dienogest
(AZFLJNIPTRTECV-FUMNGEBKSA-N)
Structure
- SMILES
- N#CC[C@]1(O)CC[C@@H]2[C@]1(C)CCC1=C3CCC(=O)C=C3CC[C@@H]21
- Type(s)
- Approved
- ATC code(s)
- G03AA16; G03AB08; G03DB08; G03FA15
- Molecular Formula:
- C20H25NO2
- Molecular Weight:
- 311.418
- Log P:
- 3.8372
- Hydrogen Bond Acceptor:
- 3
- Hydrogen Bond Donor:
- 1
- TPSA:
- 61.09
- CAS Number(s):
- 65928-58-7
Synonym(s)
1.
dienogest
2.
17 alpha-cyanomethyl-17 beta-hydroxy-13 beta-methylgona-4,9-dien-3-one
3.
17 alpha-cyanomethyl-17 beta-hydroxyestra-4,9(10)-diene-3-one
4.
19-norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17alpha)-
5.
STS 557
6.
STS-557
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Drug dose omission | FAERS: 33 | US FAERS | |
| 2 | Metrorrhagia | FAERS: 32 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 3 | Pregnancy on oral contraceptive | FAERS: 13 | US FAERS | |
| 4 | Product use issue | FAERS: 9 | US FAERS | |
| 5 | Inappropriate schedule of drug administration | FAERS: 8 | US FAERS | |
| 6 | No adverse event | FAERS: 8 | US FAERS | |
| 7 | Abnormal withdrawal bleeding | FAERS: 6 | US FAERS | |
| 8 | Extra dose administered | FAERS: 5 | US FAERS | |
| 9 | Vomiting | FAERS: 5 | 10574641 | CTD US FAERS |
| 10 | Drug ineffective | FAERS: 4 | US FAERS | |
| 11 | Menorrhagia | FAERS: 4 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 12 | Therapeutic response unexpected | FAERS: 4 | US FAERS | |
| 13 | Abdominal Pain | FAERS: 3 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 14 | Chest discomfort | FAERS: 3 | US FAERS | |
| 15 | Drug administration error | FAERS: 3 | US FAERS | |
| 16 | Headache | FAERS: 3 Canada Vigilance: 4 | 10574641 12616963 | CTD Canada Vigilance US FAERS |
| 17 | Medication Error | FAERS: 3 | US FAERS | |
| 18 | Nausea | FAERS: 3 Canada Vigilance: 4 | 10574641 | CTD Canada Vigilance US FAERS |
| 19 | Product use in unapproved indication | FAERS: 3 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 20 | Pruritus | FAERS: 3 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 21 | Biliary Colic | FAERS: 2 | US FAERS | |
| 22 | Cerebrovascular accident | FAERS: 2 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 23 | Deep Vein Thrombosis | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 24 | Dizziness | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 25 | Feeling abnormal | FAERS: 2 | US FAERS | |
| 26 | Pregnancy | FAERS: 2 | US FAERS | |
| 27 | Product dose omission | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 28 | Psoriasis | FAERS: 2 | US FAERS | |
| 29 | Pulmonary Embolism | FAERS: 2 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 30 | Urinary Incontinence | FAERS: 2 | US FAERS | |
| 31 | Weight decreased | FAERS: 2 | US FAERS | |
| 32 | Acne | FAERS: 1 | US FAERS | |
| 33 | Alopecia | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 34 | Blood cholesterol increased | FAERS: 1 | US FAERS | |
| 35 | Breast tenderness | FAERS: 1 | US FAERS | |
| 36 | Chest Pain | FAERS: 1 Canada Vigilance: 3 | Canada Vigilance US FAERS | |
| 37 | Circumstance or information capable of leading to medication error | FAERS: 1 | US FAERS | |
| 38 | Drug withdrawal syndrome | FAERS: 1 | US FAERS | |
| 39 | Dry skin | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 40 | Endometriosis | FAERS: 1 | US FAERS | |
| 41 | Genital pain | FAERS: 1 | US FAERS | |
| 42 | Genital rash | FAERS: 1 | US FAERS | |
| 43 | Hypersensitivity | FAERS: 1 | US FAERS | |
