MetaADEDB 2.0 @ LMMD
Metyrapone
(FJLBFSROUSIWMA-UHFFFAOYSA-N)
Structure
SMILES
O=C(C(c1cccnc1)(C)C)c1cccnc1
Type(s)
Approved; Investigational
ATC code(s)
V04CD01
Molecular Formula:
C14H14N2O
Molecular Weight:
226.274
Log P:
2.6371
Hydrogen Bond Acceptor:
3
Hydrogen Bond Donor:
0
TPSA:
42.85
CAS Number(s):
54-36-4
Synonym(s)
1.
Metyrapone
2.
Methbipyranone
3.
Methopyrapone
4.
Metopiron
5.
Metopirone
6.
Métopirone
7.
SU 4885
External Link(s)
MeSHD008797
PubChem Compound4174
BindingDB50028166
ChEBI44241
CHEMBLCHEMBL934
DrugBankDB01011
DrugCentral1791
IUPHAR/BPS Guide to PHARMACOLOGY5224
KEGGcpd:C07205
dr:D00410
Therapeutic Target DatabaseD0Q9JT
ZINC1728
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Pneumocystis jiroveci pneumoniaFAERS: 8US FAERS
2Deep Vein ThrombosisFAERS: 6US FAERS
3NauseaFAERS: 6
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
4Bronchoalveolar LavageFAERS: 5US FAERS
5MalaiseFAERS: 5US FAERS
6CellulitisFAERS: 4US FAERS
7HypotensionFAERS: 4773571CTD
SIDER
US FAERS
8Maternal exposure during pregnancyFAERS: 4US FAERS
9Pulmonary EmbolismFAERS: 4US FAERS
10Septic ShockFAERS: 4US FAERS
11ThrombocytopeniaFAERS: 4US FAERS
12AgranulocytosisFAERS: 3US FAERS
13Drug exposure during pregnancyFAERS: 3US FAERS
14HeadacheFAERS: 3SIDER
US FAERS
15Respiratory FailureFAERS: 3US FAERS
16Respiratory arrestFAERS: 3US FAERS
17AdrenalectomyFAERS: 2US FAERS
18Blood corticosterone increasedFAERS: 2US FAERS
19Cortisol free urine increasedFAERS: 2US FAERS
20HypophysectomyFAERS: 2US FAERS
21RhabdomyolysisFAERS: 2US FAERS
22Transaminases increasedFAERS: 2US FAERS
23Abdominal PainFAERS: 1SIDER
US FAERS
24AcneFAERS: 1US FAERS
25Acute kidney injuryFAERS: 1US FAERS
26AstheniaFAERS: 1US FAERS
27Blood glucose increasedFAERS: 1US FAERS
28Cardiac ArrestFAERS: 1US FAERS
29Disease ProgressionFAERS: 1US FAERS
30DizzinessFAERS: 1SIDER
US FAERS
31Factor V Leiden mutationFAERS: 1US FAERS
32FlushingFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
33General physical health deteriorationFAERS: 1US FAERS
34Gestational DiabetesFAERS: 1US FAERS
35Glucocorticoid deficiencyFAERS: 1US FAERS
36Incorrect route of drug administrationFAERS: 1US FAERS
37LipohypertrophyFAERS: 1US FAERS
38Low birth weight babyFAERS: 1US FAERS
39Muscle strainFAERS: 1US FAERS
40NeutropeniaFAERS: 1US FAERS
41Oral candidiasisFAERS: 1US FAERS
42PallorFAERS: 1US FAERS
43PneumoniaFAERS: 1US FAERS
44Pre-EclampsiaFAERS: 1US FAERS
45Respiratory distressFAERS: 1US FAERS
46StillbirthFAERS: 1US FAERS
47SyncopeFAERS: 1US FAERS
48TachycardiaFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
49VasculitisFAERS: 1US FAERS
50VomitingFAERS: 1
Canada Vigilance: 3		Canada Vigilance
SIDER
US FAERS
51jaundiceFAERS: 1US FAERS
52Abdominal discomfortSIDER
53Adrenal Gland Diseases638031CTD
54Allergic rashSIDER
55AlopeciaSIDER
56Apparent mineralocorticoid excess15521956CTD
57Arteriosclerosis638031CTD
58Bone marrow depressionSIDER
59Cardiomegaly638031CTD
60Chemical and Drug Induced Liver Injury3187193
21546349		CTD
61Cocaine-Related Disorders18588533
18692521		CTD
62Cushing Syndrome11308052CTD
63Gastrointestinal PainSIDER
64HirsutismSIDER
65Kidney Diseases638031CTD
66Memory Disorders16515786CTD
67PainSIDER
68PancytopeniaSIDER
69Rash erythematousCanada Vigilance: 1Canada Vigilance
70Seizures871909CTD
71Substance Withdrawal Syndrome18341515CTD
72Vertigo5102063CTD
73White blood cell count decreasedSIDER
74nervous system disorderSIDER
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