elagolix
(HEAUOKZIVMZVQL-VWLOTQADSA-N)
Structure
- SMILES
- COc1cccc(c1F)c1c(=O)n(C[C@@H](c2ccccc2)NCCCC(=O)O)c(=O)n(c1C)Cc1c(F)cccc1C(F)(F)F
- Type(s)
- Approved; Investigational
- Molecular Formula:
- C32H30F5N3O5
- Molecular Weight:
- 631.590
- Log P:
- 5.9259
- Hydrogen Bond Acceptor:
- 8
- Hydrogen Bond Donor:
- 2
- TPSA:
- 102.56
- CAS Number(s):
- 834153-87-6
Synonym(s)
1.
elagolix
2.
R-(+)-4-(2-(5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl)-1-phenylethylamino)butyrate
External Link(s)
Adverse Drug Event(s)
| Name | Number of Reports | Reference(s) | Data Source | |
|---|---|---|---|---|
| 1 | Nausea | FAERS: 41 | US FAERS | |
| 2 | Pain | FAERS: 25 | US FAERS | |
| 3 | Drug ineffective | FAERS: 19 Canada Vigilance: 2 | Canada Vigilance US FAERS | |
| 4 | Headache | FAERS: 17 | US FAERS | |
| 5 | Endometriosis | FAERS: 13 | 21657270 | CTD US FAERS |
| 6 | Mood swings | FAERS: 12 | US FAERS | |
| 7 | Arthralgia | FAERS: 11 | US FAERS | |
| 8 | Anxiety | FAERS: 10 | US FAERS | |
| 9 | Fatigue | FAERS: 10 | US FAERS | |
| 10 | Menorrhagia | FAERS: 9 | US FAERS | |
| 11 | Vomiting | FAERS: 9 | US FAERS | |
| 12 | Dizziness | FAERS: 8 | US FAERS | |
| 13 | Urticaria | FAERS: 7 | US FAERS | |
| 14 | Crying | FAERS: 6 | US FAERS | |
| 15 | Feeling abnormal | FAERS: 6 | US FAERS | |
| 16 | Night sweats | FAERS: 6 | US FAERS | |
| 17 | Pelvic Pain | FAERS: 5 | US FAERS | |
| 18 | Abdominal Pain | FAERS: 4 | US FAERS | |
| 19 | Acne | FAERS: 4 | US FAERS | |
| 20 | Adverse event | FAERS: 4 | US FAERS | |
| 21 | Chest Pain | FAERS: 4 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 22 | Emotional disorder | FAERS: 4 | US FAERS | |
| 23 | Metrorrhagia | FAERS: 4 | US FAERS | |
| 24 | Product dose omission | FAERS: 4 | US FAERS | |
| 25 | Alopecia | FAERS: 3 | US FAERS | |
| 26 | Back Pain | FAERS: 3 | US FAERS | |
| 27 | Dyspepsia | FAERS: 3 | US FAERS | |
| 28 | Hysterectomy | FAERS: 3 | US FAERS | |
| 29 | Vulvovaginal dryness | FAERS: 3 | US FAERS | |
| 30 | Abdominal discomfort | FAERS: 2 | US FAERS | |
| 31 | Anger | FAERS: 2 | US FAERS | |
| 32 | Constipation | FAERS: 2 | US FAERS | |
| 33 | Cyst | FAERS: 2 | US FAERS | |
| 34 | Dyspareunia | FAERS: 2 | US FAERS | |
| 35 | Emotional distress | FAERS: 2 | US FAERS | |
| 36 | Intentional product misuse | FAERS: 2 | US FAERS | |
| 37 | Musculoskeletal Pain | FAERS: 2 | US FAERS | |
| 38 | Palpitations | FAERS: 2 Canada Vigilance: 1 | Canada Vigilance US FAERS | |
| 39 | Product dispensing error | FAERS: 2 | US FAERS | |
| 40 | Somnolence | FAERS: 2 | US FAERS | |
| 41 | Tachycardia | FAERS: 2 | US FAERS | |
| 42 | Tremor | FAERS: 2 | US FAERS | |
| 43 | Urge Incontinence | FAERS: 2 | US FAERS | |
| 44 | Altered state of consciousness | FAERS: 1 | US FAERS | |
| 45 | Anorgasmia | FAERS: 1 | US FAERS | |
| 46 | Arthritis | FAERS: 1 | US FAERS | |
| 47 | Aura | FAERS: 1 | US FAERS | |
| 48 | Bone pain | FAERS: 1 | US FAERS | |
| 49 | Carpal Tunnel Syndrome | FAERS: 1 | US FAERS | |