| 44 | Hysterectomy | FAERS: 1 | US FAERS | |
| 45 | Inappropriate schedule of product administration | FAERS: 1 | US FAERS | |
| 46 | Incorrect dose administered | FAERS: 1 | US FAERS | |
| 47 | Incorrect drug administration duration | FAERS: 1 | US FAERS | |
| 48 | Influenza | FAERS: 1 | US FAERS | |
| 49 | Lethargy | FAERS: 1 | US FAERS | |
| 50 | Malaise | FAERS: 1 | US FAERS | |
| 51 | Mood swings | FAERS: 1 Canada Vigilance: 4 | Canada Vigilance US FAERS | |
| 52 | Nervousness | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 53 | Pelvic operation | FAERS: 1 | US FAERS | |
| 54 | Pre-Eclampsia | FAERS: 1 | US FAERS | |
| 55 | Premenstrual syndrome | FAERS: 1 | US FAERS | |
| 56 | Product packaging quantity issue | FAERS: 1 | US FAERS | |
| 57 | Product physical issue | FAERS: 1 | US FAERS | |
| 58 | Pulmonary thrombosis | FAERS: 1 | US FAERS | |
| 59 | Sinusitis | FAERS: 1 | US FAERS | |
| 60 | Syncope | FAERS: 1 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 61 | Therapeutic response changed | FAERS: 1 | US FAERS | |
| 62 | Urticaria | FAERS: 1 | US FAERS | |
| 63 | Acne Vulgaris | 12616963 | CTD | |
| 64 | Anxiety | Canada Vigilance: 3 | Canada Vigilance | |
| 65 | Arthralgia | Canada Vigilance: 2 | Canada Vigilance | |
| 66 | Asthma | Canada Vigilance: 1 | Canada Vigilance | |
| 67 | Back Pain | Canada Vigilance: 1 | Canada Vigilance | |
| 68 | Breast Diseases | 12616963 | CTD | |
| 69 | Burning sensation | Canada Vigilance: 1 | Canada Vigilance | |
| 70 | Cellulitis | Canada Vigilance: 1 | Canada Vigilance | |
| 71 | Crying | Canada Vigilance: 2 | Canada Vigilance | |
| 72 | Depressed mood | Canada Vigilance: 1 | Canada Vigilance | |
| 73 | Depression suicidal | Canada Vigilance: 1 | Canada Vigilance | |
| 74 | Depressive disorder | 10574641 | CTD | |
| 75 | Diabetes mellitus inadequate control | Canada Vigilance: 1 | Canada Vigilance | |
| 76 | Discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 77 | Dysmenorrhea | 10574641 12616963 | CTD | |
| 78 | Dyspepsia | Canada Vigilance: 1 | Canada Vigilance | |
| 79 | Hypotension | Canada Vigilance: 1 | Canada Vigilance | |
| 80 | Intentional self-injury | Canada Vigilance: 1 | Canada Vigilance | |
| 81 | Intracranial Aneurysm | Canada Vigilance: 1 | Canada Vigilance | |
| 82 | Limb discomfort | Canada Vigilance: 1 | Canada Vigilance | |
| 83 | Maternal exposure during pregnancy | Canada Vigilance: 2 | Canada Vigilance | |
| 84 | Musculoskeletal stiffness | Canada Vigilance: 1 | Canada Vigilance | |
| 85 | Myalgia | Canada Vigilance: 1 | Canada Vigilance | |
| 86 | Myocardial Infarction | Canada Vigilance: 1 | Canada Vigilance | |
| 87 | Palpitations | Canada Vigilance: 1 | Canada Vigilance | |
| 88 | Pelvic Pain | Canada Vigilance: 2 | Canada Vigilance | |
| 89 | Peptic Ulcer | Canada Vigilance: 1 | Canada Vigilance | |
| 90 | Peripheral swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 91 | Pyelonephritis | Canada Vigilance: 1 | Canada Vigilance | |
| 92 | Quality of life decreased | Canada Vigilance: 1 | Canada Vigilance | |
| 93 | Sarcoma | Canada Vigilance: 1 | Canada Vigilance | |
| 94 | Swelling | Canada Vigilance: 1 | Canada Vigilance | |
| 95 | Urinary tract infection | Canada Vigilance: 1 | Canada Vigilance | |
| 96 | Visual Impairment | Canada Vigilance: 1 | Canada Vigilance | |
| 97 | Vitreous floaters | Canada Vigilance: 1 | Canada Vigilance | |
| 98 | Weight Gain | 10574641 | CTD |
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