharyngeal painSIDER
97PalpitationsSIDER
98Sinus headacheSIDER
99SinusitisSIDER
100SomnolenceSIDER
101TachycardiaSIDER
102Upper respiratory tract congestionSIDER
103Upset stomachSIDER
104Urinary tract infectionSIDER
105VertigoSIDER
106WheezingSIDER
107nervous system disorderSIDER
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