| 50 | Cerebrovascular accident | FAERS: 1 | US FAERS | |
| 51 | Chest discomfort | FAERS: 1 | US FAERS | |
| 52 | Dehydration | FAERS: 1 | US FAERS | |
| 53 | Depressed mood | FAERS: 1 | US FAERS | |
| 54 | Endometrial thickening | FAERS: 1 | US FAERS | |
| 55 | Epilepsy | FAERS: 1 | US FAERS | |
| 56 | Feeling Cold | FAERS: 1 | US FAERS | |
| 57 | Fibromyalgia | FAERS: 1 | US FAERS | |
| 58 | Gastrointestinal motility disorder | FAERS: 1 | US FAERS | |
| 59 | General symptom | FAERS: 1 | US FAERS | |
| 60 | Head discomfort | FAERS: 1 | US FAERS | |
| 61 | Hernia | FAERS: 1 | US FAERS | |
| 62 | Hormone level abnormal | FAERS: 1 | US FAERS | |
| 63 | Hypersensitivity | FAERS: 1 | US FAERS | |
| 64 | Inadequate analgesia | FAERS: 1 | US FAERS | |
| 65 | Inappropriate schedule of product administration | FAERS: 1 | US FAERS | |
| 66 | Inflammatory marker increased | FAERS: 1 | US FAERS | |
| 67 | Insurance issue | FAERS: 1 | US FAERS | |
| 68 | Intentional self-injury | FAERS: 1 | US FAERS | |
| 69 | Intestinal Obstruction | FAERS: 1 | US FAERS | |
| 70 | Joint swelling | FAERS: 1 | US FAERS | |
| 71 | Malaise | FAERS: 1 | US FAERS | |
| 72 | Medication Error | FAERS: 1 | US FAERS | |
| 73 | Memory impairment | FAERS: 1 | US FAERS | |
| 74 | Muscle enzyme increased | FAERS: 1 | US FAERS | |
| 75 | Musculoskeletal chest pain | FAERS: 1 | US FAERS | |
| 76 | Musculoskeletal stiffness | FAERS: 1 | US FAERS | |
| 77 | Myalgia | FAERS: 1 | US FAERS | |
| 78 | Nasopharyngitis | FAERS: 1 | US FAERS | |
| 79 | Ovulation disorder | FAERS: 1 | US FAERS | |
| 80 | Partner stress | FAERS: 1 | US FAERS | |
| 81 | Pelvic adhesions | FAERS: 1 | US FAERS | |
| 82 | Personality Change | FAERS: 1 | US FAERS | |
| 83 | Physical assault | FAERS: 1 | US FAERS | |
| 84 | Premature Menopause | FAERS: 1 | US FAERS | |
| 85 | Product use complaint | FAERS: 1 | US FAERS | |
| 86 | Product use in unapproved indication | FAERS: 1 | US FAERS | |
| 87 | Pruritus | FAERS: 1 | US FAERS | |
| 88 | Retching | FAERS: 1 | US FAERS | |
| 89 | Rosacea | FAERS: 1 | US FAERS | |
| 90 | Salpingo-oophorectomy unilateral | FAERS: 1 | US FAERS | |
| 91 | Screaming | FAERS: 1 | US FAERS | |
| 92 | Stress | FAERS: 1 | US FAERS | |
| 93 | Suicide attempt | FAERS: 1 | US FAERS | |
| 94 | Suspected suicide attempt | FAERS: 1 | US FAERS | |
| 95 | Swelling | FAERS: 1 | US FAERS | |
| 96 | Throat irritation | FAERS: 1 | US FAERS | |
| 97 | Thrombosis | FAERS: 1 | US FAERS | |
| 98 | Toothache | FAERS: 1 | US FAERS | |
| 99 | Unevaluable event | FAERS: 1 | US FAERS | |
| 100 | Vulvovaginal swelling | FAERS: 1 | US FAERS | |
| 101 | Weight decreased | FAERS: 1 | US FAERS | |
| 102 | colonoscopy | FAERS: 1 | US FAERS | |
| 103 | jaundice | FAERS: 1 | US FAERS |
Powered by :
Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120239
Copyright © 2019-2020 Laboratory of Molecular Modeling and Design, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology. All rights reserved.